Article
Plant Sciences
Mengran Zhao, Chen Qiao, Zilu Cui, Wen Zhang, Shuyue Yang, Congmin Zhu, Feng Du, Tingting Ning, Sian Xie, Si Liu, Peng Li, Junxuan Xu, Shengtao Zhu
Summary: This study demonstrates that Moluodan (MLD) has an obvious hemostatic effect but exacerbates the severity of inflammation in a mouse model of colitis by promoting macrophage polarization towards the M1 phenotype.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Xingchen Geng, Yiwei Wang, Haohao Cui, Chengcheng Li, Boyuan Cheng, Bingbing Cui, Ruixing Liu, Junjie Zhang, Lei Zhu, Jingguo Li, Jianliang Shen, Zhanrong Li
Summary: The effect of carboxymethyl chitosan (CMCS) on subconjunctival inflammation and its mechanism were investigated. CMCS showed inhibitory effects on subconjunctival inflammation, as evidenced by reduced conjunctival edema and congestion, improved conjunctival epithelial reconstruction, and decreased expression of inflammatory factors. CMCS inhibited the infiltration of macrophages and downregulated the expressions of iNOS, IL-6, IL-8, and TNF-a in the conjunctiva.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Yingke Zhou, Xin Jin, Haixin Yu, Gengdu Qin, Penglin Pan, Jingyuan Zhao, Taoyu Chen, Xueyi Liang, Yan Sun, Bo Wang, Dianyun Ren, Shikai Zhu, Heshui Wu
Summary: This study reveals the role of HDAC5 in regulating the NF-KB signaling pathway and antitumor immune responses in PDAC. HDAC5 downregulation is associated with favorable prognosis in PDAC patients. HDAC5 regulates PD-L1 expression by interacting with NF-KB p65 and its inhibition sensitizes PDAC tumors to immune checkpoint blockade therapy.
Article
Oncology
Yu Ren, Jinying He, Wenhua Zhao, Yuzhen Ma
Summary: The study demonstrated that VB can inhibit the proliferation and migration of OC cells by downregulating CCN1, promoting apoptosis, and inducing M1 macrophage polarization. Experimental results indicated that VB achieves these effects by modulating the AKT/NF-kappa B pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Xiaowei Sun, Lusheng Ma, Xiao Li, Jiao Wang, Yuanbin Li, Zijing Huang
Summary: Ferulic acid (FA) inhibits hypoxia-induced retinal angiogenesis by regulating microglia/macrophage polarization and alleviating inflammatory response, providing a potential therapeutic strategy for retinal neovascular diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lloyd Tanner, Jesper Bergwik, Ravi K. Bhongir, Lang Pan, Caijuan Dong, Olov Wallner, Christina Kalderen, Thomas Helleday, Istvan Boldogh, Mikael Adner, Arne Egesten
Summary: This study investigates the potential of OGG1 as a clinically relevant pharmacological target for the treatment of allergic inflammation. The results show that TH5487 treatment decreases goblet cell hyperplasia and mucus production, reduces NF-κB activation, and decreases the expression of proinflammatory cytokines and chemokines, resulting in lower recruitment of immune cells to the lungs. The findings suggest that OGG1 inhibition may have therapeutic effects on allergic asthma.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Weibin Ruan, Xinyun Ji, Yating Qin, Xinxin Zhang, Xiaoning Wan, Chuanmeng Zhu, Chao Lv, Chongqing Hu, Juan Zhou, Li Lu, Xiaomei Guo
Summary: This study investigated the protective effects of harmine against sepsis-induced cardiomyopathy (SIC) and its underlying mechanisms. The results showed that harmine inhibited inflammation and apoptosis, alleviated cardiac dysfunction in mice, and suppressed M1 polarization and inflammatory responses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Plant Sciences
Xin Dong, Jialin Jiang, Zhijun Lin, Ruijia Wen, Ling Zou, Tong Luo, Zhuoji Guan, Xuan Li, Linhai Wang, Lu Lu, Huan Li, Yusheng Huang, Zhongqi Yang, Junyan Wang, Xiaohan Ye, Xiaohua Hong, Lingjun Wang, Shaoxiang Xian, Zixin Chen
Summary: This study demonstrated that Nuanxinkang (NXK) has a protective effect on ischemia/reperfusion (IR)-induced heart failure (HF). NXK modulates the ratio of proinflammatory and anti-inflammatory macrophages, reducing inflammation and improving cardiac function. The results suggest that NXK could be a natural strategy for the anti-inflammatory treatment of HF.
