Article
Immunology
Giuseppe Barilaro, Emmanuel Coloma-Bazan, Alejandro Chacur, Carlo Della Rocca, Albert Perez-Isidro, Estibaliz Ruiz-Ortiz, Odette Vinas, Dolors Tassies Penella, Joan Carles Reverter, Alicia Molina Andujar, Ricard Cervera, Gerard Espinosa
Summary: The purpose of this study was to analyze the persistence of antiphospholipid antibodies (aPL) over time in patients with antiphospholipid syndrome (APS) and its association with clinical recurrence. The results showed that more than half of the patients maintained persistent positive aPLs over a long-term follow-up, and these patients were more prone to experience recurrence of clinical manifestations.
AUTOIMMUNITY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Svetlana Vrzic Petronijevic, Aleksandra Vilotic, Zanka Bojic-Trbojevic, Sanja Kostic, Milos Petronijevic, Ljiljana Vicovac, Milica Jovanovic Krivokuca
Summary: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies (aPL). Women with APS are at high risk of recurrent early pregnancy loss and late obstetrical complications. In addition to vascular thrombosis, research has found that aPL has a direct negative effect on placental cells, which is a major mechanism of obstetric APS.
Article
Rheumatology
Medha Barbhaiya, Stephane Zuily, Ray Naden, Alison Hendry, Florian Manneville, Mary-Carmen Amigo, Zahir Amoura, Danieli Andrade, Laura Andreoli, Bahar Artim-Esen, Tatsuya Atsumi, Tadej Avcin, Michael H. Belmont, Maria Laura Bertolaccini, D. Ware Branch, Graziela Carvalheiras, Alessandro Casini, Ricard Cervera, Hannah Cohen, Nathalie Costedoat-Chalumeau, Mark Crowther, Guilherme de Jesus, Aurelien Delluc, Sheetal Desai, Maria De Sancho, Katrien M. Devreese, Reyhan Diz-Kucukkaya, Ali Duarte-Garcia, Camille Frances, David Garcia, Jean-Christophe Gris, Natasha Jordan, Rebecca K. Leaf, Nina Kello, Jason S. Knight, Carl Laskin, Alfred I. Lee, Kimberly Legault, Steve R. Levine, Roger A. Levy, Maarten Limper, Michael D. Lockshin, Karoline Mayer-Pickel, Jack Musial, Pier Luigi Meroni, Giovanni Orsolini, Thomas L. Ortel, Vittorio Pengo, Michelle Petri, Guillermo Pons-Estel, Jose A. Gomez-Puerta, Quentin Raimboug, Robert Roubey, Giovanni Sanna, Surya V. Seshan, Savino Sciascia, Maria G. Tektonidou, Angela Tincani, Denis Wahl, Rohan Willis, Cecile Yelnik, Catherine Zuily, Francis Guillemin, Karen Costenbader, Doruk Erkan
Summary: This study developed new APS classification criteria with high specificity, including clinical and laboratory domains, and improved classification accuracy through weighting and stratification.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Katja Perdan-Pirkmajer, Polona Zigon, Anja Boc, Eva Podovsovnik, Sasa Cucnik, Alenka Mavri, Ziga Rotar, Ales Ambrozic
Summary: This study suggests that negative aCL and/or anti-beta 2GPI at the time of acute DVT may not require further aPL testing, while LA should be checked after discontinuation of anticoagulant therapy. Positive aCL and/or anti-beta 2GPI at the time of acute DVT have a strong positive predictive value for APS and may impact therapeutic decisions.
Article
Medicine, General & Internal
Siobhan Quenby, Katie Booth, Louise Hiller, Arri Coomarasamy, Paulien G. de Jong, Eva N. Hamulyak, Luuk J. Scheres, Thijs F. van Haaps, Lauren Ewington, Mariette Gojjin, Shreeya Tewary, Saskia Middeldorp
Summary: The use of low-molecular-weight heparin (LMWH) did not increase livebirth rates in women with recurrent pregnancy loss and inherited thrombophilia. Therefore, the use of LMWH is not recommended in these women.
