PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling

Peroxisome Proliferator-Activated Receptor  /  Cross Talks with E2F and Attenuates Mitosis in HRAS-Expressing Cells

(2012) B. Zhu et al.   MOLECULAR AND CELLULAR BIOLOGY

Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis

(2011) Jeffrey M. Peters et al.   CANCER AND METASTASIS REVIEWS

Stable over-expression of PPARβ/δ and PPARγ to examine receptor signaling in human HaCaT keratinocytes

(2011) Michael G. Borland et al.   CELLULAR SIGNALLING

Biological Function and Prognostic Significance of Peroxisome Proliferator-Activated Receptor   in Rectal Cancer

(2011) L. Yang et al.   CLINICAL CANCER RESEARCH

WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27Kip1Degradation in Human Diploid Fibroblasts

(2011) Xiaoxiao Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional characterization of peroxisome proliferator-activated receptor-β/δ expression in colon cancer

(2011) Jennifer E. Foreman et al.   MOLECULAR CARCINOGENESIS

Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis

(2011) Alyssa L. Kennedy et al.   MOLECULAR CELL

Genomewide Analyses Define Different Modes of Transcriptional Regulation by Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ)

(2011) Till Adhikary et al.   PLoS One

Activation of Forkhead Box O Transcription Factors by Oncogenic BRAF Promotes p21cip1-Dependent Senescence

(2010) P. L. J. de Keizer et al.   CANCER RESEARCH

A ‘metastasis-prone’ signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics

(2010) Yi Hong et al.   CLINICAL & EXPERIMENTAL METASTASIS

Metabolic and nonmetabolic regulatory functions of peroxisome proliferator-activated receptor β

(2010) Paul A Grimaldi   CURRENT OPINION IN LIPIDOLOGY

RasGRP1 Is Essential for Ras Activation by the Tumor Promoter 12-O-Tetradecanoylphorbol-13-acetate in Epidermal Keratinocytes

(2010) Amrish Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemoprevention of Chemically Induced Skin Tumorigenesis by Ligand Activation of Peroxisome Proliferator-Activated Receptor- /  and Inhibition of Cyclooxygenase 2

(2010) B. Zhu et al.   MOLECULAR CANCER THERAPEUTICS

Cellular and Pharmacological Selectivity of the Peroxisome Proliferator-Activated Receptor- /  Antagonist GSK3787

(2010) P. S. Palkar et al.   MOLECULAR PHARMACOLOGY

Discovery of Novel Forkhead Box O1 Inhibitors for Treating Type 2 Diabetes: Improvement of Fasting Glycemia in Diabetic db/db Mice

(2010) T. Nagashima et al.   MOLECULAR PHARMACOLOGY

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

NF- B inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2

(2010) V. Busuttil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of integrin-linked kinase in lung squamous cell carcinoma and adenocarcinoma: correlation with E-cadherin expression, tumor microvessel density and clinical outcome

(2010) Juanhan Yu et al.   VIRCHOWS ARCHIV

3-Phosphoinositide-Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma

(2009) M. Maurer et al.   CANCER RESEARCH

Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene

(2009) Shyra J. Miller et al.   EMBO Molecular Medicine

The Intestinal Nuclear Receptor Signature With Epithelial Localization Patterns and Expression Modulation in Tumors

(2009) Salvatore Modica et al.   GASTROENTEROLOGY

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Knockdown of peroxisome proliferator-activated receptor-β induces less differentiation and enhances cell–fibronectin adhesion of colon cancer cells

(2009) L Yang et al.   ONCOGENE

Ligand Activation of Peroxisome Proliferator–Activated Receptor-β/δ and Inhibition of Cyclooxygenase-2 Enhances Inhibition of Skin Tumorigenesis

(2009) Moses T. Bility et al.   TOXICOLOGICAL SCIENCES

Quantitative expression patterns of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) protein in mice

(2008) Elizabeth E. Girroir et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Prostatic Intraepithelial Neoplasia-Dependent p27Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression

(2008) Pradip K. Majumder et al.   CANCER CELL

Ligand activation of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) inhibits chemically induced skin tumorigenesis

(2008) Moses T. Bility et al.   CARCINOGENESIS

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Role of peroxisome-proliferator-activated receptor β/δ (PPARβ/δ) in gastrointestinal tract function and disease

(2008) Jeffrey M. Peters et al.   CLINICAL SCIENCE

Ligand Activation of Peroxisome Proliferator-Activated Receptor- /  Inhibits Cell Proliferation in Human HaCaT Keratinocytes

(2008) M. G. Borland et al.   MOLECULAR PHARMACOLOGY

K-rasMutations and Benefit from Cetuximab in Advanced Colorectal Cancer

(2008) Christos S. Karapetis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Many roads lead to oncogene-induced senescence

(2008) S Courtois-Cox et al.   ONCOGENE

Effect of ligand activation of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in human lung cancer cell lines

(2008) Pengfei He et al.   TOXICOLOGY