Article
Biochemistry & Molecular Biology
Xianfeng Li, Yan Wang, Qingjie Min, Weimin Zhang, Huajing Teng, Chao Li, Kun Zhang, Leisheng Shi, Bin Wang, Qimin Zhan
Summary: In this study, a comprehensive comparison of the transcriptomes of esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) was conducted, revealing shared and distinct transcriptomic signatures between these two cancer subtypes and uncovering possible common and unique mechanisms involved in tumorigenesis.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jing Cheng, Qi Liu, Hai Jin, Dongdong Zeng, Yuehua Liao, Yuxia Zhao, Xianfu Gao, Guangyong Zheng
Summary: Integrative transcriptomics and metabolomics analysis indicated that the tyrosine pathway plays a crucial role in the tumorigenesis and metastasis of ESCC by influencing immune response and tumor microenvironment. This study provides insights into the pathogenesis of ESCC and identifies potential biomarkers for disease diagnosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Medicine, General & Internal
Zhencong Chen, Mengnan Zhao, Jiaqi Liang, Zhengyang Hu, Yiwei Huang, Ming Li, Yanrui Pang, Tao Lu, Qihai Sui, Cheng Zhan, Miao Lin, Weigang Guo, Qun Wang, Lijie Tan
Summary: This study reveals high heterogeneity of tumor cells in ESCC and widespread reprogramming across multiple cellular elements within the TME. It identifies potential new markers and therapeutic targets for clinical management of ESCC.
Article
Gastroenterology & Hepatology
Qi-Wei Liu, Hao-Jie Ruan, Wei-Xia Chao, Meng-Xiang Li, Ye-Lin Jiao, Douglas G. Ward, She-Gan Gao, Yi-Jun Qi
Summary: This study characterized the N-linked glycoproteomic profile in esophageal squamous cell carcinoma (ESCC) using two complementary approaches (2-DE and iTRAQ), identifying multiple differentially expressed glycoproteins. Western blot validation confirmed the expression changes in ESCC-associated proteins and showed differences in glycosylated fractions in patient serum. The study provides valuable insights into the aberrant N-linked glycoproteome associated with ESCC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Nutrition & Dietetics
Shanshan Li, Joshua Ye, Zheng Lin, Zhifeng Lin, Xuwei Tang, Wenqing Rao, Zhijian Hu
Summary: This study investigated the independent and interactive effects of dietary nutrients on the risk of Esophageal Squamous Cell Carcinoma (ESCC) in Chinese adults. The results showed that fat, carbohydrate, and fiber intake significantly increased ESCC risk, while fiber and riboflavin intake significantly reduced the risk.
Article
Medicine, Research & Experimental
Mengnan Zhao, Tao Lu, Guoshu Bi, Zhengyang Hu, Jiaqi Liang, Yunyi Bian, Mingxiang Feng, Cheng Zhan
Summary: The study found that down-regulation of PLK1 can inhibit the pentose phosphate pathway (PPP), reduce the levels of NADPH and GSH, promote ferroptosis, and improve the sensitivity of ESCC to radiotherapy and chemotherapy. The transcription factor YY1 has a positive regulatory effect on PLK1, and their expressions are positively correlated. PLK1 may be a target for predicting and enhancing the chemoradiotherapy sensitivity of ESCC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Chuqing Pan, Yu Wang, Qianwen Liu, Yihuai Hu, Jianhua Fu, Xiuying Xie, Shuishen Zhang, Mian Xi, Jing Wen
Summary: The study revealed the correlation between immune cell infiltration in different regions and patient prognosis in esophageal squamous cell carcinoma. The complex interplay of immune populations could be used to predict patient outcomes and guide immunotherapy.
