期刊
ONCOGENE
卷 32, 期 24, 页码 2952-2962出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2012.313
关键词
blood-brain barrier; brain metastasis; PLGF; Rho kinase; small-cell lung cancer
资金
- Trans-Century Training Program Foundation for Talents
- Ministry of Education of China [JJH2002-48]
- Innovation Team Program Foundation of Liaoning Province [2006T131, LT2011011]
- National Natural Science Foundation of China [30600270]
- Science and Technology Foundation of Liaoning Province [20102291]
Brain metastasis (BM) is a major cause of mortality in small-cell lung cancer (SCLC) patients; however, the molecular pathway of SCLC BM remains largely unknown because of a lack of investigation. Here we screen the levels of some candidate-soluble factors in the serum of SCLC patients and find that SCLC patients with high levels of placental growth factor (PLGF) are prone to BM. Using in vitro blood-brain barrier model, we show that PLGF derived from SCLC cells triggers vascular endothelial growth factor receptor1- Rho-extracellular regulated protein kinase 1/2 signaling axis activation, results in disassembly of tight junction in brain endothelial cells and promotes SCLC cell transendothelial migration. Furthermore, the downregulation of PLGF suppresses SCLC cell metastasis to the brain in an experimental BM model. These data suggest that PLGF is a potential signature of SCLC BM and a prospective therapeutic target for SCLC BM.
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