Repression of cancer cell senescence by PKCι

PTEN Level in Tumor Suppression: How Much Is Too Little?

(2011) A. Carracedo et al.   CANCER RESEARCH

Cell-to-Cell Variability in PI3K Protein Level Regulates PI3K-AKT Pathway Activity in Cell Populations

(2011) Tina L. Yuan et al.   CURRENT BIOLOGY

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

(2010) G. Gorgun et al.   BLOOD

Protein Kinase C  Is Required for Pancreatic Cancer Cell Transformed Growth and Tumorigenesis

(2010) M. L. Scotti et al.   CANCER RESEARCH

Regulation of Protein Kinase C function by phosphorylation on conserved and non-conserved sites

(2010) Michael Freeley et al.   CELLULAR SIGNALLING

Quantitative assessment of markers for cell senescence

(2010) Conor Lawless et al.   EXPERIMENTAL GERONTOLOGY

Coordination of glioblastoma cell motility by PKCι

(2010) R Mitchell Baldwin et al.   Molecular Cancer

MLN8054, an Inhibitor of Aurora A Kinase, Induces Senescence in Human Tumor Cells Both In vitro and In vivo

(2010) J. J. Huck et al.   MOLECULAR CANCER RESEARCH

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer

(2009) Krishna M. Vasudevan et al.   CANCER CELL

PIK3CA and PIK3CB Inhibition Produce Synthetic Lethality when Combined with Estrogen Deprivation in Estrogen Receptor-Positive Breast Cancer

(2009) R. J. Crowder et al.   CANCER RESEARCH

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation

(2008) David A. Gewirtz et al.   BIOCHEMICAL PHARMACOLOGY

The Polarity Protein Par6 Induces Cell Proliferation and Is Overexpressed in Breast Cancer

(2008) M. E. Nolan et al.   CANCER RESEARCH

Small-Molecule Inhibitors of PDK1

(2008) Christian Peifer et al.   ChemMedChem

The overexpression and altered localization of the atypical protein kinase C λ/ι in breast cancer correlates with the pathologic type of these tumors

(2008) Yasuyuki Kojima et al.   HUMAN PATHOLOGY

Regulation of glioblastoma cell invasion by PKCι and RhoB

(2008) R M Baldwin et al.   ONCOGENE