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Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

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Basal and Treatment-Induced Activation of AKT Mediates Resistance to Cell Death by AZD6244 (ARRY-142886) in Braf-Mutant Human Cutaneous Melanoma Cells

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Genomic and Biological Characterization of Exon 4 KRAS Mutations in Human Cancer

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Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

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The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

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BrafV600E cooperates with Pten loss to induce metastatic melanoma

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Genetic Predictors of MEK Dependence in Non-Small Cell Lung Cancer

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Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral, Small-Molecule Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) in Patients With Advanced Cancers

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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Functional Copy-Number Alterations in Cancer

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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

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