Article
Oncology
Lisa Gruentkemeier, Aditi Khurana, Farideh Zamaniyan Bischoff, Oliver Hoffmann, Rainer Kimmig, Mathew Moore, Philip Cotter, Sabine Kasimir-Bauer
Summary: The study utilized the DEPArray(TM) system for HER2/FISH analysis, which can identify HER2/FISH discordance in BC patients, aiding in determining the need for anti-HER2 therapy.
Review
Biochemistry & Molecular Biology
Blair Mcnamara, Michelle Greenman, Nicole Pebley, Levent Mutlu, Alessandro D. Santin
Summary: This review provides an overview of the application of antibody-drug conjugates (ADCs) as a targeted anti-cancer therapy, focusing on the use of HER2-targeting ADC therapy in gynecologic malignancies.
Article
Oncology
Fatma Nihan Akkoc Mustafayev, Mihir Amitabh Shukla, Amanda Lanier, Denai R. Milton, Angelica M. Gutierrez, Stephen K. Gruschkus, John E. Lewis, Rashmi K. Murthy, Banu K. Arun
Summary: BRCA1/2 mutations occurred in 6.6% of patients with human epidermal growth factor receptor 2 (HER2/neu)-positive breast cancer. However, BRCA mutation status did not affect survival outcomes in patients who had HER2/neu-positive breast cancer.
Review
Oncology
Serenella M. Pupa, Francesca Ligorio, Valeria Cancila, Alma Franceschini, Claudio Tripodo, Claudio Vernieri, Lorenzo Castagnoli
Summary: Breast cancer is a group of different tumors, with altered HER2 expression defining a particularly aggressive subtype. Understanding HER2 biology and the mechanisms underlying aggressiveness and drug susceptibility is crucial. Breast cancer stem cells play a significant role in tumor growth, aggressiveness, metastasis, and treatment resistance.
Review
Biochemistry & Molecular Biology
Vladimir V. Sobolev, Ekaterina Tchepourina, Irina M. Korsunskaya, Natalia A. Geppe, Svetlana N. Chebysheva, Anna G. Soboleva, Alexandre Mezentsev
Summary: This review discusses the role of PPAR-gamma in the pathogenesis of psoriasis and evaluates the potential of PPAR-gamma agonists as therapeutic options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Fan Lai, Jingjing Wang, Hong Tang, Xuting Bian, Kang Lu, Gang He, Pan Huang, Juan Liu, Mei Zhou, Jian Liu, Xu Tao, Kang-lai Tang
Summary: The study found that aging inhibits adipogenesis of TSPCs by down-regulating PPAR gamma signaling, rather than causing adipocyte accumulation during tendon repair due to aging of TSPCs. This may provide new targets for treating aging tendon injuries or tendinopathies.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Review
Oncology
Tiange Chi, Mina Wang, Xu Wang, Ke Yang, Feiyu Xie, Zehuan Liao, Peng Wei
Summary: PPARs are lipid sensors and metabolic regulators, with PPAR-γ showing potential in inhibiting cell proliferation, inducing apoptosis, and disrupting inflammation. However, safety concerns including drug interactions need to be addressed for clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Engineering, Biomedical
Shengwei Jiang, Weihan Liu, Dan Shi, Huan Cheng, Tingwei Deng, Guoyong Chen, Li Ma, Xianbin Zhang, Peng Gong
Summary: Black phosphorus (BP) has potential clinical applications, and this study investigates its potential as a targeting PPAR-? agonist to overcome chemoresistance in pancreatic adenocarcinoma (PAAD). The study uses different cell models and mouse models to explore the effects of BP on PPAR pathway and stem-like cancer cells. The research demonstrates that BP can inhibit cancer stem cell properties and enhance the treatment efficacy of PAAD when combined with gemcitabine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Gastroenterology & Hepatology
Xiaomin Su, Mengli Jin, Chen Xu, Yunhuan Gao, Yazheng Yang, Houbao Qi, Qianjing Zhang, Xiaorong Yang, Wang Ya, Yuan Zhang, Rongcun Yang
Summary: This study reveals that FABP4 in the Paneth cells can downregulate the expression of defensins by degrading PPAR-gamma. This downregulation not only occurs in mice, but also in humans. Additionally, a high-fat diet induces an increase in FABP4 in Paneth cells, leading to a decrease in defensin expression. These findings are important for understanding the underlying factors of modern diseases.
Article
Cell Biology
Christopher E. Eyermann, Jinyu Li, Evguenia M. Alexandrova
Summary: Pregnancy is known to reduce the risk of breast cancer, but it may promote HER2+ BC. Studies have shown that pregnancy can increase the incidence of HER2+ BC in mice models, possibly linked to the tumor-initiating properties of PIMECs. The gene p63 plays a complex role in maintaining PIMEC quantity while suppressing their tumorigenic capacity.