Article
Cell Biology
Jiaqi Fang, Qian Ou, Boheng Wu, Sisi Li, Mian Wu, Jialing Qiu, Nuo Cen, Kaixin Hu, Yangfei Che, Yuan Ma, Jianping Pan
Summary: This study investigated the influence of TcpC, a virulence factor of Uropathogenic Escherichia coli (UPEC), on the polarization of macrophages into M1 and M2 subsets and the potential mechanisms involved. The results showed that TcpC inhibits M1 macrophage polarization through down-regulation of p38, ERK/NF-κB signaling pathways, while promoting M2 macrophage polarization through up-regulation of the Akt/STAT6 signaling pathway. These findings not only shed light on the regulatory effects of TcpC on macrophage polarization and signaling pathways, but also provide a novel mechanism for TcpC-mediated evasion of macrophage-mediated innate immunity.
Article
Medicine, Research & Experimental
Li Li, Wen-Tao Zuo, Hui Liu, Lan-Shan Liao, Wen-Ying Shen, Zhen-Feng Chen, Hong Liang
Summary: In this study, we synthesized and characterized a oxoaporphine Pr(III) complex that was found to inhibit the progression and metastasis of hepatocellular carcinoma (HCC) by disrupting the communication between HCC cells and macrophages. The complex upregulated certain molecules in macrophages and inhibited their polarization, which significantly inhibited HCC cell proliferation, migration, and invasion. Additionally, the complex inhibited the migration, invasion, and chemotaxis of HCC cells by downregulating the expression of certain markers. Overall, this is the first report of a lanthanide complex exerting regulatory effects on both tumors and tumor-associated macrophages, providing a new strategy for the development of effective antitumor drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Liguo Lang, Dongju Zheng, Qingjun Jiang, Ting Meng, Xiaohu Ma, Yang Yang
Summary: This study investigated the role of uncoupling protein 2 (UCP2) in regulating macrophage polarization, metabolism, inflammation, and oxidative stress. The findings suggest that UCP2 is involved in the regulation of macrophage polarization, with M1 macrophages suppressing UCP2 expression while M2 macrophages increasing UCP2 expression. UCP2 overexpression decreased glycolysis, increased oxidative phosphorylation, and reduced reactive oxygen species production, leading to the conversion of M1 polarization to M2 polarization.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Guodong Wang, Xuegang Liu, Xia Li, Yunbo Zhao
Summary: The study identified PAPP-A as a positive regulator of atherosclerosis by modulating macrophage polarization through the STAT3 signaling pathway, suggesting it as a potential therapeutic target for atherosclerosis treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Immunology
Zhending Gan, Meiyu Zhang, Donghui Xie, Xiaoyan Wu, Changming Hong, Jian Fu, Lijuan Fan, Shengyi Wang, Sufang Han
Summary: Glycine, acting as an inhibitory neurotransmitter, not only affects the functions of macrophages but also shapes their polarization through cellular signaling pathways and microRNAs. Additionally, glycine has beneficial effects in preventing and treating macrophage-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Lu Ding, Yan Liang, Yuzhen Wang, Zheng Tong, Wen Liu, Siyu Tan, Jie Zhang, Yingchun Wang, Zhuanchang Wu, Xiaohong Liang, Chunhong Ma, Lifen Gao
Summary: Tim-4 is a critical switch that regulates macrophage polarization and maintains adipose tissue homeostasis. Its deficiency may lead to obesity. Tim-4 promotes M2-like macrophage polarization by suppressing the NF-κB signaling pathway.
