Article
Immunology
Indu Grover, Namrata Singh, Deepak Gunjan, Jaya Benjamin, Lakshmy Ramakrishnan, R. M. Pandey, Hem Chandra Sati, Anoop Saraya
Summary: This study aimed to investigate the prevalence of vitamin D deficiency and bone health in patients with cirrhosis. The results showed that both vitamin D deficiency and low bone mineral density were common in Indian patients with cirrhosis, especially in those with decompensated cirrhosis.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Nutrition & Dietetics
Luigi Di Filippo, Rebecca De Lorenzo, Andrea Giustina, Patrizia Rovere-Querini, Caterina Conte
Summary: Osteosarcopenic obesity is a clinical condition where low bone and muscle mass coexist in individuals with obesity. Vitamin D plays a key role in maintaining musculoskeletal health and glucose homeostasis. However, there is limited clinical evidence to support the belief that vitamin D improves musculoskeletal health in individuals with osteosarcopenic obesity.
Article
Multidisciplinary Sciences
Chih-Hsiang Chiang, Yu-Jun Chang, Sin-Ru He, Jih-Ning Chao, Chih-Huai Yang, Yen-Tze Liu
Summary: This study aimed to investigate the relationship between vitamin D levels, metabolic factors, and colorectal polyps (CRPs). The results showed that vitamin D deficiency was significantly associated with the risk of CRPs, especially in adults over 50 years old and women.
Article
Nutrition & Dietetics
Alicja Kolodziejczyk-Nowotarska, Renata Bokiniec, Joanna Seliga-Siwecka
Summary: A study was conducted to assess the effectiveness of monitored vitamin D supplementation in preterm infants. Results showed that a higher percentage of infants in the monitored group had safe vitamin D levels, while potential vitamin D toxicity was observed in the standard treatment group. Therefore, vitamin D intake should be between 800-1000 IU and monitored to avoid overdose.
Review
Oncology
Nasser M. Al-Daghri, Sobhy Yakout, Afnan Ghaleb, Syed Danish Hussain, Shaun Sabico
Summary: Iron and vitamin D deficiencies are common health problems that can affect bone health, but their impact on bone metabolism is not fully understood. Further investigation is needed to explore the relationship between iron and vitamin D deficiencies and the development of osteoporosis, a prevalent chronic disease. Promoting complete recovery from anemia and preventing nutrient deficiencies is crucial for improving quality of life and bone health.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shufei Zeng, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
Summary: There is a strong positive linear correlation between free 25(OH)D (f25(OH)D) and total 25(OH)D, making them useful for assessing vitamin D levels. The recommended threshold level for f25(OH)D is 8.499 pg/mL, corresponding to a target concentration of at least 30 ng/mL for t25(OH)D. The upper limit for vitamin D is still unclear, with most experts favoring a upper limit of 100 ng/mL for t25(OH)D.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rie H. Nygaard, Marlene C. Nielsen, Kristian W. Antonsen, Carsten S. Hojskov, Boe S. Sorensen, Holger J. Moller
Summary: This study reveals the importance of vitamin D metabolism in macrophage polarization, and the active C3-epimerase pathway for vitamin D in macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nasser M. Al-Daghri, Sobhy M. Yakout, Mohammed G. A. Ansari, Syed D. Hussain, Kaiser A. Wani, Shaun Sabico
Summary: This study showed that androgens are significantly associated with non-conventional vitamin D metabolites, indicating potentially clinical relevance in assessing the risk for low bone mineral density and osteoporosis in Arab postmenopausal women.
Article
Nutrition & Dietetics
Hye Ran Shin, Hyeon Ju Park, Sun Yung Ly
Summary: Vitamin D deficiency is prevalent among young Korean women. This study aimed to determine the optimal vitamin D intake level for maintaining adequate serum 25-hydroxyvitamin D (25[OH]D) levels in young Korean women throughout different seasons. The study identified seasonal factors influencing 25(OH)D levels, calculated the necessary vitamin D intake for sufficient levels, and analyzed the relationship between 25(OH)D and intact parathyroid hormone (iPTH) levels. The results showed that 25(OH)D levels were higher in summertime compared to wintertime, and an increase in vitamin D intake led to a corresponding increase in 25(OH)D levels. The study suggests that increasing UV irradiation time in summertime and consuming vitamin D supplements and foods throughout the year is beneficial for maintaining sufficient levels of 25(OH)D in young Korean women.
