Article
Economics
Masa Davidovic, Nadine Zielonke, Iris Lansdorp-Vogelaar, Nereo Segnan, Harry J. de Koning, Eveline AM. Heijnsdijk
Summary: This study assessed the impact of mammography-based screening on quality of life using DALYs and QALYs, finding that almost the same strategies were on the efficiency frontiers. The choice of outcome measure may lead to differences in ICERs.
Review
Clinical Neurology
Annie Hawton, Elizabeth Goodwin, Kate Boddy, Jennifer Freeman, Sarah Thomas, Jeremy Chataway, Colin Green
Summary: This review discusses the cost-effectiveness of multiple sclerosis treatment, explores the use of quality-adjusted life-years (QALYs) in resource allocation decisions, and highlights the limitations of this approach in the context of multiple sclerosis. The article concludes by suggesting methodological and policy developments that could address these limitations.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Chiara C. Bruck, Frank J. Wolters, Mohammad Arfan Ikram, Ingem. C. M. de
Summary: This study used the microsimulation model MISCAN-Dementia to simulate the costs and QALYs lost due to dementia in the Netherlands from 2020 to 2050. The results show that the societal costs and QALYs lost due to dementia are estimated to double by 2050. The majority of costs are incurred through institutional, formal home, and informal home care, while lost QALYs are mostly a result of shortened life expectancy and quality of life with severe dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Endocrinology & Metabolism
Li Ming Wen, Huilan Xu, Philayrath Phongsavan, Chris Rissel, Alison Hayes, Sarah Taki, Limin Buchanan, Lisa Simone, Renee Moreton, Louise A. Baur
Summary: This study examined the effectiveness of a combined telephone and SMS intervention on reducing BMI and obesity risk behaviors in 3-year-old children. The intervention group showed improved dietary and activity behaviors compared to the control group, but there was no significant difference in BMI between the two groups.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Economics
Darius N. Lakdawalla, Charles E. Phelps
Summary: The GRACE model introduces diminishing returns to QoL, reshaping conventional CEA practice in terms of WTP, treatment effectiveness adjustment, and the substitution rate between life expectancy and QoL based on health state. Implementing GRACE requires new parameters to describe risk preferences, the marginal rate of substitution, and treatment outcomes distributions.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2022)
Article
Urology & Nephrology
Phil McEwan, Oliver Darlington, Ryan Miller, John J. V. McMurray, David. C. C. Wheeler, Hiddo J. L. Heerspink, Andrew Briggs, Klas Bergenheim, Juan Jose Garcia Sanchez
Summary: CKD imposes a significant burden on patients and healthcare providers. The DAPA-CKD trial demonstrated that dapagliflozin, along with standard therapy, can reduce CKD progression and the need for kidney replacement therapy. This study aimed to evaluate the cost-effectiveness of dapagliflozin for CKD treatment from payer perspectives in the UK, Germany, and Spain.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Anne M. Neilan, Raphael J. Landovitz, Mylinh H. Le, Beatriz Grinsztejn, Kenneth A. Freedberg, Marybeth McCauley, Nattanicha Wattananimitgul, Myron S. Cohen, Andrea L. Ciaranello, Meredith E. Clement, Krishna P. Reddy, Emily P. Hyle, A. David Paltiel, Rochelle P. Walensky
Summary: The study found that although CAB-LA offers more benefits over F/TDF, effective oral PrEP limits the additional price society should be willing to pay for CAB-LA.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Rheumatology
Xingzhong Jin, Ilana N. Ackerman, Zanfina Ademi
Summary: Productivity-adjusted life-years (PALYs) provide a novel approach to quantify the productivity burden of chronic conditions in the working population. This study estimated the productivity burden of knee osteoarthritis (KOA) among working-age Australians, resulting in significant productivity loss and an economic impact of 424 billion Australian dollars in lost GDP. Public health funding and scalable population-level strategies are needed for effective KOA prevention and support.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Clinical Neurology
Xiucai Guo, Junxiao Li, Xueyan Yin, Ziping Zhang, Qiongqiong Zhong, Feng Zhu
Summary: This study aimed to assess the global burden of stroke attributable to high body mass index (HBMI). The results showed an increasing trend in deaths and disability-adjusted life-years (DALYs) caused by stroke for the past three decades. China, India, Indonesia, the Russian Federation, and the United States of America had the highest rates of stroke deaths and DALYs in 2019. Regions with high-middle and middle sociodemographic index (SDI) and middle-aged and aged populations should focus on controlling and treating stroke attributable to HBMI.
