Article
Dentistry, Oral Surgery & Medicine
Jaideep Mahendra, Little Mahendra, Dhana Divya, Paavai Ilango, Nalini Devarajan, Abirami Thanigaimalai
Summary: This study evaluates and compares the levels of lipocalin, adiponectin, and periodontal viruses in generalized periodontitis patients with and without diabetes mellitus. The results show that patients with diabetes and periodontitis have higher prevalence of EBV and CMV, as well as decreased levels of adiponectin, indicating an aggravation of the diabetic status among periodontitis patients and reinforcing the Periodontitis-DM continuum.
Article
Endocrinology & Metabolism
Hiroshi Nomoto, Kenichi Kito, Hiroshi Iesaka, Takahisa Handa, Shingo Yanagiya, Aika Miya, Hiraku Kameda, Kyu Yong Cho, Jun Takeuchi, So Nagai, Ichiro Sakuma, Akinobu Nakamura, Tatsuya Atsumi
Summary: The hepatoprotective effects of pemafibrate are dominant in patients with type 2 diabetes complicated by liver dysfunction, leading to improvement in liver function and fibrosis.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Multidisciplinary Sciences
Yuichiro Iwamoto, Tomohiko Kimura, Fuminori Tatsumi, Toshitomo Sugisaki, Masato Kubo, Erina Nakao, Kazunori Dan, Ryo Wamata, Hideyuki Iwamoto, Kaio Takahashi, Junpei Sanada, Yoshiro Fushimi, Yukino Katakura, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Summary: Morphological changes in the pancreas of subjects with type 2 diabetes mellitus are associated with the progression of vascular complications.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
J. Jendle, T. Hyotylainen, M. Oresic, T. Nystrom
Summary: Treatment with liraglutide is associated with favorable metabolic changes, particularly in lipid metabolism, compared to glimepiride. The findings shed light on the underlying biological mechanisms of the cardiovascular benefits observed with GLP-1 RAs in outcome studies. Further research on the role of GLP-1 RAs in ceramides and cardiovascular diseases, including fatty liver disease, is warranted.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Medicine, General & Internal
Ignatios Ikonomidis, George Pavlidis, Maria Tsoumani, Foteini Kousathana, Konstantinos Katogiannis, Damianos Tsilivarakis, John Thymis, Aikaterini Kountouri, Emmanouil Korakas, Loukia Pliouta, Athanasios Raptis, John Parissis, Ioanna Andreadou, Vaia Lambadiari
Summary: Oxidative stress plays a significant role in the pathogenesis of diabetes. This study found that nitrite/nitrate levels decreased, perfused boundary region increased, and coronary flow reserve and left ventricular global longitudinal strain decreased in subjects with high blood sugar, indicating a correlation with insulin resistance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Mengni Li, Rongping Fan, Xuemin Peng, Jiaojiao Huang, Huajie Zou, Xuefeng Yu, Yan Yang, Xiaoli Shi, DeLin Ma
Summary: This study found a close association between ANGPTL8, resistin, and DN in T2DM patients, especially in non-NAFLD populations. These results suggest that ANGPTL-8 and resistin may be risk predictors for DN.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Poornima Venkat, Huanjia Gao, Elizabeth L. Findeis, Zhili Chen, Alex Zacharek, Julie Landschoot-Ward, Brianna Powell, Mei Lu, Zhongwu Liu, Zhenggang Zhang, Michael Chopp
Summary: This study investigated the effects of exosomes derived from CD133+ cells harvested from human umbilical cord blood on liver dysfunction and neuro-cognitive outcome in female mice with type 2 diabetes mellitus (T2DM) and stroke. The results showed that treatment with CD133+ exosomes significantly reduced the progression of NAFLD/NASH and improved neurological and cognitive function in T2DM-stroke mice.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Sejeong Lee, Jaehyun Bae, Doo Ri Jo, Minyoung Lee, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
Summary: In newly diagnosed type 2 diabetes patients, intact ketogenesis may be associated with a decreased risk of metabolic-associated fatty liver disease (MAFLD).
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tatsumi Moriya, Akinori Hayashi, Madoka Matsubara, Akihiko Suzuki, Motoshi Ouchi
Summary: Poor glycemic control was found to impact the risk of hemodialysis induction in diabetic patients over a 16-year follow-up period. Additionally, diabetic retinopathy, particularly proliferative diabetic retinopathy, was identified as a significant risk factor for hemodialysis induction, whereas microalbuminuria and hypertension did not predict this outcome in the early stages of diabetic nephropathy in type 2 diabetic patients with normal renal function.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Endocrinology & Metabolism
Yijiong Tan, Qin Zhen, Xiaoying Ding, Tingting Shen, Fang Liu, Yufan Wang, Qidi Zhang, Renkun Lin, Lili Chen, Yongde Peng, Nengguang Fan
Summary: This study found that the use of Liraglutide treatment is associated with a reduced risk of liver fibrosis in patients with type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Joan Barrot, Jordi Real, Bogdan Vlacho, Pedro Romero-Aroca, Rafael Simo, Didac Mauricio, Manel Mata-Cases, Esmeralda Castelblanco, Xavier Mundet-Tuduri, Josep Franch-Nadal
Summary: This study found that diabetic retinopathy (DR) is associated with coronary heart disease, macrovascular events, and all-cause mortality in individuals with type 2 diabetes mellitus.
FRONTIERS IN MEDICINE
(2022)
Article
Endocrinology & Metabolism
Li-Hsin Chang, Chia-Huei Chu, Chin-Chou Huang, Liang-Yu Lin
Summary: This study found that FGF-21 levels were associated with an increased risk of renal events in Chinese patients with T2DM. FGF-21 may serve as a potential biomarker to predict renal outcomes in T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Kyuho Kim, Tae Jung Oh, Hyen Chung Cho, Yun Kyung Lee, Chang Ho Ahn, Bo Kyung Koo, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
Summary: The study found that liver fibrosis may be associated with DPN in individuals with type 2 diabetes, particularly in those with a high NAFLD liver fat score. Additionally, the NAFLD fibrosis score and FIB-4 index showed significant associations with DPN.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Jiaxian Chen, Yanan Wan, Jian Su, Zheng Zhu, Engchun Pan, Chong Shen, Jinbo Wen, Kai Wang, Hao Yu, Yu Qin, Lan Cui, Jinyi Zhou, Ming Wu
Summary: The study found that individuals with type 2 diabetes who had low BMI levels and high WHR levels had an increased risk of developing DR, indicating that isolated abdominal obesity may be involved in the pathogenesis of DR.
ACTA DIABETOLOGICA
(2022)
Article
Biochemistry & Molecular Biology
Peixian Chen, Yumin Cao, Shenren Chen, Zhike Liu, Shiyi Chen, Yali Guo
Summary: This study evaluated the effects of genetic variations in organic cation transporter genes on the response to metformin treatment in diabetic patients. The results showed significant associations between variations in SLC47A1 and SLC47A2 genes and metformin efficacy, suggesting that these variations could be predictors of insulin resistance.
Article
Chemistry, Multidisciplinary
Ruth Rodriguez-Barrueco, Jessica Latorre, Laura Devis-Jauregui, Aina Lluch, Nuria Bonifaci, Francisco J. Llobet, Mireia Olivan, Laura Coll-Iglesias, Katja Gassner, Meredith L. Davis, Jose M. Moreno-Navarrete, Anna Castells-Nobau, Laura Plata-Pena, Miki Dalmau-Pastor, Marcus Horing, Gerhard Liebisch, Vesa M. Olkkonen, Maria Arnoriaga-Rodriguez, Wifredo Ricart, Jose M. Fernandez-Real, Jose M. Silva, Francisco J. Ortega, David Llobet-Navas
Summary: The miR-424(322)/503 cluster encoded by H19X regulates multiple cellular functions and is crucial for fat mass expansion. By targeting SNCG, it controls a conserved genetic program involved in white adipocyte differentiation and commitment, allowing adipose tissue enlargement under tight regulation. Decreased miR-424(322) levels in obese individuals lead to increased SNCG expression, a mechanism normalized upon weight loss.
