Article
Pediatrics
Akshay Tayde, Medha Mittal, Rajesh Khadgawat, Shikha Sharma, V Sreenivas, Anuradha Rai
Summary: Obese children have a 2.2 times lower increase in serum vitamin D levels compared to normal BMI children after receiving the same dose of vitamin D supplementation. The increase in 25(OH)D levels is inversely correlated with BMI and fat-related parameters.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Valentina De Cosmi, Alessandra Mazzocchi, Veronica D'Oria, Alessandro Re, Giulia Carla Immacolata Spolidoro, Gregorio P. Milani, Cristiana Berti, Silvia Scaglioni, Claudia Giavoli, Silvia Bergamaschi, Giulia Rodari, Eriselda Profka, Roberto Colombo, Carlo Agostoni
Summary: This study investigated the effect of vitamin D and DHA co-supplementation on vitamin D status, body composition, and metabolic markers of obese children with vitamin D deficiency. The study found that more than 50% of the children improved their vitamin D status at the end of the study, but co-supplementation was not more effective than vitamin D plus wheat germ oil.
Article
Medicine, General & Internal
Reagan M. Mogire, Alireza Morovat, John Muthii Muriuki, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Manjinder S. Sandhu, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Summary: The study found that vitamin D deficiency rates among young African children were 0.6% and 7.8%, with factors such as country, age, season, inflammation, and malaria influencing the levels. In addition, variations in the GC gene were associated with vitamin D levels.
Article
Medicine, General & Internal
Laura Taban, Dana Stoian, Bogdan Timar, Daniela Amzar, Calin Adela, Alexandru Motofelea, Andreea Borlea, Romain Frisoni, Nadege Laguerre
Summary: This study investigates the presence of steatohepatitis in obese patients and compares the differences between diabetic and non-diabetic patients. It finds a significant correlation between vitamin D deficiency and hepatic steatosis in individuals with morbid obesity. Correcting vitamin D deficiency may have beneficial effects on treating hepatic steatosis, diabetes, and cardiovascular risk in patients with morbid obesity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Monica Ivette Pina-Aguero, Jorge Maldonado-Hernandez, Leticia Sebastian-Medina, Maria Elizabeth Tejero-Barrera, Ricardo Martin Robledo-Perez, Salvador Villalpando-Hernandez, Zobeida Analilia Ventura-Bravo, LauraKatia Morales-Ramirez
Summary: This study evaluated the relationship between FokI and BsmI polymorphisms of the VDR gene and BCF and vitamin D status in non-obese Mexican adults. The study found that the TT genotype of FokI and the GG genotype of BsmI were associated with a decrease in BCF.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Lorena Villalba-Heredia, Cristina Comeras-Chueca, Alejandro Gonzalez-Aguero, Daniel Domingo-del-Val, Pilar Calmarza, German Vicente-Rodriguez, Jose A. Casajus, Angel Matute-Llorente
Summary: The study found no significant relationship between serum 25-hydroxyvitamin D and cardiorespiratory fitness parameters in prepubertal obese and overweight children. However, the cardiorespiratory fitness of these children was found to be relatively poor compared to normal-weight children.
Review
Nutrition & Dietetics
Emilia Gospodarska, Ranjini Ghosh Dastidar, Carsten Carlberg
Summary: Vitamin D intervention studies aim to evaluate the effects of vitamin D-3 on health and disease. However, recent large-scale randomized controlled trials did not yield statistically significant results. We propose an alternative approach that involves segregating study participants into different groups based on their responsiveness to vitamin D-3 supplementation and measuring a larger set of genome-wide parameters over time.
Article
Agriculture, Dairy & Animal Science
L. P. Blakely, T. L. Wells, M. F. Kweh, S. Buoniconti, M. Reese, P. Celi, C. Cortinhas, C. D. Nelson
Summary: This study aimed to test the effects of dietary vitamin D3 compared with 25-hydroxyvitamin D3 on vitamin D status and response to an endotoxin challenge. The results showed that supplementing 25-hydroxyvitamin D3 was more effective at increasing serum 25-hydroxyvitamin D, calcium, and phosphorus concentrations compared with dietary vitamin D3.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Endocrinology & Metabolism
Dania S. Bacha, Maya Rahme, Laila Al-Shaar, Rafic Baddoura, Georges Halaby, Ravinder J. Singh, Ziyad R. Mahfoud, Robert Habib, Asma Arabi, Ghada El-Hajj Fuleihan
Summary: This study found that the nutritional status of vitamin D in elderly individuals is influenced by dosage, with high dose vitamin D-3 supplements helping to increase 25(OH)D levels. The recommended dietary allowance of 600 IU/day by the Institute of Medicine does not bring 97.5% of ambulatory elderly individuals above the desirable threshold of 20 ng/mL. Therefore, country-specific RDAs should take into account the observed variability and predictors of achieved 25(OH)D levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Mioara Desdemona Stepan, Stefanita Bianca Vintilescu, Ioana Streata, Mihaela Andreea Podeanu, Dan Nicolae Florescu
Summary: Non-alcoholic fatty liver disease (NAFLD) is a complex chronic condition that is one of the most important issues in pediatric pathology due to the lack of screening-monitoring markers and effective standardized treatment. This study analyzed the role of vitamin D supplementation in obese children with or without NAFLD and its impact on the components of metabolic syndrome (MS). The results showed that there was a statistical association between NAFLD and MS components, which were present in both simple obesity and the 6-9 years age group. Vitamin D deficiency was associated with obesity, NAFLD, and MS components, and correcting the deficiency tended to normalize the associated parameters. Treatment based solely on the regimen led to decreases in vitamin D values and additional alterations of certain parameters. Supplementation with vitamin D enhanced the effects of the specific regimen, and its effects seemed to be dependent on the MS components.