Article
Biotechnology & Applied Microbiology
Jian Xie, Xiaowei Wu, Shang Zheng, Kaili Lin, Jiansheng Su
Summary: Delayed wound healing is a challenge, and this study demonstrates that aligned electrospun nanofibers can promote wound healing by influencing macrophage morphology and phenotype, as well as alleviate the local inflammatory response and promote angiogenesis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Richard F. Knoop, Golo Petzold, Ahmad Amanzada, Sebastian C. B. Bremer, Thomas M. Gress, Volker Ellenrieder, Albrecht Neesse, Steffen Kunsch
Article
Gastroenterology & Hepatology
Masayuki Kitano, Thomas M. Gress, Pramod K. Garg, Takao Itoi, Atsushi Irisawa, Hiroyuki Isayama, Atsushi Kanno, Kei Takase, Michael Levy, Ichiro Yasuda, Phillipe Levy, Shuiji Isaji, Carlos Fernandez-Del Castillo, Asbjorn M. Drewes, Andrea R. G. Sheel, John P. Neoptolemos, Tooru Shimosegawa, Marja Boermeester, C. Mel Wilcox, David C. Whitcomb
Article
Oncology
Silke D. Werle, Julian D. Schwab, Marina Tatura, Sandra Kirchhoff, Robin Szekely, Ramona Diels, Nensi Ikonomi, Bence Sipos, Jan Sperveslage, Thomas M. Gress, Malte Buchholz, Hans A. Kestler
Summary: Unraveling mechanistic regulations is crucial for understanding tumor behavior and developing effective treatments. Mechanistic modeling offers a more comprehensive view of signaling pathways, identifying new therapeutic targets. In pancreatic cancer, CFL1 overexpression is associated with tumor promotion, and mechanistic modeling can predict its regulatory mechanisms and validate them through protein level analysis.
Article
Oncology
V Rosato, P. Gomez-Rubio, E. Molina-Montes, M. Marquez, M. Lohr, M. O'Rorke, C. W. Michalski, X. Molero, A. Farre, J. Perea, J. Kleeff, T. Crnogorac-Jurcevic, W. Greenhalf, L. Ilzarbe, A. Tardon, T. Gress, V. M. Barbera, E. Dominguez-Munoz, L. Munoz-Bellvis, J. Balsells, E. Costello, M. Iglesias, Bo Kong, J. Mora, D. O'Driscoll, I Poves, A. Scarpa, W. Ye, M. Hidalgo, L. Sharp, A. Carrato, F. X. Real, C. La Vecchia, N. Malats
Summary: The study supports the association between gallbladder conditions and pancreatic cancer, but due to the observed time-risk patterns, this relationship may be non-causal.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2021)
Article
Oncology
Sebastian Krug, Thomas Kegel, Thomas M. Gress, Anja Rinke, Leonidas Apostolidis, Henning Jann, Alexander Koenig, Dieter Hoersch, Joerg Schrader, Thomas J. Ettrich, Michael Richter, Joerg Steighardt, Patrick Michl
Summary: The study aims to investigate a new therapeutic approach using a combination of cytotoxic and targeted anti-angiogenic therapy in advanced PNET. If successful, this trial may lead to a randomized two-arm study comparing the combination of ramucirumab and DTIC against other established therapies in PNET.
Article
Endocrinology & Metabolism
Sami Matrood, Leonidas Apostolidis, Joerg Schrader, Sebastian Krug, Harald Lahner, Annette Ramaswamy, Damiano Librizzi, Zoltan Kender, Anke Kroecher, Simon Kreutzfeldt, Thomas Matthias Gress, Anja Rinke
Summary: The study found that presacral NENs are histopathologically similar to rectal NENs. The majority of tumors are non-functioning, and PRRT shows promising activity in treatment. Further investigation and molecular characterization are needed to understand this rare tumor entity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Sebastian Krug, Maryam Khosravian, Julia Weissbach, Katharina George, Marko Damm, Jakob Garbe, Jens Walldorf, Philipp A. Reuken, Tania Amin, Alexander Siebenhuener, Jonas Rosendahl, Thomas M. Gress, Patrick Michl, Joerg Schrader, Anja Rinke
Summary: The COVID-19 pandemic has posed significant challenges for the medical care of neuroendocrine tumor (NET) patients. A comprehensive survey was conducted to investigate healthcare structure and patient-specific concerns during the crisis, with a focus on social and emotional distress. The survey revealed that most NET patients were worried about their tumor treatment during the crisis and considered themselves at risk of severe COVID-19 infection. Increased distress in the social and psycho-emotional domains indicated a need for optimization in the medical care of NET patients.
