Review
Medicine, General & Internal
Antoine Boustany, Ali A. Alali, Majid Almadi, Myriam Martel, Alan N. Barkun
Summary: This systematic review and meta-analysis compared the predictive abilities of different pre-endoscopic scores in prognosticating adverse events in patients with upper gastrointestinal bleeding (UGIB). The Glasgow-Blatchford score (GBS) showed good discriminative ability and clinical utility in predicting the need for hospital-based interventions. Setting the GBS cutoff at 1 or lower effectively identified low-risk patients and allowed for outpatient management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
C. Neary, S. Naheed, D. J. McLernon, M. Black
Summary: From 2146 citations, 14 studies were included. While these studies addressed various populations of women, they all had high risk of bias due to lack of internal or external validation, as well as issues in handling missing data. Only three studies show potential for robust validation, indicating the need for further research in this area.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Health Care Sciences & Services
Crischentian Brinza, Alexandru Burlacu, Grigore Tinica, Adrian Covic, Liviu Macovei
Summary: This systematic review included 18 studies and found that bleeding risk scores have modest to good discriminatory power, with clinical models performing relatively well in predicting in-hospital bleeding events. Knowledge and utilization of current bleeding risk scores can improve the prediction of bleeding events in appropriate clinical contexts.
Review
Clinical Neurology
Amit K. Kishore, Mohammad J. Hossain, Alan Cameron, Jesse Dawson, Andy Vail, Craig J. Smith
Summary: The performance of risk scores for predicting NDAF after ischemic stroke/transient ischemic attack varies widely, with uncertainty about their utility in clinical practice. Further studies using larger cohorts and randomized control trials are needed to evaluate the usefulness of these scores for clinical decision making and preventative intervention.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Review
Emergency Medicine
Rachel A. L. Sweanor, Robert J. Redelmeier, David L. Simel, Omar T. Albassam, Steven Shadowitz, Edward E. Etchells
Summary: This study systematically reviewed the accuracy of multivariate risk stratification scores for identifying adult syncope patients at high and low risk of adverse events within 30 days, finding that the Canadian Syncope Risk Score (CSRS) performed well in this regard. However, other risk scores lacked validation or sufficient accuracy.
ACADEMIC EMERGENCY MEDICINE
(2021)
Review
Endocrinology & Metabolism
Aleena Shujaat Ali, Cecilia Pham, Grant Morahan, Elif Ilhan Ekinci
Summary: This systematic review summarizes the existing evidence of genetic risk scores (GRSs) for predicting diabetic kidney disease (DKD) in people with type 1 or type 2 diabetes. Most studies of high methodological quality reported a statistically significant association between GRS and at least one measure of DKD. GRSs can be used to identify people with diabetes at high risk of developing DKD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Nursing
Natalie Li Xin Ngin, Norasyikin Binte Hassan, Siew Lin Serena Koh
Summary: This systematic review evaluated the diagnostic accuracy of suicide risk scales in inpatient and emergency departments, and combined settings within hospitals. The results showed that none of the evaluated scales produced accurate diagnostic measurements. The Manchester Self-Harm Rule and Suicide Crisis Syndrome were recommended for use in the emergency department and inpatient setting, respectively, while the Suicide Intent Scale should be used in combined settings.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Review
Medicine, General & Internal
Majed Almaghrabi, Mandark Gandhi, Leonardo Guizzetti, Alla Iansavichene, Brian Yan, Aze Wilson, Kathryn Oakland, Vipul Jairath, Michael Sey
Summary: This study compares the prognostic performance of different LGIB risk scores and found that the Oakland score performs the best in predicting safe discharge, major bleeding, and need for transfusion, while the Strate score is the most accurate in predicting the need for hemostasis.
Review
Genetics & Heredity
Judit Kumuthini, Brittany Zick, Angeliki Balasopoulou, Constantina Chalikiopoulou, Collet Dandara, Ghada El-Kamah, Laura Findley, Theodora Katsila, Rongling Li, Ebner Bon Maceda, Henrietta Monye, Gabriel Rada, Meow-Keong Thong, Thilina Wanigasekera, Hannah Kennel, Veeramani Marimuthu, Marc S. Williams, Fahd Al-Mulla, Marc Abramowicz
Summary: Genomic medicine aims to improve health using individual genomic data, but its clinical utility in polygenic traits is less evident. Although polygenic risk scores have potential clinical application, further research is needed.
Article
Endocrinology & Metabolism
Bingsi Gao, Xingping Zhao, Pan Gu, Dan Sun, Xinyi Liu, Waixing Li, Aiqian Zhang, Enuo Peng, Dabao Xu
Summary: This study aimed to develop a nomogram based on clinical markers for predicting the malignancy of ovarian tumors. The results showed that the nomogram had superior prognostic predictive accuracy compared to traditional markers such as CA125, HE4, or ROMA index.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Clinical Neurology
Minhui Zhong, Han Zhang, Chan Yu, Jinxia Jiang, Xia Duan
Summary: This study synthesized and evaluated the quality of studies on the application of machine learning techniques in predicting postpartum depression (PPD) risk. The researchers found that many models had a high risk of bias and applied ML techniques were yet to be deployed in clinical environments. More attention needs to be focused on model validation, improvement, and innovation.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Genetics & Heredity
Padraig Dixon, Edna Keeney, Jenny C. Taylor, Sarah Wordsworth, Richard M. Martin
Summary: This study assessed the cost-effectiveness of using polygenic risk scores for cancer screening and found that polygenic risk-informed screening may be more cost-effective. However, due to the lack of robust evidence, the practical application of polygenic risk stratification in cancer screening remains uncertain.
