Article
Medicine, General & Internal
Da Hea Seo, Yongin Cho, Seongha Seo, Seong Hee Ahn, Seongbin Hong, Kyung Hwa Ha, Jee-Seon Shim, Hyeon Chang Kim, Dae Jung Kim, So Hun Kim
Summary: We found no significant association between metabolically healthy obesity and subclinical atherosclerosis in patients without previous cardiovascular disease, suggesting that metabolic health may not play a role in the development of early stage atherosclerosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Qiyu Li, Pengbo Wang, Guangxiao Li, Ye Chang, Xiaofan Guo, Yingxian Sun, Xingang Zhang
Summary: This study selected six easily measurable and calculable anthropometric indices and evaluated their associations with the onset of Metabolic Syndrome (MetS). The results showed that an increase in all six indices was associated with a higher risk of MetS, with waist circumference (WC) and waist-to-hip ratio (WHtR) changes being the strongest predictors. An increase of 5 cm in WC and 0.025 in WHtR were recommended as the optimal cut-offs for MetS prediction.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Benjamin C. Cossins, Inge van den Munckhof, Joost H. W. Rutten, Marinette van der Graaf, Rinke Stienstra, Leo A. B. Joosten, Mihai G. Netea, Yang Li, Niels P. Riksen
Summary: This study examined the association between adipocyte size, adipose tissue inflammation, systemic inflammation, and metabolic and atherosclerotic complications of obesity in a sex-specific manner. The results showed that inflammation in abdominal subcutaneous adipose tissue is more related to metabolic complications than atherosclerotic complications, and there are significant sex-specific differences in this association.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Lars Lind, Hanna Markstad, Hakan Ahlstrom, Oskar Angeras, John Brandberg, Mattias Brunstrom, Gunnar Engstrom, Jan E. Engvall, Maria J. Eriksson, Mats Eriksson, Anders Gottsater, Emil Hagstrom, Benno Krachler, Erik Lampa, Maria Mannila, Peter M. Nilsson, Fredrik H. Nystrom, Anders Persson, Bjorn Redfors, Anette Sandstro, Raquel Themudo, Sebastian Volz, Johan Arnlov, Carl Johan Ostgren, Goran Bergstrom
Summary: This study investigated whether individuals who are obese but do not have metabolic syndrome (MetS) are associated with increased coronary artery calcium and carotid plaques. The results showed that individuals who are obese but do not have MetS had increased severity of coronary artery stenosis, but no increased occurrence of carotid plaques, further emphasizing that obesity is not a benign condition even in the absence of MetS.
Article
Biochemistry & Molecular Biology
Reyna Rodriguez-Mortera, Russell Caccavello, Ricardo Hermo, Maria Eugenia Garay-Sevilla, Alejandro Gugliucci
Summary: In a study comparing obese adolescents to lean controls, it was found that obese participants exhibited higher levels of hepcidin, ferritin, and IL-6. Differences in iron metabolism markers were not significant between the two groups except for ferritin. Hepcidin levels in obese adolescents were more correlated with inflammation and metabolic alterations than with iron metabolism.
Review
Nutrition & Dietetics
In-Seon Lee, Seok-Jae Ko, Yu Na Lee, Gahyun Lee, Hasanur Rahman, Bonglee Kim
Summary: Metabolic syndrome is a medical condition characterized by abdominal obesity, insulin resistance, high blood pressure, and hyperlipidemia. The brown seaweed Laminaria japonica may have therapeutic effects on metabolic syndrome due to its anti-inflammatory and antioxidant properties.
Article
Nutrition & Dietetics
Anh Kim Dang, Mai Tuyet Truong, Huong Thi Le, Khan Cong Nguyen, Mai Bach Le, Lam Thi Nguyen, Khanh Nam Do, Lan Huong Thi Nguyen, Abdullah A. Mamun, Dung Phung, Phong K. Thai
Summary: Recent studies have shown that using international guidelines to diagnose metabolic syndrome (MetS) may underestimate its prevalence in different Asian populations. This study aims to determine the validity of anthropometric indicators and appropriate cut-off values to predict MetS for Vietnamese adults. The results suggest that health personnel in Vietnam should apply lower thresholds of anthropometry, which are more suitable for the local population, in order to avoid under-diagnosis.
Article
Medicine, General & Internal
Shuzo Kobayashi, Yasuhiro Mochida, Kunihiro Ishioka, Machiko Oka, Kyoko Maesato, Hidekazu Moriya, Sumi Hidaka, Takayasu Ohtake
Summary: The prevalence of metabolic syndrome (Mets) was investigated in hemodialysis (HD) patients, along with the validation of waist circumference (WC) criteria using computed tomography (CT) measurement of visceral fatty area (VFA). The study found that Mets was more prevalent in male HD patients (31.9%) compared to female HD patients (13.6%), despite a low proportion of patients with a body mass index over 25 (11.2%). The VFA measured by CT showed a strong positive correlation with WC, and factors such as shorter duration of HD, higher high-sensitive C-reactive protein, and higher Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were associated with Mets in HD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Zhi Yu, Morgan E. Grams, Chiadi E. Ndumele, Lynne Wagenknecht, Eric Boerwinkle, Kari E. North, Casey M. Rebholz, Edward L. Giovannucci, Josef Coresh
Summary: This study found that midlife obesity measures were associated with decline in kidney function among White and Black women over 30 years of follow-up, but the association was less consistent in men. Obesity indicators were independently associated with risk for kidney failure with replacement therapy for all sex-race groups except White men. Loss to follow-up during the study period was a limitation.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Majid Valizadeh, Erfan Tasdighi, Maryam Barzin, Ramyar Hariri, Maryam Mahdavi, Pooneh Dehghan, Amin Momeni Moghaddam, Fereidoun Azizi, Farhad Hosseinpanah
Summary: This study investigated the association of MetS and metabolic phenotypes with a high CIMT in early adulthood. The results showed that the presence of MetS and certain metabolic phenotypes were associated with an increased risk of high CIMT.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Bum Ju Lee, Mi Hong Yim
Summary: Both anthropometric and body composition indices are associated with metabolic risk factors, but anthropometric indices such as waist-to-height ratio and waist circumference are generally better predictors for certain risk factors, particularly in men for hypertension and hyperlipidemia with regards to waist-to-height ratio, and in women for diabetes and hypo-HDL cholesterolemia with regards to waist circumference.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Athanasia Tragomalou, George Paltoglou, Maria Manou, Ioannis V. Kostopoulos, Sofia Loukopoulou, Maria Binou, Ourania E. Tsitsilonis, Flora Bacopoulou, Penio Kassari, Marina Papadopoulou, George Mastorakos, Evangelia Charmandari
Summary: Obesity in adolescence is linked to cardiovascular disease. Non-traditional risk factors can be used as biomarkers to predict future CVD. Lifestyle intervention programs can improve these risk factors.
Review
Biochemistry & Molecular Biology
Alieh Alipour, Vafa Baradaran Rahimi, Vahid Reza Askari
Summary: This study reviewed and discussed the significant impacts of 6-gingerol, a derivative of ginger, on metabolic syndrome, suggesting its potential as a treatment agent. More pre-clinical and clinical investigations are needed.
Article
Nutrition & Dietetics
Yating Huo, Suixia Cao, Jingchun Liu, Binyan Zhang, Kun Xu, Yutong Wang, Huimeng Liu, Peiying Yang, Lingxia Zeng, Hong Yan, Shaonong Dang, Baibing Mi
Summary: This study investigated the association between a plant-based diet and metabolic syndrome (MetS) in Chinese adults. The findings suggest a possible causal relationship between a healthy plant-based diet and a reduced risk of MetS, particularly abdominal obesity. BMI was found to mediate the relationship between a healthy plant-based diet and MetS. Controlling early dietary patterns and BMI may help reduce the risk of MetS.
Review
Biochemistry & Molecular Biology
Anna Och, Marek Och, Renata Nowak, Dominika Podgorska, Rafal Podgorski
Summary: Berberine, a plant alkaloid, has various health benefits including preventing atherosclerosis, type 2 diabetes, obesity, and cancer. It improves blood glucose and insulin resistance, stimulates insulin secretion, and inhibits glucose and fat synthesis in the liver. It also has anti-inflammatory, neuroprotective, and anticancer effects.
Article
Medicine, General & Internal
Ankit Maheshwari, Faye L. Norby, Riccardo M. Inciardi, Wendy Wang, Michael J. Zhang, Elsayed Z. Soliman, Alvaro Alonso, Michelle C. Johansen, Rebecca F. Gottesman, Scott D. Solomon, Amil M. Shah, Lin Yee Chen
Summary: This study evaluated the association between left atrial function and size and ischemic stroke, and determined whether these measures could improve the accuracy of stroke prediction using CHA(2)DS(2)-VASc score variables. The results showed that left atrial size and function were associated with ischemic stroke, and the cumulative incidence rates of severe left atrial enlargement were 2.99%, 3.18%, and 1.99% for left atrial reservoir, conduit, and contractile strain, respectively. Adding left atrial function measures to CHA(2)DS(2)-VASc score variables improved stroke prediction accuracy.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Hematology
Brian T. Steffen, James S. Pankow, Faye L. Norby, Pamela L. Lutsey, Ryan T. Demmer, Weihua Guan, Nathan Pankratz, Aixin Li, Guning Liu, Kunihiro Matsushita, Adrienne Tin, Weihong Tang
