Review
Gastroenterology & Hepatology
Corey Saraceni, John Birk
Summary: Despite advances in therapy, HBV and HCV remain significant global health burdens, leading to cirrhosis, hepatocellular carcinoma, and death worldwide. The development of HBV vaccine has greatly reduced spread of the virus, while new direct acting antivirals have improved treatment for HCV. However, challenges such as treatment failures and limitations in vaccine efficacy still exist.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Daniel Castaneda, Adalberto Jose Gonzalez, Mohammad Alomari, Kanwarpreet Tandon, Xaralambos Bobby Zervos
Summary: Viral infections affecting the liver have significant impact on human health, leading to high morbidity and mortality rates. Understanding hepatitis A, B, C, D, and E is crucial for healthcare professionals to provide proper care for patients. Scientific advancements have made controlling and curing these infections a possibility, with a focus on preventive medicine through vaccination.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biophysics
Ru Cheng, Fu Zhu, Min Huang, Qiang Zhang, Hui Hong Yan, Xiao Hui Zhao, Fu Kang Luo, Chun Mei Li, Hui Liu, Gao Lin Liang, Cheng Zhi Huang, Jian Wang
Summary: In this study, a new biosensor named hepatitis virus indicator was developed for the simultaneous detection of HBV and HCV. The biosensor utilized Exo III assisted signal amplification strategy and particle counting technology with a dark-field microscopy, enabling sensitive and selective detection.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Immunology
Isabelle Desombere, Freya Van Houtte, Ali Farhoudi, Lieven Verhoye, Caroline Buysschaert, Yvonne Gijbels, Sibyl Couvent, Wilfried Swinnen, Hans Van Vlierberghe, Andre Elewaut, Andrea Magri, Zania Stamataki, Philip Meuleman, Jane A. McKeating, Geert Leroux-Roels
Summary: Hepatitis C virus can be transmitted by B cells, but B cells from recently infected patients failed to transmit the virus to mice, while all serum samples were infectious. The study also observed an association between circulating antibodies and B cell transmission of HCV.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Nicole E. Skinner, Clinton O. Ogega, Nicole Frumento, Kaitlyn E. Clark, Srinivasan Yegnasubramanian, Kornel Schuebel, Jennifer Meyers, Anuj Gupta, Sarah Wheelan, Andrea L. Cox, James E. Crowe Jr, Stuart C. Ray, Justin R. Bailey
Summary: By analyzing the B cell receptors (BCRs) of HCV-infected individuals, researchers identified distinctive BCR features associated with broad neutralization of HCV. These features include long heavy chain complementarity determining region 3 (CDRH3) regions, specific VH gene usage, increased frequencies of somatic hypermutation, and particular VH gene mutations. Further study of these antibodies can inform HCV vaccine development.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Public, Environmental & Occupational Health
S. Mehmandoost, M. Khezri, G. Mousavian, F. Tavakoli, F. Mehrabi, H. Sharifi, K. Dolan, M. Shokoohi
Summary: This study systematically summarized the prevalence of HIV, HBV, and HCV infections among incarcerated people in Iran. The results showed that the prevalences of these infections are relatively high in this population. Meta-analysis and regression analysis found a decrease in HIV and HCV infections over time.
Article
Oncology
Yung-Rung Lai, Ya-Lan Chang, Chiu-Hsiang Lee, Tung-Han Tsai, Kuang-Hua Huang, Chien-Ying Lee
Summary: The study found that patients with HBV and HCV have a higher incidence of NHL, indicating a significant correlation.
Article
Gastroenterology & Hepatology
Erkin Musabaev, Chris Estes, Shakhlo Sadirova, Shokhista Bakieva, Krestina Brigida, Rick Dunn, Shyamasundaran Kottilil, Poonam Mathur, Ameer Abutaleb, Kathryn Razavi-Shearer, Tim Anstiss, Bakhodir Yusupaliev, Homie Razavi
Summary: Chronic infection with HBV and HCV is a major cause of liver disease and mortality in Uzbekistan. This study demonstrated the feasibility of large-scale simplified testing and treatment to implement a national viral hepatitis elimination program.
