期刊
ODONTOLOGY
卷 103, 期 3, 页码 348-355出版社
SPRINGER
DOI: 10.1007/s10266-014-0160-7
关键词
Alpha-mangostin; HGFs; IL-6/8
资金
- Faculty of Dentistry, Naresuan University [R2556C081]
This study aims to investigate the effect of alpha-mangostin on interleukin (IL)-6 and IL-8 expression in human gingival fibroblasts (HGFs). HGFs were challenged with Porphyromonas gingivalis LPS and then treated with various concentrations of alpha-mangostin. The cytotoxicity was determined using MTS assay and cytokine expressions were evaluated by Real-time PCR and ELISA. The results showed that 5 mu g/ml P. gingivalis LPS and alpha-mangostin at 1 mu g/ml or less did not affect the viability of HGFs. Alpha-mangostin reduced IL-6 and IL-8 mRNA and protein in P. gingivalis LPS-stimulated HGFs. These findings suggested that alpha-mangostin might be used as an adjunct to the periodontal therapy.
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