期刊
TALANTA
卷 138, 期 -, 页码 71-76出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2015.01.013
关键词
Electrochemical sensors; Gemcitabine; Molecularly imprinted polymers; Microporous metal organic framework; Gold nanoparticles
资金
- European Social Fund, Human Resources Development Operational Programme [POSDRU/159/1.5/S/136893]
- EC through the Marie Curie NANODEV [318524]
- EC through the NATO's Public Diplomacy Division [CBP.NUKR SFP 984173]
- China Scholarship Council
- [PN-II-ID-PCE-2011-3-0355]
A simple and highly sensitive approach for the detection of the anti-neoplastic drug gemcitabine is presented, based on a one-step electropolymerized molecularly imprinted microporous-metal-organic-framework. The sensitive layer was prepared by electropolymerization of the aniline moieties of p-aminothiophenol- gold nanoparticles on the surface of gold electrodes tethered with p-aminothiophenol, in the presence of gemcitabine as a template molecule. Experimental parameters that control the performance of the sensor were investigated and optimized. Under optimal conditions a calibration curve was obtained in the linear range from 3.8 fM to 38 nM with a limit of detection of 3 fM. The obtained imprinted sensor has the advantages of easy manufacture, high sensitivity and selectivity and good reproducibility. Furthermore the feasibility of the proposed technique has been investigated on spiked serum samples and infusion solution containing gemcitabine. (C) 2015 Elsevier B.V. All rights reserved.
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