FRONTIERS IN NEUROLOGY
(2023)
Article
Economics
Maaike Hoedemakers, Apostolos Tsiachristas, Maureen Rutten-van Molken
Summary: This study investigates how multicriteria decision analysis (MCDA) can complement cost-effectiveness analysis (CEA) in supporting investment decisions in elderly care at the local level. Using an integrated elderly care program in the Netherlands as a case study, the study demonstrates that MCDA can provide decision-makers with a broader measurement of effectiveness and consider the preferences of multiple stakeholders.
Article
Health Care Sciences & Services
Mutsa Gumbie, Emma Olin, Bonny Parkinson, Ross Bowman, Henry Cutler
Summary: Research shows that unilateral cochlear implants are more cost-effective than hearing aids for Swedish adults with severe to profound hearing loss. Early implantation of unilateral CIs improves cost-effectiveness among eligible patients.
BMC HEALTH SERVICES RESEARCH
(2021)
Article
Clinical Neurology
Anders Wimo, Ron Handels, Riitta Antikainen, Maria Eriksdotter, Linus Jonsson, Martin Knapp, Jenni Kulmala, Tiina Laatikainen, Jenni Lehtisalo, Markku Peltonen, Anders Skoldunger, Hilkka Soininen, Alina Solomon, Timo Strandberg, Jaakko Tuomilehto, Tiia Ngandu, Miia Kivipelto
Summary: This study estimated the potential cost-effectiveness of the FINGER program in Finland. The results showed that the FINGER program could save costs and improve quality-adjusted life years, supporting its effectiveness in preventing cognitive impairment and disability.
ALZHEIMERS & DEMENTIA
(2023)
Article
Pediatrics
Michael D. Rollins, Brian T. Bucher, Justin C. Wheeler, Joshua J. Horns, Niraj Paudel, James M. Hotaling
Summary: This study aimed to analyze the cumulative 5-year healthcare costs and healthcare days in children with anorectal malformation (ARM) and compare them with healthy, premature, and congenital heart disease (CHD) cohorts. The results showed that the healthcare costs of children with ARM were similar to those in the premature cohort and lower than the CHD cohort, while the healthcare days were comparable to both the CHD and premature cohorts. Outpatient care accounted for the majority of healthcare days in children with ARM.
JOURNAL OF PEDIATRICS
(2022)
Article
Integrative & Complementary Medicine
Devesh V. Oberoi, Christopher J. Longo, Erica Nicole Reed, Jessa Landmann, Katherine-Ann Laura Piedalue, Linda E. Carlson
Summary: Group acupuncture was found to be superior to individual acupuncture in cancer patients, especially in improving pain-discomfort. QALYs at 6 weeks were slightly higher for group acupuncture compared with individual acupuncture, with the cost of delivering group acupuncture treatment being nearly half of individual acupuncture.
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
(2021)
Article
Immunology
Fernanda Rodrigues, Robin Marlow, Catarina Gouveia, Paula Correia, Ana Brett, Catarina Silva, Ines Gameiro, Ines Rua, Joao Dias, Marta Martins, Rui Diogo, Teresa Lopes, Elsa Hipolito, Diana Moreira, Manuela Costa Alves, Filipa Prata, Miguel Labrusco, Susana Gomes, Alexandre Fernandes, Alexandra Andrade, Catarina Granjo Morais, Maria Joao Virtuoso, Maria Manuel Zarcos, Ana Teresa Raposo, Adam Boon, Adam Finn
Summary: This study aimed to assess the impact of varicella on health-related quality of life (HRQoL) in children and their families, providing important information for cost-utility analysis. Through surveys and assessments of children in the community and admitted to hospitals in Portugal, the study found significant HRQoL losses in children with varicella and their caregivers.
