Article
Biochemistry & Molecular Biology
Taeyeon Hong, Hahyun Park, Garam An, Junho Park, Gwonhwa Song, Whasun Lim
Summary: This study identified the developmental toxicity of the herbicide fluchloralin in zebrafish, leading to decreased survival rate, body length, and increased yolk sac edema. Fluchloralin exposure also resulted in inhibition of neurogenesis and motor neuron defects, as well as organ dysfunction in the heart, liver, and pancreas. The study highlights the importance of controlling pollutants in aquatic environments.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Cell Biology
Chang Liu, Rui Li, Young Li, Xiumei Lin, Kaichen Zhao, Qun Liu, Shuowen Wang, Xueqian Yang, Xuyang Shi, Yuting Ma, Chenyu Pei, Hui Wang, Wendai Bao, Junhou Hui, Tao Yang, Zhicheng Xu, Tingting Lai, Michael Arman Berberoglu, Sunil Kumar Sahu, Miguel A. Esteban, Kailong Ma, Guangyi Fan, Yuxiang Li, Shiping Liu, Ao Chen, Xun Xu, Zhiqiang Dong, Longqi Liu
Summary: This study used Stereo-seq and scRNA-seq data to analyze the spatially resolved developmental trajectories of cell-fate transitions and molecular changes during zebrafish embryogenesis. Important interactions were identified, providing a fundamental reference for further studies on vertebrate development.
DEVELOPMENTAL CELL
(2022)
Article
Biochemistry & Molecular Biology
Ivanildo Inacio da Silva Jr, Niely Priscila Correia da Silva, James A. Marrs, Pabyton Goncalves Cadena
Summary: This study evaluated the effects of lemongrass, thyme, and oregano essential oils on zebrafish embryos and larvae, and found that these oils can influence the development and cause morphological defects and behavioral changes in the embryos and larvae. Essential oil exposure may have neurodevelopmental toxicity on zebrafish. Therefore, careful use of essential oils, especially during pregnancy, should be considered.
Article
Plant Sciences
Mohsen Hosseini, Abbas Saidi, Reza Maali-Amiri, Amin Abbasi, Fariba Khosravi-Nejad
Summary: The study investigated the relationships between developmental regulations and metabolic changes during low temperature acclimation and vernalization in wheat. Different wheat genotypes were cultivated under field conditions, showing variations in growth and metabolic characteristics.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Cell Biology
Martin R. Silic, Ziyu Dong, Yueyi Chen, Adam Kimbrough, Guangjun Zhang
Summary: Research has revealed that zebrafish embryos exhibit specific cellular bioelectric signals at different stages of development, suggesting a potentially important role in zebrafish embryogenesis that could underlie human congenital diseases.
Article
Biochemistry & Molecular Biology
Liana Bastos Freitas-Fernandes, Gabriela Pereira Fontes, Aline dos Santos Letieri, Ana Paula Valente, Ivete Pomarico Ribeiro de Souza, Tatiana Kelly da Silva Fidalgo
Summary: The objective of this study was to identify the salivary metabolic profile of healthy infants and young children and correlate it with age, salivary gland maturation, and dentition. Saliva samples were collected from 48 children and analyzed using 1H NMR. The results showed distinct salivary metabolomic profiles associated with age and developmental phase, with more evident changes observed in children older than 30 months. The findings suggest that saliva profiling can be a useful tool for monitoring physiological changes during infancy.
Article
Behavioral Sciences
Jaquelinne Pinheiro-da-Silva, Ana Carolina Luchiari
Summary: Ethanol exposure during embryogenesis can have harmful effects on zebrafish, leading to reduced body size, decreased heartbeat rate, increased apoptotic cell numbers, and differences in hatching time. This study highlights the zebrafish as a suitable model for studying fetal alcohol spectrum disorders (FASD).
BRAIN AND BEHAVIOR
(2021)
Article
Automation & Control Systems
Jing Cao, Yuning Wang, Yong Zhang, Kun Qian
Summary: Recent developments in mass spectrometry-based metabolic fingerprinting analysis have facilitated its practical clinical applications by addressing challenges such as rapid signal readout, high throughput, direct MS analysis, and intelligent data mining of complex biological samples.
