Therapeutic implications of activation of the host gene (Dleu2) promoter for miR-15a/16-1 in chronic lymphocytic leukemia

Coordinated Expression of Pax-5 and FAK1 in Metastasis

(2012) Nicolas Crapoulet et al.   Anti-Cancer Agents in Medicinal Chemistry

HDAC isoenzyme expression is deregulated in chronic lymphocytic leukemia B-cells and has a complex prognostic significance

(2012) Michaël Van Damme et al.   Epigenetics

CD19 is a major B cell receptor–independent activator of MYC-driven B-lymphomagenesis

(2012) Elaine Y. Chung et al.   JOURNAL OF CLINICAL INVESTIGATION

Minimal Residual Disease Quantification Is an Independent Predictor of Progression-Free and Overall Survival in Chronic Lymphocytic Leukemia: A Multivariate Analysis From the Randomized GCLLSG CLL8 Trial

(2012) Sebastian Böttcher et al.   JOURNAL OF CLINICAL ONCOLOGY

Histone deacetylases and cancer

(2012) Bruna Barneda-Zahonero et al.   Molecular Oncology

Detectable clonal mosaicism from birth to old age and its relationship to cancer

(2012) Cathy C Laurie et al.   NATURE GENETICS

Histone Deacetylase in Chronic Lymphocytic Leukemia

(2012) J.C. Wang et al.   ONCOLOGY

Neuronal mRNAs travel singly into dendrites

(2012) M. Batish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia

(2011) D. Sampath et al.   BLOOD

The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications

(2011) E. Campo et al.   BLOOD

The Pax-5 Gene: A Pluripotent Regulator of B-cell Differentiation and Cancer Disease

(2011) P. O'Brien et al.   CANCER RESEARCH

Phase I Study of Decitabine in Combination with Vorinostat in Patients with Advanced Solid Tumors and Non-Hodgkin's Lymphomas

(2011) Anastasios Stathis et al.   CLINICAL CANCER RESEARCH

Analysis of apoptosis regulatory genes altered by histone deacetylase inhibitors in chronic lymphocytic leukemia cells

(2011) Alba Pérez-Perarnau et al.   Epigenetics

Systemic in vivo lentiviral delivery of miR-15a/16 reduces malignancy in the NZB de novo mouse model of chronic lymphocytic leukemia

(2011) S Kasar et al.   GENES AND IMMUNITY

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

(2011) Omar Khan et al.   IMMUNOLOGY AND CELL BIOLOGY

Opportunities and Challenges in the Development of Experimental Drug Combinations for Cancer

(2011) R. W. Humphrey et al.   JNCI-Journal of the National Cancer Institute

Immunophenotypic and gene expression analysis of monoclonal B-cell lymphocytosis shows biologic characteristics associated with good prognosis CLL

(2011) M C Lanasa et al.   LEUKEMIA

Evaluation of PAX5 gene in the early stages of leukemic B cells in the childhood B cell acute lymphoblastic leukemia

(2011) Sinem Firtina et al.   LEUKEMIA RESEARCH

Myc represses miR-15a/miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas

(2011) X Zhang et al.   ONCOGENE

13q14 deletions in CLL involve cooperating tumor suppressors

(2010) A. Palamarchuk et al.   BLOOD

c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster

(2010) Elaine Y. Chung et al.   CANCER BIOLOGY & THERAPY

The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia

(2010) Ulf Klein et al.   CANCER CELL

The New Zealand black mouse as a model for the development and progression of chronic lymphocytic leukemia

(2010) Erica Salerno et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Overexpression of PAX5 induces apoptosis in multiple myeloma cells

(2010) Maryse Proulx et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Phase II Study of Belinostat (PXD101), a Histone Deacetylase Inhibitor, for Second Line Therapy of Advanced Malignant Pleural Mesothelioma

(2010) Suresh S. Ramalingam et al.   Journal of Thoracic Oncology

Restoring the functional immunogenicity of chronic lymphocytic leukemia using epigenetic modifiers

(2010) Jason A. Dubovsky et al.   LEUKEMIA RESEARCH

The Histone Deacetylase Inhibitor MGCD0103 Induces Apoptosis in B-Cell Chronic Lymphocytic Leukemia Cells through a Mitochondria-Mediated Caspase Activation Cascade

(2010) V. El-Khoury et al.   MOLECULAR CANCER THERAPEUTICS

The Novel Deacetylase Inhibitor AR-42 Demonstrates Pre-Clinical Activity in B-Cell Malignancies In Vitro and In Vivo

(2010) David M. Lucas et al.   PLoS One

Vorinostat in solid and hematologic malignancies

(2009) David Siegel et al.   Journal of Hematology & Oncology

PAX5 activates the transcription of the human telomerase reverse transcriptase gene in B cells

(2009) Stéphanie Bougel et al.   JOURNAL OF PATHOLOGY

PAX5 is expressed in small-cell lung cancer and positively regulates c-Met transcription

(2009) Rajani Kanteti et al.   LABORATORY INVESTIGATION

Chronic lymphocytic leukemia and 13q14: miRs and more

(2009) Daniel Mertens et al.   LEUKEMIA & LYMPHOMA

Correcting miR-15a/16 genetic defect in New Zealand Black mouse model of CLL enhances drug sensitivity

(2009) E. Salerno et al.   MOLECULAR CANCER THERAPEUTICS

Investigating the Targets of MIR-15a and MIR-16-1 in Patients with Chronic Lymphocytic Leukemia (CLL)

(2009) Katy Hanlon et al.   PLoS One

Further progress in CLL therapy

(2008) E. Montserrat   BLOOD

The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells

(2008) H. Zhao et al.   BLOOD

Development of an isoform-specific gene suppression system: the study of the human Pax-5B transcriptional element

(2008) G. A. Robichaud et al.   NUCLEIC ACIDS RESEARCH

MiR-15a and miR-16-1 cluster functions in human leukemia

(2008) George A. Calin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA