Article
Oncology
Pengfei Qiao, Zhentao Tian
Summary: This study investigated the effects of Hsp27 and Atractylenolide I (ATL-1) on the proliferation of prostate cancer cells DU145 and PC-3. The results showed that ATL-1 inhibited the proliferation of these cells and induced apoptosis. Furthermore, ATL-1 enhanced the antitumor effect of cabozantinib.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Maotuan Huang, Fuxiu Zhong, Mingyuan Chen, Lingju Hong, Weihong Chen, Xiahenazi Abudukeremu, Feifei She, Yanling Chen
Summary: Through bioinformatics analysis, five key genes of GBC were identified, among which CEP55 was found to be overexpressed in GBC and associated with advanced TNM stage, differentiation grade, and poorer survival. Inhibition of CEP55 in GBC cells resulted in decreased proliferation, cell cycle arrest, DNA damage, and increased apoptosis. CEP55 inhibition in vivo attenuated tumor growth and promoted apoptosis in GBC cells. The tumor suppressor effect of CEP55 knockdown is mechanistically associated with dysregulation of the AKT and ERK signaling networks.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hanna Grasshoff, Konstantinos Fourlakis, Sara Comduhr, Gabriela Riemekasten
Summary: Systemic sclerosis is a rare connective tissue disorder characterized by immune dysregulation, inflammation, fibrosis and vasculopathy. Alterations in the B-cell compartment, including polyclonal B-cell hyperreactivity and autoantibody production, are important in the pathogenesis of the disease. Autoantibodies serve as biomarkers and contribute to pathological mechanisms. Therapeutic approaches targeting B cells and autoantibodies may hold promise in the treatment of systemic sclerosis.
Article
Oncology
Lin Zhang, Guang-Zhi Jin, Dong Li
Summary: A novel endogenous peptide derived from HSPB1 protein, Tat-hspb1, was discovered to inhibit the proliferation and migration of ccRCC cells with lower cytotoxicity to normal cells, suggesting its potential as a therapeutic agent for renal cancer.
Article
Neurosciences
Xiao-yan Zhou, Jing-yi Sun, Wei-qi Wang, Shu-xian Li, Han-xia Li, Hui-juan Yang, Ming-feng Yang, Hui Yuan, Zong-yong Zhang, Bao-liang Sun, Jin-Xiang Han
Summary: This study found that the level of heat shock protein 27 (HSP27) is increased in early brain injury after subarachnoid hemorrhage (SAH) in both SAH patients and rat models. HSP27 plays a protective role by inhibiting apoptosis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Keqin Chen, Changmiao Hou, Lei Xu, Hanwu Peng, Chaogui He, Jing Liu, Guoqing Wang, Shaoshuai Huang, Xiehong Liu
Summary: Loss of HSPB1 promotes autophagy and inhibits apoptosis in vascular smooth muscle cells (VSMCs) of ASO patients. HSPB1 and its downstream signaling pathways could be potential therapeutic targets for ASO treatment.
CARDIOVASCULAR THERAPEUTICS
(2022)
Review
Oncology
Oystein Bruserud, Hakon Reikvam
Summary: Acute myeloid leukemia (AML) is a blood cancer disease that requires intensive anticancer treatment and stem cell transplantation. Inhibiting the protein kinase CK2 shows promise as a strategy for treating AML, both as monotherapy and in combination with other drugs. CK2 plays a vital role in signaling pathways in AML cells, and high CK2 levels are associated with decreased survival. Further research is needed to investigate the potential benefits of CK2 inhibition in AML treatment.
Article
Oncology
Yuhao Deng, Huantao Wen, Hanjie Yang, Zhengqiang Zhu, Qiongzhen Huang, Yuewei Bi, Pengfei Wang, Ming Zhou, Jianwei Guan, Wangming Zhang, Min Li
Summary: Medulloblastoma (MB) is the most common malignant brain tumor in pediatrics. Current standard treatment often results in high morbidity, so there is a need for more effective and less toxic therapies. This study identified an upregulated gene (PDZ binding kinase) in MB and found its aberrant expression to be associated with poor clinical outcomes. Targeting this gene with an inhibitor impaired MB cell proliferation and induced apoptosis.
