Article
Cardiac & Cardiovascular Systems
Parveen K. Garg, J'Neka S. Claxton, Elsayed Z. Soliman, Lin Y. Chen, Tene T. Lewis, Thomas Mosley, Alvaro Alonso
Summary: The study found that vital exhaustion and anti-depressant use are associated with incident atrial fibrillation, while anger and poor social ties are not significantly related to the development of atrial fibrillation.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Urology & Nephrology
Zhi Yu, Morgan E. Grams, Chiadi E. Ndumele, Lynne Wagenknecht, Eric Boerwinkle, Kari E. North, Casey M. Rebholz, Edward L. Giovannucci, Josef Coresh
Summary: This study found that midlife obesity measures were associated with decline in kidney function among White and Black women over 30 years of follow-up, but the association was less consistent in men. Obesity indicators were independently associated with risk for kidney failure with replacement therapy for all sex-race groups except White men. Loss to follow-up during the study period was a limitation.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Hasan K. Siddiqi, Manickavasagar Vinayagamoorthy, Baris Gencer, Chee Ng, Julie Pester, Nancy R. Cook, I-Min Lee, Julie Buring, JoAnn E. Manson, Christine M. Albert
Summary: This study examines sex differences in atrial fibrillation (AF) incidence in a contemporary cohort without prevalent cardiovascular disease (CVD). It suggests that after controlling for height and/or body size, women without CVD at baseline were at higher risk for AF than men.
Article
Clinical Neurology
Mauro F. F. Mediano, Yejin Mok, Josef Coresh, Anna Kucharska-Newton, Priya Palta, Kamakshi Lakshminarayan, Wayne D. Rosamond, Kunihiro Matsushita, Silvia Koton
Summary: Higher levels of total prestroke physical activity, as well as work and leisure activities, are associated with a lower risk of mortality after incident stroke. It is suggested that promoting physical activity throughout life could be beneficial in reducing long-term mortality post-stroke.
Article
Endocrinology & Metabolism
Mary R. Rooney, Jingsha Chen, Justin B. Echouffo-Tcheugui, Keenan A. Walker, Pascal Schlosser, Aditya Surapaneni, Olive Tang, Jinyu Chen, Christie M. Ballantyne, Eric Boerwinkle, Chiadi E. Ndumele, Ryan T. Demmer, James S. Pankow, Pamela L. Lutsey, Lynne E. Wagenknecht, Yujian Liang, Xueling Sim, Rob van Dam, E. Shyong Tai, Morgan E. Grams, Elizabeth Selvin, Josef Coresh
Summary: This study identified 47 plasma proteins predictive of incident diabetes, established causal effects for 3 proteins, and identified diabetes-associated inflammation and lipid pathways with potential implications for diagnosis and therapy.
Article
Cardiac & Cardiovascular Systems
Laura M. Raffield, Annie Green Howard, Misa Graff, Dan-Yu Lin, Susan Cheng, Ellen Demerath, Chiadi Ndumele, Priya Palta, Casey M. Rebholz, Sara Seidelmann, Bing Yu, Penny Gordon-Larsen, Kari E. North, Christy L. Avery
Summary: Research examining the association between obesity subclasses and cardiovascular disease risk suggests that there is heterogeneity in the impact of obesity severity, distribution, and duration on CVD. Different obesity subclasses identified based on changes in body mass index and waist circumference show varying associations with CVD risk factors. The consideration of heterogeneity and longitudinal changes in obesity measures is essential for a more personalized approach to assessing cardiovascular disease risk in clinical care.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Meisha Mandal, Josh Levy, Cataia Ives, Stephen Hwang, Yi-Hui Zhou, Alison Motsinger-Reif, Huaqin Pan, Wayne Huggins, Carol Hamilton, Fred Wright, Stephen Edwards
Summary: This study aimed to streamline the integration of data from existing human cohorts by programmatically identifying related variables within each study. Through manual review and natural language processing, the clusters were evaluated and further consolidated into cluster groups. The data-driven approach can facilitate data harmonization and improve the efficiency of data curation efforts.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Chenkai Wu, Kehan Zhang, Michelle C. Odden, Anna M. Kucharska-Newton, Priya Palta, Kunihiro Matsushita, Rebecca F. Gottesman, B. Gwen Windham
Summary: The study found that a high burden of subclinical vascular disease in middle-aged adults is associated with an increased risk of premature mortality, providing better predictive ability for premature death. When designing interventions to reduce premature mortality, the importance of considering subclinical vascular disease factors should be taken into account.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Imo A. Ebong, Machelle D. Wilson, Duke Appiah, Erin D. Michos, Susan B. Racette, Amparo Villablanca, Khadijah Breathett, Pamela L. Lutsey, Melissa Wellons, Karol E. Watson, Patricia Chang, Alain G. Bertoni