GENETICS IN MEDICINE
(2022)
Review
Surgery
Amogh Patil, Krishan Kulkarni, Shuqiao Xie, Anthony M. J. Bull, Gareth G. Jones
Summary: This systematic review investigates the accuracy of predicting 3D models from 2D imaging using statistical shape modelling. Out of 2127 papers screened, 34 studies were included for data extraction. The results showed that the best achievable accuracy was 0.45 mm (root mean square error) and 0.16 mm (average error). Therefore, statistical shape modelling can accurately predict detailed 3D anatomical models from limited 2D imaging.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2023)
Review
Endocrinology & Metabolism
Ziyu Chen, Zesi Liu, Hongxia Yang, Chaosheng Liu, Fandou Kong
Summary: This study conducted a systematic review and meta-analysis to examine the association between metabolic syndrome (MetS) and ovarian cancer risk. The results showed no significant correlation between MetS and ovarian cancer risk. Only the unadjusted stratification of smoking and hysterectomy risk demonstrated a relationship between MetS and ovarian cancer risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Qing-Qing Tan, Xin-Yi Du, Chen-Lin Gao, Yong Xu
Summary: Individuals with higher Dietary Inflammatory Index (DII) scores have a higher risk of diabetes mellitus (DM), but further evidence from larger prospective studies in different countries is needed to clarify this association.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Albertine J. Vroom, Luca Aerts, Marlies Y. Bongers, Arianne C. Lim, Bart J. Pielkenrood, Peggy M. A. J. Geomini, Nehalennia van Hanegem
Summary: The study assessed the quality of endometrial samples obtained by office endometrial aspiration before or after saline contrast sonohysterography (SCSH) in women with postmenopausal bleeding and a thickened endometrium. The results showed that SCSH did not affect the quality of endometrial samples, suggesting that both procedures can be performed in one outpatient visit for optimal diagnostic workup.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Pleun Beelen, Marleen G. A. M. van der Velde, Malou C. Herman, Peggy M. Geomini, Marian J. van den Brink, Ruben G. Duijnhoven, Marlies Y. Bongers
Summary: This study aimed to compare the reintervention rates of women choosing different treatments and found that women receiving LNG-IUS were more likely to undergo additional interventions. There were no significant differences in reintervention rates between women in the observational cohort and those in the randomized controlled trial.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Pleun Beelen, Marian J. van den Brink, Malou C. Herman, Peggy M. Geomini, Ruben G. Duijnhoven, Marlies Y. Bongers
Summary: This study identified factors associated with failure of treatment using LNG-IUS in women with heavy menstrual bleeding, with younger age and severe dysmenorrhea found to be risk factors for discontinuation of treatment. High discontinuation rates were observed in this group of women.
Review
Obstetrics & Gynecology
Tamara J. Oderkerk, Majorie M. A. van de Kar, Carlijn H. M. van Der Zanden, Peggy M. A. J. Geomini, Malou C. Herman, Marlies Y. Bongers
Summary: Immediately inserting a levonorgestrel-intrauterine system (LNG-IUS) after endometrial ablation/resection seems to reduce the need for re-intervention and hysterectomy rates, and improve patient satisfaction. However, limited observational studies with low methodological quality are currently available, highlighting the need for higher quality research to confirm these findings.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
M. J. van den Brink, P. Beelen, M. C. Herman, P. M. Geomini, J. H. Dekker, K. M. Vermeulen, M. Y. Bongers, M. Y. Berger
Summary: This study compared the costs and non-inferiority of starting treatment for heavy menstrual bleeding with LNG-IUS versus EA. The findings suggest that starting with LNG-IUS is cheaper but slightly less effective than starting with EA.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Imke M. A. Reinders, Gaston R. Cremers, Stefanus J. van Rooijen, Jaklien C. Leemans, Christel W. Perquin, Peggy M. A. J. Geomini, Jacques W. M. Maas, Marlies Y. Bongers
Summary: Adding an informative 360-degree VR video to conventional information did not result in a reduction of anxiety prior to visiting the one-stop clinic. However, the majority of women who watched the video felt that it was of added value. Interestingly, women who reported higher anxiety at baseline seemed less willing to watch the video.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Surgery
Suzanne J. Dedden, Esther V. A. Bouwsma, Peggy M. A. J. Geomini, Marlies Y. Bongers, Judith A. F. Huirne
Summary: This study aimed to identify predictors of recovery following different approaches of hysterectomy. The study found that older age and same day removal of indwelling catheter were predictors of shorter duration until full return to work after hysterectomy.
