HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases

Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity

(2015) Hiroshi Maeda   ADVANCED DRUG DELIVERY REVIEWS

Synthesis and therapeutic effect of styrene-maleic acid copolymer-conjugated pirarubicin

(2015) Kenji Tsukigawa et al.   CANCER SCIENCE

Styrene maleic acid copolymer–pirarubicin induces tumor-selective oxidative stress and decreases tumor hypoxia as possible treatment of colorectal cancer liver metastases

(2015) Jurstine Daruwalla et al.   SURGERY

Hormone and Radiotherapy versus Hormone or Radiotherapy Alone for Non-metastatic Prostate Cancer: A Systematic Review with Meta-analyses

(2014) M. Schmidt-Hansen et al.   CLINICAL ONCOLOGY

Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls

(2014) Hideaki Nakamura et al.   Expert Opinion on Drug Delivery

Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage

(2013) Hideaki Nakamura et al.   JOURNAL OF CONTROLLED RELEASE

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

(2012) Hiroshi Maeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Macromolecular therapeutics in cancer treatment: The EPR effect and beyond

(2012) Hiroshi Maeda   JOURNAL OF CONTROLLED RELEASE

Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting

(2012) Hiroshi MAEDA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Comparison of High-Dose Proton Radiotherapy and Brachytherapy in Localized Prostate Cancer: A Case-Matched Analysis

(2011) John J. Coen et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; unique intracellular disintegration of SMA micelles

(2011) Hideaki Nakamura et al.   JOURNAL OF CONTROLLED RELEASE

The Potential Benefit of Radiotherapy with Protons in Head and Neck Cancer with Respect to Normal Tissue Sparing: A Systematic Review of Literature

(2011) T. A. van de Water et al.   ONCOLOGIST

In vitro and in vivo evaluation of tumor targeting styrene-maleic acid copolymer-pirarubicin micelles: Survival improvement and inhibition of liver metastases

(2010) Jurstine Daruwalla et al.   CANCER SCIENCE

Structural and chemical aspects of HPMA copolymers as drug carriers☆

(2009) Karel Ulbrich et al.   ADVANCED DRUG DELIVERY REVIEWS

HPMA copolymers: Origins, early developments, present, and future☆

(2009) Jindřich Kopeček et al.   ADVANCED DRUG DELIVERY REVIEWS

Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application

(2009) Takahiro Seki et al.   CANCER SCIENCE

Image-guided and passively tumour-targeted polymeric nanomedicines for radiochemotherapy

(2008) T Lammers et al.   BRITISH JOURNAL OF CANCER

Tumour-targeted nanomedicines: principles and practice

(2008) T Lammers et al.   BRITISH JOURNAL OF CANCER

Docetaxel Plus Prednisone or Mitoxantrone Plus Prednisone for Advanced Prostate Cancer: Updated Survival in the TAX 327 Study

(2008) Dominik R. Berthold et al.   JOURNAL OF CLINICAL ONCOLOGY

Styrene Maleic Acid-Pirarubicin Disrupts Tumor Microcirculation and Enhances the Permeability of Colorectal Liver Metastases

(2008) Jurstine Daruwalla et al.   JOURNAL OF VASCULAR RESEARCH