Article
Medicine, General & Internal
Chia-Chen Lin, Keng-Hao Liu, Li-Ang Lee, Li-Pang Chuang, Yu-Sheng Lin, Li-Jen Hsin, Wan-Ni Lin, Yen-Ting Chiang, Wen-Nuan Cheng, Hsueh-Yu Li
Summary: This study proposes a comprehensive technique called combined airway and bariatric surgery (CABS) to improve both obesity and obstructive sleep apnea (OSA). The retrospective study showed that CABS can significantly improve AHI and BMI in morbidly obese OSA patients, with high success and cure rates for OSA, as well as improved quality of life and general health.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
M. Leentjens, Abdulmohsen Alterki, Mohamed Abu-Farha, P. F. N. Bosschieter, CAL. de Raaff, CEE. de Vries, Eman Al Shawaf, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Sina Kavalakatt, B. A. van Wagensveld, N. de Vries, Jehad Abubaker
Summary: This study found significantly increased levels of ANGPTL7 in both the circulation and adipose tissue of patients with OSA, which were associated with increased inflammation and OSA severity. Bariatric surgery was shown to significantly reduce ANGPTL7 levels and improve OSA.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Sofie Jacobs, Emilie Mylemans, Marijke Ysebaert, Eline Vermeiren, Ann De Guchtenaere, Hilde Heuten, Luc Bruyndonckx, Benedicte Y. De Winter, Kim Van Hoorenbeeck, Stijn L. Verhulst, Annelies Van Eyck
Summary: This study investigated the effect of weight loss on endothelial function and OSA in obese children, finding that weight loss significantly improved endothelial function. However, even after weight loss, the improvement in endothelial function was less pronounced in patients with OSA.
Article
Otorhinolaryngology
Stephen R. Chorney, Karen B. Zur
Summary: The study aimed to investigate the effects of adenoidectomy on obstructive sleep apnea in young children. The results showed that OSA symptoms improved in some children after the surgery, but younger children were more likely to require subsequent tonsillectomy. Additional prospective studies are needed to validate these findings.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Clinical Neurology
Elisabet Martinez-Ceron, Raquel Casitas, Raul Galera, Begona Sanchez-Sanchez, Ester Zamarron, Aldara Garcia-Sanchez, Ana Jaureguizar, Carolina Cubillos-Zapata, Francisco Garcia-Rio
Summary: The prevalence of dyslipidemia in patients with obstructive sleep apnea (OSA) increases with the severity of the disease. In OSA patients, smoking, apnea-hypopnea index (AHI), and mean nocturnal saturation are factors independently associated with dyslipidemia. Additionally, sleep fragmentation and increased sympathetic activity may contribute to lipid dysregulation in OSA patients.
Article
Otorhinolaryngology
Christine H. Heubi, Philip Knollman, Susan Wiley, Sally R. Shott, David F. Smith, Stacey L. Ishman, Jareen Meinzen-Derr
Summary: In children with Down syndrome, 32.5% had sleep efficiency <80%; 75.6% had an elevated arousal index; and 15.9% had total sleep time <360 minutes. More than a third of the patients had >= 3 markers of poor sleep architecture. There was no difference in children with or without obstructive sleep apnea.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Biology
Clara Garcia-Vicente, Gonzalo C. Gutierrez-Tobal, Jorge Jimenez-Garcia, Adrian Martin-Montero, David Gozal, Roberto Hornero
Summary: A novel deep-learning approach using raw electrocardiogram tracing (ECG) was proposed to simplify the diagnosis of pediatric OSA. A convolutional neural network (CNN) regression model was implemented to predict pediatric OSA and derive severity categories. The diagnostic performance of the CNN model outperformed previous algorithms relying on ECG-derived features. The proposed CNN model provides a simpler, faster, and more accessible diagnostic test for pediatric OSA.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Pediatrics
Mandip Kang, Fan Mo, Manisha Witmans, Vicente Santiago, Mary Anne Tablizo
Summary: Obstructive sleep apnea in children is associated with various problems, and diagnosing it accurately can be challenging. Alternative methods like home sleep testing are being researched.
