Article
Cardiac & Cardiovascular Systems
Jennifer J. Stuart, Lauren J. Tanz, Eric B. Rimm, Donna Spiegelman, Stacey A. Missmer, Kenneth J. Mukamal, Kathryn M. Rexrode, Janet W. Rich-Edwards
Summary: This study aimed to evaluate the association between hypertensive disorders of pregnancy (HDP) and long-term cardiovascular disease (CVD) and identify the proportion mediated by established CVD risk factors. The results showed that women with HDP during their first pregnancy had a higher risk of CVD, which was mainly mediated by established CVD risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Clinical Neurology
Hendrikus J. A. van Os, Jos P. Kanning, Michel D. Ferrari, Tobias N. Bonten, Janet M. Kist, Hedwig M. M. Vos, Rimke C. Vos, Hein Putter, Rolf H. H. Groenwold, Marieke J. H. Wermer
Summary: The addition of female-specific factors and psychosocial risk factors improves the discriminatory performance of prediction models for stroke in women younger than 50 years.
Article
Obstetrics & Gynecology
U. Vivian Ukah, Natalie Dayan, Brian J. Potter, Aimina Ayoub, Nathalie Auger
Summary: This study found that severe maternal morbidity is associated with an increased risk of long-term mortality after pregnancy, particularly with severe cardiac complications, acute renal failure, and cerebrovascular accidents. Women with serious pregnancy complications may benefit from more intensive clinical follow-up.
OBSTETRICS AND GYNECOLOGY
(2021)
Review
Peripheral Vascular Disease
Kavia Khosla, Sarah Heimberger, Kristin M. Nieman, Avery Tung, Sajid Shahul, Anne Cathrine Staff, Sarosh Rana
Summary: Women with a history of hypertensive disorders of pregnancy have higher rates of long-term cardiovascular events, and the American Heart Association calls for early identification and risk reduction by physicians. This review discusses the epidemiology, pathophysiology, and outcomes of HDP-associated cardiovascular disease.
Article
Medicine, General & Internal
Samantha J. Benton, Erika E. Mery, David Grynspan, Laura M. Gaudet, Graeme N. Smith, Shannon A. Bainbridge
Summary: Preeclampsia is associated with increased risk of cardiovascular disease in later life. Placental lesions may be a useful tool for identifying high-risk women. The study found that high-risk women had more severe maternal vascular malperfusion lesions in the placenta, which were associated with a 3-fold increased risk of cardiovascular disease screening at 6 months postpartum.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Guan Wang, Yanbo Zhang, Sijin Li, Jun Zhang, Dongkui Jiang, Xiuzhen Li, Yulin Li, Jie Du
Summary: This study developed a model based on machine learning to predict postpartum cardiovascular risk in preeclamptic women. The Random Forest algorithm showed the best performance in predicting cardiovascular risk, with good calibration and high net benefit.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Weikai Wang, Ru Lin, Lan Yang, Yanxia Wang, Baohong Mao, Xiaoying Xu, Jing Yu
Summary: This study aimed to evaluate cardiovascular risk factors in children of preeclampsia (PE) pregnancies. Case-control studies on cardiovascular risk factors in the offspring of PE pregnancies from 2010 to 2019 were collected and analyzed. The meta-analysis showed that PE pregnancy offspring had elevated blood pressure, dyslipidemia, and increased BMI, all of which are risk factors for cardiovascular diseases.
Article
Public, Environmental & Occupational Health
Elisabetta Micelli, Cinzia Fatini, Eleonora Ralli, Michela Cirillo, Chiara Romanelli, Laura Badolato, Valentina Basile, Rita Picone, Giulia Orlandi, Claudia Giachini, Paolo Evangelisti, Rossella Fucci, Gianmartin Cito, Francesca Rizzello, Maria Elisabetta Coccia
Summary: The study focused on assessing the vascular risk profile of patients undergoing ART programs with oocyte donation, revealing a high prevalence of metabolic syndrome, overweight, family history, and personal history among these women. The findings recommend a careful evaluation of preconceptional status for patients undergoing ART programs with oocyte donation.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Virology
Ivana Lapic, Margareta Radic Antolic, Ivana Horvat, Vedran Premuzic, Jozefina Palic, Dunja Rogic, Renata Zadro
Summary: The present study aimed to evaluate the association between 16 genetic polymorphisms related to prothrombotic and cardiovascular risk factors and the severity of COVID-19. The study found that ITGB3 and ss-Fbg -455 G > A gene polymorphisms were associated with increased severity of COVID-19. The combined effect of polymorphisms in genes encoding prothrombotic and cardiovascular risk factors may also contribute to disease severity.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Environmental Sciences
Gyeyoon Yim, Yuting Wang, Caitlin G. Howe, Megan E. Romano
Summary: This scoping review summarizes the literature on the cardiotoxicity of exposure to metal mixtures and identifies the trends and focus areas in the research. The majority of the studies were conducted in the United States and China, with an increase in publications in recent years. The commonly investigated metals included cadmium, lead, arsenic, and cobalt, with a focus on their impact on blood pressure, preeclampsia, dyslipidemia, and cardiovascular disease outcomes.
Article
Cardiac & Cardiovascular Systems
Christy N. N. Taylor, Dongyu Wang, Martin G. G. Larson, Emily S. S. Lau, Emelia J. J. Benjamin, Ralph B. B. D'Agostino, Ramachandran S. S. Vasan, Daniel Levy, Susan Cheng, Jennifer E. E. Ho
Summary: A parental history of cardiovascular disease (CVD) increases the risk of future CVD in offspring. However, it is unclear whether parental modifiable risk factors contribute to or modify this risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Peripheral Vascular Disease
Roshni Mansfield, Paulina Cecula, Carmen Traseira Pedraz, Ioanna Zimianiti, Malaz Elsaddig, Rebecca Zhao, Sundar Sathiyamurthy, Carmel M. McEniery, Christoph Lees, Jayanta Banerjee
Summary: This review aimed to summarize the associations between the perinatal environment and arterial biophysical properties in childhood, in order to understand the possible perinatal origins of adult cardiovascular disease (CVD). A systematic search of the PubMed database identified 52 relevant studies. Low birth weight, maternal factors during pregnancy, and prematurity were found to be associated with increased intima-media thickness (aIMT) in children. However, more research is needed to understand the associations between other arterial biophysical properties and perinatal factors.
JOURNAL OF HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Anna C. O'Kelly, Erin D. Michos, Chrisandra L. Shufelt, Jane V. Vermunt, Margo B. Minissian, Odayme Quesada, Graeme N. Smith, Janet W. Rich-Edwards, Vesna D. Garovic, Samar R. El Khoudary, Michael C. Honigberg
Summary: In addition to conventional risk factors, women also face sex-specific risk factors for cardiovascular disease. Key stages of a woman's reproductive history, such as early and late menarche, polycystic ovary syndrome, infertility, adverse pregnancy outcomes, and absence of breastfeeding, are associated with increased future cardiovascular disease risk. The menopause transition period also represents an accelerated cardiovascular disease risk, with timing, mechanism, and symptoms of menopause playing a role. Differences in conventional risk factors explain some, but not all, of the observed associations between reproductive history and cardiovascular disease; further research is needed to understand hormonal effects and unique sex-specific mechanisms. A history of reproductive risk factors provides an opportunity for comprehensive screening, refinement of risk assessment, and implementation of prevention strategies to optimize women's long-term cardiometabolic health.
CIRCULATION RESEARCH
(2022)
Review
Medicine, General & Internal
Sylwia Slawek-Szmyt, Katarzyna Kawka-Paciorkowska, Aleksandra Cieplucha, Maciej Lesiak, Mariola Ropacka-Lesiak
Summary: Cardiovascular diseases (CVDs) are the top cause of death in women worldwide. Traditional risk factors and pregnancy-related complications both impact a woman's future CVD risk. Some pregnancy complications and CVDs may share common pathophysiological pathways.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Maria-Jose Castro, Jose-Maria Jimenez, Maria Lopez, Maria-Jose Cao, Manuel Duran, Irene Albertos, Sara Garcia, Jaime Ruiz-Tovar
Summary: The study showed that the relationship between breast volume and body mass index can be used as a predictor of cardiovascular risk in premenopausal women who are overweight and mildly obese.
