Article
Surgery
Samuel Hunter Dunn, Sanaa Tejani, Jaime P. Almandoz, Sarah E. Messiah, Jeffrey Schellinger, Elisa Morales Marroquin, Matthew Mathew, Jay Horton, Anna Tavakkoli
Summary: Transoral gastric outlet reduction (TORe) is a safe and effective treatment for post-prandial hypoglycemia and weight regain after Roux-en-Y gastric bypass (RYGB) in patients with symptoms refractory to medications and dietary changes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Samuel Hunter Dunn, Sanaa Tejani, Jaime P. Almandoz, Sarah E. Messiah, Jeffrey Schellinger, Elisa Morales Marroquin, Matthew Mathew, Jay Horton, Anna Tavakkoli
Summary: TORe is a safe and effective treatment for patients with refractory symptoms of post-prandial hypoglycemia and weight regain after RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Endocrinology & Metabolism
Marzieh Salehi, Amalia Gastaldelli, Ralph DeFronzo
Summary: Roux-en Y gastric bypass surgery and sleeve gastrectomy alter postprandial glucose metabolism, increasing the risk of hypoglycemia. After surgery, there is a reduced hepatic glucose production response during insulin-induced hypoglycemia. However, the counterregulatory response to hypoglycemia is similar among individuals with surgery and without surgery.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Endocrinology & Metabolism
Tal Schiller, Alena Kirzhner, Taiba Zornitzki, Lee Cohen, Yael Winter Shafran, Viviana Ostrovsky, Hilla Knobler, Edi Vaisbuch
Summary: Post-bariatric surgery hypoglycemia (PBH) is a serious and relatively common complication of bariatric surgery, which is often underdiagnosed due to lack of awareness. PBH can have a profound impact on health and quality of life. Data on the natural history and management of PBH during pregnancy are limited.
OBESITY RESEARCH & CLINICAL PRACTICE
(2022)
Article
Surgery
Claude Tayar, Haydar A. Nasser, Dana Lawand, Ammar Ghazale
Summary: Post-bariatric surgery hypoglycemia is a complex condition seen in patients with a history of gastric bypass surgery. Non-surgical management is preferred initially, with surgical options considered in case of failure. The choice of surgery should be individualized based on the patient's condition.
Review
Biochemistry & Molecular Biology
Francesca Porcellati, Stefania Di Mauro, Alessio Mazzieri, Alessandra Scamporrino, Agnese Filippello, Michelantonio De Fano, Carmine Giuseppe Fanelli, Francesco Purrello, Roberta Malaguarnera, Salvatore Piro
Summary: Hypoglycemia poses challenges in diabetes treatment, causing resistance and lack of acceptance. New glucagon formulations and scientific knowledge offer potential benefits for managing hypoglycemia effectively. Novel scientific evidence is advancing understanding of physiopathological mechanisms related to glycemic homeostasis.
Article
Endocrinology & Metabolism
Daniel Lee, Jonathan M. Dreyfuss, Amanda Sheehan, Alexa Puleio, Christopher M. Mulla, Mary Elizabeth Patti
Summary: The study found that patients with post-bariatric hypoglycemia experience higher glycemic variability and frequency of low sensor glucose values compared to healthy controls, especially at night.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Christian Laugesen, Ajenthen G. Ranjan, Signe Schmidt, Kirsten Norgaard
Summary: This study compared the efficacy of low-dose subcutaneous dasiglucagon with oral glucose in preventing insulin-induced hypoglycemia in individuals with type 1 diabetes. The results showed that low-dose dasiglucagon was able to elevate blood glucose levels faster and effectively prevent hypoglycemia.