Article
Endocrinology & Metabolism
Sigrun S. Skuladottir, Alfons Ramel, Hrafnhildur Eymundsdottir, Ingibjorg Hjaltadottir, Lenore J. Launer, Mary-Frances Cotch, Kristin Siggeirsdottir, Vilmundur Gudnason, Gunnar Sigurdsson, Laufey Steingrimsdottir, Thorhallur Halldorsson
Summary: Observational studies have consistently shown a higher risk of fractures in individuals with low serum 25-hydroxyvitamin D levels. This study aimed to examine the extent to which baseline measures of bone mineral density and physical function explain incident hip fractures in older adults with different serum 25(OH)D levels. The results indicated that deficient serum 25(OH)D status was associated with a higher risk of hip fractures, with this association being partially explained by poorer bone mineral density and physical function in males.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Anita Vergatti, Veronica Abate, Aquilino Flavio Zarrella, Fiore Manganelli, Stefano Tozza, Rosa Iodice, Gianpaolo De Filippo, Lanfranco D'Elia, Pasquale Strazzullo, Domenico Rendina
Summary: This meta-analysis found a significant association between 25(OH)D levels <= 8.5 ng/mL at the first stroke and an increased risk of recurrent stroke.
Article
Nutrition & Dietetics
Ji-Juan Zhang, Han-Cheng Yu, Yue Li, Yan-Bo Zhang, Ting-Ting Geng, Qi Lu, Yun-Fei Liao, Kun-Quan Guo, Liang Du, Hua-Ling Ruan, Kun Yang, Gang Liu, An Pan
Summary: This study suggests a nonlinear inverse association between serum 25(OH)D concentrations and all-cause mortality among patients with MAFLD/NAFLD, with a threshold effect at approximately 50.0 nmol/L of serum 25(OH)D.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Laszlo Horvath, Sara Mirani, Michael Magdy Fahmy Girgis, Szilvia Racz, Ildiko Bacskay, Harjit Pal Bhattoa, Bela E. Toth
Summary: This study aimed to examine the vitD status of patients, explore the relationship between vitD deficiency and certain diseases, assess seasonality and trends, and reveal the indirect impact of the COVID-19 pandemic on vitD(3) supplementation at the population level. The results showed that 20% of all patients had hypovitaminosis D and males had higher odds for hypovitaminosis or vitD deficiency. VitD consumption exhibited seasonality, with higher consumption in autumn and winter. The findings highlight the importance of vitD(3) supplementation for at-risk groups and health education promoting vitamin D-3 supplementation.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Tae-Eun Kim, Su Kang Kim, Min Kyung Shin, Ki-Heon Jeong, Mu-Hyoung Lee
Summary: The study investigated the serum vitamin D levels in vitiligo patients and compared the association of VDR gene polymorphisms in vitiligo patients and healthy controls. The results showed that there were no significant differences in serum vitamin D levels between vitiligo patients and the Korean population, as well as in the genotypic distributions of VDR gene between vitiligo patients and healthy controls.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Immunology
Yuchen Tang, Bo Peng, Jinmin Liu, Zhongcheng Liu, Yayi Xia, Bin Geng
Summary: This study explores the association between systemic immune-inflammation index (SII) and bone mineral density (BMD) in postmenopausal women. The results suggest that higher SII is associated with lower BMD and increased risk of osteoporosis. Other inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR) and the product of platelet count and neutrophil count (PPN), are also negatively associated with BMD and positively associated with the risk of osteoporosis. These associations are more significant in postmenopausal women aged >=65 years or with normal BMI.
FRONTIERS IN IMMUNOLOGY
(2022)