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Wyanne A. Noortman, Jacob M. Mostert, Jan Booij, Catherine B. Brouwer, Bart de Keizer, John M. H. de Klerk, Wim J. G. Oyen, Floris H. P. van Velden, Lioe-Fee De Geus-Oei, Dennis Vriens
Summary: The study aimed to evaluate whether quantitative [F-18]FDG-PET/CT assessment and radiomic analysis of [F-18]FDG-positive thyroid nodules could improve the preoperative differentiation of indeterminate thyroid nodules. The results showed that applying distinct SUV cut-offs for non-Hurthle cell and Hurthle cell nodules can optimize the ability to rule out malignancy, while radiomic analysis did not provide additional differentiation for [F-18]FDG-positive nodules.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Lioe-Fee de Geus-Oei, Adrienne H. Brouwers, Eveline W. C. M. van Dam, Lioe-Ting Dijkhorst-Oei, Adriana C. H. van Engen-van Grunsven, Wilbert B. van den Hout, Tamira K. Klooker, Romana T. Netea-Maier, Marieke Snel, Wim J. G. Oyen, Dennis Vriens
Summary: The study aimed to assess the impact of an [F-18]FDG-PET/CT-driven diagnostic workup on patients with indeterminate thyroid nodules. The results showed that this workup accurately reduced futile surgeries by 40% and should be limited to non-Hurthle cell nodules.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Dennis Vriens, Maarten O. van Aken, Lioe-Ting Dijkhorst-Oei, Wim J. G. Oyen, Robin P. Peeters, Abbey Schepers, Lioe-Fee De Geus-Oei, Wilbert B. van den Hout
Summary: This study evaluates the cost-effectiveness of an [F-18]FDG-PET/CT-driven diagnostic workup compared to diagnostic surgery for thyroid nodules with Bethesda III/IV cytology. The results show that [F-18]FDG-PET/CT avoids unnecessary diagnostic surgeries and reduces costs while maintaining quality of life.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fijs W. B. van Leeuwen, Margret Schottelius, Felix M. Mottaghy, Fabien Hyafil, Mark Lubberink, Gabriela Kramer-Marek, Wim J. G. Oyen
Article
Oncology
Maarten J. van der Doelen, Irma M. Oving, Dirk N. J. Wyndaele, Jean-Paul van Basten, Frederiek Terheggen, Addy C. M. van de Luijtgaarden, Wim J. G. Oyen, W. Dick van Schelven, Franchette van den Berkmortel, Niven Mehra, Marcel J. R. Janssen, Judith B. Prins, Winald R. Gerritsen, Jose A. E. Custers, Inge M. van Oort
Summary: This study evaluated the health-related quality of life, psychological distress, and fatigue in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with radium-223. The study found that patients who discontinued radium-223 therapy had worse HR-QoL, psychological distress, and fatigue at baseline and more frequent deterioration over time compared to patients who completed therapy.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Endocrinology & Metabolism
Elizabeth J. de Koster, Olga Husson, Eveline W. C. M. van Dam, G. Sophie Mijnhout, Romana T. Netea-Maier, Wim J. G. Oyen, Marieke Snel, Lioe-Fee de Geus-Oei, Dennis Vriens
Summary: The study examined HRQoL in patients undergoing FDG-PET/CT for an indeterminate thyroid nodule, finding that active surveillance following a negative FDG result resulted in stable HRQoL scores over a year. Patients with benign histopathology who underwent diagnostic surgery had more cognitive impairment and physical problems, but improved goitre symptoms and anxiety. Anxiety also decreased in patients with malignant histopathology.
ENDOCRINE CONNECTIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Adriana C. H. van Engen-van Grunsven, Johan Bussink, Cathelijne Frielink, Lioe-Fee de Geus-Oei, Benno Kusters, Hans Peters, Wim J. G. Oyen, Dennis Vriens
Summary: This study explored the association between [F-18]FDG uptake and the quantitative expression of immunohistochemical markers related to glucose metabolism, hypoxia, and cell proliferation in benign and malignant thyroid nodules of indeterminate cytology. The results showed that the expression of GLUT1, HK2, and MCT4 increased in [F-18]FDG-positive benign nodules and thyroid carcinomas as compared to [F-18]FDG-negative benign nodules, and VEGF expression was higher in thyroid carcinomas.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Dennis Vriens, Elizabeth J. de Koster, Lioe-Fee de Geus-Oei, Wim J. G. Oyen, EfFECTS trial consortium
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, General & Internal
Lidija Antunovic, Alessia Artesani, Michael Coniglio, Wim J. G. Oyen, Michele Ciccarelli, Carlo Selmi, Arturo Chiti, Martina Sollini
Summary: This study evaluated the diagnostic accuracy of [F-18]-fluorodeoxyglucose ([F-18]FDG) PET/CT in large vessel vasculitis (LVV) and found that an experienced reader had higher accuracy compared to a less experienced one. The expert reader performed better in patients with normal BMI, normal glycemia, younger age, and no ongoing therapy. The use of semi-quantitative parameters did not improve the diagnostic performance of the readers.