Summary: Obesity exacerbates the risk of heart failure, particularly in women with older menopausal age, compared to those with lower body mass index and waist circumference.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Psychology, Multidisciplinary
Alexander Wettstein, Sandra Schneider, Gabriel Jenni, Martin grosse Holtforth, Wolfgang Tschacher, Roberto La Marca
Summary: This study investigates the association between workaholism, vital exhaustion (VE), and hair cortisol concentration (HCC) as indicators of chronic stress. It also explores the moderating role of the personality trait neuroticism on the relationship between workaholism and chronic stress indicators. The results show that both workaholism and neuroticism are positively associated with VE, but not with HCC. Additionally, there is a positive relationship between workaholism and VE in teachers with high neuroticism, but no such association is observed in teachers with low neuroticism.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Medical Laboratory Technology
Carine E. Hamo, Justin B. Echouffo-Tcheugui, Sui Zhang, Roberta Florido, James S. Pankow, Erin D. Michos, Ronald Goldberg, Vijay Nambi, Gary Gerstenblith, Wendy S. Post, Roger S. Blumenthal, Christie Ballantyne, Elizabeth Selvin, Josef Coresh, Chiadi E. Ndumele
Summary: There is a strong association between the duration of diabetes and subclinical myocardial injury, with longer duration associated with greater risk of myocardial damage.
CLINICAL CHEMISTRY
(2022)
Article
Critical Care Medicine
Pamela L. Lutsey, Islam Zineldin, Jeffrey R. Misialek, Kelsie M. Full, Kamakshi Lakshminarayan, Junichi Ishigami, Logan T. Cowan, Kunihiro Matsushita, Ryan T. Demmer
Summary: This study found that severe obstructive sleep apnea (OSA) is associated with an increased risk of hospitalization for pneumonia. The results showed that patients with severe OSA had a 1.87 times higher risk of hospitalization with pneumonia compared to those with a normal breathing pattern.
Article
Geriatrics & Gerontology
Dongze Li, Yu Jia, Jing Yu, Yi Liu, Fanghui Li, Wei Zhang, Yongli Gao, Xiaoyang Liao, Zhi Wan, Zhi Zeng, Rui Zeng
Summary: BackgroundClinical cardiovascular disease (CVD) and cognition impairment are common in aging populations, and there may be a link between impaired cognition and subclinical CVD. This study found that baseline cognitive function was associated with subclinical myocardial damage and cardiac dysfunction.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
You-jung Choi, Kyung-do Han, Eue-Keun Choi, Jin-Hyeung Jung, So-Ryoung Lee, Seil Oh, Gregory Y. H. Lip
Summary: Alcohol abstinence was associated with a reduced risk of atrial fibrillation development in patients newly diagnosed with type 2 diabetes mellitus. This association was particularly significant in men, older patients, those with lower CHA(2)DS(2)-VASc scores, non-insulin users, and patients with lower BMI.
Review
Immunology
Maria Teresa Palano, Martina Cucchiara, Matteo Gallazzi, Federica Riccio, Lorenzo Mortara, Gian Franco Gensini, Gaia Spinetti, Giuseppe Ambrosio, Antonino Bruno
Summary: Atherosclerosis, the leading cause of cardiovascular disease worldwide, is influenced not only by dyslipidemia but also chronic inflammation and immune system abnormalities. Natural killer cells, an understudied immune cell type, may play a role in vascular homeostasis and offer potential for new therapies. Understanding the pathophysiology of natural killer cells in atherosclerosis and associated risk factors could lead to preventive and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Josie Dickerson, Philippa K. Bird, Maria Bryant, Nimarta Dharni, Sally Bridges, Kathryn Willan, Sara Ahern, Abigail Dunn, Dea Nielsen, Eleonora P. Uphoff, Tracey Bywater, Claudine Bowyer-Crane, Pinki Sahota, Neil Small, Michaela Howell, Gill Thornton, Kate E. Pickett, Rosemary R. C. McEachan, John Wright
Article
Health Care Sciences & Services
Shahid Islam, Neil Small, Maria Bryant, Sally Bridges, Nicola Hancock, Josie Dickerson
HEALTH EXPECTATIONS
(2019)
Article
Public, Environmental & Occupational Health
M. Bryant, N. Dharni, J. Dickerson, K. Willan, R. McEachan, J. Duffy, M. Howell
Review
Endocrinology & Metabolism
Vishal Sharma, Susanne Coleman, Jane Nixon, Linda Sharples, Julian Hamilton-Shield, Harry Rutter, Maria Bryant
Article
Public, Environmental & Occupational Health
Wendy Burton, Maureen Twiddy, Pinki Sahota, Julia Brown, Maria Bryant
Article
Medicine, Research & Experimental
Maria Bryant, Wendy Burton, Michelle Collinson, Amanda Farrin, Jane Nixon, June Stevens, Kim Roberts, Robbie Foy, Harry Rutter, Bethan Copsey, Suzanne Hartley, Sandy Tubeuf, Julia Brown
Summary: In a trial evaluating an implementation optimisation intervention for childhood obesity prevention programmes, no evidence of effectiveness was found due to unexpected national service restructuring that led to center closures and reduced funding, impacting the implementation and parental participation rates in the HENRY programme.
