期刊
OBESITY
卷 21, 期 5, 页码 910-917出版社
WILEY-BLACKWELL
DOI: 10.1002/oby.20167
关键词
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资金
- Georgia State University
- NIH [R01 DK35254]
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1121886] Funding Source: National Science Foundation
Objective: In rodents, diets exceeding nutritional requirements (i.e., high-energy diets; HED) impair hippocampal-dependent memory. Our research suggests that the effects likely involve HED-induced increases in liver lipids. In this experiment, rats were provided with diet choices to test whether voluntary consumption of a HED impairs spatial memory, whether differences in initial weight gain predict memory deficits, and whether increases in liver lipids are associated with the memory deficits. Design and Methods: Adult male Sprague-Dawley rats were given a control diet or cafeteria-style HED for 8 weeks. Weight gain during the first 5 days on the diet was used to divide rats into a HED-Lean group and a HED-Obese group. Spatial water maze memory was tested 8 weeks later and postmortem liver lipid concentrations were quantified. Results: Compared with the HED-Lean and control rats, the HED-Obese rats had impaired spatial memory and met the human diagnostic criterion of non-alcoholic fatty liver disease (>5% liver lipids relative to liver weight). Moreover, liver lipids were correlated with memory deficits. Conclusions: These findings show that voluntary consumption of a HED impairs memory, that initial weight gain predicts fatty liver and memory deficits, and that fatty liver may contribute to the memory-impairing effects of obesity.
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