Article
Nutrition & Dietetics
A. V. Ganpule-Rao, D. Bhat, C. S. Yajnik, E. Rush
Summary: This study revealed widespread nutritional deficiencies among rural youth in India, especially in terms of vitamin B12 and anemia. The youths had low dietary diversity scores, primarily consuming cereals, legumes, and vegetables, with boys consuming more milk, flesh, and nutrient-dense foods compared to girls. Associations between dietary diversity scores and micronutrient deficiencies indicate the validity of using DDS to predict vitamin B12 deficiency and anemia.
BRITISH JOURNAL OF NUTRITION
(2021)
Review
Food Science & Technology
Tung Thanh Diep, Elaine C. Rush, Michelle Ji Yeon Yoo
Summary: Tamarillo is a sub-tropical fruit known for its unique flavor and color that is highly nutritious and possesses various health benefits. This review summarizes the chemical composition, bioactive properties, and nutritional adequacy of tamarillo from different countries. Tamarillo is rich in vitamins, dietary fiber, and potassium, and is a good source of phenolics, carotenoids, and anthocyanins. It has been found to have antioxidant, anti-obesity, anti-cancer, and prebiotic properties, as well as antimicrobial and antifungal activities. Tamarillo also exhibits higher antioxidant activity than apples and kiwifruit, and its functional applications in various industries are highlighted.
FOOD REVIEWS INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Isaac Amoah, Carolyn Cairncross, Elaine Rush
Summary: This study compared breads of increasing nutrient density in terms of their physical, sensory, and ease-of-chewing and swallowing properties. Vegetable-enriched breads were found to be more liked, easier to chew, and easier to swallow compared to white and wheatmeal breads, especially suitable for older individuals.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Heliodoro Aleman-Mateo, Lesley Evelyn Antunez-Roman, Julian Esparza-Romero, Mauro E. Valencia, Julissa J. Salguero, Manuel Ramirez-Zea, Eduardo Ferriolli, Rose N. Ndour, Manuel Hernandez-Triana, Gabriela Salazar, Elaine C. Rush
Summary: This study designed and validated an anthropometry-based equation to estimate total daily energy expenditure (TDEE) for older people. The results show that the new Mexican equation performed well and accurately estimated energy requirements for community-living older people in five Latin American countries and one African country.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Food Science & Technology
Tung Thanh Diep, Michelle Ji Yeon Yoo, Chris Pook, Saeedeh Sadooghy-Saraby, Abhishek Gite, Elaine Rush
Summary: This study compared the volatile profiles of tamarillo under different processing methods, showing that freeze-drying preserved most volatile compounds and some became more concentrated with the loss of water. Tamarillo extracts exhibited significant antibacterial activity and have the potential to be used as a natural preservative.
Article
Multidisciplinary Sciences
Elaine C. Rush, Tara Coppinger, Shabnam Jalili-Moghaddam, El-Shadan Tautolo, Lindsay D. Plank
Summary: The Pacific Islands Families (PIF) study aims to understand the growth and development of Pacific children in New Zealand. This study investigated the associations between physical function, body composition, and metabolic health in adolescents. The findings suggest that appendicular skeletal muscle mass (ASMM) and fat mass are related to handgrip strength, and age is negatively associated with walking distance.
Article
Nutrition & Dietetics
Isaac Amoah, Carolyn Cairncross, Fabrice Merien, Elaine Rush
Summary: This experimental study compared the effects of different types of bread on serum glucose, insulin response, and subjective appetite suppression. The results showed that vegetable-enriched bread (VB) could reduce insulin release and increase satiety over 120 minutes compared to commercial white bread (WB) and wheatmeal bread (WMB). Further exploration into the role of vegetable and fruit fibers in bread and insulin response is warranted.
