Article
Immunology
Heidi Braumueller, Bernhard Mauerer, Christopher Berlin, Dorothea Plundrich, Patrick Marbach, Pierre Cauchy, Claudia Laessle, Esther Biesel, Philipp Anton Holzner, Rebecca Kesselring
Summary: More than half of colorectal cancer patients develop distant metastasis and up to 48% of patients have peritoneal carcinomatosis. Tumor cells of peritoneal carcinomatosis exhibit senescence and stem cell features. A murine model demonstrated that the peritoneal metastatic site induces senescence and stemness in tumor cells, independent of oncogene activation or therapy. Additionally, senescence-associated secretory phenotype (SASP) factors in peritoneal carcinomatosis lead to immunosenescence in the tumor microenvironment, contributing to the resistance of peritoneal carcinomatosis to current therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ritama Paul, Jay F. Dorsey, Yi Fan
Summary: Cancer stem cells (CSCs) play a crucial role in cancer progression, metastasis, relapse, and therapy resistance. They maintain their self-renewal capability and resist the tumor microenvironment and treatments through mechanisms such as cellular plasticity, senescence, and quiescence. Understanding these mechanisms is important for future therapeutic implications.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Mehrdad Aghasizadeh, Tayebe Moghaddam, Ahmad Reza Bahrami, Hamid Sadeghian, Seyed Jamal Alavi, Maryam M. Matin
Summary: Carbostyril derivatives have been found to inhibit the growth of prostate cancer cells. These compounds effectively inhibit 15-LOX activity and induce cytotoxicity in prostate cancer cells through apoptosis. In vivo studies show that 8-GQ has stronger anti-tumor effects and fewer side effects on normal tissues compared to cisplatin.
Review
Oncology
Ravindran Caspa Gokulan, Lee Fah Yap, Ian C. Paterson
Summary: Homeobox genes, including HOPX, play crucial roles in development and their malfunction is associated with various diseases, including cancer. HOPX lacks DNA-binding capacity and instead functions by interacting with transcriptional regulators. The loss of HOPX expression is common in cancer, where it acts as a tumor suppressor gene. Understanding the molecular mechanisms of HOPX in carcinogenesis could lead to the development of new therapeutic approaches.
Article
Oncology
Liqin Wang, Haojie Jin, Fleur Jochems, Siying Wang, Cor Lieftink, Isabel Mora Martinez, Giulia De Conti, Finn Edwards, Rodrigo Leite de Oliveira, Arnout Schepers, Yangyang Zhou, Jiaojiao Zheng, Wei Wu, Xingling Zheng, Shengxian Yuan, Jing Ling, Kathy Jastrzebski, Matheus Dos Santos Dias, Ji-Ying Song, Patrick N. H. Celie, Hideo Yagita, Ming Yao, Weiping Zhou, Roderick L. Beijersbergen, Wenxin Qin, Rene Bernards
Summary: Senolytics are drugs that kill senescent cells, and this study identifies cFLIP as a common vulnerability of senescent cancer cells. Activation of DR5 signaling can lead to efficient killing of senescent cancer cells and non-senescent cells can be sensitized to DR5 agonist through a bystander effect mediated by secretion of cytokines. Animal models confirm the effectiveness of combining pro-senescence therapy with DR5 activation.
Article
Biochemistry & Molecular Biology
Jinok Noh, Jinyeong Yu, Wootak Kim, Aran Park, Ki-Sook Park
Summary: The tumor microenvironment in prostate cancer plays vital roles in tumor cell metastasis and re-growth. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are crucial in forming this microenvironment. The study found that N-cadherin is a key mediator of BM-MSCs migration towards hormone-insensitive prostate tumor cells.
Article
Biochemistry & Molecular Biology
Cansu Tatar, Cigir Biray Avci, Eda Acikgoz, Gulperi Oktem
Summary: This study aims to investigate the effects of senescence induction on prostate cancer stem cells (CSCs). The results showed that Doxorubicin (DOX) is a potent inducer of senescence for prostate CSCs, inhibiting proliferation by arresting the cell cycle, and senescent prostate CSCs develop resistance to apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Alberta Palazzo, Hector Hernandez-Vargas, Delphine Goehrig, Jean-Jacques Medard, David Vindrieux, Jean-Michel Flaman, David Bernard
Summary: Cancer cells arising from senescent cells display more aggressive features and resistance to drugs. A molecular signature of these cells can serve as a prognostic marker for several human cancers.