CELL DEATH & DISEASE
(2021)
Review
Immunology
Daniel Toobian, Pradipta Ghosh, Gajanan D. Katkar
Summary: This review article focuses on the potential roles of peroxisome proliferator-activated receptors (PPARs) in macrophage biology, as well as the modulation of immune cell function, microbial infection, and inflammatory diseases by dual and pan PPAR agonists.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Hao Yue, Zhibing Leng, Yuying Bo, Yingying Tian, Ziyi Yan, Changhu Xue, Ping Dong, Jingfeng Wang
Summary: The effect of sea cucumber intestinal peptide (SCIP) on the differentiation fate of bone mesenchymal stem cells (BMSCs) was investigated in this study. It was found that SCIP promotes the proliferation and osteogenic differentiation of BMSCs, and maintains the phosphorylation of PPAR gamma Ser112 through the AMPK/ERK and TAZ signaling pathways, thereby inducing the osteogenic differentiation of BMSCs. These results suggest that SCIP has potential as a functional food to improve obesity and osteoporosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Endocrinology & Metabolism
Nagendra P. Palani, Carla Horvath, Pascal N. Timshel, Pytrik Folkertsma, Alexander G. B. Gronning, Tora I. Henriksen, Lone Peijs, Verena H. Jensen, Wenfei Sun, Naja Z. Jespersen, Christian Wolfrum, Tune H. Pers, Soren Nielsen, Camilla Scheele
Summary: This study reveals the presence of an adipogenic and a structural branch of cells, known as SWAT cells, in progenitor cells from human adipose depots. The adipogenic branch is characterized by mitochondrial activity genes and is associated with fat distribution traits. The structural branch, called SWAT cells, display a multipotent phenotype and can revert back to progenitor state or differentiate into new adipogenic cells. This differentiation map provides a new perspective on adipose tissue regulation.
Article
Peripheral Vascular Disease
Wen-Lin Cheng, Quan Zhang, Jian-Lei Cao, Xi-Lu Chen, Wenyan Li, Lin Zhang, Sheng-Ping Chao, Fang Zhao
Summary: ALK7 is upregulated in oxidized LDL-induced BMDMs and MPMs from ApoE-deficient mice, and ALK7 knockdown attenuates pro-inflammatory markers while promoting anti-inflammatory markers expression. Additionally, ALK7 silencing reduces foam cell formation by regulating genes involved in cholesterol efflux and influx, with upregulation of PPAR gamma.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Article
Pharmacology & Pharmacy
Antonio Fernando Leis-Filho, Patricia de Faria Lainetti, Priscila Emiko Kobayashi, Carlos Eduardo Fonseca-Alves, Renee Laufer-Amorim
Summary: HER2 is widely used in breast cancer as a prognostic marker. Lapatinib, a tyrosine kinase inhibitor, can inhibit cell proliferation in HER2+ breast cancer, with higher HER2 expression correlating to greater sensitivity to treatment. However, it may not always effectively inhibit cell migration.
Article
Oncology
Leila Kokabee, Xianhui Wang, Christopher J. Sevinsky, Wei Lin Winnie Wang, Lindsay Cheu, Sridar V. Chittur, Morteza Karimipoor, Martin Tenniswood, Douglas S. Conklin
CANCER BIOLOGY & THERAPY
(2015)
Article
Oncology
Jan Baumann, Jason Wong, Yan Sun, Douglas S. Conklin
Article
Oncology
Xianhui Wang, Jason Wong, Christopher J. Sevinsky, Leila Kokabee, Faiza Khan, Yan Sun, Douglas S. Conklin
MOLECULAR CANCER THERAPEUTICS
(2016)
Article
Chemistry, Multidisciplinary
Yanxiang Deng, Steven P. Davis, Fan Yang, Kevin S. Paulsen, Maneesh Kumar, Rebecca Sinnott DeVaux, Xianhui Wang, Douglas S. Conklin, Assad Oberai, Jason I. Herschkowitz, Aram J. Chung
Review
Biochemistry & Molecular Biology
Jan Baumann, Christopher Sevinsky, Douglas S. Conklin
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2013)
Article
Oncology
Alejandro P. Adam, Ajish George, Denis Schewe, Paloma Bragado, Bibiana V. Iglesias, Aparna C. Ranganathan, Antonis Kourtidis, Douglas S. Conklin, Julio A. Aguirre-Ghiso
Article
Oncology
Antonis Kourtidis, Ritu Jain, Richard D. Carkner, Cheryl Eifert, M. Julia Brosnan, Douglas S. Conklin
Article
Oncology
Cheryl Eifert, Xianhui Wang, Leila Kokabee, Antonis Kourtidis, Ritu Jain, Michael J. Gerdes, Douglas S. Conklin
GENES CHROMOSOMES & CANCER
(2013)
Article
Biotechnology & Applied Microbiology
John P. Rooney, Ajish D. George, Ashish Patil, Ulrike Begley, Erin Bessette, Maria R. Zappala, Xin Huang, Douglas S. Conklin, Richard P. Cunningham, Thomas J. Begley
Article
Cell Biology
Christopher B. O'Connell, Jadranka Loncarek, Polla Hergert, Antonis Kourtidis, Douglas S. Conklin, Alexey Khodjakov
JOURNAL OF CELL BIOLOGY
(2008)
Article
Biochemistry & Molecular Biology
Daiying Xu, Vamsee-Krishna Chatakonda, Antonis Kourtidis, Douglas S. Conklin, Hua Shi
NUCLEIC ACID THERAPEUTICS
(2014)
Article
Oncology
Christopher J. Sevinsky, Faiza Khan, Leila Kokabee, Anza Darehshouri, Krishna Rao Maddipati, Douglas S. Conklin
BREAST CANCER RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Nicolas Garnier, Genevieve G. J. Redstone, Michael S. Dahabieh, Jessica N. Nichol, Sonia V. del Rincon, Yuxuan Gu, D. Scott Bohle, Yan Sun, Douglas S. Conklin, Koren K. Mann, Wilson H. Miller
MOLECULAR PHARMACOLOGY
(2014)
Article
Oncology
Antonis Kourtidis, Rekha Srinivasaiah, Richard D. Carkner, M. Julia Brosnan, Douglas S. Conklin
BREAST CANCER RESEARCH
(2009)