Article
Obstetrics & Gynecology
Kristen A. Matteson, Josie Valcin, Christina A. Raker, Melissa A. Clark
Summary: This study compared the effectiveness of the levonorgestrel intrauterine system and combined oral contraceptives in improving quality of life for individuals with heavy menstrual bleeding, and found no significant differences between the two treatments.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Pleun Beelen, Marian J. van den Brink, Malou C. Herman, Peggy M. Geomini, Ruben G. Duijnhoven, Marlies Y. Bongers
Summary: This study identified factors associated with failure of treatment using LNG-IUS in women with heavy menstrual bleeding, with younger age and severe dysmenorrhea found to be risk factors for discontinuation of treatment. High discontinuation rates were observed in this group of women.
Article
Obstetrics & Gynecology
Pleun Beelen, Marleen G. A. M. van der Velde, Malou C. Herman, Peggy M. Geomini, Marian J. van den Brink, Ruben G. Duijnhoven, Marlies Y. Bongers
Summary: This study aimed to compare the reintervention rates of women choosing different treatments and found that women receiving LNG-IUS were more likely to undergo additional interventions. There were no significant differences in reintervention rates between women in the observational cohort and those in the randomized controlled trial.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Tamara J. Oderkerk, Pleun Beelen, Peggy M. A. J. Geomini, Malou C. Herman, Jaklien C. Leemans, Ruben G. Duijnhoven, Judith E. Bosmans, Justine N. Pannekoek, Thomas J. Clark, Ben Willem J. Mol, Marlies Y. Bongers
Summary: This study aims to evaluate whether the combination of endometrial ablation and LNG-IUS is superior to endometrial ablation alone in reducing the need for hysterectomy due to ongoing bleeding and/or pain symptoms. The multicentre randomised controlled trial will assess participants' satisfaction, complications, side effects, and compare the rates of hysterectomy between the two groups at 24 months.
Review
Obstetrics & Gynecology
Tamara J. Oderkerk, Majorie M. A. van de Kar, Carlijn H. M. van Der Zanden, Peggy M. A. J. Geomini, Malou C. Herman, Marlies Y. Bongers
Summary: Immediately inserting a levonorgestrel-intrauterine system (LNG-IUS) after endometrial ablation/resection seems to reduce the need for re-intervention and hysterectomy rates, and improve patient satisfaction. However, limited observational studies with low methodological quality are currently available, highlighting the need for higher quality research to confirm these findings.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Hong Yang, Shengtan Wang, Xiaoyan Fu, Ruihong Lan, Humin Gong
Summary: The modified LNG-IUS is a safe and cost-effective method for reducing downward movement and expulsion rates in patients with adenomyosis and heavy menstrual bleeding.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Review
Medicine, General & Internal
Sijing Chen, Jianhong Liu, Shiyi Peng, Ying Zheng
Summary: This study compared the efficacy and safety of the levonorgestrel-releasing intrauterine system (LNG-IUS) with medical treatments for women with heavy menstrual bleeding. The results showed that LNG-IUS was superior to medical treatments in terms of short-term and medium-term clinical responses, blood loss control, compliance, and satisfaction.
FRONTIERS IN MEDICINE
(2022)
Article
Psychology, Developmental
Misha Khalighi, Allison P. Wheeler, Oluyemisi A. Adeyemi-Fowode, Peter A. Kouides, Ramon A. Durazo-Arvizu, Kristina Haley, Candice M. Dersch, Angela C. Weyand, Maureen K. Baldwin, Claudia Borzutzky
Summary: This study compared patient outcomes in adolescents with and without inherited bleeding disorders (BD) who underwent treatment for heavy menstrual bleeding (HMB) using the 52-mg levonorgestrel-releasing intrauterine system (52-LNG-IUS) within 12 months of insertion. The findings showed that both groups experienced improvement in bleeding outcomes and had similar rates of spontaneous expulsion.
