Review
Surgery
Arnold W. van de Laar, Marloes Emous, Eric J. Hazebroek, Evert-Jan Boerma, Ian F. Faneyte, Simon W. Nienhuijs
Summary: The prevailing recommendations on reporting weight loss after bariatric and metabolic surgery are not evidence-based, as the suggested outcome metric of percentage excess weight loss (%EWL) is inaccurate and error-sensitive. The Dutch Society for Metabolic and Bariatric Surgery recommends stopping the use of %EWL and calls on the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) to promote this evidence-based recommendation.
Letter
Clinical Neurology
Laurens A. van Kleef, Tian Xiao, Robert J. de Knegt, M. Arfan Ikram
Summary: In our recent study, we found no evidence to suggest that fatty liver disease increases the risk of dementia or impairs cognitive function, regardless of the duration of follow-up. We appreciate Dr. Gupta's interest in our findings.
Article
Medicine, General & Internal
Filip K. Knop, Vanita R. Aroda, Ruben D. do Vale, Thomas Holst-Hansen, Peter N. Laursen, Julio Rosenstock, Domenica M. Rubino, W. Timothy Garvey
Summary: This study assessed the efficacy and safety of oral semaglutide in overweight or obese adults without type 2 diabetes. The findings showed that oral semaglutide 50 mg once per day led to a significantly greater reduction in bodyweight compared to placebo. Gastrointestinal adverse events were the most common side effects. Oral semaglutide could be an effective option for weight management.
Article
Multidisciplinary Sciences
Cassidy McCarthy, Grant M. Tinsley, Anja Bosy-Westphal, Manfred J. Mueller, John Shepherd, Dympna Gallagher, Steven B. Heymsfield
Summary: Sarcopenia, sarcopenic obesity, frailty, and cachexia all involve skeletal muscle as a main component. Whole-body magnetic resonance imaging is the reference method for measuring skeletal muscle mass, but dual-energy X-ray absorptiometry appendicular lean mass can serve as a practical surrogate. This study developed and validated prediction equations for total body and extremity skeletal muscle mass using a large sample, providing an important opportunity for evaluating skeletal muscle mass in research and clinical settings.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Katrina Cachero, Rebecca Mollard, Semone Myrie, Dylan MacKay
Summary: This study evaluated the clinically-managed weight loss program at the Wellness Institute and found that the program was effective prior to the pandemic but faced barriers to weight-loss during the pandemic.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Sofus C. Larsen, Jake Turicchi, Gitte L. Christensen, Charlotte S. Larsen, Niklas R. Jorgensen, Marie-Louise K. Mikkelsen, Graham Horgan, Ruairi O'Driscoll, Joanna Michalowska, Cristiana Duarte, Sarah E. Scott, Ines Santos, Jorge Encantado, Antonio L. Palmeira, R. James Stubbs, Berit L. Heitmann
Summary: Several cross-sectional studies have shown an association between hair cortisol concentration and adiposity, but the relationship with longitudinal changes in measures of adiposity remains largely unknown. In this study of 786 adults who achieved successful weight loss, increased hair cortisol concentration during a 12-month weight loss maintenance period was associated with slightly higher body weight variability in the subsequent 6 months.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Nutrition & Dietetics
Audrey Tay, Hannah Hoeksema, Rinki Murphy
Summary: This review analyzed qualitative data to explore the barriers and facilitators of weight loss and weight loss maintenance. Four aggregate themes were identified: internal factors, program-specific factors, social factors, and environmental factors. The findings highlight the importance of considering participant acceptability and engagement in future interventions, and suggest strategies such as tailored interventions, relapse management plans, and strategies to enhance motivation and emotional self-regulation.
Article
Nutrition & Dietetics
Christina Holzapfel, Sabine Sag, Johanna Graf-Schindler, Marcus Fischer, Theresa Drabsch, Thomas Illig, Harald Grallert, Lynne Stecher, Christina Strack, Ian D. Caterson, Susan A. Jebb, Hans Hauner, Andrea Baessler
Summary: This study analyzed the association between certain obesity-related genetic variants and anthropometric changes during weight loss interventions. While specific SNPs in the MC4R gene were found to be significantly associated with weight and BMI reduction, SNPs in other genes showed no significant correlation with anthropometric parameters. Overall, the study concluded that these investigated SNPs do not play a consistent role in anthropometric changes during behavioral weight loss interventions.
Article
Medicine, General & Internal
Jonathan R. Wing, Allison Kimball, Michelle Rengarajan
Summary: A 68-year-old man with metastatic melanoma presented with fatigue, weight loss, and hyperglycemia. He was previously diagnosed with hypothyroidism.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Physiology
Marijana Ranisavljev, Jovan Kuzmanovic, Nikola Todorovic, Roberto Roklicer, Milorad Dokmanac, Mario Baic, Valdemar Stajer, Sergej M. Ostojic, Patrik Drid
Summary: This study investigated the most widespread rapid weight loss methods and sources of influence used by grappling athletes. The results showed that a majority of athletes engaged in rapid weight loss prior to weigh-in, with coaches and teammates being the most influential sources. There were also differences between male and female athletes in terms of sources of influence and weight loss methods used.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Nutrition & Dietetics
Simone Perna, Zahra Ilyas, Attilio Giacosa, Clara Gasparri, Gabriella Peroni, Milena Anna Faliva, Chiara Rigon, Maurizio Naso, Antonella Riva, Giovanna Petrangolini, Ali A. Redha, Mariangela Rondanelli
Summary: This meta-analysis study found that probiotic supplementation can significantly reduce BMI, waist circumference, and hip circumference in overweight and obese patients, but the effect on body weight is not significant. Although there is a positive trend, further research is needed before recommending probiotics as a therapeutic strategy for these patients.
Article
Management
Qi Chen, Zeqiong Huang, Xu Jiang, Gaoqing Zhang, Yun Zhang
Summary: The study shows that a reporting system with more timely disclosure of bad news than good news encourages speculators to trade on private information, leading to higher expected investment levels and firm value.
MANAGEMENT SCIENCE
(2021)
Article
Endocrinology & Metabolism
Is-Haq O. Malik, Max C. Petersen, Samuel Klein
Summary: Achieving long-term weight loss in people with obesity is difficult, highlighting the need for effective pharmacotherapy. New poly-agonists, such as semaglutide and tirzepatide, have shown promising results in terms of weight loss. However, the long-term efficacy, safety, and economic implications of chronic pharmacotherapy for obesity need to be further analyzed.
Article
Food Science & Technology
Christopher Papandreou, Jesus Garcia-Gavilan, Lucia Camacho-Barcia, Thea Toft Hansen, Joanne A. Harrold, Anders Sjodin, Jason C. G. Halford, Monica Bullo
Summary: This study examines the relationship between changes in circulating metabolites during diet-induced weight loss and changes in adiposity, finding significant associations between lipid species and citric acid with body weight and adiposity reduction. The results also show that changes in lysophosphatidylcholines and citric acid concentrations during weight loss are linked to adiposity regain and loss during the maintenance period, highlighting the importance of adipose lipid metabolism in weight and adiposity maintenance.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Health Care Sciences & Services
Scott Hagan, Karin Nelson
Summary: There is significant controversy surrounding the clinical benefits and risks of weight loss interventions for individuals with obesity. Traditional weight-centric approaches may increase weight stigma and cycling without sufficient evidence to support their purported clinical benefits. However, metabolic surgery and pharmacotherapy show clear benefits in certain cases.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