Review
Pharmacology & Pharmacy
Ariela Hoxha, Daniela Tormene, Elena Campello, Paolo Simioni
Summary: This study conducted a systematic review on the additional treatments used in refractory and high-risk antiphospholipid antibody syndrome (APS) pregnancies. The results showed that combination therapy with IVIG and PEX achieved a 100% live birth rate in refractory APS pregnancies, while Pravastatin, IA, and PEX showed higher live birth rates in high-risk APS pregnancies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Microbiology
Marc Emmenegger, Sreedhar Saseendran F. Kumar, Vishalini J. Emmenegger, Tomas J. Malinauskas, Thomas Buettner, Laura Rose, Peter Schierack, Martin B. Sprinzl, Clemens Sommer, Karl B. Lackner, Adriano Aguzzi, Dirk B. Roggenbuck, Katrin B. M. Frauenknecht
Summary: SARS-CoV-2 infection can lead to diverse symptoms, with some patients developing hypercoagulation and autoantibody responses. Research has shown that infection with SARS-CoV-2 can result in the production of autoantibodies, particularly IgM antibodies targeting coagulation proteins. Further investigation is needed to explore the relationship between SARS-CoV-2 infection, autoantibody production, and disease severity.
Article
Biochemistry & Molecular Biology
Cecilia Nalli, Daniele Lini, Laura Andreoli, Francesca Crisafulli, Micaela Fredi, Maria Grazia Lazzaroni, Viktoria Bitsadze, Antonia Calligaro, Valentina Canti, Roberto Caporali, Francesco Carubbi, Cecilia Beatrice Chighizola, Paola Conigliaro, Fabrizio Conti, Caterina De Carolis, Teresa Del Ross, Maria Favaro, Maria Gerosa, Annamaria Iuliano, Jamilya Khizroeva, Alexander Makatsariya, Pier Luigi Meroni, Marta Mosca, Melissa Padovan, Roberto Perricone, Patrizia Rovere-Querini, Gian Domenico Sebastiani, Chiara Tani, Marta Tonello, Simona Truglia, Dina Zucchi, Franco Franceschini, Angela Tincani
Summary: The study found that decreased complement levels before pregnancy are associated with an increased risk of adverse pregnancy outcomes in women with triple antiphospholipid antibodies positivity, while this trend was not observed in those with single or double positivity. Complement levels are cost-effective and easy to measure, making them a potentially useful tool for identifying pregnant women at risk of pregnancy loss.
Article
Biochemistry & Molecular Biology
Simona Caraiola, Laura Voicu, Ciprian Jurcut, Alina Dima, Cristian Baicus, Anda Baicus, Claudia Oana Cobilinschi, Razvan Adrian Ionescu
Summary: This research aimed to evaluate the correlations between the titres of non-criteria aPLs and the already studied criteria aPLs in APS patients. The results showed moderate correlations mainly between the tested non-criteria antibodies and the criteria ones, suggesting little added value for the use of the tested non-criteria aPLs.
Article
Rheumatology
Elena Gkrouzman, Ecem Sevim, Jackie Finik, Danieli Andrade, Vittorio Pengo, Savino Sciascia, Maria G. Tektonidou, Amaia Ugarte, Cecilia B. Chighizola, H. Michael Belmont, Chary Lopez-Pedrera, Lanlan Ji, Paul Fortin, Maria Efthymiou, Guilherme Ramires de Jesus, D. Ware Branch, Cecilia Nalli, Michelle Petri, Esther Rodriguez, Ricard Cervera, Jason S. Knight, Tatsuya Atsumi, Rohan Willis, Maria Laura Bertolaccini, Hannah Cohen, Jacob Rand, Doruk Erkan
Summary: The study revealed that approximately 80% of patients with persistently antiphospholipid antibody (aPL) positive remained stable in their aPL profiles over a 5-year follow-up period. Additionally, the decrease in triple aPL positivity at baseline was associated with increased odds of stable aPL profile.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Immunology
Michael A. Cole, Gloria F. Gerber, Shruti Chaturvedi
Summary: Complement is a major driver of antiphospholipid syndrome (APS) and a promising therapeutic target. Reliable, rapid-turnaround biomarkers are needed in APS to predict adverse clinical outcomes and determine who will benefit most from complement inhibition. Current studies highlight the inconsistencies in testing, suggesting that cell-based testing or multiplex panels may be most clinically relevant.
CLINICAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alex A. Gandhi, Shanea K. Estes, Christine E. Rysenga, Jason S. Knight
Summary: Antiphospholipid syndrome (APS) is a leading cause of thrombosis, with pathogenic antibodies circulating at stable levels in blood, but thrombotic events often requiring a second hit. Investigators have turned to animal models to explore APS mechanisms, with each model having potential advantages and disadvantages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Simona Truglia, Antonella Capozzi, Silvia Mancuso, Valeria Manganelli, Luca Rapino, Gloria Riitano, Serena Recalchi, Serena Colafrancesco, Fulvia Ceccarelli, Tina Garofalo, Cristiano Alessandri, Agostina Longo, Roberta Misasi, Fabrizio Conti, Maurizio Sorice
Summary: Antiphospholipid syndrome (APS) is more common in women than in men, with male patients often exhibiting high levels of IgM anti-cardiolipin antibodies and a higher incidence of arterial thrombosis and myocardial infarction. Gender appears to influence the serological and clinical profiles of APS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ariadna Anunciacion-Llunell, Candido Munoz, Dirk Roggenbuck, Stefano Frasca, Josep Pardos-Gea, Enrique Esteve-Valverde, Jaume Alijotas-Reig, Francesc Miro-Mur
Summary: Antiphospholipid syndrome (APS) is a systemic autoimmune condition characterized by the presence of antiphospholipid antibodies (aPL) associated with vascular thrombosis and/or pregnancy complications. The study found that OAPS and TAPS patients displayed different but overlapping clusters based on their aPL reactivities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Marco Capecchi, Maria Abbattista, Alessandro Ciavarella, Mario Uhr, Cristina Novembrino, Ida Martinelli
Summary: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies and thrombosis or obstetrical complications. Anticoagulant therapy is the mainstay of treatment, but its optimal intensity and risk stratification for thrombosis are still unclear.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Francesca L. Facco, Susan Redline, Shannon M. Hunter, Phyllis C. Zee, William A. Grobman, Robert M. Silver, Judette M. Louis, Grace W. Pien, Brian Mercer, Judith H. Chung, C. Noel Bairey Merz, David M. Haas, Chia-Ling Nhan-Chang, Hyagriv N. Simhan, Frank P. Schubert, Samuel Parry, Uma Reddy, George R. Saade, Matthew K. Hoffman, Lisa D. Levine, Ronald J. Wapner, Janet M. Catov, Corette B. Parker
Summary: There is a link between sleep-disordered breathing (SDB) during pregnancy and/or after delivery with hypertension (HTN) and metabolic syndrome (MS). This study found that an apnea-hypopnea index (AHI) >= 5 during pregnancy was associated with an increased risk of MS, while an oxygen desaturation index (ODI) >= 5 during pregnancy was significantly associated with both HTN and MS. Participants who had persistently elevated AHI and ODI during pregnancy and at 2-7 years after delivery had the highest risk for HTN and MS.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Obstetrics & Gynecology
Samuel Parry, Benjamin A. Carper, William A. Grobman, Ronald J. Wapner, Judith H. Chung, David M. Haas, Brian Mercer, Robert M. Silver, Hyagriv N. Simhan, George R. Saade, Uma M. Reddy, Corette B. Parker
Summary: The study aimed to investigate placental physiology and identify novel biomarkers related to adverse pregnancy outcomes. The findings indicate that certain analytes in maternal serum during early pregnancy are associated with adverse pregnancy outcomes, but the test characteristics of these analytes do not support their use as clinical biomarkers for predicting adverse pregnancy outcomes, either alone or in combination with maternal clinical characteristics.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Behavioral Sciences
Morgan R. Firestein, Russell D. Romeo, Hailey Winstead, Danielle A. Goldman, William A. Grobman, David Haas, Brian Mercer, Corette Parker, Samuel Parry, Uma Reddy, Robert Silver, Hyagriv Simhan, Ronald J. Wapner, Frances A. Champagne
Summary: Fetal exposure to testosterone may increase the risk of autism spectrum disorder (ASD). The role of placental aromatase in preventing fetal exposure to maternal testosterone and its implications for child neurodevelopment have not been fully explored. This study examined the relationships between prenatal maternal testosterone and estradiol levels, cord blood testosterone and estradiol levels, placental aromatase expression, and neurodevelopment in children. The findings suggest that maternal testosterone levels are associated with SCQ scores, while maternal estradiol levels are negatively associated with BASC-3 Clinical Probability scores in males.