Article
Multidisciplinary Sciences
Zhiyuan Song, Kaifeng Guo, Weijun Huang, Huajun Xu, Yupu Liu, Jian Guan, Shankai Yin, Haoyong Yu, Hongliang Yi, Jianyin Zou
Summary: The study found that RYGB surgery significantly reduced AHI and betatrophin, while also decreasing abdominal fat area and HOMA-IR. Preoperative and postoperative betatrophin levels were significantly correlated with AHI. The change in betatrophin was independently associated with the change in minimum oxygen saturation.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Swathi Rayasam, Romaine Johnson, Danielle Lenahan, Claire Abijay, Ron B. Mitchell
Summary: The study identified predictors of severe obstructive sleep apnea (OSA) in children under 3 years of age to be Down syndrome and tonsillar hypertrophy, with children more likely to be male and have gastroesophageal reflux disease (GERD). Therefore, children with these conditions should be prioritized for polysomnography.
Article
Multidisciplinary Sciences
Laura Mihalache, Dimitrie Siriopol, Lidia Iuliana Arhire, Sergiu Padureanu, Cristina Preda, Daniela Boisteanu, Dragos Scripcariu, Silvia Cusai, Adrian Covic
Summary: This study assessed the influence of obstructive sleep apnea syndrome (OSAS) on anthropometric parameters and body composition changes in patients undergoing laparoscopic sleeve gastrectomy (LSG). The results show that patients with OSAS had less significant decreases in percent fat compared to those without OSAS at the 12-month follow-up after LSG.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Riku Huttunen, Timo Leppanen, Brett Duce, Arie Oksenberg, Sami Myllymaa, Juha Toyras, Henri Korkalainen
Summary: This study developed an automatic sleep staging method based on photoplethysmography (PPG) signal, successfully differentiating between obstructive sleep apnea (OSA) severity categories and revealing that better sleep continuity evaluation results are achieved using shorter epoch-to-epoch intervals.
Article
Endocrinology & Metabolism
Rinki Murphy, Lindsay D. Plank, Michael G. Clarke, Nicholas J. Evennett, James Tan, David D. W. Kim, Richard Cutfield, Michael W. C. Booth
Summary: SR-LRYGB provided superior diabetes remission and weight loss compared with LSG at 5 years, with similar low risks of complications.
Review
Health Care Sciences & Services
Andreea Zabara-Antal, Ionela Grosu-Creanga, Mihai Lucian Zabara, Andrei Tudor Cernomaz, Bogdan Mihnea Ciuntu, Oana Melinte, Cristian Lupascu, Antigona Carmen Trofor
Summary: This review discusses the role of surgery in the treatment of sleep apnea and emphasizes the importance of individualized therapy. Depending on the type and severity of the apnea, the causal factor, obesity, hypercapnia, and associated pathologies, the optimal therapeutic method is determined for each individual case.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ville A. Palomaki, Petri Lehenkari, Sanna Merilainen, Tuomo J. Karttunen, Vesa Koivukangas
Summary: This case-control study analyzed the macrophage infiltration in subcutaneous adipose tissue after bariatric surgery or conservative treatment of obesity, and investigated whether these features could predict weight loss outcome. The study found a significant decline in crown-like structures (CLS) density after surgery, regardless of weight loss. However, surgery had no effect on the infiltration of single-cell macrophages, and the abundance of these macrophage populations before surgery did not predict weight loss or response to surgery.
