期刊
ONCOGENE
卷 31, 期 12, 页码 1493-1503出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2011.336
关键词
Fos-related antigen-1; cell motility; bladder cancer
资金
- Association for International Cancer Research [07-0083]
- National Health and Medical Research Council of Australia
- French Ligue Nationale contre le Cancer
Fos-related antigen 1 (Fra-1) is a Fos family member overexpressed in several types of human cancers. Here, we report that Fra-1 is highly expressed in the muscle-invasive form of the carcinoma of the bladder (80%) and to a lesser extent in superficial bladder cancer (42%). We demonstrate that in this type of cancer Fra-1 is regulated via a C-terminal instability signal and C-terminal phosphorylation. We show that manipulation of Fra-1 expression levels in bladder cancer cell lines affects cell morphology, motility and proliferation. The gene coding for AXL tyrosine kinase is directly upregulated by Fra-1 in bladder cancer and in other cell lines. Importantly, our data demonstrate that AXL mediates the effect of Fra-1 on tumour cell motility but not on cell proliferation. We suggest that AXL may represent an attractive therapeutic target in cancers expressing high Fra-1 levels. Oncogene (2012) 31, 1493-1503; doi:10.1038/onc.2011.336; published online 8 August 2011
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