Editorial Material
Biochemistry & Molecular Biology
Raghav Jain, Judith Simcox
Summary: Localized hyperthermia has been found to activate thermogenic mechanisms, leading to increased energy expenditure and reduced body weight in both mice and humans.
Article
Biochemistry & Molecular Biology
Gemma Arderiu, Guiomar Mendieta, Alex Gallinat, Carmen Lambert, Alberto Diez-Caballero, Carlos Ballesta, Lina Badimon
Summary: Obesity is linked to metabolic disorders and increased cardiovascular risk. The presence of type 2 diabetes mellitus (T2DM) affects the protein composition in adipose tissue and serum, leading to changes in systemic markers and dysregulation of metabolic pathways in visceral adipose tissue (VAT).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Margarete Milek, Yusef Moulla, Matthias Kern, Christine Stroh, Arne Dietrich, Michael R. Schoen, Daniel Gaertner, Tobias Lohmann, Miriam Dressler, Peter Kovacs, Michael Stumvoll, Matthias Blueher, Esther Guiu-Jurado
Summary: This study found that serum adipsin concentrations are strongly related to obesity and age, but not to parameters of glucose or lipid metabolism in patients with obesity with or without T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tiago Morais, Alexandre L. Seabra, Barbara G. Patricio, Marta Guimaraes, Mario Nora, Pedro F. Oliveira, Marco G. Alves, Mariana P. Monteiro
Summary: The study revealed that there are differences in VAT metabolic fingerprint between obesity and different glycemic statuses, characterized by higher isoleucine consumption, lower acetate production, and lower pyruvate and pyroglutamate consumption in pre-diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Shuchao Pang, Zhengjun Zhang, Yu Zhou, Jie Zhang, Bo Yan
Summary: Genetic variants within the SIRT1 gene promoter have been found to be associated with the development of T2D, with two SNPs showing a strong correlation with the disease. These variants may alter SIRT1 levels, contributing to the pathogenesis of T2D.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Lindsey J. Anderson, Jonathan Lee, Barbara Anderson, Benjamin Lee, Dorota Migula, Adam Sauer, Nicole Chong, Haiming Liu, Peter C. Wu, Atreya Dash, Yi-Ping Li, Jose M. Garcia
Summary: Cancer-related weight loss is associated with elevated levels of inflammation, lipolysis, and browning markers. BMI is associated with increased energy expenditure.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Multidisciplinary Sciences
Chad C. Doucette, Davide Barteselli, Daniel C. Nguyen, Sophia Blanchard, Mason Pelletier, Devesh Kesharwani, Ed Jachimowicz, Su Su, Michele Karolak, Aaron C. Brown
Summary: In this study, an optogenetic approach was used to activate UCP1-dependent thermogenesis in brown adipocytes. This system allows for precise, chemical free, temporal control of UCP1-dependent thermogenesis, which can contribute to our understanding of brown adipocyte biology and the development of therapies for obesity-related disorders.
Article
Gastroenterology & Hepatology
Benjamin Schroeder, Sabine Kahl, Michael Roden
Summary: Individuals with obesity or type 2 diabetes have an increased risk of developing non-alcoholic fatty liver disease, with altered adipose tissue function and hepatic mitochondrial dysfunction playing key roles in the pathogenesis. Genetic testing for high-risk individuals, particularly for the rs738409(G) SNP of the PNPLA3 gene, could improve future screening strategies.
LIVER INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Kosuke Otani, Hiroshi Funada, Risa Teranishi, Muneyoshi Okada, Hideyuki Yamawaki
Summary: This study investigated changes in cardiovascular dynamics, adipose tissue, and kidney pathology associated with obesity and T2D in ZFDM rats. The results showed that heart rate and plasma adrenaline concentration decrease with the progression of obesity and T2D in ZFDM rats. In addition, inflammation occurs in perirenal white adipose tissue, while degeneration and whitening occur in interscapular brown adipose tissue. Furthermore, renal function is impaired. ZFDM rats will be useful for studying metabolic changes associated with obesity and T2D progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Guan Huang, Cuishan Yang, Sheng Guo, Miaoling Huang, Liping Deng, Ying Huang, Puxin Chen, Feng Chen, Xiaohong Huang
Summary: This study reveals the crucial role of PIP5K1c in regulating obesity, hyperlipidaemia, hepatic steatosis, and insulin resistance induced by a high fat diet. PIP5K1c deficiency reduces adipocyte volume and enhances energy expenditure, protecting against weight gain. These findings suggest that targeting PIP5K1c could be a potential strategy for treating obesity.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Endocrinology & Metabolism
Agne Kulyte, Alisha Aman, Rona J. Strawbridge, Peter Arner, Ingrid A. Dahlman
Summary: Interindividual differences in the generation of new fat cells are associated with body fat and type 2 diabetes risk. This study identified several genetic loci and candidate genes, including SPATS2L, KCTD18, RPL8, HSD17B12, and PEPD, that are potentially important in controlling fat cell numbers, body fat size, and diabetes risk.