Review
Oncology
Pinaki Banerjee, Prachi Kapse, Shehnaz Siddique, Moumita Kundu, Jasoda Choudhari, Varshasnata Mohanty, Diksha Malhotra, Suresh W. Gosavi, Rajesh N. Gacche, Gopal C. Kundu
Summary: Prostate cancer is a heterogeneous disease involving multiple cell types, with tumor heterogeneity resulting from genomic instability and sub-clone differentiation. Prostate cancer stem cells (PCSCs), a small subset of cells with tumor-initiating and stem-like properties, play crucial roles in disease progression, drug resistance, and relapse. This review discusses the origin, hierarchy, and plasticity of PCSCs, methods for their isolation and enrichment, as well as cellular and metabolic signaling pathways involved in their induction and maintenance, and potential therapeutic targeting.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Oncology
Quoc Thang Bui, Kuan-Der Lee, Yu-Ching Fan, Branwen S. Lewis, Lih-Wen Deng, Yuan-Chin Tsai
Summary: Cancer cells and MSCs secrete CCL2, which attracts TAMs and promotes malignant progression. Blocking CCL2 expression in MSCs showed anti-tumor effects when injected with prostate cancer cells in mice. The inhibitory effect was associated with an increase of mononuclear myeloid cells in tumors.
Review
Biochemistry & Molecular Biology
Pieter Jan Koopmans, Ahmed Ismaeel, Katarzyna Goljanek-Whysall, Kevin A. Murach
Summary: This article provides evidence for the role of miRNAs in controlling satellite cell function in adult skeletal muscle. It emphasizes the indispensability of miRNAs for satellite cell viability and the phases of myogenesis. The interplay between miRNAs and myogenic cell redox status, senescence, and communication to other muscle-resident cells during muscle adaptation is also discussed. Recent satellite cell miRNA profiling studies are summarized, and the need for novel genetic tools to further investigate miRNA control of satellite cell behavior in adult skeletal muscle in vivo is identified.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Yaprak Dilber Simay Demir, Aysun Ozdemir, Ceren Sucularli, Elifnur Benhur, Mustafa Ark
Summary: The study found that inhibiting the Rho/Rho kinase pathway can reduce the secretory activity of senescent cancer cells, change the composition of SASP, and inhibit the proliferation and migration of non-senescent cancer cells. This suggests that ROCK inhibitors may serve as novel therapeutic drugs targeting senescent cancer cells.
CELLULAR SIGNALLING
(2021)
Article
Andrology
Yu Tong, Yi-Jun Guo, Qin Zhang, Hai-Xia Bi, Kai Kai, Ren-Yuan Zhou
Summary: The study demonstrates that DHT increases TNF-α expression from lipopolysaccharide-treated M1 macrophages, promoting proliferation of prostate stromal cells. TNF-α mediates the activation of NF-kappa B and MAPK pathways, affecting the differentiation and proliferation of prostate cells.
