期刊
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
卷 14, 期 6, 页码 665-677出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/omi.2010.0041
关键词
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资金
- Department of Biotechnology [BT/PR9100/Med/29/03/2007, BT/PR9563/BRB/10/567/2007, BT/PR11158/BRB/10/640/2008]
- National Science Foundation [EPS 0236913, MCB 0455318, DBI 0521587]
- Kansas Technology Enterprise Corporation
- K-IDeA Networks of Biomedical Research Excellence (INBRE) of National Institute of Health [P20RR16475]
- Johnson Cancer Center
- Kansas State University
- University Grants Commission
- Council of Scientific and Industrial Research, Government of India
- American Society of Microbiology
By employing electrospray ionization tandem mass spectrometry (ESI-MS/MS), the phospholipidomes of eight hemiascomycetous human pathogenic Candida species have been characterized. Over 200 phospholipid molecular species were identified and quantified. There were no large differences among Candida species in phosphoglyceride class composition; however, differences in phosphoglycerides components (i.e., fatty acyl chains) were identified. In contrast, differences in sphingolipid class composition as well as in molecular species were quite evident. The phospholipid compositions of C. albicans, C. glabrata, C. parapsilosis, C. kefyr, C. tropicalis, C. dubliniensis, C. krusei, and C. utilis could be further discriminated by principal component analysis. Notwithstanding that a single strain of each species was analyzed, our data do point to a typical molecular species imprint of Candida strains.
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