Article
Food Science & Technology
Tung Thanh Diep, Michelle Ji Yeon Yoo, Elaine Rush
Summary: This study investigated the effects of adding freeze-dried tamarillo powder to milk and yoghurt starter before or after fermentation. The addition of tamarillo before fermentation resulted in a more yellow color and higher vitamin E concentrations, while adding it after fermentation led to higher elastic modulus, PUFAs, pro-vitamin A content, and vitamin C retention. All tamarillo yoghurts showed improvement in syneresis, lower lactose content, and higher concentrations of antioxidant vitamins compared to commercial fruit yoghurt.
Article
Biochemistry & Molecular Biology
Tung Thanh Diep, Michelle Ji Yeon Yoo, Elaine Rush
Summary: This study investigated the stability of amino acids and antioxidant capacity of polyphenols in yoghurt fortified with tamarillo powder. The results showed that the fruit polyphenols were retained and the yoghurt had increased levels of free essential amino acids, total phenolic content, and antioxidant activity after digestion. The fortified yoghurt also had higher bioaccessibility of chlorogenic acid and kaempferol-3-rutinoside. This suggests that the yoghurt matrix can protect compounds from degradation and increase their absorption in the small intestine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tung Thanh Diep, Michelle Ji Yeon Yoo, Elaine Rush
Summary: This study explored the potential of encapsulated tamarillo polyphenols in cubosome nanoparticles for improving the stability of the polyphenols during digestion and fortifying yoghurt. The encapsulated polyphenols showed high stability during the gastric phase and slow release in the intestinal phase. Addition of encapsulated polyphenols to yoghurt improved its nutritional properties and antioxidant activity. The cubosomal delivery system demonstrated potential for value-added food product development with yoghurt as the vehicle.
Review
Plant Sciences
Isaac Amoah, Carolyn Cairncross, Emmanuel Ofori Osei, Jacqueline Afua Yeboah, Jesse Charles Cobbinah, Elaine Rush
Summary: Bread, as a commonly consumed staple, can be enhanced with plant-based functional ingredients to increase its health-promoting effects, such as increased antioxidant activity, lower blood pressure, and improved blood sugar control. However, most of these health effects are short-lived, and further long-term studies are needed for validation.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Review
Food Science & Technology
Isaac Amoah, Jia Jiet Lim, Emmanuel Ofori Osei, Michael Arthur, Phyllis Tawiah, Ibok Nsa Oduro, Margaret Saka Aduama-Larbi, Samuel Tetteh Lowor, Elaine Rush
Summary: Cocoa consumption for >= 2 weeks is associated with reductions in systolic and diastolic blood pressure. Chocolate has a greater effect on systolic blood pressure compared to cocoa beverage. Higher daily doses of flavanols and epicatechin result in better outcomes.
Article
Obstetrics & Gynecology
Janet Alison Rowan, Elaine Carolyn Rush, Lindsay Dudley Plank
Summary: The study analyzed data from 98 women in the Metformin in Gestational Diabetes trial and dual-energy X-ray absorptiometry studies of their children at nine years to investigate the relationship between maternal measures during pregnancy and their children's size and adiposity. The results showed that in boys, fat-free mass indexed to height squared was associated with maternal weight, body mass index, maternal glycaemia, and metformin treatment. In both boys and girls, fat mass indexed to height squared was associated with maternal glycaemia measures before gestational diabetes treatment.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Nutrition & Dietetics
Leon Iusitini, El-Shadan Tautolo, Lindsay D. Plank, Elaine Rush
Summary: The nutritional environment in early life plays a crucial role in brain development and function. Research shows a significant relationship between early-life nutrition and academic achievement in adolescence. Maternal food security and early-life nutrition have a significant impact on the academic success and well-being of future generations.
Article
Nutrition & Dietetics
Elaine C. Rush, Lindsay D. Plank, Himangi Lubree, Dattatray S. Bhat, Anjali Ganpule, Chittaranjan S. Yajnik
Summary: Maternal size, weight gain in pregnancy, fetal gender, environment, and gestational age are important factors influencing birth weight. This study found that measuring maternal total body water can help predict birth weight during pregnancy. The research also highlighted the differences in body composition between rural and urban environments and the potential impact of nutrition transition on maternal body composition and fetal growth.
JOURNAL OF NUTRITIONAL SCIENCE
(2022)