Article
Obstetrics & Gynecology
Aili Tan, Peng Ruan, Pengxing Sun
Summary: APEX1 promotes ESC proliferation and inhibits apoptosis by upregulating miR-24 expression. Overexpression of APEX1 and miR-24 enhances ESC proliferation and suppresses apoptosis, while their effects can be reversed by silencing APEX1 and miR-24. Moreover, APEX1 and miR-24 may modulate apoptosis-related protein expression in ESC.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Multidisciplinary Sciences
Junjie Gao, Dandan Yang, Zheng Huang, Xueshan Pan, Ruoxue Cao, Chaoqun Lian, Jia Ma, Yuyun Li, Zhiwei Wang, Jun Xia
Summary: Nitric oxide synthase-interacting protein (Nosip) interacts with nitric oxide synthase (NOS) and regulates NO synthesis and release, participating in various physiological and pathological processes. Nosip was found to be elevated in hepatocellular carcinoma (HCC) tissues and cells. Silencing Nosip inhibited HCC cell proliferation and motility, and promoted apoptosis, while overexpression of Nosip had the opposite effects. Quercetin, a natural compound, inhibited the proliferation and motility of HCC cells possibly by repressing Nosip expression. Our findings suggest that Nosip acts as an oncogene in HCC progression and quercetin may be a potential natural compound for treating HCC by targeting Nosip expression.
Article
Cell Biology
Praveen Guruvaiah, Suresh Chava, Chiao-Wang Sun, Nirupama Singh, Courtney A. Penn, Romi Gupta
Summary: Ovarian cancer is a complex disease with genetic and epigenetic alterations. Overexpression of ATAD2 in ovarian cancer is associated with metastasis and recurrence. Inhibiting ATAD2 or CENPE can suppress ovarian cancer growth, and their combined inhibition is more potent. ATAD2 is a potential target for effective ovarian cancer therapy.
CELL DEATH & DISEASE
(2023)
Review
Pharmacology & Pharmacy
Emma L. Solly, Peter J. Psaltis, Christina A. Bursill, Joanne T. M. Tan
Summary: Diabetes is estimated to affect 700 million people by 2045, leading to significant health and economic burden. Current treatments are not satisfactory, highlighting the need for therapies that stimulate angiogenesis to improve ischaemic complications. MicroRNAs, including miR-181c, show promise as therapeutic targets for rescuing diabetes-impaired angiogenesis by regulating key angiogenic pathways and cellular processes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Jiao Sun, Qi Liu, Yanfang Jiang, Zhihui Cai, Hui Liu, Huaiwen Zuo
Summary: This study identifies HSPB1 as a key player in the resistance of hepatocellular carcinoma cells to sorafenib. It also demonstrates that miR-654-5p can enhance sorafenib-induced ferroptosis by targeting HSPB1. Furthermore, the use of small extracellular vesicles as carriers for miR-654-5p delivery shows promising results in restoring sensitivity to sorafenib in resistant cells.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Bao-Biao Zhuo, Lun-Qing Zhu, Chen Yao, Xi-Hua Wang, Shi-Xian Li, Rong Wang, Yuan Li, Zhuo-Yan Ling
Summary: We have shown that ADCK1, a mitochondrial protein, is upregulated in human osteosarcoma tissues and cells. ADCK1 plays a crucial role in cell viability, proliferation, migration, apoptosis, and mitochondrial functions. Inhibition of ADCK1 enhances doxorubicin-induced apoptosis and decreases cell growth. The mTOR pathway is important for ADCK1 expression. ADCK1 is a novel therapeutic target for osteosarcoma.
CELL DEATH & DISEASE
(2022)
Article
Obstetrics & Gynecology
Raquel L. Martin, Mayra L. Sottile, Analia L. Redondo, Laura C. Gomez, Gisel V. Gauna, Marina I. Flamini, Carina Grajeda, Alfonsa C. Anzalone, Eduardo Rodriguez-Echandia, Silvina B. Nadin, Laura M. Vargas-Roig
Summary: This study indicates that elevated circulating levels of HSPB1 in the first and second trimester may be useful for predicting the occurrence of pre-eclampsia in asymptomatic women. Further validation studies are necessary to confirm HSPB1 as a potential predictive biomarker for pre-eclampsia.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Chemistry, Multidisciplinary
Thomas Robert, Jared L. Johnson, Roxane Guichaoua, Tomer M. Yaron, Stephane Bach, Lewis C. Cantley, Pierre Colas
FRONTIERS IN CHEMISTRY
(2020)
Review
Medicine, Research & Experimental
Stephane Bach, Pierre Colas, Marc Blondel
M S-MEDECINE SCIENCES
(2020)
Article
Chemistry, Medicinal
Nada Ibrahim, Pascal Bonnet, Jean-Daniel Brion, Jean-Francois Peyrat, Jerome Bignon, Helene Levaique, Beatrice Josselin, Thomas Robert, Pierre Colas, Stephane Bach, Samir Messaoudi, Mouad Alami, Abdallah Hamze
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Review
Genetics & Heredity
Pierre Colas
ORPHANET JOURNAL OF RARE DISEASES
(2020)
Article
Cell Biology
Kevin Berthenet, Camila Castillo Ferrer, Deborah Fanfone, Nikolay Popgeorgiev, David Neves, Philippe Bertolino, Benjamin Gibert, Hector Hernandez-Vargas, Gabriel Ichim
Article
Endocrinology & Metabolism
Laura Gerard, Jessica Garcia, Arnaud Gauthier, Jonathan Lopez, Alice Durand, Valerie Hervieu, Annie Lemelin, Laurence Chardon, Verena Landel, Benjamin Gibert, Catherine Lombard-Bohas, Lea Payen, Thomas Walter
Summary: This study aimed to describe ctDNA mutations in GEPNEC patients and assess their predictive value for response to chemotherapy and disease progression. The results showed a high sensitivity of ctDNA assessment, which is expected to play an important role in the future management of GEPNEC.
NEUROENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Simon Renders, Arthur Flohr Svendsen, Jasper Panten, Nicolas Rama, Maria Maryanovich, Pia Sommerkamp, Luisa Ladel, Anna Rita Redavid, Benjamin Gibert, Seka Lazare, Benjamin Ducarouge, Katharina Schoenberger, Andreas Narr, Manon Tourbez, Bertien Dethmers-Ausema, Erik Zwart, Agnes Hotz-Wagenblatt, Dachuan Zhang, Claudia Korn, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Simon Mendez-Ferrer, Mathias Heikenwaelder, Maik Brune, Daniel Klimmeck, Leonid Bystrykh, Paul S. Frenette, Patrick Mehlen, Gerald de Haan, Nina Cabezas-Wallscheid, Andreas Trumpp
Summary: Haematopoietic stem cells are characterized by their self-renewal potential and dormancy. This study shows that niche-produced netrin-1 preserves HSC quiescence and self-renewal through neogenin-1, with a decline in netrin-1 production during aging leading to decreased Neo1-mediated HSC self-renewal.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Shan Jiang, Mathieu Richaud, Pauline Vieugue, Nicolas Rama, Jean-Guy Delcros, Maha Siouda, Mitsuaki Sanada, Anna-Rita Redavid, Benjamin Ducarouge, Maeva Hervieu, Silvia Breusa, Ambroise Manceau, Charles-Henry Gattolliat, Nicolas Gadot, Valerie Combaret, David Neves, Sandra Ortiz-Cuaran, Pierre Saintigny, Olivier Meurette, Thomas Walter, Isabelle Janoueix-Lerosey, Paul Hofman, Peter Mulligan, David Goldshneider, Patrick Mehlen, Benjamin Gibert
Summary: Netrin-3 is specifically expressed in neuroblastoma (NB) and small cell lung cancer (SCLC), showing a mutually exclusive expression pattern with netrin-1 in these tumors. Targeting netrin-3 in NB and SCLC may delay tumor growth and improve overall survival based on preclinical studies.
EMBO MOLECULAR MEDICINE
(2021)
Article
Genetics & Heredity
Thomas Robert, Anne-Catherine Dock-Bregeon, Pierre Colas
Summary: The study revealed that the truncated variants of CDK10 and CycM can still form a CDK10/CycM heterodimer, with the CycM variant partially activating CDK10 activity in vitro, while the CDK10 variant remains surprisingly inactive. Furthermore, the CDK10 and CycM variants are shown to be strongly and partially degraded by the proteasome when expressed in human cells.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Romain Barnault, Claire Verzeroli, Carole Fournier, Maud Michelet, Anna Rita Redavid, Ievgeniia Chicherova, Marie-Laure Plissonnier, Annie Adrait, Olga Khomich, Fleur Chapus, Mathieu Richaud, Maeva Hervieu, Veronika Reiterer, Federica Grazia Centonze, Julie Lucifora, Birke Bartosch, Michel Rivoire, Hesso Farhan, Yohann Coute, Valbona Mirakaj, Thomas Decaens, Patrick Mehlen, Benjamin Gibert, Fabien Zoulim, Romain Parent
Summary: This study identifies Netrin-1 as an inflammation-inducible factor in the liver and reveals its contribution to hepatic inflammation through an atypical mechanism. Additionally, the study finds that an anti-Netrin-1 antibody has anti-inflammatory activity in hepatic inflammation.
Review
Biochemistry & Molecular Biology
Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, Solange Desagher, David Devos, Svetlana Dokudovskaya, Laurence Dubrez, Jerome Estaquier, Germain Gillet, Isabelle Guenal, Philippe P. Juin, Guido Kroemer, Patrick Legembre, Romain Levayer, Stephen Manon, Patrick Mehlen, Olivier Meurette, Olivier Micheau, Bernar Mignotte, Florence Nguyen-Khac, Nikolay Popgeorgiev, Jean-Lu Poyet, Muriel Priault, Jean-Ehrlan Ricci, Franck B. Riquet, Santos A. Susin, Magal Suzanne, Pierre Vacher, Ludivine Walter, Bertran Mollereau
Summary: Since the Nobel Prize was awarded more than twenty years ago for discovering the core apoptotic pathway in C. elegans, researchers around the world have conducted extensive research on apoptosis and various other forms of regulated cell death. Although there are still many aspects of regulated cell death that need to be clarified in specific cell subtypes and disease conditions, the last decade has seen the description of multiple cell death modalities, some of which have been successfully used in clinical therapy. To keep research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN), which is at the forefront of emerging topics in cell death research. These research efforts will enhance our mechanistic knowledge of regulated cell death and its therapeutic applications in the coming years.