Review
Cell Biology
Zhou Xu, Kai Hu, Peter Bailey, Christoph Springfeld, Susanne Roth, Roma Kurilov, Benedikt Brors, Thomas Gress, Malte Buchholz, Jingyu An, Kongyuan Wei, Teresa Peccerella, Markus W. Buechler, Thilo Hackert, John P. Neoptolemos
Summary: Pancreatic ductal adenocarcinoma is a highly lethal malignancy with a high mortality rate. Treatment of pancreatic cancer is challenging due to factors such as genetic mutations, activation of gene signaling pathways, and tumor microenvironment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Simone Luecke, Christian Fottner, Harald Lahner, Henning Jann, Dominik Zolnowski, Detlef Quietzsch, Patricia Grabowski, Birgit Cremer, Sebastian Maasberg, Ulrich-Frank Pape, Hans-Helge Mueller, Thomas Matthias Gress, Anja Rinke
Summary: This study analyzed real-world data from the German NET Registry, focusing on therapeutic and prognostic aspects. The study found that the median overall survival for NEN G3 patients was 31 months, and stage, performance status, and Ki67 value were significant prognostic factors in multivariate analysis.
Article
Gastroenterology & Hepatology
Petros Stathopoulos, Malte Zumblick, Sabine Waechter, Leif Schiffmann, Thomas M. Gress, Detlef Bartsch, Guido Seitz, Ulrike W. Denzer
Summary: Through retrospective analysis, we confirmed the effectiveness of endoscopic vacuum therapy (EVT) in the treatment of acute esophageal perforation. Prompt initiation of EVT is crucial for preventing abscess formation and promoting defect closure.
ENDOSCOPY INTERNATIONAL OPEN
(2022)
Article
Endocrinology & Metabolism
Elettra Merola, Aurel Perren, Anja Rinke, Alessandro Zerbi, Mairead G. McNamara, Ruza Arsenic, Nicola Fazio, Wouter de Herder, Juan W. Valle, Thomas M. Gress, Bertram Wiedenmann, Andreas Pascher, Marianne E. Pavel
Summary: The study found that in more than half of the cases with relapse after radical surgery for entero-pancreatic neuroendocrine tumors, a higher proliferative index and potentially more aggressive behavior were observed. Therefore, histological reassessment should be considered at disease recurrence to guide tailored therapeutic strategies.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Gastroenterology & Hepatology
Thomas Seufferlein, Julia Mayerle, Stefan Boeck, Thomas Brunner, Thomas J. Ettrich, Lars Grenacher, Thomas Mathias Gress, Thilo Hackert, Volker Heinemann, Angelika Kestler, Marianne Sinn, Andrea Tannapfel, Ulrich Wedding, Waldemar Uhl
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2022)
Article
Virology
Christian Bauer, Elisabeth Mack, Veronique Hefter, Alexandra Fischer, Kirsten Volland, Chrysanthi Skevaki, Andreas Neubauer, Thomas Gress, Stephan Becker, Christian Keller
Summary: Clearance of nucleocapsid antigen is delayed in severely ill COVID-19 patients, and detecting the antigen after 8 days postdiagnosis is a characteristic of patients requiring intensive care.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Gastroenterology & Hepatology
Malte Zumblick, Petros Stathopoulos, Thomas Mathias Gress, Ulrike Walburga Denzer
Summary: Serious iatrogenic bowel injuries during screening colonoscopy are rare. This report presents a successful case of endoscopic vacuum therapy (EVT) for a rectal perforation during colonoscopy. EVT should be considered for iatrogenic rectal perforation when signs of systemic inflammation are present and primary mechanical wound closure appears critical due to the depth of the defect and the presumed risk of abscess formation.
CASE REPORTS IN GASTROENTEROLOGY
(2022)
Article
Endocrinology & Metabolism
R. Fijalkowski, D. Reher, A. Rinke, T. M. Gress, J. Schrader, R. P. Baum, D. Kaemmerer, D. Hoersch
NEUROENDOCRINOLOGY
(2022)