JOURNAL OF ADOLESCENT HEALTH
(2022)
Article
Obstetrics & Gynecology
Tasuku Harada, Ikuko Ota, Jo Kitawaki, Mikio Momoeda, Nagamasa Maeda, Shigeo Akira, Mikiko Umeyama, Toshiyuki Sunaya, Kazufumi Hirano
Summary: This study examined the safety and clinical outcomes of the levonorgestrel-releasing intrauterine system (LNG-IUS) for heavy menstrual bleeding and dysmenorrhea. The results showed that LNG-IUS effectively reduced dysmenorrhea and chronic pelvic pain, but patients with underlying organic disease should be monitored for the risk of expulsion.
Article
Obstetrics & Gynecology
Sener Gezer, Emre Kole, Lale Aksoy
Summary: This study compared the efficacy of vaginal micronized progesterone (VMP) with the levonorgestrel-releasing intrauterine system (LNG-IUS) in patients with non-atypical endometrial hyperplasia. The Menorrhagia Impact Questionnaire (MIQ) was used to assess quality of life. The results showed that there was no significant difference in regression rate between the two groups after 3 months of treatment, but the VMP group had better scores in terms of perception of blood loss.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Lueder M. Fels, Dustin Costescu, Carolina S. Vieira, Jeffrey F. Peipert, Eeva Lukkari-Lax, Birte M. Hofmann, Isabel Reinecke, Stefan Klein, Katrin Wiesinger, Bernhard Lindenthal, Runa Speer
Summary: This study aimed to evaluate the efficacy of adding indomethacin to the levonorgestrel-releasing intrauterine system in reducing the number of bleeding and spotting days during the first 90 days of use. The results showed that all three doses of indomethacin significantly reduced the number of bleeding and spotting days compared to the unmodified system. The lowest dose group achieved the highest reduction rate of 32%. Additionally, adding indomethacin did not affect the safety profile.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Medicine, General & Internal
Paola Bianchi, Sun-Wei Guo, Marwan Habiba, Giuseppe Benagiano
Summary: This literature review examines the use of levonorgestrel-releasing intrauterine devices for heavy menstrual bleeding and/or dysmenorrhea. The review highlights that the insertion of a levonorgestrel-releasing intrauterine system is a useful option for long-term treatment, improving the quality of life and reducing menstrual blood loss and dysmenorrhea symptoms. Its ability to induce amenorrhea is considered to be the most important mechanism of action.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Alexey B. Ilyin, Albir A. Khasanov, Larisa V. Suturina, Natalia I. Borisova, Zakhar S. Reshetov, Jean-Michel Foidart, Judit Alexandra Deri, Vera Toth
Summary: The study showed that the levonorgestrel-releasing intrauterine system Donasert (R) has equivalent efficacy and safety in alleviating heavy menstrual bleeding compared to the reference product Mirena (R) during the first 6 months.
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2021)
Article
Obstetrics & Gynecology
Juan Giles, Pilar Alama, Pilar Gamiz, Carmen Vidal, Paloma Badia, Antonio Pellicer, Ernesto Bosch
Summary: This study compared ovarian response and reproductive outcomes in oocyte donors undergoing pituitary suppression with MPA versus a GnRH antagonist. Results showed no significant differences between the two groups, and MPA can be recommended for ovarian stimulation in oocyte donation.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Rebeca M. Furlani, Elaine Garcia, Sara Castro, Helymar C. Machado, Luis Bahamondes, Ilza Monteiro
Summary: The study compared the expulsion rates of the levonorgestrel intrauterine system among women with heavy menstrual bleeding and those using it solely for contraception. Results showed similar expulsion rates between the two groups, with previous cesarean delivery identified as a risk factor for expulsion. The study recommends placement of the LNG IUS after the cessation of bleeding or a reduction of menstrual flow among women with heavy menstrual bleeding.