LIVER INTERNATIONAL
(2023)
Review
Public, Environmental & Occupational Health
Yahya Shadi, Bahram Heshmati, Jalal Poorolajal
Summary: This meta-analysis examines the relationship between hepatitis B virus (HBV), hepatitis C virus (HCV), smoking, and the development of hepatocellular carcinoma (HCC). The results show that the combined impact of HBV and smoking, HCV and smoking, as well as coinfection of HBV and HCV are associated with the development of HCC.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Microbiology
Ghobad Moradi, Seyed Moayed Alavian, Fatemeh Gholami, Rashid Ramezani, Leila Ahangarzadeh, Yousef Moradi, Heidar Sharafi
Summary: This study in Iranian prisons revealed high prevalence of hepatitis B and C infections, with risk factors such as history of imprisonment, drug use, unprotected sexual contact, and tattooing contributing to transmission. Special attention to prisons, continuing HBV vaccination, and implementing screening and treatment protocols for HCV-infected individuals can help achieve the goal of eliminating hepatitis by 2030.
Article
Gastroenterology & Hepatology
Po-Yao Hsu, Yu-Ju Wei, Po-Cheng Liang, Jia-Jung Lee, Sheng-Wen Niu, Jiun-Chi Huang, Cheng-Ting Hsu, Tyng-Yuan Jang, Ching- Huang, Yi-Hung Lin, Ming-Yen Hsieh, Meng-Hsuan Hsieh, Szu-Chia Chen, Chia-Yen Dai, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Jer-Ming Chang, Ming-Lun Yeh, Chung-Feng Huang, Yi-Wen Chiu, Shang-Jyh Hwang, Wan-Long Chuang, Ming-Lung Yu
Summary: Hemodialysis patients are at increased risk of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. This study found that hemodialysis patients with HCV exhibited a higher burden of comorbidities, especially in ischemic heart diseases, respiratory disorders, and mental/behavioral disorders, compared to patients with HBV and those without viral hepatitis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Samina Ejaz, Iqra Abdullah, Waqas Nazir Malik, Shazia Anjum, Muhammad Ashraf, Naveed Akhtar, Aurangzeb Khan, Yasir Hameed, Muhammad Usman, Usman Cheema, Safeena Sidiq
Summary: This study aims to investigate the prevalence and associated risk factors of hepatitis among students and employees in Pakistan and implement measures to make IUB hepatitis free. The study found that hepatitis is more prevalent in men and is associated with sharing of needles and certain behavioral and medical factors.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Immunology
Eddy Fadlyana, Kusnandi Rusmil, Meita Dhamayanti, Rodman Tarigan, Cissy B. Kartasasmita, Rini Mulia Sari, Muhammad Gilang Dwi Putra, Hadyana Sukandar
Summary: This study evaluated the immunogenicity of the DTP-HB-Hib vaccine using a different source of hepatitis B. The vaccine was found to be immunogenic, well tolerated, and suitable as a replacement for licensed-equivalent vaccines. No serious adverse events related to the study vaccine occurred.
Article
Biophysics
Suchanat Boonkaew, Abdulhadee Yakoh, Nattaya Chuaypen, Pisit Tangkijvanich, Sirirat Rengpipat, Weena Siangproh, Orawon Chailapakul
Summary: Electrochemical paper-based analytical devices (ePADs) are simple, portable, and low-cost analytical devices for point-of-care testing of clinical biomarkers. A sequential ePAD has been developed for simultaneous detection of hepatitis B surface antigen and hepatitis C core antigen by integrating dual flow behaviors, avoiding the need for complex multi-step reagent manipulation by the user. The proposed ePAD shows high promise as an easy-to-use, portable, and extendable sensor for other multiplex biological assays.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Medicine, General & Internal
Yi-Tse Su, Ming-Ling Chang, Yun-Fan Liaw
Summary: Concurrent infection of hepatitis B virus (HBV) and hepatitis C virus (HCV) is not uncommon, as they have similar routes of transmission. HBV is usually suppressed by HCV, but HBV reactivation can occur during or after anti-HCV treatment. In this report, we describe an unusual viral evolution in a patient with concurrent HBV and HCV infection. HCV reactivation occurred during entecavir therapy to treat severe HBV flare, and subsequent anti-HCV therapy triggered a second HBV flare despite sustained virological response to HCV infection. Further entecavir therapy successfully treated the flare.
FRONTIERS IN MEDICINE
(2023)