ADVANCED INTELLIGENT SYSTEMS
(2022)
Article
Engineering, Environmental
Zulvikar Syambani Ulhaq, William Ka Fai Tse
Summary: In this study, zebrafish embryos were exposed to PFHxS and it was found that PFHxS accumulated in the embryos, leading to phenotypic abnormalities and disruption of cellular processes. Further analysis revealed that PFHxS affected glucose metabolism, lipid metabolism, and oxidative stress, resulting in increased reactive oxygen species, lipid accumulation, and cell cycle arrest. These findings highlight the potential toxicities of PFHxS.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Karem N. Vazquez Roman, Warren W. Burggren
Summary: The morphological effects of crude oil exposure on early fish development have been well-studied, but the metabolic effects and critical windows of exposure remain unclear. This study found that zebrafish exposed to crude oil showed increased routine oxygen consumption and critical oxygen tension, depending on the day of exposure. The most significant effects on body mass and oxygen consumption occurred when exposure happened at around 3 days post-fertilization, which aligns with the vulnerable period of hatching in zebrafish development.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Immunology
Tarannum Taznin, Kaushalya Perera, Yann Gibert, Alister C. Ward, Clifford Liongue
Summary: This study investigated the expression and function of CRLF3, an evolutionarily significant protein, in early development, particularly in blood and immune cells, using zebrafish as a model. The study found that CRLF3 was expressed in multiple embryonic tissues and played a crucial role in primitive hematopoiesis and early definitive hematopoiesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Margarete Diaz-Cuadros, Teemu P. Miettinen, Owen S. Skinner, Dylan Sheedy, Carlos Manlio Diaz-Garcia, Svetlana Gapon, Alexis Hubaud, Gary Yellen, Scott R. Manalis, William M. Oldham, Olivier Pourquie
Summary: Animals display inter-species variation in embryonic development rates, with differences in biochemical reaction rates being thought responsible for species-specific rates. This study establishes an in vitro system using pluripotent stem cells to simulate the twofold difference in developmental rates between mouse and human embryos. The mass-specific metabolic rates were found to scale with developmental rate, higher in mouse cells than in human cells. Manipulating metabolic rates could control developmental rate and have translational applications.
Article
Biotechnology & Applied Microbiology
Liqin Liao, Ziqi Yao, Jie Kong, Xinheng Zhang, Hongxin Li, Weiguo Chen, Qingmei Xie
Summary: This study conducted transcriptome analysis of five early developmental stages in White Leghorn chicken, covering 17,478 genes with about 807 million clean reads of RNA-sequencing. Comparative analysis of differentially expressed TFs between neighboring developmental timepoints revealed significantly enriched biological categories associated with differentiation, development, and morphogenesis. The study identified Zf-C2H2, Homeobox, and bHLH as three dominant transcription factor families in early embryogenesis, and constructed a TFs co-expression network to identify critical TFs.
Article
Biotechnology & Applied Microbiology
Rayan Awada, Maud Lepelley, David Breton, Aline Charpagne, Claudine Campa, Victoria Berry, Frederic Georget, Jean-Christophe Breitler, Sophie Leran, Doaa Djerrab, Federico Martinez-Seidel, Patrick Descombes, Dominique Crouzillat, Benoit Bertrand, Herve Etienne
Summary: This study investigated the transcriptome profiling of somatic embryogenesis (SE) in coffee and identified key developmental phase switches and related genes. The study also analyzed the expression patterns of hormone-related genes, transcription factor-related genes, and secondary metabolism-related genes during SE. The results provide valuable information for optimizing SE protocols in various plant species.
Review
Biochemistry & Molecular Biology
Gaia Pucci, Giusi Irma Forte, Vincenzo Cavalieri
Summary: Radiotherapy is not yet personalized in cancer treatment plans, as its effectiveness varies depending on the radiosensitivity of tumor cells. Research is focusing on enhancing cancer cell response to ionizing radiation and protecting healthy tissues, using zebrafish as an effective model system for testing radiation modifiers for potential radiotherapeutic purposes in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)