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Biochemistry & Molecular Biology
Antonietta Notaro, Marianna Lauricella, Diana Di Liberto, Sonia Emanuele, Michela Giuliano, Alessandro Attanzio, Luisa Tesoriere, Daniela Carlisi, Mario Allegra, Anna De Blasio, Giuseppe Calvaruso, Antonella D'Anneo
Summary: Methyl gallate (MG), a gallotannin found in plants, showed potential as an anti-tumor phytomolecule for colon cancer treatment. It reduced the viability of HCT116 colon cancer cells but had no effect on differentiated Caco-2 cells. MG induced early ROS generation and ER stress, leading to autophagy and apoptotic cell death. The increase in p53 played a crucial role in the mechanism, which was tightly linked to oxidative injury.
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Medicine, General & Internal
Liang Dai, Weiyan Guo, Xingwei Xuan, Baohua Wang, Haixia Chai, Guanghua Yang, Jianli Chen, Xiaodong Meng, Yinhua Wang, Jianyi Pu
Summary: This study found that high expression of miR-142-3p in colon cancer is associated with poor prognosis. MiR-142-3p may promote colon cancer progression through autophagy- and metabolism-related pathways, and could be a potential target for the treatment of colon cancer.
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Medicine, Research & Experimental
Weiwei Wang, Linxia Chen, Wenjin Zhu, Xianjin Huang, Lin Lin, Zhenhao Quan, Kaiyu Sun, Qingwen Xu
Summary: The study revealed that in colon cancer cells resistant to cisplatin, miR-4486 expression was significantly reduced, and the overexpression of miR-4486 could increase sensitivity to cisplatin by inhibiting autophagy in HCT116/DDP and SW480/DDP cells. Additionally, ATG7 was identified as a target gene of miR-4486, indicating its role in reversing drug resistance.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
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Oncology
Ying Shi, Jinying Li, Ming Tang, Jingwen Liu, Yalu Zhong, Wei Huang
Summary: The differential expression of circHADHA in plasma may serve as a potential biomarker for screening precancerous colon polyps and a therapeutic target for colon cancer treatment. CircHADHA promotes autophagy by regulating ATG13 through miR-361, inhibiting cell growth and tumor formation in colon cancer cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Physiology
Wenmin Dong, Huiqian Zhang, Cheng Zhao, Yun Luo, Ying Chen
Summary: The study revealed that silencing miR-150-5p played a protective role in the kidneys of DN mice by targeting SIRT1, leading to activation of AMPK-dependent autophagy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Lili Zhan, Jing Yang, Yang Liu, Yanxiang Cheng, Hua Liu
Summary: Aberrant expression of GINS2 and miR-502-5p has been associated with ovarian cancer progression. Upregulation of miR-502-5p inhibited cell proliferation and migration levels, while GINS2 overexpression enhanced proliferation and migration but hampered apoptosis in OC cells. miR-502-5p targeting GINS2 suppressed OC progression by inhibiting cell growth and promoting cell apoptosis.
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Neurosciences
Xiang Xu, Caifeng Li, Junping Zou, Liang Liu
Summary: This study investigated the impact of miR-34a on sevoflurane-induced neuronal apoptosis and autophagy in neonatal mice, as well as the interactions between miR-34a, SIRT1, and p53. The results showed that sevoflurane impaired learning and memory abilities, increased cell apoptosis in the hippocampus, and hindered the survival of hippocampal neurons. MiR-34a overexpression promoted neural damage, while SIRT1 inhibition or p53 upregulation counteracted the protective effects of miR-34a knockdown. SIRT1 was identified as a target of miR-34a and played a role in p53 deacetylation.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Oncology
Jinhui Yang, Xiaoyun Liu, Guangcheng Dai, Lanying Qu, Bo Tan, Bo Zhu, Fuming Qi, Xinyu Gai, Bo Cheng
Summary: The study found that circNT5E expression is increased in bladder cancer tissues, positively correlated with larger tumor size and lower survival rate. Inhibition of circNT5E can suppress the growth and metastasis of bladder cancer cells, and circNT5E enhances HOXC8 expression by capturing miR-502-5p.
Article
Cell Biology
Zhanqin Zhang, Hongtao Zhu, Jianguo Hu
Summary: This study revealed that circRAB11FIP1 is upregulated in epithelial ovarian cancer and can mediate autophagy by sponging miR-129 to regulate ATG7 and ATG14. CircRAB11FIP1 may serve as a candidate biomarker for diagnosis and treatment of EOC.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Doil Park, Ji Hoon Jung, Hyun Min Ko, Wona Jee, Hyungsuk Kim, Hyeung-Jin Jang
Summary: This study found that Cycloastragenol (CY) induces apoptosis through p53 activation and inhibits the proliferation of colon cancer cells. CY enhances p53 expression and is expected to have a synergistic effect when used in combination with existing treatments for colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Sherin Zakaria, Samar Elsebaey, Shady Allam, Alaa El-Sisi
Summary: This study investigated the effects of vitamin K3 as a Siah2 inhibitor and hydroxychloroquine as an autophagy inhibitor on colon cancer management and CSCs growth. The results showed that both vitamin K3 and hydroxychloroquine downregulated the expression of Siah2 and HIF-1 alpha, and had an impact on the expression of other related proteins. These therapeutic options were also correlated with the downregulation of cancer stem cell markers.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Olga Fedorova, Alexandra Daks, Sergey Parfenyev, Oleg Shuvalov, Sofia Netsvetay, Julia Vasileva, Anastasia Gudovich, Vasilii Golotin, Oleg Semenov, Alexey Petukhov, Ekaterina Baiduik, Nurken Berdigaliyev, Eugene M. Tulchinsky, Nikolai A. Barlev
Summary: The text delves into the role of autophagy in cellular processes, exploring the relationship between autophagy and DNA damage, as well as the mechanisms through which tumor cells and breast cancer cells handle anticancer drugs and drug resistance.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jingwen Xu, Yihai Wang, Yi Wang, Zhe Wang, Xiangjiu He
Summary: The study showed that A-24 induces apoptosis and autophagy in both p53 wild-type and deficient gastric cancer cells, with a significant proliferation inhibition effect on the latter. The p53 status influenced the occurrence of autophagy induced by A-24, but had no effect on ROS-mediated apoptosis. Furthermore, A-24 acted through different pathways in p53 wild-type and deficient cells, suggesting its potential as a phytotherapeutic candidate for gastric cancer treatment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Thomas Wilson, Giacomo Pirovano, Gu Xiao, Zachary Samuels, Sheryl Roberts, Tara Viray, Navjot Guru, Pat Zanzonico, Marc Gollub, Naga Vara Kishore Pillarsetty, Thomas Reiner, Jill Bargonetti
Summary: The PARP inhibitor 123I-MAPi shows promise for the systemic treatment of p53 mutant cancers, delivering therapeutic levels of Auger radiation without significant off-site toxicity. Studies also demonstrate that its stable isotopologue, I-127-PARPi, has minimal off-site toxicity when administered systemically.