Article
Surgery
Caroline C. Ohrstrom, Dorte L. Hansen, Urd Lynge Kielgast, Marianne Lerbok Bergmann, Simon Veedfald, Jens Juul Holst, Dorte Worm
Summary: This study evaluated counterregulatory responses during postprandial hypoglycemia in patients with postbariatric hypoglycemia who underwent Rouxen-Y gastric bypass surgery. The findings showed that individuals with postbariatric hypoglycemia had minor increases in counterregulatory hormones during postprandial hypoglycemia, but larger hormone responses occurred when glucose levels were lowered during treatment with sitagliptin.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Endocrinology & Metabolism
Joseph R. Herges, Jordan D. Haag, Kimberly A. Kosloski-Tarpenning, Kristin C. Mara, Rozalina G. McCoy
Summary: The study aimed to examine the prescribing trends of glucagon among high-risk patients of severe hypoglycemia and determine if glucagon prescription is associated with lower rates of hospitalization for severe hypoglycemia. The researchers conducted a retrospective analysis of electronic health records and found that glucagon prescribing was infrequent and varied among different patient characteristics. Furthermore, patients prescribed with glucagon did not have lower rates of hospitalization for hypoglycemia.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Clare J. Lee, Jeanne M. Clark, Josephine M. Egan, Olga D. Carlson, Michael Schweitzer, Susan Langan, Todd Brown
Summary: The study compared meal-stimulated hormonal responses in patients with postbariatric surgery hypoglycemia (PBH) after sleeve gastrectomy (SG) and after Roux-en-Y gastric bypass (RYGB). The results showed significant differences in glucagon and GLP-1 responses between the two groups, while insulin and GIP responses were similar.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Sevasti Gaspari, Gwenael Labouebe, Alexandre Picard, Xavier Berney, Ana Rodriguez Sanchez-Archidona, Bernard Thorens
Summary: In this study, Tmem117 in vasopressin neurons is identified as a physiological regulator of glucagon secretion in response to hypoglycemia. Tmem117 inactivation increases ER stress, ROS production, and intracellular calcium levels, leading to elevated vasopressin production and secretion.
Article
Endocrinology & Metabolism
Joseph R. Herges, Jordan D. Haag, Kimberly A. Kosloski-Tarpenning, Kristin C. Mara, Rozalina G. McCoy
Summary: This study investigated the underutilization of glucagon, whether it is due to inadequate prescribing or the patients' inability to fill prescriptions. Among 216 commercially insured, high-risk individuals with diabetes who were prescribed glucagon in our healthcare system, 142 (65.4%) had a claim indicating its fill within 30 days.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Nutrition & Dietetics
Nirubasini Paramalingam, Barbara L. L. Keating, Tarini Chetty, Paul A. A. Fournier, Wayne H. K. Soon, Joanne M. M. O'Dea, Alison G. G. Roberts, Michael Horowitz, Timothy W. W. Jones, Elizabeth A. A. Davis
Summary: This study examined the impact of consuming 50 grams of protein on blood glucose levels after moderate-intensity exercise in individuals with type 1 diabetes. The results showed that consuming protein increased blood glucose levels compared to water alone, but also lowered the risk of hypoglycemia by stimulating glucagon-mediated glucose production. However, a protein intake of 50 grams may be excessive for maintaining stable blood glucose levels.
Review
Pharmacology & Pharmacy
Angela L. Goodhart
Summary: Dasiglucagon is a novel glucagon analogue that has been proven to be effective and safe in treating severe hypoglycemia. It offers a significant benefit in rapid glucose recovery and does not require reconstitution prior to administration, making it a valuable option for emergency glucagon treatment.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Donald C. Simonson, Florencia Halperin, Kathleen Foster, Ashley Vernon, Allison B. Goldfine
Article
Endocrinology & Metabolism
Alejandro J. Laguna Sanz, Christopher M. Mulla, Kristen M. Fowler, Emilie Cloutier, Allison B. Goldfine, Brett Newswanger, Martin Cummins, Sunil Deshpande, Steven J. Prestrelski, Poul Strange, Howard Zisser, Francis J. Doyle, Eyal Dassau, Mary-Elizabeth Patti
