期刊
OBESITY
卷 22, 期 1, 页码 243-248出版社
WILEY
DOI: 10.1002/oby.20521
关键词
-
资金
- NIH [R01DK083380, R01DK088925, RC1EB010384, T32DK07758604]
- Genentech Center for Clinical Research
- Endocrine Fellows Foundation
- GE Healthcare
Objective In nonobese youth, to investigate whether hepatic fat deposition and its metabolic consequences vary between ethnic groups. Design and Methods Thirty-two nonobese girls (12 Hispanic White [H] and 20 non-Hispanic White [NHW] girls), aged 11-14 years old were recruited. Outcome measures were MRI measured hepatic proton density fat fraction (hepatic PDFF), BMI Z-score, waist circumference, fasting insulin, glucose, adiponectin, sex hormone-binding globulin [SHBG], ALT, AST, triglycerides, and HOMA-IR. Results There were no significant differences in mean BMI Z-scores (P=0.546) or hepatic PDFF (P=0.275) between H and NHW girls; however, H girls showed significant correlations between hepatic PDFF and markers of IR (fasting insulin, HOMA-IR, adiponectin, SHBG, triglycerides; all P<0.05), while NHW girls showed no significant correlations. Matched by hepatic PDFF or BMI Z-score, H girls had more evidence of IR for a given hepatic PDFF (mean insulin, HOMA-IR, and SHBG; all P<0.05) or BMI Z-score (mean insulin and HOMA-IR; all P<0.01) than NHW girls. Conclusions In nonobese female youth, ethnicity-related differences in effects of hepatic fat on IR are evident, so that in H girls, a given amount of hepatic fat appears to result in a more predictable and greater degree of IR than in NHW girls.
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