Review
Oncology
N. Baldewpersad Tewarie, W. J. van Driel, M. A. P. C. van Ham, M. W. Wouters, R. M. Rome, C. K. Hogdall, E. Pagano, T. Hogberg, R. Kruitwagen
Summary: This study aimed to identify and summarize the characteristics, processes, and quality indicators of clinical quality registries (CQRs) for gynecological oncology, and to determine the feasibility of international comparison. Results showed variations in CQRs among different countries, making international comparison difficult due to differences in numerators or denominators. It is necessary to harmonize these registries and establish international standards for measuring quality of care.
Article
Public, Environmental & Occupational Health
Tamara J. Oderkerk, Pleun Beelen, Peggy M. A. J. Geomini, Malou C. Herman, Jaklien C. Leemans, Ruben G. Duijnhoven, Judith E. Bosmans, Justine N. Pannekoek, Thomas J. Clark, Ben Willem J. Mol, Marlies Y. Bongers
Summary: This study aims to evaluate whether the combination of endometrial ablation and LNG-IUS is superior to endometrial ablation alone in reducing the need for hysterectomy due to ongoing bleeding and/or pain symptoms. The multicentre randomised controlled trial will assess participants' satisfaction, complications, side effects, and compare the rates of hysterectomy between the two groups at 24 months.
Article
Oncology
Nishita M. S. Baldewpersad Tewarie, Maaike van Ham, Michel Wouters, Roy Kruitwagen, Willemien van Driel
Summary: This study investigated the adherence to surgical staging guidelines and the regional variation of surgical staging in patients with early-stage ovarian carcinoma in the Netherlands. The results showed lower than expected guideline adherence and identified reasons for incomplete surgical staging, such as perioperative findings. Regional variation in surgical staging was also observed.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Obstetrics & Gynecology
J. Van Gemert, M. C. Herman, P. Beeien, P. M. Geomini, M. Y. Bongers
Summary: This study demonstrates that in the treatment of hysteroscopic transcervical resection of endometrial polyps, tissue removal device (TRD) is superior to the electrosurgical polyp snare (DPS) in complete polyp removal. TRD has a faster operation time and higher patient satisfaction. However, a serious adverse event occurred in the DPS group, indicating the need for safety precautions.
FACTS VIEWS AND VISION IN OBGYN
(2022)
Article
Obstetrics & Gynecology
Koen De Decker, Hans H. B. Wenzel, Joost Bart, Maaike A. van der Aa, Roy F. P. M. Kruitwagen, Hans W. W. Nijman, Arnold-Jan Kruse
Summary: This study aimed to report trends in stage, primary treatment, and relative survival of low-grade serous carcinoma (LGSC) of the ovary in a large cohort of patients. The results showed that LGSC was increasingly diagnosed as advanced stage and interval debulking surgery was preferred more often. Relative survival did not change significantly, and worse survival outcomes were observed after interval debulking surgery.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Oncology
Tamara J. Oderkerk, Mileen R. D. van de Kar, Karlijn M. C. Cornel, Marlies Y. Bongers, Peggy M. A. J. Geomini
Summary: Previous endometrial ablation is not associated with the development and diagnosis of endometrial cancer. Most cases of endometrial cancer after ablation present with vaginal bleeding as the initial symptom. Diagnostic work-up is not impeded by previous endometrial ablation, and endometrial cancers after ablation are usually detected at early stages.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Oncology
Marc Daniel Algera, Nishita M. S. Baldewpersad Tewarie, Willemien J. van Driel, Maaike A. P. C. van Ham, Brigitte F. M. Slangen, Roy F. P. M. Kruitwagen, Michel W. J. M. Wouters
Summary: This study aims to develop the first case-mix adjustment model for complications after surgery for advanced-stage ovarian cancer, enabling an accurate comparison between hospitals. The population-based study analyzed all patients undergoing cytoreductive surgery for ovarian cancer in the Netherlands from 2017 to 2019. The results showed variation between hospitals regarding complicated course rates and limited impact of case-mix adjustment on hospital outcomes.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Lilian van Wagensveld, Juliette O. A. M. van Baal, Maite Timmermans, Duco Gaillard, Lauri Borghuis, Seth B. Coffelt, Efraim H. Rosenberg, Christianne A. R. Lok, Hans W. Nijman, Loes F. S. Kooreman, Joyce Sanders, Marco de Bruijn, Lodewyk F. A. Wessels, Rianne van der Wiel, Christian Rausch, Annegien Broeks, Roy F. P. M. Kruitwagen, Maaike A. van der Aa, Gabe S. Sonke, Philip C. Schouten, Koen K. van de Vijver, Hugo M. Horlings
Summary: Ovarian cancer is a deadly gynecological cancer, and high-grade serous ovarian carcinoma (HGSOC) is the most common subtype. This study investigated the associations between the tumor microenvironment (TME), genetic profiles, and overall survival (OS) in HGSOC. The results showed that HGSOC can be categorized into different entities based on molecular profiles and TME. Higher immune cell densities in the TME were associated with better survival, regardless of the molecular profiles.