Article
Endocrinology & Metabolism
Youn Ju Kim, Hye Jin Kim, Sang Gyu Lee, Do Hyun Kim, Su In Jang, Hye Sun Go, Won Jun Lee, Je Kyung Seong
Summary: Exercise training has positive effects on metabolic health, helping to counteract weight gain, fatty liver, and insulin resistance. This may be attributed to its ability to enhance the browning of white fat, whole-body oxygen uptake, and heat generation.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Geriatrics & Gerontology
Kirsten E. Bell, Michael T. Paris, Egor Avrutin, Marina Mourtzakis
Summary: This study compared body composition, muscle and subcutaneous adipose tissue thickness, and ultrasound-based texture features in older adults with type 2 diabetes (T2D) or prediabetes compared to healthy controls. The study found a novel body composition phenotype specific to older adults with T2D or prediabetes, and also reported a correlation between ultrasound-based texture features and functional outcomes. Further research is needed to uncover the mechanisms underlying these regional body composition differences.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Environmental Sciences
Celia Rodriguez-Perez, Celia Gomez-Pena, Francisco M. Perez-Carrascosa, Petra Vrhovnik, Ruth Echeverria, Inmaculada Salcedo-Bellido, Vicente Mustieles, Fiket Zeljka, Juan Pedro Arrebola
Summary: This study revealed that adipose tissue concentrations of chromium, iron, and copper were associated with the incidence of T2DM over a 16-year follow-up period. Additionally, vanadium and zinc concentrations were positively correlated with pancreatic cell function, while selenium showed an inverse association. These findings suggest that certain trace elements in adipose tissue may play a role in the development of T2DM and have potential implications for identifying individuals at risk.
ENVIRONMENTAL POLLUTION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shan Huang, Yuan Li, Li Jiang, Yan Ren, Jin Wang, Ke Shi, Wei-Feng Yan, Wen-Lei Qian, Zhi-Gang Yang
Summary: Type 2 diabetes has a negative impact on epicardial adipose tissue and myocardial microvascular function in postmenopausal women, leading to impaired microcirculation.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Letter
Endocrinology & Metabolism
Manfred J. Mueller, Michael Krawczak, Steven Heymsfield, Yves Schutz, Abdul Dulloo, John Blundell, Corinna Geisler, Anja Bosy-Westphal
INTERNATIONAL JOURNAL OF OBESITY
(2019)
Article
Endocrinology & Metabolism
Julie Calonne, Laurie Isacco, Jennifer Miles-Chan, Denis Arsenijevic, Jean-Pierre Montani, Christelle Guillet, Yves Boirie, Abdul G. Dulloo
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Nutrition & Dietetics
Harris Ramuth, Yves Schutz, Julie Calonne, Noorjehan Joonas, Abdul G. Dulloo
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2020)
Article
Nutrition & Dietetics
Harris Ramuth, Sadhna Hunma, Vinaysing Ramessur, Magalutcheemee Ramuth, Cathriona Monnard, Jean-Pierre Montani, Yves Schutz, Noorjehan Joonas, Abdul G. Dulloo
BRITISH JOURNAL OF NUTRITION
(2020)
Article
Endocrinology & Metabolism
Philippe Jacquet, Yves Schutz, Jean-Pierre Montani, Abdul Dulloo
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Article
Endocrinology & Metabolism
Cathriona R. Monnard, Abdul G. Dulloo
Summary: Recent research has shown that the amount and type of dietary fat consumed play a crucial role in metabolic health. High intake of polyunsaturated fatty acids may help reduce cardiovascular disease risk, improve glucose homeostasis, and impact long-term regulation of body weight and composition.