Article
Oncology
Zhao Shu, Junfeng Guo, Qian Xue, Qi Tang, Bingqiang Zhang
Summary: This study constructed a single-cell atlas of ESCC and revealed a novel subpopulation of SAA1+ malignant cells that are closely associated with distant metastasis of ESCC. A prediction model based on the gene expression pattern of SAA1+ cells was also established to identify high-risk patients with worse prognosis. These findings enhance our understanding of the mechanisms underlying distant metastasis in ESCC and provide a theoretical basis for improved therapies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Huy Q. Dinh, Feng Pan, Geng Wang, Qing-Feng Huang, Claire E. Olingy, Zhi-Yong Wu, Shao-Hong Wang, Xin Xu, Xiu-E Xu, Jian-Zhong He, Qian Yang, Sandra Orsulic, Marcela Haro, Li-Yan Li, Guo-Wei Huang, Joshua J. Breunig, H. Phillip Koeffler, Catherine C. Hedrick, Li-Yan Xu, De-Chen Lin, En-Min Li
Summary: This study utilized single-cell RNA sequencing to characterize the heterogeneous microenvironment of ESCC, identifying a tumor-specific subset of CST1(+) myofibroblasts with prognostic values and immunosuppressive features. The analysis of stromal cell types in the ESCC microenvironment provides a rich resource for further understanding of ESCC biology.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Y. Doki, J. A. Ajani, K. Kato, J. Xu, L. Wyrwicz, S. Motoyama, T. Ogata, H. Kawakami, C. -H. Hsu, A. Adenis, F. El Hajbi, M. Di Bartolomeo, M. I. Braghiroli, E. Holtved, S. A. Ostoich, H. R. Kim, M. Ueno, W. Mansoor, W. -C. Yang, T. Liu, J. Bridgewater, T. Makino, I. Xynos, X. Liu, M. Lei, K. Kondo, A. Patel, J. Gricar, I. Chau, Y. Kitagawa
Summary: In patients with advanced esophageal squamous-cell carcinoma, both first-line treatment with nivolumab plus chemotherapy and first-line treatment with nivolumab plus ipilimumab resulted in significantly longer overall survival than chemotherapy alone, with no new safety signals identified.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Yuji Shishido, Masataka Amisaki, Yoshiaki Matsumi, Haruna Yakura, Yuji Nakayama, Wataru Miyauchi, Kozo Miyatani, Tomoyuki Matsunaga, Takehiko Hanaki, Kyoichi Kihara, Manabu Yamamoto, Naruo Tokuyasu, Shuichi Takano, Teruhisa Sakamoto, Soichiro Honjo, Toshimichi Hasegawa, Yoshiyuki Fujiwara
Summary: 5-ALA induced ferroptosis through modulation of GPX4 and HMOX1 in esophageal squamous cell carcinoma (ESCC). Upregulation of GPX4 and downregulation of HMOX1 were found to be poor prognostic factors in ESCC. The antitumor effect of 5-ALA was seen both in vitro and in vivo, with an increase in lipid peroxidation and suppression of tumor growth.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Pan Pan Wang, Xin Song, Xue Ke Zhao, Meng Xia Wei, She Gan Gao, Fu You Zhou, Xue Na Han, Rui Hua Xu, Ran Wang, Zong Min Fan, Jing Li Ren, Xue Min Li, Xian Zeng Wang, Miao Miao Yang, Jing Feng Hu, Kan Zhong, Ling Ling Lei, Liu Yu Li, Yao Chen, Ya Jie Chen, Jia Jia Ji, Yuan Ze Yang, Jia Li, Li Dong Wang
Summary: Esophageal squamous cell carcinoma (ESCC) is a common and aggressive malignancy, especially in northern China. However, the lack of specific early symptoms and biomarkers often leads to late-stage diagnosis. By studying the metabolic profile, potential biomarkers for early detection and prognosis of ESCC were identified. Additionally, perturbed amino acid and lipid metabolism pathways were found to be important in ESCC. This study provides new insights for early detection and risk stratification of ESCC and has the potential to improve patient outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Adam N. Bennett, Rui Xuan Huang, Qian He, Nikki P. Lee, Wing-Kin Sung, Kei Hang Katie Chan
Summary: Esophageal cancer, particularly esophageal squamous cell carcinoma, is a significant challenge globally, with high incidence and mortality rates. The limited number of effective therapeutic options contributes to the high mortality rate. Repurposing existing drugs approved for other diseases through drug repositioning is a more time and cost-effective strategy. This study identified potential therapeutic drugs for esophageal cancer patients through gene expression analysis and network analysis, including both known drugs like Doxorubicin and potential psychiatric drugs like Venlafaxine.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Yao Chen, Fang-Xun Liu, Hong Liu
Summary: The study investigated the effects of dietary zinc deficiency on esophageal squamous cell proliferation in mice. Zinc deficiency was found to promote cell proliferation, potentially through the upregulation of COX-2, P38, PCNA, and NF-kappa B. Switching to a zinc-replenished diet decreased the expression of these proteins, reversing the proliferation process.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Ning Zhao, Zicheng Zhang, Qiang Wang, Lin Li, Zichao Wei, Hongyan Chen, Meng Zhou, Zhihua Liu, Jianzhong Su
Summary: This study characterizes DNA damage repair (DDR) subtypes in esophageal squamous cell carcinoma (ESCC) and investigates their prognostic value. Two distinct DDR subtypes, DDRactive and DDRsilent, are identified, and their independent prognostic values are observed in locoregional ESCC. Additionally, a combination immunotherapy strategy is proposed and validated for high-risk locoregional ESCC tumors.