Article
Nutrition & Dietetics
Reagan M. Mogire, John Muthii Muriuki, Alireza Morovat, Alexander J. Mentzer, Emily L. Webb, Wandia Kimita, Francis M. Ndungu, Alex W. Macharia, Clare L. Cutland, Sodiomon B. Sirima, Amidou Diarra, Alfred B. Tiono, Swaib A. Lule, Shabir A. Madhi, Andrew M. Prentice, Philip Bejon, John M. Pettifor, Alison M. Elliott, Adebowale Adeyemo, Thomas N. Williams, Sarah H. Atkinson
Summary: There is a significant association between vitamin D and iron deficiency in African children. The risk of iron deficiency is increased in children with vitamin D deficiency, and vitamin D concentration variably influences iron status. Therefore, the link between vitamin D and iron status should be considered in strategies to manage these nutrient deficiencies.
Article
Nutrition & Dietetics
Dominique Ulrike Glatt, Emeir McSorley, L. Kirsty Pourshahidi, Raquel Revuelta Iniesta, Jane McCluskey, Laura Beggan, Mary Slevin, Nigel Gleeson, Diego F. Cobice, Sara Dobbin, Pamela J. Magee
Summary: This study investigated the vitamin D status and related factors in children in Northern Ireland. The results showed that over half of the children were deficient or insufficient in vitamin D. Additionally, vitamin D intake, outdoor activity time, and muscle strength were positively correlated with vitamin D levels. Therefore, it is recommended to supplement vitamin D, consume foods rich in vitamin D, and increase outdoor activities in winter to prevent vitamin D inadequacy.
Article
Endocrinology & Metabolism
Gulin Karacan Kucukali, Ozlem Gulbahar, Servan Ozalkak, Hasan Dagli, Serdar Ceylaner, Zehra Aycan, Senay Savas Erdeve
Summary: The study found that obese children had significantly higher levels of parathyroid hormone and vitamin D-binding protein in winter, while lower levels of free and bioavailable vitamin D. Although total, free, and bioavailable vitamin D levels were similar between obese and control groups in autumn, free and bioavailable vitamin D were lower in obese children during winter, with higher parathyroid hormone levels observed in the obese group in both autumn and winter. Further research is needed to evaluate the variability of free and bioavailable vitamin D according to body habitus, season, and any potential effects of differences.
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2021)
Article
Pediatrics
Zehra E. Onal, Abdulkadir Tekin, Tamay Gurbuz, Cigdem Sag, Cagatay Nuhoglu
Summary: This study found that vitamin D levels were lower and PTH levels were higher in pubertal children compared to prepubertal children. Factors such as gender, weight, height, BMI, family socioeconomic status, and education level did not affect serum vitamin D levels. Therefore, it is important to support children with vitamin D supplements during puberty for rapid increase in bone mass.
MINERVA PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Karolina Sledzinska, Piotr Landowski, Michal A. Zmijewski, Barbara Kaminska, Konrad Kowalski, Anna Liberek
Summary: The study showed that IBD children have higher levels of vitamin D compared to controls, but a significant portion still lack optimal vitamin D levels. Despite the higher level of vitamin D, IBD children had lower calcium levels compared to healthy controls, with no correlation to disease activity or location of lesions in the gastrointestinal tract.