Article
Endocrinology & Metabolism
Yves Schutz, Jean-Pierre Montani, Abdul G. Dulloo
Summary: The debate over the most appropriate type of diet for maintaining or losing body weight, including the controversial ketogenic and Mediterranean diets, has continued for over half a century. While the Mediterranean diet is considered suitable for long-term use and provides health benefits, the low-carbohydrate ketogenic diet may pose risks such as metabolic acidosis and renal dysfunction.
Article
Endocrinology & Metabolism
Julie Calonne, Helena Marcelino, Christelle Veyrat-Durebex, Isabelle Scerri, Abdul G. Dulloo
Summary: The study showed that a high-fat diet may accelerate fat deposition and decrease insulin sensitivity, while refeeding on a diet rich in essential polyunsaturated fatty acids can prevent increases in fat mass and blood sugar, with only a minor impact on insulin sensitivity.
NUTRITION & DIABETES
(2021)
Article
Endocrinology & Metabolism
Abdul G. Dulloo
Summary: The Biology of Human Starvation, published in 1950, has been a significant scientific reference for understanding the impact of long-term food deprivation on human physiology and behavior. The book has guided the development of famine and relief programs, explored the effects of food deprivation on eating disorders, and provided insights into metabolic adaptations that influence obesity therapy and cachexia rehabilitation. The application of a systems approach to the book's data has revealed important control systems governing body composition regulation during weight regain.
Article
Endocrinology & Metabolism
Abdul G. Dulloo, Jean-Pierre Montani
Summary: The contribution of Ancel Keys to obesity research is significant and still widely applied today, particularly in the areas of diagnosis, dietary fat types, low carbohydrate diets, famine reactions, and weight cycling.
Article
Endocrinology & Metabolism
Celia Di Munno, Rosa Anna Busiello, Julie Calonne, Anna Maria Salzano, Jennifer Miles-Chan, Andrea Scaloni, Michele Ceccarelli, Pieter de Lange, Assunta Lombardi, Rosalba Senese, Federica Cioffi, Theo J. Visser, Robin P. Peeters, Abdul G. Dulloo, Elena Silvestri
Summary: In a rat model of semistarvation-refeeding, catch-up fat is associated with metabolic and contractile adjustments in skeletal muscle, as well as potential implications for thyroid hormone metabolism as a part of adaptive thermogenesis sustaining body fat recovery.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Letter
Endocrinology & Metabolism
Yves Schutz, Jean-Pierre Montani, Abdul G. Dulloo
Article
Biochemistry & Molecular Biology
Julie Calonne, Elie-Jacques Fares, Jean-Pierre Montani, Yves Schutz, Abdul Dulloo, Laurie Isacco
Summary: The study investigated the dynamics of fat oxidation during light-intensity leg cycling exercise in inactive, healthy young adults. Results showed distinct subgroups among subjects based on perceived exhaustion rate and respiratory quotient, reinforcing the potential importance of light physical activity in preventing obesity.
Review
Nutrition & Dietetics
Lena Pelissier, Sarah Bagot, Jennifer Lynn Miles-Chan, Bruno Pereira, Yves Boirie, Martine Duclos, Abdul Dulloo, Laurie Isacco, David Thivel
Summary: The present study aimed to systematically review the studies implicating diet restriction and body weight evolution in normal-weight individuals. The findings suggest that dieting could be a major risk factor for long-term weight gain in this population. Observational studies showed a relationship between dieting and significant later weight gain, while the meta-analysis indicated that 'dieters' have a higher body weight than 'non-dieters'. However, caution should be exercised due to methodological heterogeneity and publication bias.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Endocrinology & Metabolism
Abdul G. Dulloo
Summary: The concept of dual-adaptive thermogenesis suggests that there are two control systems governing energy sparing during prolonged energy deficit. The adipose-specific control system plays a role in accelerating fat store replenishment during weight regain. Adaptive thermogenesis during weight loss is primarily regulated by central suppression of the sympathetic nervous system and hypothalamic-pituitary-thyroid axis, while during weight regain it mainly operates through peripheral tissue resistance. Evidence of altered deiodination of thyroid hormones in skeletal muscle and liver offers insights into the molecular mechanisms behind adipose-specific control of thermogenesis and potential targets to counter obesity recidivism.