Article
Gastroenterology & Hepatology
M. C. Valenzano, E. Rybakovsky, V Chen, K. Leroy, J. Lander, E. Richardson, S. Yalamanchili, S. McShane, A. Mathew, B. Mayilvaganan, L. Connor, R. Urbas, W. Huntington, A. Corcoran, S. Trembeth, E. McDonnell, P. Wong, G. Newman, G. Mercogliano, M. Zitin, B. Etemad, J. Thornton, G. Daum, J. Raines, A. Kossenkov, L. Y. Fong, J. M. Mullin
Summary: This prospective study aimed to investigate the potential chemopreventive action of zinc in Barrett's esophagus (BE) by analyzing mRNA, miRNA, and protein changes in patients with BE who were given oral zinc gluconate. The results showed significant changes in gene and protein expression related to inflammation, epithelial-to-mesenchymal transition, and tumor suppression, suggesting a possible role of zinc in chemoprevention of esophageal cancer. Further prospective clinical trials are warranted to confirm these findings.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Multidisciplinary Sciences
Francesca Lovat, Pierluigi Gasparini, Giovanni Nigita, Karilyn Larkin, John C. Byrd, Mark D. Minden, Michael Andreeff, Bing Z. Carter, Carlo M. Croce
Summary: The study found that the loss of both miR-15/16 clusters may act as a potential oncogenic driver in the transition from chronic phase to blast crisis in CML patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Editorial Material
Genetics & Heredity
Gerd A. Blobel, Douglas R. Higgs, Jennifer A. Mitchell, Dimple Notani, Richard A. Young
Summary: In this Viewpoint, five experts discuss our biological understanding of super-enhancers, how we can responsibly study their functions, and their opinions on whether names for enhancer clusters are an informative reflection of their functional properties.
NATURE REVIEWS GENETICS
(2021)
Letter
Multidisciplinary Sciences
Liguo Zhang, Alexsia Richards, M. Inmaculada Barrasa, Stephen H. Hughes, Richard A. Young, Rudolf Jaenisch
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Maria Rosaria Sapienza, Giuseppe Benvenuto, Manuela Ferracin, Saveria Mazzara, Fabio Fuligni, Claudio Tripodo, Beatrice Belmonte, Daniele Fanoni, Federica Melle, Giovanna Motta, Valentina Tabanelli, Jessica Consiglio, Vincenzo Mazzara, Marcello Del Corvo, Stefano Fiori, Alessandro Pileri, Gaetano Ivan Dellino, Lorenzo Cerroni, Fabio Facchetti, Emilio Berti, Elena Sabattini, Marco Paulli, Carlo Maria Croce, Stefano A. Pileri
Summary: This study described neuronal features in blastic plasmacytoid dendritic cell neoplasm (BPDCN) for the first time, potentially changing our understanding of the disease and leading to new strategies for treatment. The identified neural metastatic inducers in BPDCN may offer therapeutic approaches for patients. The upregulation of neural genes in BPDCN is currently being investigated as therapeutic targets.
Article
Multidisciplinary Sciences
Felice Pepe, Laura Z. Rassenti, Yuri Pekarsky, Jadwiga Labanowska, Tatsuya Nakamura, Giovanni Nigita, Thomas J. Kipps, Veronica Balatti, Carlo M. Croce
Summary: Chronic lymphocytic leukemia (CLL) is a common adult leukemia characterized by chromosomal aberrations. This study found that some CLL patients have undetected microdeletions, which are closely associated with chromosomal alterations in cancer. These findings may have clinical relevance for successful stratification of patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Computer Science, Artificial Intelligence
Chiara Vischioni, Fabio Bove, Federica Mandreoli, Riccardo Martoglia, Valentino Pisi, Cristian Taccioli
Summary: The study of Copy Number Variations (CNVs) is a hot topic in biomedical cancer research. VarNuCopy is a novel platform that allows visual, interactive exploration and analysis of CNV data across multiple species, providing a comprehensive and efficient solution for researchers to identify complex trends and patterns in a large amount of data.