Review
Cell Biology
Angela del Castillo-Izquierdo, Jordi Mayneris-Perxachs, Jose Manuel Fernandez-Real
Summary: The composition of the human gut microbiota is influenced by environmental and host factors, including diet, drugs, geography, sanitation, age, and sexual development. The impact of gender on the gut microbiota is minimal before and after adulthood, but significant during adulthood. Adult women have higher abundances of certain bacteria in their gut microbiota compared to men, while adult men have higher abundances of other bacteria, particularly associated with a diet rich in animal proteins. The gut microbiota of women becomes more similar to men after menopause. The gut microbiota is also linked to the levels of sexual hormones and their precursors in blood, and can participate in the metabolism of these hormones.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jessica Ares Blanco, Carmen Lambert, Manuel Fernandez-Sanjurjo, Paula Morales-Sanchez, Pedro Pujante, Paola Pinto-Hernandez, Eduardo Iglesias-Gutierrez, Edelmiro Menendez Torre, Elias Delgado
Summary: The aim of this study was to investigate the glucose tolerance status after 15 years of pregnancy in women diagnosed with gestational diabetes mellitus (GDM) and to assess the long-term effect of GDM on circulating miRNA profile. The study included 30 randomly selected women diagnosed with GDM during 2005-2006, and glucose tolerance was measured using the National Diabetes Data Group criteria. Four miRNAs were analyzed in the plasma of women 15 years after the diagnosis of GDM. The study found that 50% of women had some degree of glucose intolerance 15 years after the diagnosis of GDM, which was directly related to body weight and body mass index during pregnancy. Dysglycemic women also showed significantly increased levels of circulating hsa-miR-24-3p. Thus, initial weight and BMI, along with circulating expression levels of hsa-miR-24-3p, could be good predictors of the future development of dysglycemia in women with a previous diagnosis of GDM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Milton Fabian Suarez-Ortegon, Alejandra Arbelaez, Jose Maria Moreno-Navarrete, Jose Guillermo Ortega-Avila, Mildrey Mosquera, Jose Manuel Fernandez-Real
Summary: Excessive body iron levels are associated with insulin resistance and cardiometabolic risk, and oxidative stress may play a role in this relationship. This study investigated the association between soluble transferrin receptor (sTfR) levels, antioxidant status, and cardiometabolic risk markers. The results showed that sTfR levels were positively correlated with total antioxidant capacity (TAC) in both men and women. In men, sTfR levels were inversely associated with waist circumference and fasting glucose, and positively associated with LDL cholesterol. The findings suggest that sTfR levels are associated with antioxidant status and specific cardiometabolic risk variables, independent of other factors such as serum ferritin and hepcidin.
