Article
Immunology
Anne L. Dunlop, Glen A. Satten, Yi-Juan Hu, Anna K. Knight, Cherie C. Hill, Michelle L. Wright, Alicia K. Smith, Timothy D. Read, Bradley D. Pearce, Elizabeth J. Corwin
Summary: An early pregnancy vaginal community state type III or IV was associated with an increased risk of spontaneous preterm birth (sPTB) but not early term birth (sETB) in African American women. Specific taxa within the early pregnancy vaginal microbiome were associated with either sPTB or sETB.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Obstetrics & Gynecology
Joan Camunas-Soler, Elaine P. S. Gee, Mitsu Reddy, Jia Dai Mi, Mainou Thao, Tiffany Brundage, Farooq Siddiqui, Natasha L. Hezelgrave, Andrew H. Shennan, Eugeni Namsaraev, Carrie Haverty, Maneesh Jain, Michal A. Elovitz, Morten Rasmussen, Rachel M. Tribe
Summary: The study found that cell-free RNA profiles in maternal blood during early pregnancy can effectively predict the risk of spontaneous preterm birth, providing a window into the future possibility of preterm birth. The research also identified specific genes and pathways associated with the risk of spontaneous preterm birth.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Environmental Sciences
Weichao Wang, Zhiwen Li, Qun Lu, Luyao Zhang, Dawei Lu, Hang Yang, Xuezhi Yang, Le Zhang, Yali Zhang, Qian Liu, Bin Wang, Yuming Guo, Aiguo Ren, Guibin Jiang
Summary: This study explored the association and mechanism of copper imbalance with spontaneous preterm birth (SPB) using natural stable copper isotopes. The study found that SPB cases had significantly heavier serum copper isotopes compared to controls, and the risk of SPB increased with higher copper isotopic values. The study also revealed the importance of dietary intake and blood ceruloplasmin in the copper imbalance associated with SPB.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Clinical Neurology
Xi Chen, Xiaoli Zhang, Wenhua Li, Wendong Li, Yong Wang, Shan Zhang, Changlian Zhu
Summary: Preterm births with different etiologies are associated with varying neonatal complications, but no differences in neurodevelopmental outcomes were observed at 12 months of corrected age.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Emelyne Lefizelier, Emilie Misbert, Marion Brooks, Aurelie Le Thuaut, Norbert Winer, Guillaume Ducarme
Summary: In singleton pregnancies, prepregnancy underweight BMI is associated with higher rates of preterm birth and small-for-gestational age infants. Identifying this high-risk group is important for physicians to be aware of perinatal outcomes in underweight women.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Denise L. Jacobson, Daniela Neri, Audrey Gaskins, Lynn Yee, Armando J. Mendez, Kristy Hendricks, Suzanne Siminski, Rebecca Zash, Laurie Hyzy, Jennifer Jao
Summary: Women living with HIV have a higher prevalence of anemia during the third trimester of pregnancy, with anemia being associated with a higher risk of preterm births. These findings emphasize the importance of addressing underlying factors and clinical outcomes of anemia in this population.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Pediatrics
Dustin D. Flannery, Erika M. Edwards, Karen M. Puopolo, Jeffrey D. Horbar
Summary: This study investigated the epidemiology and microbiology of early-onset sepsis (EOS) among very preterm infants from 2018 to 2019. The findings revealed an incidence rate of 13.5 per 1000 very preterm births, with Escherichia coli and group B Streptococcus being the most common pathogens. Infected infants had longer hospital stays and lower survival rates, emphasizing the need for novel preventive strategies.
Article
Multidisciplinary Sciences
Joan T. Price, Bellington Vwalika, Michael France, Jacques Ravel, Bing Ma, Humphrey Mwape, Katelyn J. Rittenhouse, Kristina De Paris, Marcia Hobbs, Julie A. Nelson, Margaret P. Kasaro, Elizabeth M. Stringer, Jeffrey S. A. Stringer
Summary: A Lactobacillus-deficient, anaerobe-rich vaginal microbiome is associated with local inflammation and spontaneous preterm birth (sPTB) in the setting of HIV. Inflammatory scores positively correlate with vaginal microbiome diversity. HIV is associated with anaerobe-rich vaginal microbiome. High abundance of a novel Gardnerella metagenomic subspecies in the vaginal microbiome predicts sPTB. The risk for sPTB among women with HIV may be mediated by the vaginal microbiome and inflammation.