DIABETES TECHNOLOGY & THERAPEUTICS
(2018)
Article
Endocrinology & Metabolism
Ana Maria Grizales, Mary-Elizabeth Patti, Alexander P. Lin, Joshua A. Beckman, V. Anik Sahni, Emilie Cloutier, Kristen M. Fowler, Jonathan M. Dreyfuss, Hui Pan, Chisayo Kozuka, Adrienne Lee, Rita Basu, David M. Pober, Robert E. Gerszten, Allison B. Goldfine
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2018)
Article
Medicine, General & Internal
Elisabetta Patorno, Allison B. Goldfine, Sebastian Schneeweiss, Brendan M. Everett, Robert J. Glynn, Jun Liu, Seoyoung C. Kim
BMJ-BRITISH MEDICAL JOURNAL
(2018)
Article
Cell Biology
Gustavo W. Fernandes, Barbara M. L. C. Bocco, Tatiana L. Fonseca, Elizabeth A. McAninch, Sungro Jo, Lattoya J. Lartey, InSug O-Sullivan, Terry G. Unterman, Nailliw Z. Preite, Robin M. Voigt, Christopher B. Forsyth, Ali Keshavarzian, Richard Sinko, Allison B. Goldfine, Mary E. Patti, Miriam O. Ribeiro, Balazs Gereben, Antonio C. Bianco
Article
Medicine, General & Internal
Elisabetta Patorno, Allison B. Goldfine, Sebastian Schneeweiss, Brendan M. Everett, Robert J. Glynn, Jun Liu, Seoyoung C. Kim
BMJ-BRITISH MEDICAL JOURNAL
(2018)
Article
Surgery
Elisa Franquet, George Watts, Gerald M. Kolodny, Allison B. Goldfine, Mary-Elizabeth Patti
SURGERY FOR OBESITY AND RELATED DISEASES
(2019)
Article
Surgery
Christopher M. Mulla, Allison B. Goldfine, Jonathan M. Dreyfuss, Sander Houten, Hui Pan, David M. Pober, Nicolai J. Wewer Albrechtsen, Maria S. Svane, Julie B. Schmidt, Jens Juul Holst, Colleen M. Craig, Tracey L. McLaughlin, Mary-Elizabeth Patti
Article
Surgery
Donald C. Simonson, Ashley Vernon, Kathleen Foster, Florencia Halperin, Mary Elizabeth Patti, Allison B. Goldfine
SURGERY FOR OBESITY AND RELATED DISEASES
(2019)
Article
Endocrinology & Metabolism
Maryam Afkarian, Sarit Polsky, Afshin Parsa, Ronnie Aronson, Maria Luiza Caramori, David Z. Cherney, Jill P. Crandall, Ian H. de Boer, Thomas G. Elliott, Andrzej T. Galecki, Allison B. Goldfine, J. Sonya Haw, Irl B. Hirsch, Amy B. Karger, Ildiko Lingvay, David M. Maahs, Janet B. McGill, Mark E. Molitch, Bruce A. Perkins, Rodica Pop-Busui, Marlon Pragnell, Sylvia E. Rosas, Peter Rossing, Peter Senior, Ronald J. Sigal, Catherine Spino, Katherine R. Tuttle, Guillermo E. Umpierrez, Amisha Wallia, Ruth S. Weinstock, Chunyi Wu, Michael Mauer, Alessandro Doria
Article
Endocrinology & Metabolism
L. Chen, J. H. Li, V. Kaur, A. Muhammad, M. Fernandez, M. S. Hudson, A. B. Goldfine, J. C. Florez
Article
Endocrinology & Metabolism
Aaron W. Aday, Allison B. Goldfine, Justin M. Gregory, Joshua A. Beckman
Article
Medicine, General & Internal
A. Doria, A. T. Galecki, C. Spino, R. Pop-Busui, D. Z. Cherney, I. Lingvay, A. Parsa, P. Rossing, R. J. Sigal, M. Afkarian, R. Aronson, M. L. Caramori, J. P. Crandall, I. H. de Boer, T. G. Elliott, A. B. Goldfine, J. S. Haw, I. B. Hirsch, A. B. Karger, D. M. Maahs, J. B. McGill, M. E. Molitch, B. A. Perkins, S. Polsky, M. Pragnell, W. N. Robiner, S. E. Rosas, P. Senior, K. R. Tuttle, G. E. Umpierrez, A. Wallia, R. S. Weinstock, C. Wu, M. Mauer
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Chintan V. Dave, Seoyoung C. Kim, Allison B. Goldfine, Robert J. Glynn, Angela Tong, Elisabetta Patorno
Summary: The study indicates that adding SGLT2 inhibitors to GLP-1 receptor agonist therapy in patients with type 2 diabetes can provide additional cardiovascular benefits, especially in reducing cardiovascular endpoint events and heart failure hospitalizations.
Article
Endocrinology & Metabolism
Daniel J. Rader, Eleftheria Maratos-Flier, Amanda Nguyen, Doug Hom, Michael Ferriere, Yifang Li, Jill Kompa, Miljen Martic, Markus Hinder, Craig T. Basson, David Yowe, John Diener, Allison B. Goldfine, Archna Bajaj, Maricer Escalon, Melanie Fein, Allen Hunt, Martin K. Kankam, Michael Koren, William Smith, Jessica Wilson
Summary: LLF580, a genetically engineered variant of human fibroblast growth factor-21, demonstrated significant effects on triglyceride lowering, weight loss, and hepatic fat reduction, suggesting its potential efficacy for treating metabolic disorders.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)