HORMONES AND BEHAVIOR
(2022)
Article
Obstetrics & Gynecology
Lauren H. Theilen, Philip Greenland, Jasmina Varagic, Janet Catov, Anthony Shanks, Vanessa Thorsten, Corette B. Parker, Rebecca McNeil, Brian Mercer, Matthew Hoffman, Ronald Wapner, David Haas, Hyagriv Simhan, William Grobman, Judith H. Chung, Lisa D. Levine, Shannon Barnes, Noel Bairey Merz, George Saade, Robert M. Silver
Summary: After analyzing the association between aspirin use during the first pregnancy and later cardiovascular risk, the study found no significant correlation between aspirin use and specific cardiovascular diagnoses after adjusting for aspirin use propensity score.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Obstetrics & Gynecology
Austin Oberlin, Jacqueline Wallace, Janet L. Moore, Sarah Saleem, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Lester Figueroa, Nancy F. Krebs, Fabian Esamai, Edward Liechty, Sheri Bucher, Archana B. Patel, Patricia L. Hibberd, Elwyn Chomba, Waldemar A. Carlo, Shivaprasad Goudar, Richard J. Derman, Marion Koso-Thomas, Elizabeth M. McClure, Robert L. Goldenberg
Summary: This study explores maternal morbidity using quality data from LMICs and compares it to the WHO estimate. The results show that delivery location and birth attendant type have an impact on maternal morbidity, with lower rates observed in non-hospital healthcare facilities and among non-physician clinicians.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Pediatrics
T. Michael O'Shea, Monica McGrath, Judy L. Aschner, Barry Lester, Hudson P. Santos, Carmen Marsit, Annemarie Stroustrup, Crisma Emmanuel, Mark Hudak, Elisabeth McGowan, Simran Patel, Rebecca C. Fry
Summary: The National Institutes of Health's ECHO Program conducts research on the links between children's environment and health, with a focus on very preterm infants. The program utilizes data from three cohorts to study the effects of environmental factors on the health outcomes of preterm infants.
PEDIATRIC RESEARCH
(2023)
Article
Obstetrics & Gynecology
Robert I. Goldenberg, Sarah Saleem, Sk Masum Billah, Jean Kim, Janet L. Moore, Najia Karim Ghanchi, Rashidul Haque, Lester Figueroa, Alejandra Ayala, Adrien Lokangaka, Antoinette Tshefu, Shivaprasad S. Goudar, Avinash Kavi, Manjunath Somannavar, Fabian Esamai, Musaku Mwenechanya, Elwyn Chomba, Archana Patel, Prabir Das, Wilfred Injera Emonyi, Samuel Edidi, Madhavi Deshmukh, Biplob Hossain, Shahjahan Siraj, Manolo Mazariegos, Ana L. Garces, Melissa Bauserman, Carl L. Bose, William A. Petri, Nancy F. Krebs, Richard J. Derman, Waldemar A. Carlo, Edward A. Liechty, Patricia L. Hibberd, Marion Koso-Thomas, Nalini Peres-da-Silva, Tracy L. Nolen, Elizabeth M. McClure
Summary: This study aimed to determine the COVID-19 antibody positivity rates over time and its relationship to pregnancy outcomes in low- and middle-income countries. The results showed that the COVID-19 antibody positivity increased during pregnancy, but most adverse pregnancy outcomes were not significantly associated with antibody positivity.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medicine, General & Internal
Alan T. N. Tita, Waldemar A. Carlo, Elizabeth M. McClure, Musaku Mwenechanya, Elwyn Chomba, Jennifer J. Hemingway-Foday, Avinash Kavi, Mrityunjay C. Metgud, Shivaprasad S. Goudar, Richard Derman, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Carl Bose, Poonam Shivkumar, Manju Waikar, Archana Patel, Patricia L. Hibberd, Paul Nyongesa, Fabian Esamai, Osayame A. Ekhaguere, Sherri Bucher, Saleem Jessani, Shiyam S. Tikmani, Sarah Saleem, Robert L. Goldenberg, Sk M. Billah, Ruth Lennox, Rashidul Haque, William Petri, Lester Figueroa, Manolo Mazariegos, Nancy F. Krebs, Janet L. Moore, Tracy L. Nolen, Marion Koso-Thomas