SCIENTIFIC REPORTS
(2022)
Article
Obstetrics & Gynecology
Anoop Rehal, Zsofia Benko, Catalina De Paco Matallana, Argyro Syngelaki, Deepa Janga, Simona Cicero, Ranjit Akolekar, Mandeep Singh, Petya Chaveeva, Jorge Burgos, Francisca S. Molina, Makrina Savvidou, Maria De la Calle, Nicola Persico, Maria Soledad Quezada Rojas, Ashis Sau, Elena Greco, Neil O'Gorman, Walter Plasencia, Susana Pereira, Jacques C. Jani, Nuria Valino, Maria del Mar Gil, Kate Maclagan, Alan Wright, David Wright, Kypros H. Nicolaides
Summary: Research indicates that vaginal progesterone does not reduce the incidence of spontaneous preterm birth in women with twin pregnancies. Post hoc analysis suggests that progesterone may reduce the risk of spontaneous preterm birth before 32 weeks' gestation in women with a cervical length of <30 mm, but increase the risk for those with a cervical length of >= 30 mm.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Pediatrics
Henni Hiltunen, Maria Carmen Collado, Helena Ollila, Terhi Kolari, Satu Tolkko, Erika Isolauri, Seppo Salminen, Samuli Rautava
Summary: The gut microbiota in preterm neonates differs from those born full term. Spontaneous preterm birth is reflected in changes in the gut microbiota composition of both preterm neonates and their mothers. The maternal gut microbiota plays a more significant role in determining the initial neonatal gut colonization after spontaneous preterm delivery than iatrogenic preterm delivery.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Yusuf Topal, Bilge Nur Yardimci-Lokmanoglu, Semra Topuz, Akmer Mutlu
Summary: This study aimed to analyze the spatiotemporal gait characteristics of preterm children from 3 to 4 years old and examine their relationship with general movements assessment. The results showed that extremely preterm and very preterm children had shorter step lengths, while moderate to late preterm children had greater step length variability. The study concluded that the early movement patterns of preterm children may be a marker of later neurodevelopmental dysfunction.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Obstetrics & Gynecology
Heather H. Burris, Kristin D. Gerson, Alexa Woodward, Allyson M. Redhunt, Rachel Ledyard, Kasey Brennan, Andrea A. Baccarelli, Jonathan L. Hecht, Ai-Ris Y. Collier, Michele R. Hacker
Summary: Preterm birth remains a major public health issue, and the pathogenesis of spontaneous preterm birth is not fully understood. This study aims to identify a subset of microRNAs that can predict spontaneous preterm birth through analyzing the association between cervical microRNA expression and preterm birth.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Biochemistry & Molecular Biology
Carl P. Weiner, Helen Zhou, Howard Cuckle, Argyro Syngelaki, Kypros H. Nicolaides, Mark L. Weiss, Yafeng Dong
Summary: The prediction of spontaneous preterm birth (sPTB) in the first trimester has been difficult. Currently, screening relies heavily on obstetric history, but this is not applicable to nullipara who are at a higher risk for sPTB <= 32 weeks. A panel of maternal plasma cell-free RNAs has been tested for prediction at 16-20 weeks, but its applicability in the first trimester for nullipara is still uncertain due to a small sample size in this study.
Article
Multidisciplinary Sciences
Andrea M. Weckman, Robyn E. Elphinstone, John M. Ssenkusu, Vanessa Tran, Kathleen Zhong, Mwayiwawo Madanitsa, Carole Khairallah, Linda Kalilani-Phiri, Victor Mwapasa, Andrea L. Conroy, Feiko O. Ter Kuile, Chloe R. McDonald, Kevin C. Kain
Summary: Preterm birth is a leading cause of death in children under five. Sequential disruptions to inflammatory and angiogenic pathways during pregnancy increase the risk of placental insufficiency and preterm labor. Study findings suggest a potential causal link between early inflammation, subsequent angiogenic dysregulation, and preterm birth, highlighting the importance of interventions before 24 weeks gestation.