ASIAN JOURNAL OF ANDROLOGY
(2022)
Article
Cell Biology
Alexander M. Wolf
Summary: The factors determining human biological aging remain unknown, while efforts to prevent aging are unlikely to succeed without understanding the molecular mechanisms. The tumor suppression theory proposes somatic mutation as the cause of aging, but suggests that oncogenic transformation and clonal expansion are the relevant consequences. Obesity and caloric restriction can accelerate or decelerate aging through their effects on cell proliferation, leading to various aging phenotypes.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Cell Biology
Jiaming Gao, Hao Wang, Junyan Shen, Xiaojing Liu, Xiaoqi Zhu, Ce Huang, Gongchen Li, Yao Sun, Zhongmin Liu, Yi Eve Sun, Hailiang Liu
Summary: This study reveals the mechanism by which GDF11 reverses aging of mesenchymal stem cells (MSCs) through the activation of the Smad2/3-PI3K-AKT-mTOR signaling pathway and upregulation of the DNA demethylase Tet2. The mutual regulatory relationship between GDF11 and Tet2 plays a crucial role in the anti-aging effects.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Junya Tomida, Kei-ichi Takata, Sarita Bhetawal, Maria D. Person, Hsueh-Ping Chao, Dean G. Tang, Richard D. Wood
Article
Oncology
Tae Gyu Choi, Minh Nam Nguyen, Jieun Kim, Yong Hwa Jo, Miran Jang, Ngoc Ngo Yen Nguyen, Hyeong Rok Yun, Wonchae Choe, Insug Kang, Joohun Ha, Dean G. Tang, Sung Soo Kim
JOURNAL OF PATHOLOGY
(2018)
Review
Oncology
Dingxiao Zhang, Dean G. Tang, Kiera Rycaj
SEMINARS IN CANCER BIOLOGY
(2018)
Review
Cell & Tissue Engineering
Sergej Skvortsov, Ira-Ida Skvortsova, Dean G. Tang, Anna Dubrovska
Article
Cell & Tissue Engineering
Dingxiao Zhang, Collene Jeter, Shuai Gong, Amanda Tracz, Yue Lu, Jianjun Shen, Dean G. Tang
Article
Biochemistry & Molecular Biology
Jin-Hwan Kim, Tae Gyu Choi, Seolhui Park, Hyeong Rok Yun, Ngoc Ngo Yen Nguyen, Yong Hwa Jo, Miran Jang, Jieun Kim, Joungmok Kim, Insug Kang, Joohun Ha, Michael P. Murphy, Dean G. Tang, Sung Soo Kim
CELL DEATH AND DIFFERENTIATION
(2018)
Article
Multidisciplinary Sciences
Qiuhui Li, Qu Deng, Hsueh-Ping Chao, Xin Liu, Yue Lu, Kevin Lin, Bigang Liu, Gregory W. Tang, Dingxiao Zhang, Amanda Tracz, Collene Jeter, Kiera Rycaj, Tammy Calhoun-Davis, Jiaoti Huang, Mark A. Rubin, Himisha Beltran, Jianjun Shen, Gurkamal Chatta, Igor Puzanov, James L. Mohler, Jianmin Wang, Ruizhe Zhao, Jason Kirk, Xin Chen, Dean G. Tang
NATURE COMMUNICATIONS
(2018)
Editorial Material
Medicine, General & Internal
Dingxiao Zhang, Dean G. Tang
Article
Developmental Biology
Evangelia Koutelou, Li Wang, Andria C. Schibler, Hsueh-Ping Chao, Xianghong Kuang, Kevin Lin, Yue Lu, Jianjun Shen, Collene R. Jeter, Andrew Salinger, Marenda Wilson, Yi Chun Chen, Boyko S. Atanassov, Dean G. Tang, Sharon Y. R. Dent
Article
Biotechnology & Applied Microbiology
Hsueh-Ping Chao, Yueping Chen, Yoko Takata, Mary W. Tomida, Kevin Lin, Jason S. Kirk, Melissa S. Simper, Carol D. Mikulec, Joyce E. Rundhaug, Susan M. Fischer, Taiping Chen, Dean G. Tang, Yue Lu, Jianjun Shen
Article
Cell Biology
Daric J. Wible, Hsueh-Ping Chao, Dean G. Tang, Shawn B. Bratton
Article
Multidisciplinary Sciences
Qiuhui Li, Bigang Liu, Hsueh-Ping Chao, Yibing Ji, Yue Lu, Rashid Mehmood, Collene Jeter, Taiping Chen, John R. Moore, Wenqian Li, Can Liu, Kiera Rycaj, Amanda Tracz, Jason Kirk, Tammy Calhoun-Davis, Jie Xiong, Qu Deng, Jiaoti Huang, Barbara A. Foster, Abhiram Gokhale, Xin Chen, Dean G. Tang
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Dingxiao Zhang, Qiang Hu, Xiaozhuo Liu, Yibing Ji, Hsueh-Ping Chao, Yan Liu, Amanda Tracz, Jason Kirk, Silvia Buonamici, Ping Zhu, Jianmin Wang, Song Liu, Dean G. Tang
NATURE COMMUNICATIONS
(2020)
Meeting Abstract
Urology & Nephrology
Bin Xu, Ruifang Liu, Ming Chen, Dean G. Tang
JOURNAL OF UROLOGY
(2019)
Review
Oncology
Dingxiao Zhang, Shuhong Zhao, Xinyun Li, Jason S. Kirk, Dean G. Tang