Summary: In women planning a vaginal delivery, a single oral dose of azithromycin significantly reduced the risk of maternal sepsis or death compared to placebo, but had little effect on newborn sepsis or death.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Obstetrics & Gynecology
Avinash Kavi, Shivaprasad S. S. Goudar, Manjunath S. S. Somannavar, Janet L. L. Moore, Richard J. J. Derman, Sarah Saleem, Seemab Naqvi, Sk Masum Billah, Rashidul Haque, Lester Figueroa, Manolo Mazariegos, Adrien Lokangaka, Antoinette Tshefu, Fabian Esamai, Musaku Mwenechanya, Elwyn Chomba, Archana Patel, Prabirkumar Das, Melissa Bauserman, William A. A. Petri Jr, Nancy F. F. Krebs, Waldemar A. A. Carlo, Sherri Bucher, Patricia L. L. Hibberd, Marion Koso-Thomas, Elizabeth M. M. McClure, Robert L. L. Goldenberg
Summary: This study aimed to investigate the relationship between COVID-19 symptoms and COVID-19 antibody positivity in unvaccinated pregnant women in low- and middle-income countries (LMICs). The results showed that unvaccinated pregnant women who were antibody-positive had slightly more symptoms during their pregnancy, with a small but significantly greater increase in fever. However, evaluating COVID-19-related symptoms does not appear to be useful in differentiating pregnant women who have had a COVID-19 infection.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Obstetrics & Gynecology
Robert Goldenberg, Sarah S. Saleem, Shivaprasad Goudar, Janet Moore, Gowdar Guruprasad, Vardendra M. Kulkarni, Sangappa Dhaded, Shiyam Sunder Tikmani, Sidrah Nausheen, Shazia G. Masheer, Mangala K. Kallapur, Najia U. Ghanchi, Sheetal Harakuni, Imran Ahmed, Kay Hwang, S. S. Yogeshkumar, Manjunath Somannavar, Haleema Yasmin, Jean M. Kim, Carla M. Bann, Robert M. Silver, Elizabeth McClure, PURPOSe Study Grp
Summary: The study aimed to determine the cause of death for stillbirths and preterm neonatal deaths using clinical data and tissue sampling methods. The major findings suggest that most stillbirths were caused by fetal asphyxia, often associated with placental malperfusion and conditions like pre-eclampsia. Preterm neonatal deaths were primarily caused by birth asphyxia and various infections, with a significant number of deaths attributed to nosocomial infections acquired after neonatal intensive care.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Avinash Kavi, Matthew K. Hoffman, Manjunath S. Somannavar, Mrityunjay C. Metgud, Shivaprasad S. Goudar, Janet Moore, Eleanor Nielsen, Norman Goco, Elizabeth M. McClure, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Musaku Mwenechanya, Elwyn Chomba, Waldemar A. Carlo, Lester Figueroa, Nancy F. Krebs, Saleem Jessani, Sarah Saleem, Robert L. Goldenberg, Prabirkumar Das, Archana Patel, Patricia L. Hibberd, Fabian Esamai, Sherri Bucher, Marion Koso-Thomas, Robert Silver, Richard J. Derman
Summary: Assessing the impact of low-dose aspirin starting in early pregnancy, it was found that it can delay the occurrence of preterm hypertensive disorders of pregnancy. Compared with the placebo group, women who received aspirin had lower proportions of developing hypertensive disorders of pregnancy before 28 weeks, before 34 weeks, and before 37 weeks. The results of this study suggest that early administration of low-dose aspirin can delay the onset of hypertension.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Obstetrics & Gynecology