Summary: This study identified proteomic signatures and pathways related to 23 gene loci associated with abdominal aortic aneurysm (AAA). The results suggest that low levels of neogenin and kit ligand may be novel risk factors for AAA development.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Oncology
Shuo Wang, Guillaume C. Onyeaghala, Nathan Pankratz, Heather H. Nelson, Bharat Thyagarajan, Weihong Tang, Faye L. Norby, Chinenye Ugoji, Corinne E. Joshu, Christian R. Gomez, David J. Couper, Josef Coresh, Elizabeth A. Platz, Anna E. Prizment
Summary: The study found that MICA and MICB are associated with colorectal cancer development, and low sMICA levels are related to lower risk of colorectal cancer. These findings highlight the importance of immune surveillance in colorectal cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Faye L. Norby, Harpriya Chugh, Kyndaron Reinier, Sumeet S. Chugh
Meeting Abstract
Cardiac & Cardiovascular Systems
Rob F. Walker, Neil A. Zakai, Richard F. Maclehose, Faye L. Norby, Wendy Wang, Alvaro Alonso, Pamela L. Lutsey
Meeting Abstract
Cardiac & Cardiovascular Systems
Wendy Wang, Lin Y. Chen, Rob F. Walker, Alvaro Alonso, Faye L. Norby, Kamakshi Lakshminarayan, Pamela L. Lutsey
Article
Cardiac & Cardiovascular Systems
Harpriya S. Chugh, Arayik Sargsyan, Kotoka Nakamura, Audrey Uy-Evanado, Bernadine Dizon, Faye L. Norby, Christopher Young, Katy Hadduck, Jonathan Jui, Daniel Shepherd, Angelo Salvucci, Sumeet S. Chugh, Kyndaron Reinier
Summary: This study assessed the impact of COVID-19 on sudden cardiac arrest (SCA) and found that during the pandemic, SCA incidence increased significantly and survival rates decreased. Hispanics faced more difficulties in bystander CPR and resuscitation compared to non-Hispanics. Therefore, it is necessary to urgently evaluate and intervene in the acute care of SCA, especially among specific ethnic groups.
Article
Cardiac & Cardiovascular Systems
Muhammad Imtiaz Ahmad, Mai Z. Soliman, Elsayed Z. Soliman
Summary: The presence of premature ventricular complexes (PVCs) is associated with an increased risk of stroke mortality, particularly in individuals with coronary heart disease (CHD). Prospective studies are needed to investigate whether improved hospital care or modification of PVCs could improve outcomes.
JOURNAL OF ELECTROCARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jesus Diaz-Gutierrez, Miguel angel Martinez-Gonzalez, Alvaro Alonso, Estefania Toledo, Jordi Salas-Salvado, Jose Sorli, Emilio Ros, Montse Fito, Ramon Estruch, Fernando Aros, Miquel Fiol, Jose Lapetra, Enrique Gomez-Gracia, Lluis Serra-Majem, Xavier Pinto, Olga Portoles, Nancy Babio, Olga Castaner, Miguel Ruiz-Canela
Summary: This study aimed to assess the association between adherence to the 7 ideal cardiovascular health metrics proposed by the American Heart Association and the incidence of atrial fibrillation (AF). The results showed that adherence to these metrics was not associated with AF incidence.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Dulce Maria Calvo, Luis Carlos Saiz, Leire Leache, Maria Concepcion Celaya, Marta Gutierrez-Valencia, Alvaro Alonso, Juan Erviti, Natalia Alzueta, Amaya Echeverria, Javier Garjon, Carmen Fontela, Lorea Sanz, Maria Teresa Acin, Maria Loreto Fernandez, Nerea Gomez
Summary: This study found that the concomitant use of diuretics, RAAS inhibitors, and NSAIDs or metamizole increases the risk of hospitalization for acute kidney injury (AKI), particularly in elderly patients.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Nutrition & Dietetics
Linzi Li, Pamela L. Lutsey, Lin Yee Chen, Elsayed Z. Soliman, Mary R. Rooney, Alvaro Alonso
Summary: Higher serum magnesium is associated with a lower risk of cardiovascular events, especially myocardial infarction, in patients with atrial fibrillation.
Article
Public, Environmental & Occupational Health
Emily A. Groene, Faye L. Norby, Anne A. Eaton, Susan M. Mason, Eva A. Enns, Shalini Kulasingam, David M. Vock
Summary: Gonorrhea diagnosis is associated with pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility in women, and this association has not changed in recent years.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Medicine, General & Internal
Wendy Wang, Lin Yee Chen, Rob F. Walker, Lisa S. Chow, Faye L. Norby, Alvaro Alonso, James S. Pankow, Pamela L. Lutsey
Summary: The objective of this study was to assess the association between SGLT2 inhibitors and other second-line diabetes therapies with the risk of cardiovascular disease (CVD) and conduct head-to-head comparisons between SGLT2 inhibitors. Using data from the MarketScan databases, SGLT2 inhibitor users were matched with other second-line therapy users. The results showed that SGLT2 inhibitors were associated with a lower risk of CVD compared to other second-line therapies. No significant differences were found when comparing individual SGLT2 inhibitors.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Clinical Neurology
Aozhou Wu, A. Richey Sharrett, Aaron R. Folsom, Alvaro Alonso, Keenan A. Walker, Rebecca F. Gottesman, Alden L. Gross, Andreea M. Rawlings, Andrea Lauren Christman Schneider, Josef Coresh
Summary: This study found consistent associations between blood coagulation status in middle age and cognitive decline and dementia risk in late life, possibly due to vascular pathologies.