Article
Medicine, General & Internal
Josie Dickerson, Brian Kelly, Bridget Lockyer, Sally Bridges, Christopher Cartwright, Kathryn Willan, Katy Shire, Kirsty Crossley, Maria Bryant, Najma Siddiqi, Trevor A. Sheldon, Deborah A. Lawlor, John Wright, Rosemary Rc McEachan, Kate E. Pickett
Summary: This study explores the increase in depression and anxiety during the first UK COVID-19 lockdown and factors related to this change, with a focus on ethnic differences. The findings suggest that mental health has worsened for many during the lockdown, particularly for those who experience loneliness and economic insecurity. The magnitude of associations between key exposures and worsening mental health varied between ethnic groups.
Article
Medicine, General & Internal
Tiffany C. Yang, Madeleine Power, Rachael H. Moss, Bridget Lockyer, Wendy Burton, Bob Doherty, Maria Bryant
Summary: This study found that many children experience food insecurity regardless of whether they receive free school meals. Food insecure children are more likely to have poor mental health. Therefore, it is necessary to expand the eligibility criteria for free school meals to prevent overlooking those in need.
Article
Environmental Sciences
Liina Mansukoski, Alexandra Albert, Yassaman Vafai, Chris Cartwright, Aamnah Rahman, Jessica Sheringham, Bridget Lockyer, Tiffany C. Yang, Philip Garnett, Maria Bryant
Summary: In this study, a core outcome set (COS) for systems-wide public health interventions was developed to promote early life health and wellbeing. Through research and consultations, a final COS of 40 outcomes prioritized from the perspectives of local communities was established.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
Maria Bryant, Michelle Collinson, Wendy Burton, Elizabeth Stamp, Holly Schofield, Bethan Copsey, Suzanne Hartley, Edward Webb, Amanda J. Farrin
Summary: The study evaluated the feasibility of conducting a multi-centre definitive trial to assess the effectiveness and cost-effectiveness of HENRY in preventing obesity. Results indicated that conducting a cluster RCT of HENRY to assess its impact on childhood obesity prevention is feasible, with attention needed on potential sources of contamination and their impact.
PILOT AND FEASIBILITY STUDIES
(2021)
Article
Medicine, Research & Experimental
Claudine Bowyer-Crane, Dea Nielsen, Maria Bryant, Nimarta Dharni, Rebecca Heald, Chloe Storr, Josie Dickerson
PILOT AND FEASIBILITY STUDIES
(2019)
Review
Psychology, Clinical
Nicole Gridley, Sarah Blower, Abby Dunn, Tracey Bywater, Maria Bryant
CLINICAL CHILD AND FAMILY PSYCHOLOGY REVIEW
(2019)
Article
Pediatrics
Nimarta Dharni, Josie Dickerson, Kathryn Willan, Sara Ahern, Abigail Dunn, Dea Nielsen, Eleonora Uphoff, Rosemary R. C. McEachan, Maria Bryant
BMJ PAEDIATRICS OPEN
(2019)
Review
Psychology, Clinical
Nicole Gridley, Sarah Blower, Abby Dunn, Tracey Bywater, Karen Whittaker, Maria Bryant
CLINICAL CHILD AND FAMILY PSYCHOLOGY REVIEW
(2019)
Article
Health Policy & Services
Shahid Islam, Neil Small, Maria Bryant, Tiffany Yang, Anna Cronin de Chavez, Fiona Saville, Josie Dickerson
INTERNATIONAL JOURNAL OF HUMAN RIGHTS IN HEALTH CARE
(2019)