期刊
ONCOGENE
卷 32, 期 5, 页码 621-630出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2012.78
关键词
apoptosis; BH3-only proteins; Bad; Bmf; hematopoiesis; cancer
资金
- Tiroler Krebshilfe
- Tiroler Wissenschaftsfond (TWF)
- Austrian Science Fund, FWF [Y212-B12, P23510-B19, SFB021]
- Integrated Center for Research and Therapy (IFTZ) of the Innsbruck Medical University
- Austrian Academy of Science (OAW)
- Austrian Science Fund (FWF) [P 23510] Funding Source: researchfish
- Austrian Science Fund (FWF) [P23510] Funding Source: Austrian Science Fund (FWF)
Proapoptotic Bcl-2 family members of the Bcl-2 homology (BH)3-only subgroup are critical for the establishment and maintenance of tissue homeostasis and can mediate apoptotic cell death in response to developmental cues or exogenously induced forms of cell stress. On the basis of the biochemical experiments as well as genetic studies in mice, the BH3-only proteins Bad and Bmf have been implicated in different proapoptotic events such as those triggered by glucose- or trophic factor-deprivation, glucocorticoids, or histone deacetylase inhibition, as well as suppression of B-cell lymphomagenesis upon aberrant expression of c-Myc. To address possible redundancies in cell death regulation and tumor suppression, we generated compound mutant mice lacking both genes. Our studies revealed lack of redundancy in most paradigms of lymphocyte apoptosis tested in tissue culture. Only spontaneous cell death of thymocytes kept in low glucose or that of pre-B cells deprived of cytokines was significantly delayed when both genes were lacking. Of note, despite these minor apoptosis defects we observed compromised lymphocyte homeostasis in vivo that affected mainly the B-cell lineage. Long-term follow-up revealed significantly reduced latency to spontaneous tumor formation in aged mice when both genes were lacking. Together our study suggests that Bad and Bmf co-regulate lymphocyte homeostasis and limit spontaneous transformation by mechanisms that may not exclusively be linked to the induction of lymphocyte apoptosis. Oncogene (2013) 32, 621-630; doi:10.1038/onc.2012.78; published online 19 March 2012
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