Article
Acoustics
D. O. C. Anumba, V Stern, J. T. Healey, S. Dixon, B. H. Brown
Summary: The study examined the predictive performance of cervical probe device based on electrical impedance spectroscopy (EIS) for preterm birth (PTB). Cervical EIS showed promising results in predicting spontaneous PTB, especially when combined with a history of previous PTB. Larger confirmatory studies are needed to assess the clinical utility of mid-trimester cervical EIS assessment.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Gabriel Conzuelo Rodriguez, Lisa M. Bodnar, Maria M. Brooks, Abdus Wahed, Edward H. Kennedy, Enrique Schisterman, Ashley Naimi
Summary: This study compared the performance of correctly specified parametric models and nonparametric models in evaluating effect modification. The findings suggest that generalized linear models have the highest power for detecting effect modification with binary exposures, while the DR-learner is comparable to flexible parametric models for continuous modifiers, especially in capturing quadratic and nonlinear monotonic functions.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Abigail R. Cartus, Marian P. Jarlenski, Katherine P. Himes, Alton Everette James, Ashley Naimi, Lisa M. Bodnar
Summary: The study found that severe maternal morbidity (SMM) is associated with an increased risk of adverse cardiovascular events in the 2 years postpartum, particularly heart failure, ischemic heart disease, and stroke/transient ischemic attack. Women who survive SMM may benefit from more comprehensive postpartum care.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Obstetrics & Gynecology
Anna Binstock, Lisa M. Bodnar, Katherine P. Himes
Summary: This study used the gold standard definition outlined by the ACOG to determine the timing and cause of severe maternal morbidity (SMM) in twin pregnancies. The majority of SMM occurred in the postpartum period, with hemorrhage being the most common cause.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Lisa M. Bodnar, Katherine P. Himes, Sara M. Parisi, Jennifer A. Hutcheon
Summary: This study explores the relationship between maternal weight gain in triplet pregnancies and neonatal outcomes in the United States, providing valuable information for developing guidelines on gestational weight gain for triplets.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Letter
Obstetrics & Gynecology
Lisa M. Bodnar, Julie M. Petersen, Ashley I. Naimi, Sharon I. Kirkpatrick
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Nutrition & Dietetics
Lisa M. Bodnar, Sharon I. Kirkpatrick, James M. Roberts, Edward H. Kennedy, Ashley I. Naimi
Summary: Diets dense in fruits and vegetables are associated with a reduced risk of preeclampsia, but the pathways underlying this relationship are unclear.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Obstetrics & Gynecology
Tiffany E. E. Deihl, Lisa M. M. Bodnar, Sara M. M. Parisi, Katherine P. P. Himes
Summary: This study aimed to investigate the association between early gestational weight gain (GWG) in dichorionic twin pregnancies and the risk of preeclampsia, taking into account the body mass index (BMI) of the mothers. The results showed that among women with normal BMI, an increased early GWG was associated with an increased incidence of preeclampsia. However, early GWG had minimal impact on the risk of preeclampsia in women with overweight or obesity.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Obstetrics & Gynecology
Jaclyn M. M. Phillips, Lisa M. M. Bodnar, Katherine P. P. Himes
Summary: Preterm births are associated with higher rates of severe maternal morbidity, and the specific indicators of morbidity vary depending on gestational age.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Lisa M. Bodnar, Angela Odoms-Young, Sharon I. Kirkpatrick, Ashley I. Naimi, Julie M. Petersen, Chantel L. Martin
Summary: There is no significant association between experiences of racial discrimination and adherence to the Dietary Guidelines for Americans, indicating the need to consider institutional, systemic, and practice factors in addition to interpersonal racism to address inequalities in diet and perinatal health.
JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Julie M. Petersen, Jennifer A. Hutcheon, Lisa M. Bodnar, Samantha E. Parker, Katherine A. Ahrens, Martha M. Werler
Summary: This study investigated the relationship between gestational weight gain (GWG) and the size of infants at birth, and found that weight maintenance during the second and third trimesters may be associated with better birth weight for gestational age. However, it is unclear how this can be achieved (e.g., through diet and exercise interventions) due to the observational design of the study.
Article
Obstetrics & Gynecology
Jill R. Demirci, Melissa Glasser, Debra L. Bogen, Susan M. Sereika, Dianxu Ren, Kristin Ray, Lisa M. Bodnar, Therese A. O'Sullivan, Katherine Himes
Summary: This ongoing randomized controlled trial in the United States evaluates the effectiveness of telelactation-delivered antenatal milk expression (AME) education intervention among birthing people with pre-pregnancy BMI >= 25 kg/m(2). The study aims to assess lactation outcomes and factors associated with breastfeeding success through surveys, data abstraction, and milk sample collection. This study will provide evidence on the effectiveness and acceptability of telelactation-delivered AME.
INTERNATIONAL BREASTFEEDING JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Julie M. Petersen, Ashley I. Naimi, Lisa M. Bodnar
Summary: SuperLearner has the strength of accommodating key interactions between model variables without prior specification. Heterogeneity may partly explain differences in estimates from logistic regression versus SuperLearner with targeted maximum likelihood estimation (TMLE) when examining the protective associations between fruit intake and pre-eclampsia.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Lisa M. Bodnar, Jennifer A. Hutcheon
Summary: In this study, the researchers added detailed behavioral, psychosocial, and environmental measurements to the association between pregnancy weight gain and adverse outcomes, but found that these measurements had minimal impact on controlling confounding.
Meeting Abstract
Psychology, Multidisciplinary
Ellen Beckjord, Lisa Bodnar, Roger Peng, Kate Y. Wolin, David E. Conroy
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Correction
Medicine, General & Internal
Y. Zhong, M. M. Brooks, E. H. Kennedy, L. M. Bodnar, A. Naimi