Article
Cell Biology
A. Huyghe, G. Furlan, J. Schroeder, E. Cascales, A. Trajkova, M. Ruel, F. Studer, M. Larcombe, Y. Bo Yang Sun, F. Mugnier, L. De Matteo, A. Baygin, J. Wang, Y. Yu, N. Rama, B. Gibert, J. Kielbassa, L. Tonon, P. Wajda, N. Gadot, M. Brevet, M. Siouda, P. Mulligan, R. Dante, P. Liu, H. Gronemeyer, M. Mendoza-Parra, J. M. Polo, F. Lavial
Summary: Coordinated changes of cellular plasticity and identity are critical for pluripotent reprogramming and oncogenic transformation. This study provides insights into the partitioned control of cellular plasticity and identity for both regenerative and cancer biology.
NATURE CELL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
David Kryza, Jennifer Wischhusen, Mathieu Richaud, Maeva Hervieu, Jacqueline Sidi Boumedine, Jean-Guy Delcros, Sophie Besse, Thomas Baudier, Pierre-Alexandre Laval, Silvia Breusa, Erwan Boutault, Hugo Clermidy, Nicolas Rama, Benjamin Ducarouge, Mojgan Devouassoux-Shisheboran, Jean-Michel Chezal, Anne-Laure Giraudet, Thomas Walter, Patrick Mehlen, David Sarrut, Benjamin Gibert
Summary: Targeted radionuclide therapy is a revolutionary tool for treating metastatic cancers. This study identifies netrin-1, a molecule known to promote cancer progression, as a potential target for radiotherapy. The development of a therapeutic anti-netrin-1 antibody and an imaging contrast agent allows for the specific detection and treatment of netrin-1-positive tumors. Preclinical studies demonstrate the effectiveness of the therapy in tumor mouse models. These findings suggest that netrin-1 may be a promising target for advanced solid cancers.
EMBO MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Benjamin Ducarouge, Anna-Rita Redavid, Camille Victoor, Ruxanda Chira, Aurelien Fonseca, Maeva Hervieu, Romeo Berge, Justine Lengrand, Pauline Vieugue, David Neves, Isabelle Goddard, Mathieu Richaud, Pierre-Alexandre Laval, Nicolas Rama, David Goldschneider, Andrea Paradisi, Nicolas Gourdin, Sylvie Chabaud, Isabelle Treilleux, Nicolas Gadot, Isabelle Ray-Coquard, Stephane Depil, Didier Decaudin, Fariba Nemati, Elisabetta Marangoni, Eliane Mery-Lamarche, Catherine Genestie, Severine Tabone-Eglinger, Mojgan Devouassoux-Shisheboran, Kathryn J. Moore, Benjamin Gibert, Patrick Mehlen, Agnes Bernet
Summary: Netrin-1 is an independent prognostic marker for clinical progression of breast and ovary cancers. Interfering with netrin-1 alleviates resistance to chemotherapy and delays tumor relapse, possibly by affecting cancer stem cells. Netrin-1 interference also limits tumor resistance to immune checkpoint inhibitors by reducing the recruitment of a specific type of myeloid-derived suppressor cells. This enhanced anti-tumor efficacy may provide therapeutic opportunities for combining conventional chemotherapies and immunotherapies with netrin-1 interfering drugs.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Oncology
Marie Piecyk, Mouna Triki, Pierre-Alexandre Laval, Cedric Duret, Joelle Fauvre, Laura Cussonneau, Christelle Machon, Jerome Guitton, Nicolas Rama, Benjamin Gibert, Gabriel Ichim, Frederic Catez, Fleur Bourdelais, Sebastien Durand, Jean-Jacques Diaz, Isabelle Coste, Toufic Renno, Serge N. Manie, Nicolas Aznar, Stephane Ansieau, Carole Ferraro-Peyret, Cedric Chaveroux
Summary: Nutrient availability is crucial for tumor cell behavior, with scarcity and glutamine starvation promoting dedifferentiation and chemoresistance. This study reveals that the amino acid sensor GCN2 regulates ribosome biogenesis plasticity and cell fate in colon adenocarcinoma models. Inhibition of the GCN2-MetRS axis improves the efficacy of chemotherapy and induces cell death.
MOLECULAR ONCOLOGY
(2023)