Article
Pediatrics
Kumaravel Rajakumar, Evelyn Cohen Reis, Michael F. Holick
CLINICAL PEDIATRICS
(2013)
Article
Endocrinology & Metabolism
Javier de las Heras, Kumaravel Rajakumar, SoJung Lee, Fida Bacha, Michael F. Holick, Silva A. Arslanian
Review
Endocrinology & Metabolism
Christian M. Girgis, Roderick J. Clifton-Bligh, Mark W. Hamrick, Michael F. Holick, Jenny E. Gunton
Article
Endocrinology & Metabolism
Pawel Pludowski, Elzbieta Karczmarewicz, Milan Bayer, Graham Carter, Danuta Chlebna-Sokol, Justyna Czech-Kowalska, Romuald Debski, Tamas Decsi, Anna Dobrzanska, Edward Franek, Piotr Gluszko, William B. Grant, Michael F. Holick, Liudmila Yankovskaya, Jerzy Konstantynowicz, Janusz B. Ksiazyk, Krystyna Ksiezopolska-Orlowska, Andrzej Lewinski, Mieczyslaw Litwin, Szimonetta Lohner, Roman S. Lorenc, Jacek Lukaszkiewicz, Ewa Marcinowska-Suchowierska, Andrzej Milewicz, Waldemar Misiorowski, Michal Nowicki, Vladyslav Povoroznyuk, Piotr Rozentryt, Ema Rudenka, Yehuda Shoenfeld, Piotr Socha, Bogdan Solnica, Mieczyslaw Szalecki, Marek Talalaj, Szabolcs Varbiro, Michal A. Zmijewski
ENDOKRYNOLOGIA POLSKA
(2013)
Letter
Gastroenterology & Hepatology
Hannah L. Miller, Francis A. Farraye, Jennifer Coukos, Lauren A. Howard, Michael F. Holick, Arthur F. Stucchi, James M. Becker
INFLAMMATORY BOWEL DISEASES
(2013)
Article
Endocrinology & Metabolism
J. M. Mata-Granados, J. R. Cuenca-Acevedo, M. D. Luque de Castro, M. F. Holick, J. M. Quesada-Gomez
ARCHIVES OF OSTEOPOROSIS
(2013)
Article
Nutrition & Dietetics
Uwe Groeber, Michael F. Holick
Review
Nutrition & Dietetics
Nipith Charoenngam, Michael F. Holick
Article
Nutrition & Dietetics
Nipith Charoenngam, Sara M. Alexanian, Caroline M. Apovian, Michael F. Holick
Summary: This study found that in COVID-19 patients without T2D, hyperglycemia may be associated with worse outcomes including mortality rate, ICU admission, and acute kidney injury. However, in patients with T2D, hyperglycemia was only associated with ICU admission and acute kidney injury.
Article
Pediatrics
Michael F. Holick, Arash Shirvani, Nipith Charoenngam
Summary: This case report described a male infant with multiple intrauterine fractures resembling osteogenesis imperfecta, whose genetic testing did not support a diagnosis of osteogenesis imperfecta, but identified a new genetic cause for these fractures.
Editorial Material
Nutrition & Dietetics
Michael F. Holick
Article
Nutrition & Dietetics
Ulrich Amon, Raul Yaguboglu, Madeleine Ennis, Michael F. Holick, Julian Amon
Summary: The study shows that high doses of orally applied vitamin D3 for the treatment of autoimmune diseases are safe with proper supervision by experienced physicians. The participants in the study did not experience hypercalcemia or impaired renal function while following a low-calcium diet and adequate fluid intake.
Review
Genetics & Heredity
Nipith Charoenngam, Aryan Nasr, Arash Shirvani, Michael F. Holick
Summary: Hereditary metabolic bone diseases encompass a diverse group of rare diseases with genetic abnormalities in skeletal homeostasis. This review examines 25 selected diseases and genetic variations of 78 genes, covering sclerosing bone disorders, disorders of defective bone mineralization, and disorder of bone matrix and cartilage formation. Advancements in molecular genetics have enabled accurate genetic diagnosis and novel therapeutic strategies for some diseases, but further research is needed for diseases with unclear genetic basis and pathophysiology.
Review
Nutrition & Dietetics
Michael F. F. Holick
Summary: McCollum discovered a fat-soluble nutrient with antirachitic activity and no vitamin A activity, which he named vitamin D. This vitamin has had significant health benefits for children and adults. This review explores the evolution and importance of vitamin D in land vertebrates, beginning with the connection between sunlight, vitamin D production, and the prevention of rickets.
Review
Nutrition & Dietetics
Pawel Pludowski, Beata Kos-Kudla, Mieczyslaw Walczak, Andrzej Fal, Dorota Zozulinska-Ziolkiewicz, Piotr Sieroszewski, Jaroslaw Peregud-Pogorzelski, Ryszard Lauterbach, Tomasz Targowski, Andrzej Lewinski, Robert Spaczynski, Miroslaw Wielgos, Jaroslaw Pinkas, Teresa Jackowska, Ewa Helwich, Artur Mazur, Marek Ruchala, Arkadiusz Zygmunt, Mieczyslaw Szalecki, Artur Bossowski, Justyna Czech-Kowalska, Marek Wojcik, Beata Pyrzak, Michal A. Zmijewski, Pawel Abramowicz, Jerzy Konstantynowicz, Ewa Marcinowska-Suchowierska, Andrius Bleizgys, Spirydon N. Karras, William B. Grant, Carsten Carlberg, Stefan Pilz, Michael F. Holick, Waldemar Misiorowski
Summary: It is found that vitamin D deficiency is prevalent among the Polish population based on epidemiological studies. To address this concern, a Polish multidisciplinary group reviewed the evidence and formulated recommendations for prevention and treatment of vitamin D deficiency. The final Polish recommendations included a range of serum vitamin D levels indicating deficiency, guidelines for prophylaxis and treatment, and the importance of improving the overall population's vitamin D status and treating at-risk patient groups.