Article
Radiology, Nuclear Medicine & Medical Imaging
H. Adams, E. M. W. van de Garde, D. J. Vugts, J. C. Grutters, Wim. J. G. Oyen, R. G. Keijsers
Summary: This study investigates the use of imaging CD20-positive cells in predicting the response to anti-CD20 treatment for immune-mediated interstitial lung disease. PET/CT imaging was performed on 21 patients, and it was found that the uptake of [89Zr]-rituximab in the lungs correlated with changes in pulmonary function test results and treatment outcomes. Patients with a higher uptake of [89Zr]-rituximab had better response to treatment. Therefore, [89Zr]-rituximab PET imaging may serve as a potential predictive biomarker for anti-CD20 therapy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Acoustics
W. H. Heidema, J. Van Drongelen, M. E. A. Spaanderman, R. R. Scholten
Summary: This study investigates the interaction between body mass index (BMI) and a history of pre-eclampsia (PE) on vascular health. The results indicate that both obesity and PE have negative effects on endothelial function, insulin resistance, and physical fitness. Recognizing and addressing these cardiovascular risk factors is essential for patient education and targeted interventions.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Oncology
Christoph Thomssen, Martina Vetter, Eva J. J. Kantelhardt, Christoph Meisner, Marcus Schmidt, Pierre M. M. Martin, Florian Clatot, Doris Augustin, Volker Hanf, Daniela Paepke, Wolfgang Meinerz, Gerald Hoffmann, Wolfgang Wiest, Fred C. G. J. Sweep, Manfred Schmitt, Fritz Jaenicke, Sibylle Loibl, Gunter von Minckwitz, Nadia Harbeck
Summary: The NNBC-3 Europe trial aimed to assess the risk of recurrence in node-negative breast cancer patients and to determine whether taxanes can improve disease-free survival in high-risk patients. The study found that patients with high-risk node-negative breast cancer have a favorable prognosis in the first few years after diagnosis regardless of the type of chemotherapy.
Article
Oncology
Elizabeth J. de Koster, Willem E. Corver, Lioe-Fee de Geus-Oei, Wim J. G. Oyen, Dina Ruano, Abbey Schepers, Marieke Snel, Tom van Wezel, Dennis Vriens, Hans Morreau
Summary: This study described the patterns of copy number alterations (CNA) in benign and malignant oncocytic cell thyroid neoplasms (OCN) using a next-generation sequencing (NGS) panel. The study found that the CNA patterns differed between benign and malignant cases, and suggested the application of CNA-LOH analysis using the NGS panel in the molecular diagnostics of OCN.
ENDOCRINE-RELATED CANCER
(2023)
Article
Oncology
Stefano Fanti, Alberto Briganti, Louise Emmett, Karim Fizazi, Silke Gillessen, Karolien Goffin, Boris A. Hadaschik, Ken Herrmann, Jolanta Kunikowska, Tobias Maurer, Steven MacLennan, Nicolas Mottet, Declan G. Murphy, Daniela E. Oprea-Lager, Joe M. O'Sullivan, Wim J. G. Oyen, Olivier Rouviere, Oliver Sartor, Arnulf Stenzl, Hendrik Van Poppel, Jochen Walz, Wim Witjes, Anders Bjartell
Summary: The use and potential of PSMA PET/CT in prostate cancer treatment and management were assessed and achieved consensus among a panel of experts, particularly in utilizing PSMA PET/CT for patient selection and guiding [177Lu]Lu-PSMA therapy.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Review
Oncology
Miriam N. Mikhail Lette, Diana Paez, Lawrence N. Shulman, Mathias Guckenberger, Jean-Yves Douillard, Wim J. G. Oyen, Francesco Giammarile, Venkatesh Rangarajan, Michelle Ginsberg, Olivier Pellet, Zhongxing Liao, May Abdel Wahab
Summary: This paper emphasizes the importance of improving medical imaging and nuclear medicine infrastructure globally to achieve better outcomes for lung cancer patients. It highlights the significant role of imaging findings in treatment selection and patient outcomes, and discusses the current gaps in diagnostics and therapies. The paper also emphasizes the high burden of lung cancer in low- and middle-income countries and the need for strategic planning to improve population-based outcomes.
JCO GLOBAL ONCOLOGY
(2022)
