期刊
ONCOGENE
卷 30, 期 15, 页码 1733-1743出版社
SPRINGERNATURE
DOI: 10.1038/onc.2010.572
关键词
hPNPase(old-35); senescence; RNA degradation; c-myc; miRNA
资金
- NIH [R01 CA097318, R01 CA127641, CA134721, P01 CA104177, R01 CA134721]
- Samuel Waxman Cancer Research Foundation
- National Foundation for Cancer Research
Human polynucleotide phosphorylase (hPNPase(old-35)) is an evolutionary conserved RNA-processing enzyme with expanding roles in regulating cellular physiology. hPNPase(old-35) was cloned using an innovative 'overlapping pathway screening' strategy designed to identify genes coordinately regulated during the processes of cellular differentiation and senescence. Although hPNPase(old-35) structurally and biochemically resembles PNPase of other species, overexpression and inhibition studies reveal that hPNPase(old-35) has evolved to serve more specialized and diversified functions in humans. Targeting specific mRNA or non-coding small microRNA, hPNPase(old-35) modulates gene expression that in turn has a pivotal role in regulating normal physiological and pathological processes. In these contexts, targeted overexpression of hPNPase(old-35) represents a novel strategy to selectively downregulate RNA expression and consequently intervene in a variety of pathophysiological conditions. Oncogene (2011) 30, 1733-1743; doi:10.1038/onc.2010.572; published online 13 December 2010
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