MOLECULAR PHARMACEUTICS
(2021)
Article
Oncology
Balawant Kumar, Rizwan Ahmad, Swagat Sharma, Saiprasad Gowrikumar, Mark Primeaux, Sandeep Rana, Amarnath Natarajan, David Oupicky, Corey R. Hopkins, Punita Dhawan, Amar B. Singh
Summary: Colorectal cancer (CRC) therapy faces challenges due to cancer stem cells (CSCs) resistance to chemotherapy. Inhibiting autophagy with 36-077, a potent PIK3C3/VPS34 inhibitor, shows promise in improving the efficacy of CRC therapy by targeting CSCs.
Article
Multidisciplinary Sciences
Xin Chen, Yue Bi, Tianyang Wang, Pengfei Li, Xin Yan, Shanshan Hou, Catherine E. Bammert, Jingfang Ju, K. Michael Gibson, William J. Pavan, Lanrong Bi
SCIENTIFIC REPORTS
(2015)
Article
Multidisciplinary Sciences
Nazmiye B. Yapici, Yue Bi, Pengfei Li, Xin Chen, Xin Yan, Srinivas Rao Mandalapu, Megan Faucett, Steffen Jockusch, Jingfang Ju, K. Michael Gibson, William J. Pavan, Lanrong Bi
SCIENTIFIC REPORTS
(2015)
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Oncology
Shixiang Guo, Xuejun Xu, Yichen Tang, Chaobin Zhang, Jian Li, Yongsheng Ouyang, Jingfang Ju, Ping Bie, Huaizhi Wang
Article
Oncology
Peixin Dong, Masanori Kaneuchi, Ying Xiong, Liping Cao, Muyan Cai, Xishi Liu, Sun-Wei Guo, Jingfang Ju, Nan Jia, Yosuke Konno, Hidemichi Watari, Masayoshi Hosaka, Satoko Sudo, Noriaki Sakuragi
Review
Cell Biology
Haiyan Zhai, Andrew Fesler, Jingfang Ju
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Oncology
Haiyan Zhai, Andrew Fesler, Kristina Schee, Oystein Fodstad, Kjersti Flatmark, Jingfang Ju
CLINICAL COLORECTAL CANCER
(2013)
Editorial Material
Chemistry, Medicinal
Jingfang Ju, Jingting Jiang, Andrew Fesler
FUTURE MEDICINAL CHEMISTRY
(2013)
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Genetics & Heredity
Weipeng Wang, Jing Sun, Fang Li, Rui Li, Yongping Gu, Cuiping Liu, Peng Yang, Ming Zhu, Lujun Chen, Wenyan Tian, Huan Zhou, Yong Mao, Liang Zhang, Jingting Jiang, Changping Wu, Dong Hua, Weichang Chen, Binfeng Lu, Jingfang Ju, Xueguang Zhang
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Gastroenterology & Hepatology
Ming Wang, Chenglong Li, Beiqin Yu, Liping Su, Jianfang Li, Jingfang Ju, Yingyan Yu, Qinlong Gu, Zhenggang Zhu, Bingya Liu
JOURNAL OF GASTROENTEROLOGY
(2013)
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Biochemistry & Molecular Biology
Xiaoxiang Guan, Hongliang Liu, Jingfang Ju, Yangkai Li, Peng Li, Li-E Wang, Abenaa M. Brewster, Thomas A. Buchholz, Banu K. Arun, Qingyi Wei, Zhensheng Liu
MOLECULAR CARCINOGENESIS
(2015)
Review
Genetics & Heredity
Andrew Fesler, Jingting Jiang, Haiyan Zhai, Jingfang Ju
MOLECULAR DIAGNOSIS & THERAPY
(2014)
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Biochemistry & Molecular Biology
P. Dong, M. Karaayvaz, N. Jia, M. Kaneuchi, J. Hamada, H. Watari, S. Sudo, J. Ju, N. Sakuragi
Review
Biotechnology & Applied Microbiology
Andrew Fesler, Haiyan Zhai, Jingfang Ju
ONCOTARGETS AND THERAPY
(2014)
Article
Cell Biology
M. Karaayvaz, H. Zhai, J. Ju
CELL DEATH & DISEASE
(2013)