Oncogenic KRAS and BRAF activation of the MEK/ERK signaling pathway promotes expression of dual-specificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition

Post-translational regulation of mitogen-activated protein kinase phosphatase-2 (MKP-2) by ERK

(2010) Peng Dong et al.   CELL CYCLE

SHP-1 inhibits β-catenin function by inducing its degradation and interfering with its association with TATA-binding protein

(2010) Mélanie Simoneau et al.   CELLULAR SIGNALLING

Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas

(2010) Jochen Gaedcke et al.   GENES CHROMOSOMES & CANCER

KRAS and BRAF: drug targets and predictive biomarkers

(2010) Efsevia Vakiani et al.   JOURNAL OF PATHOLOGY

KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer

(2010) Wendy De Roock et al.   LANCET ONCOLOGY

The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis

(2010) Sébastien Bergeron et al.   Molecular Cancer

Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK

(2009) Anna Kucharska et al.   CELLULAR SIGNALLING

Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis

(2009) Étienne Lemieux et al.   INTERNATIONAL JOURNAL OF CANCER

KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer

(2009) J. J. Yeh et al.   MOLECULAR CANCER THERAPEUTICS

Gonadotropin-Releasing Hormone and Protein Kinase C Signaling to ERK: Spatiotemporal Regulation of ERK by Docking Domains and Dual-Specificity Phosphatases

(2009) Stephen Paul Armstrong et al.   MOLECULAR ENDOCRINOLOGY

Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors

(2008) Laure Voisin et al.   BMC CANCER

The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells

(2008) Joe W. Ramos   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Epidermal Growth Factor Receptor and Protein Kinase C Signaling to ERK2

(2008) Christopher J. Caunt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatiotemporal Regulation of ERK2 by Dual Specificity Phosphatases

(2008) Christopher J. Caunt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Total Number of Genome Alterations in Sporadic Gastrointestinal Cancer Inferred from Pooled Analyses in the Literature

(2008) Takafumi Nishimura   TUMOR BIOLOGY

Krüppel-Like Factor 5 Mediates Cellular Transformation During Oncogenic KRAS-Induced Intestinal Tumorigenesis

(2007) Mandayam O. Nandan et al.   GASTROENTEROLOGY