Seemab Naqvi, Sarah Saleem, Sk Masum Billah, Janet Moore, Musaku Mwenechanya, Waldemar A. A. Carlo, Fabian Esamai, Sherri Bucher, Richard J. J. Derman, Shivaprasad S. S. Goudar, Manjunath Somannavar, Archana Patel, Patricia L. L. Hibberd, Lester Figueroa, Nancy F. F. Krebs, William A. A. Petri, Adrien Lokangaka, Melissa Bauserman, Marion Koso-Thomas, Elizabeth M. M. McClure, Robert L. L. Goldenberg
Summary: With limited data available, the Global Network conducted four studies in LMICs to understand the impact of COVID-19 in pregnancy. The studies evaluated healthcare utilization, knowledge and practices of pregnant women, vaccine acceptance, and antibody status. The findings showed little reduction in healthcare utilization and no significant change in pregnancy outcomes. Knowledge about COVID-19 and vaccine safety was generally poor, and infection rates increased over time. However, most infected pregnant women did not experience worse pregnancy outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Gowdar R. Guruprasad, Chaitali R. M. Raghoji, Sangappa M. Dhaded, Shiyam Sunder Tikmani, Sarah S. Saleem, Shivaprasad S. Goudar, Kay Hwang, S. S. Yogeshkumar, Manjunath S. Somannavar, Sayyeda Reza, Haleema L. Yasmin, Janet L. M. Moore, Carla M. M. Bann, Elizabeth M. L. McClure, Robert L. Goldenberg
Summary: This study evaluated perinatal outcomes in preterm multiple and singleton pregnancies in India and Pakistan. The results showed that neonatal mortality rate was higher in preterm multiples compared to singletons, and the main causes of death were intrauterine hypoxia and infections. In contrast, singletons had lower mortality rate.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Emily E. Nuss, Matthew K. Hoffman, Shivaprasad S. Goudar, Avinash Kavi, Mrityunjay Metgud, Manjunath Somannavar, Jean Okitawutshu, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Abigail Mwapule Tembo, Elwyn Chomba, Waldemar A. Carlo, Lester Figueroa, Nancy F. Krebs, Saleem Jessani, Sarah Saleem, Robert L. Goldenberg, Kunal Kurhe, Prabir Das, Patricia L. Hibberd, Emmah Achieng, Paul Nyongesa, Fabian Esamai, Edward A. Liechty, Sherri Bucher, Norman Goco, Jennifer Hemingway-Foday, Janet Moore, Elizabeth M. McClure, Robert M. Silver, Richard J. Derman
Summary: This study aimed to compare the differential benefits of low-dose aspirin in preventing preterm birth and hypertensive disorders of pregnancy in nulliparous women with and without additional risk factors. The study found that low-dose aspirin similarly reduced the risk of preterm birth and hypertensive disorders of pregnancy in both groups. However, it was significantly more effective in reducing preterm birth before 34 weeks of gestation in women without additional risk factors.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Public, Environmental & Occupational Health
Jackie K. Patterson, Simon Neuwahl, Norman Goco, Janet Moore, Shivaprasad S. Goudar, Richard J. Derman, Matthew Hoffman, Mrityunjay Metgud, Manjunath Somannavar, Avinash Kavi, Jean Okitawutshu, Adrien Lokangaka, Antoinette Tshefu, Carl L. Bose, Abigail Mwapule, Musaku Mwenechanya, Elwyn Chomba, Waldemar A. Carlo, Javier Chicuy, Lester Figueroa, Nancy F. Krebs, Saleem Jessani, Sarah Saleem, Robert L. Goldenberg, Kunal Kurhe, Prabir Das, Archana Patel, Patricia L. Hibberd, Emmah Achieng, Paul Nyongesa, Fabian Esamai, Sherri Bucher, Edward A. Liechty, Brian W. Bresnahan, Marion Koso-Thomas, Elizabeth M. McClure
Summary: The 2020 ASPIRIN trial demonstrated the efficacy of low-dose aspirin in preventing preterm birth in nulliparous, singleton pregnancies. This cost-effectiveness study showed that low-dose aspirin treatment is a cost-effective strategy to reduce the risk of preterm birth and perinatal death in low-income and middle-income countries.
LANCET GLOBAL HEALTH
(2023)