Article
Surgery
Jill L. Kaar, Nazeen Morelli, Samuel P. Russell, Ishaah Talker, Jaime M. Moore, Thomas H. Inge, Kristen J. Nadeau, Stephen M. M. Hawkins, Mark S. Aloia, Stacey L. Simon
Summary: This study investigated the prevalence of OSA and factors associated with OSA remission post-MBS in adolescents with severe obesity. The findings indicated that OSA patients were typically older, more likely to be male, and had higher baseline weights, while OSA remission was correlated with lower pre-MBS BMI and weight.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Endocrinology & Metabolism
Meg H. Zeller, Katherine M. Kidwell, Jennifer Reiter-Purtill, Todd M. Jenkins, Marc P. Michalsky, James E. Mitchell, Anita P. Courcoulas, Thomas H. Inge
Summary: This study tracked conventional cigarette smoking behaviors and correlates in adolescents with severe obesity who underwent or did not undergo metabolic and bariatric surgery up to 4 years after surgery/baseline. Results showed that factors associated with current smoking in Year 4 included dysregulation, internalizing symptoms, alcohol use, caregiver and friend smoking behavior, perception of low harm, and greater percent weight loss in the surgical group. Upstream identification, monitoring, and intervention to prevent smoking uptake and escalation in youth with obesity should be prioritized.
Article
Pediatrics
Sarah B. Ogle, Lindel C. Dewberry, Todd M. Jenkins, Thomas H. Inge, Megan Kelsey, Matias Bruzoni, Janey S. A. Pratt
Summary: The differences in outcomes of metabolic and bariatric surgery between younger and older adolescents were few. Younger adolescents showed better results in some aspects compared to older adolescents.
Article
Cell Biology
Maria E. Moreno-Fernandez, Daniel A. Giles, Jarren R. Oates, Calvin C. Chan, Michelle S. M. A. Damen, Jessica R. Doll, Traci E. Stankiewicz, Xiaoting Chen, Kashish Chetal, Rebekah Karns, Matthew T. Weirauch, Lindsey Romick-Rosendale, Stavra A. Xanthakos, Rachel Sheridan, Sara Szabo, Amy S. Shah, Michael A. Helmrath, Thomas H. Inge, Hitesh Deshmukh, Nathan Salomonis, Senad Divanovic
Summary: Recent evidence suggests that Th17 cells play a key role in the pathogenesis of NAFLD, with a distinct population of inflammatory hepatic CXCR3(+)Th17 cells exacerbating the disease. The pathogenic characteristics of these cells include increased chromatin accessibility, glycolytic output, and production of IL-17A, IFN-γ, and TNF-α. Modulation of glycolysis pathways can potentially reverse the inflammatory vigor of ihTh17 cells and severity of NAFLD.
Article
Pediatrics
Jose Diaz-Miron, Sarah Ogle, Alex Kaizer, Shannon N. Acker, Kyle O. Rove, Thomas H. Inge
Summary: The study found that adoption of telemedicine was slow in surgical specialties before the COVID-19 pandemic, with both surgeons and caregivers reporting low prior experience. However, satisfaction with telemedicine during the pandemic was generally high. Surgeon age was inversely related to satisfaction with telemedicine, while higher income households reported higher audiovisual satisfaction with telemedicine.
PEDIATRIC SURGERY INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Suzanne S. Summer, Todd Jenkins, Thomas Inge, Ranjan Deka, Jane C. Khoury
Summary: This study found that American adolescents have poor diet quality and low levels of physical activity, and about half of them suffer from metabolic syndrome. Abdominal obesity is significantly associated with the severity of metabolic syndrome, while diet and exercise habits are related to the development of metabolic syndrome.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Pediatrics
Lorraine Kelley-Quon, Eveline Shue, Rita Burke, Caitlin Smith, Karen Kling, Elaa Mahdi, Shadassa Ourshalimian, Michael Fenlon, Matthew Dellinger, Stephen B. Shew, Justin Lee, Benjamin Padilla, Thomas Inge, Jonathan Roach, Ahmed Marwan, Katie W. Russell, Romeo Ignacio, Elizabeth Fialkowski, Amar Nijagal, Cecilia Im, Kenneth S. Azarow, Daniel J. Ostlie, Kasper Wang
Summary: Early Kasai portoenterostomy at tertiary-level centers significantly increases likelihood for transplant-free survival among infants with biliary atresia. Within 1 year, most infants experience readmission, over half develop cholangitis, and a small percentage require reoperation.