Article
Obstetrics & Gynecology
Mariane N. De Nadai, Omero B. Poli-Neto, Silvio A. Franceschini, Erciliene M. M. Yamaguti, Ilza M. U. Monteiro, Julia K. Troncon, Cassia R. T. Juliato, Laura F. Santana, Luis Bahamondes, Carolina Sales Vieira
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Review
Obstetrics & Gynecology
Luis Bahamondes, Arlete Fernandes, Ilza Monteiro, M. Valeria Bahamondes
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2020)
Article
Reproductive Biology
Leo Han, Walker Andrews, Karsten Wong, Jeffrey T. Jensen
BIOLOGY OF REPRODUCTION
(2020)
Letter
Obstetrics & Gynecology
Jeffrey T. Jensen, Mitchell D. Creinin
Article
Obstetrics & Gynecology
Melissa J. Chen, Mitchell D. Creinin, David K. Turok, David F. Archer, Kurt T. Barnhart, Carolyn L. Westhoff, Michael A. Thomas, Jeffrey T. Jensen, Bruce Variano, Regine Sitruk-Ware, Anita Shanker, Jill Long, Diana L. Blithe
Article
Public, Environmental & Occupational Health
Jeffrey T. Jensen, Johannes Bitzer, Rossella E. Nappi, Christiane Ahlers, Ralf Bannemerschult, Susanne Parke
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2020)
Article
Pharmacology & Pharmacy
Elizabeth A. Micks, Jeffrey T. Jensen
EXPERT OPINION ON DRUG DELIVERY
(2020)
Article
Obstetrics & Gynecology
Mitchell D. Creinin, Jeffrey T. Jensen
Article
Obstetrics & Gynecology
David W. Erikson, Steven W. Blue, Kristopher M. Fecteau, Alison B. Edelman, Jeffrey T. Jensen, Diana L. Blithe
Article
Obstetrics & Gynecology
Rebeca M. Furlani, Elaine Garcia, Sara Castro, Helymar C. Machado, Luis Bahamondes, Ilza Monteiro
Summary: The study compared the expulsion rates of the levonorgestrel intrauterine system among women with heavy menstrual bleeding and those using it solely for contraception. Results showed similar expulsion rates between the two groups, with previous cesarean delivery identified as a risk factor for expulsion. The study recommends placement of the LNG IUS after the cessation of bleeding or a reduction of menstrual flow among women with heavy menstrual bleeding.
Article
Public, Environmental & Occupational Health
Mariane N. De Nadai, Carolina S. Vieira, Ilza M. U. Monteiro, Cassia R. T. Juliato, S. A. Franceschini, E. M. M. Yamaguti, G. C. Braga, L. Bahamondes
Summary: The study found that clinical and theoretical training of healthcare professionals is important in promoting the use of contraceptive implants and reducing rates of unintended pregnancies.
EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
(2021)
Article
Obstetrics & Gynecology
Rebecca L. Thompson, Jack Hu, Philip Custodio, Clint Dart, Jeffrey T. Jensen
Summary: This study aimed to determine the incidence of out-of-range NES concentrations in participants using a continuous use contraceptive vaginal ring and investigate its association with ovulation risk. The results showed that out-of-range NES concentrations, indicative of improper ring use, were associated with an increased risk of ovulation, and the number of out-of-range events was directly related to the relative risk.
Article
Obstetrics & Gynecology
Jeffrey T. Jensen, Eeva Lukkari-Lax, Andrea Schulze, Yesmean Wahdan, Marco Serrani, Robin Kroll
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Jeffrey T. Jensen, Isabel Reinecke, Teun M. Post, Eeva Lukkari-Lax, Birte M. Hofmann
Summary: The study aimed to characterize the performance of the 52mg levonorgestrel-releasing intrauterine system (LNG-IUS) over 8 years and compare it with the 19.5mg and 13.5mg LNG-IUS. The results showed that the release rate of the 52mg LNG-IUS decreased over 8 years, similar to the 5-year use of the 19.5mg LNG-IUS and higher than the 3-year use of the 13.5mg LNG-IUS.
Article
Obstetrics & Gynecology
Barbara Zantut Wittmann, Ilza Monteiro, Cassia Juliato, Arlete Fernandes
REVISTA BRASILEIRA DE GINECOLOGIA E OBSTETRICIA
(2020)