Article
Genetics & Heredity
Chiara Vischioni, Fabio Bove, Matteo De Chiara, Federica Mandreoli, Riccardo Martoglia, Valentino Pisi, Gianni Liti, Cristian Taccioli
Summary: This study identified novel gene targets linked to tumor predisposition and found that miRNA copy number patterns are associated with cancer progression and susceptibility.
Article
Biochemistry & Molecular Biology
Nicoletta Bianchi, Luisa Doneda, Luca Elli, Cristian Taccioli, Valentina Vaira, Alice Scricciolo, Vincenza Lombardo, Anna Terrazzan, Patrizia Colapietro, Leonardo Terranova, Carlo Bergamini, Maurizio Vecchi, Lucia Scaramella, Nicoletta Nandi, Leda Roncoroni
Summary: This study identified a set of microRNAs in serum that can differentiate between different types of refractory diseases and aid in monitoring disease progression. The study also revealed the functions of these microRNAs, including cell signaling, epigenetic regulation, and inflammatory profiles.
Article
Biology
Carlo M. Bergamini, Nicoletta Bianchi, Valerio Giaccone, Paolo Catellani, Leonardo Alberghini, Alessandra Stella, Stefano Biffani, Sachithra Kalhari Yaddehige, Tania Bobbo, Cristian Taccioli
Summary: This study demonstrates for the first time that machine learning algorithms can identify and discriminate probiotic bacteria from pathogenic organisms in the human gut. The information content within tRNA sequences was found to be the key genomic feature in characterizing probiotics.
Biographical-Item
Oncology
Gary S. Stein, Carlo M. Croce
Article
Oncology
Alessandro La Ferlita, Nipin Sp, Marina Goryunova, Giovanni Nigita, Raphael E. Pollock, Carlo M. Croce, Joal D. Beane
Summary: Soft-tissue sarcomas (STS), a rare and diverse group of tumors, have various subtypes characterized by differences in tumor biology and clinical outcomes. Small non-coding RNAs (sncRNAs), including miRNAs and tRNA-derived ncRNAs, play important roles in STS tumorigenesis and differentiation. However, the translation of these findings into clinical applications, such as biomarkers or therapeutic targets, remains challenging. This review summarizes the current understanding of sncRNAs in STS, with a focus on liposarcoma, and discusses their potential as novel biomarkers and therapeutic targets.
MOLECULAR CANCER RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Yazavinder Singh, Marco Cullere, Davide Bertelli, Severino Segato, Giovanni Franzo, Antonio Frangipane di Regalbono, Paolo Catellani, Cristian Taccioli, Silvia Cappellozza, Antonella Dalle Zotte
Summary: Insects, such as silkworm chrysalis, can be a sustainable and alternative feed ingredient due to their rich nutritional profile. This research aimed to understand the potential of silkworm chrysalis as a feedstuff for laying quails, finding that it can be included up to 12% in the feed formulation for optimal performance and egg quality.
Article
Biochemistry & Molecular Biology
Henry R. Kilgore, Peter G. Mikhael, Kalon J. Overholt, Ann Boija, Nancy M. Hannett, Catherine Van Dongen, Tong Ihn Lee, Young-Tae Chang, Regina Barzilay, Richard A. Young
Summary: This research reveals that different types of intracellular condensates have distinct chemical environments that affect molecular distribution. Machine learning approaches can predict the selective partitioning of molecules in condensates, providing insights for the development of small molecule therapeutics with optimal subcellular distribution and therapeutic benefits.
NATURE CHEMICAL BIOLOGY
(2023)
Meeting Abstract
Oncology
Lucia Casadei, Patricia Sarchet, Luciano Cascione, Giovanni Nigita, Fernanda Costas Casal de Faria, Carlo Maria Croce, Valerie Grignol, Raphael E. Pollock