Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8

A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer

(2011) P N Munster et al.   BRITISH JOURNAL OF CANCER

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

(2011) D Li et al.   CELL DEATH AND DIFFERENTIATION

Phase II Study of Vorinostat for Treatment of Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma and Mantle Cell Lymphoma

(2011) Mark Kirschbaum et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification of type-specific anticancer histone deacetylase inhibitors: road to success

(2010) Nighat Noureen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Inside HDAC with HDAC inhibitors

(2010) Philippe Bertrand   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Characterization of Functional Domains Necessary for Mutant p53 Gain of Function

(2010) Wensheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer DNA Methylation: Molecular Mechanisms and Clinical Implications

(2009) M. T. McCabe et al.   CLINICAL CANCER RESEARCH

Identification of GRO1 as a Critical Determinant for Mutant p53 Gain of Function

(2009) Wensheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

(2008) Nagma Khan et al.   BIOCHEMICAL JOURNAL

Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors†,‡

(2008) Daniel P. Dowling et al.   BIOCHEMISTRY

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

Histone Deacetylase 8 in Neuroblastoma Tumorigenesis

(2008) I. Oehme et al.   CLINICAL CANCER RESEARCH

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

(2008) T. Terzian et al.   GENES & DEVELOPMENT

A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas

(2008) S Balasubramanian et al.   LEUKEMIA