PEDIATRIC SURGERY INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Kristina M. Decker, Jennifer Reiter-Purtill, Carolina M. Bejarano, Andrea B. Goldschmidt, James E. Mitchell, Todd M. Jenkins, Michael Helmrath, Thomas H. Inge, Marc P. Michalsky, Meg H. Zeller
Summary: This study found that adolescent bariatric surgery appears to be beneficial for problematic eating and eating-related psychopathology. The results also suggest that clinical intervention related to problematic eating and associated psychosocial concerns may be needed for young adults with obesity, regardless of surgical status.
OBESITY SCIENCE & PRACTICE
(2022)
Article
Endocrinology & Metabolism
Sandeep Dhindsa, Husam Ghanim, Todd Jenkins, Thomas H. Inge, Carroll M. Harmon, Amit Ghoshal, Zengru Wu, Michael J. McPhaul, Farid Saad, Paresh Dandona
Summary: Bariatric surgery led to significant weight loss and an increase in testosterone concentrations in 34 obese adolescent males. The maximum weight loss was achieved at 24 months post-surgery. Prior to surgery, 73% of the participants had subnormal free testosterone levels, which decreased to 20% and 33% after 2 and 5 years, respectively.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Surgery
Lorraine Kelley-Quon, Shadassa Ourshalimian, Justin Lee, Katie W. Russell, Karen Kling, Stephen B. Shew, Claudia Mueller, Aaron R. Jensen, Lan Vu, Benjamin Padilla, Daniel Ostlie, Caitlin Smith, Thomas Inge, Jonathan Roach, Romeo Ignacio, Katrine Lofberg, Stephanie Radu, Autumn Rohan, Kasper S. Wang
Summary: This study aimed to minimize opioid prescribing in children after appendectomy using Quality Improvement methodology. The results showed a significant decrease in opioid prescribing after the Quality Improvement intervention, without significant changes in emergency room visits or patient satisfaction.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2022)
Article
Surgery
Eric G. Campbell, Ahmed Alasmar, Rosa Lawrence, Marinda Kurpius-Brock, Matthew DeCamp, Alexandra Kovar, Jonathan Schoen, Thomas Inge, Megan M. Kelsey, Richard Boles, Scott Engel
Summary: This study suggests that the primary barriers to MBS for adolescents with severe obesity are related to a general lack of information about MBS, social stigma, and access issues related to costs.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Pediatrics
Amy A. Rydin, Cameron Severn, Laura Pyle, Kathleen Dorris, Christina Chambers, Debra Stiller, Todd C. Hankinson, Thomas Inge, Matthew A. Haemer, David M. Mirsky, Jaime Moore, Megan M. Kelsey
Summary: Hypothalamic obesity is common in children with hypothalamic tumors. A clinical algorithm can help in the recognition and management of this condition, but further research is needed to develop effective treatment.
Editorial Material
Gastroenterology & Hepatology
Thomas H. Inge, Justin R. Ryder
Summary: Severe obesity in adolescents has negative effects on their health and quality of life. Currently, metabolic and bariatric surgery is the only effective intervention, but it is not widely utilized. Therefore, there is a need for vigorous research in this area to benefit adolescents with obesity.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Shikha S. Sundaram, Miriam Ben Abdallah, Emily Cooper, Kristen Nadeau, Megan Kelsey, Ronald J. Sokol, Thomas H. Inge
Meeting Abstract
Rheumatology
Isaac Harley, Calvin Chan, Paul Pfluger, Trompette Aurelien, Traci Stankiewicz, Jessica Allen, Maria Moreno-Fernandez, Michelle Damen, Jarren Oates, Pablo Alarcon, Jessica Doll, Matthew Flick, Leah Flick, Juan Sanchez-Gurmaches, Rajib Mukherjee, Rebekah Karns, Michael Helmrath, Thomas Inge, Stuart Weisberg, Sunje Pamp, David Relman, Randy Seeley, Matthias Tschoep, Chris Karp, Senad Divanovic
ARTHRITIS & RHEUMATOLOGY
(2021)