Review
Endocrinology & Metabolism
Miguel Lopez, Manuel Fernandez-Real, Stanislav I. Tomarev
Summary: Classically, the regulation of energy balance has been based on central and peripheral mechanisms sensing energy, nutrients, metabolites, and hormonal cues. Recent data have added more complexity to the homeostatic regulation of metabolism by introducing the key role of olfaction in energy homeostasis. Olfactory inputs contribute to the regulation of feeding, energy expenditure, and whole body metabolism.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Hinojosa-Moscoso, Anna Motger-Alberti, Elena De la Calle-Vargas, Marian Marti-Navas, Carles Biarnes, Maria Arnoriaga-Rodriguez, Gerard Blasco, Josep Puig, Diego Luque-Cordoba, Feliciano Priego-Capote, Jose Maria Moreno-Navarrete, Jose Manuel Fernandez-Real
Summary: Excess iron is associated with dysfunction in adipose tissue and insulin resistance. In this study, it was found that markers of iron status were linked to changes in abdominal adipose tissue over one year. These associations were mainly observed in women and non-obese subjects, and were independent of insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Maria Arnoriaga-Rodriguez, Yenny Leal, Jordi Mayneris-Perxachs, Vicente Perez-Brocal, Andres Moya, Wifredo Ricart, Merce Fernandez-Balsells, Jose Manuel Fernandez-Real
Summary: Sleep disruption is associated with worse glucose metabolic control and altered gut microbiota. This study found an association between rapid eye movement (REM) sleep duration and glucose levels as well as gut microbiota composition. Sleep deprivation can lead to poor glucose control and microbiota imbalance, negatively impacting metabolic health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Luca Valenti, Elena Corradini, Leon A. Adams, Elmar Aigner, Saleh Alqahtani, Marco Arrese, Edouard Bardou-Jacquet, Elisabetta Bugianesi, Jose-Manuel Fernandez-Real, Domenico Girelli, Hannes Hagstrom, Benjamin Henninger, Kris Kowdley, Guido Ligabue, Donald McClain, Fabrice Laine, Koji Miyanishi, Martina U. Muckenthaler, Alessia Pagani, Patrizia Pedrotti, Antonello Pietrangelo, Daniele Prati, John D. Ryan, Laura Silvestri, C. Wendy Spearman, Per Stal, Emmanuel A. Tsochatzis, Francesca Vinchi, Ming-Hua Zheng, Heinz Zoller
Summary: Hyperferritinaemia is often associated with metabolic dysfunction and fatty liver and is linked to an increased risk of cardiometabolic and liver diseases. The main determinants of ferritin levels in individuals with metabolic dysfunction are genetic variants that affect iron metabolism. However, there is currently a lack of validated criteria for the diagnosis and staging of metabolic hyperferritinaemia, and the benefits of iron depletion therapy remain unclear. In this article, the authors provide an overview of the relationship between hyperferritinaemia and iron accumulation in individuals with metabolic dysfunction and propose updated definitions and staging systems, highlighting research gaps and suggesting future study designs and outcome measures.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lidia Sojo, Elena Santos-Gonzalez, Lidia Riera, Alex Aguilera, Rebeca Barahona, Paula Pellicer, Maria Buxo, Jordi Mayneris-Perxachs, Merce Fernandez-Balsells, Jose-Manuel Fernandez-Real
Summary: In this study, we investigated the plasma lipidomics profiles of patients with T1DM and explored potential associations. We found significant associations between certain lipid species and subclinical atherosclerosis, as well as differences according to overweight status. Our findings suggest that personalized approaches targeting specific lipid molecules may be useful in preventing cardiovascular disease in T1DM patients.
Review
Endocrinology & Metabolism
Marisel Rosell-Diaz, Jose Manuel Fernandez-Real
Summary: The decline in cognitive function and the prevalence of neurodegenerative disorders are serious threats to health in old age, with dementia affecting 50 million people worldwide. Type 2 diabetes is linked to an increased risk of cognitive impairment and dementia. Studies have shown that metformin, a medication used to treat type 2 diabetes, may partially restore gut dysbiosis related to diabetes and potentially improve cognitive function.
Article
Endocrinology & Metabolism
Jiuwen Sun, Alberic Germain, Gracia Kaglan, Florence Servant, Benjamin Lelouvier, Massimo Federici, Jose Manuel Fernandez Real, Daniela Tatiana Sala, Radu Mircea Neagoe, Anne Bouloumie, Remy Burcelin
Summary: This study found that specific bacterial families in the visceral adipose tissue of obese patients can trigger inflammation and adipose depot development. There are significant differences in the bacterial composition between obese patients and non-obese individuals. These findings generate new hypotheses regarding the relationship between obesity and gut tissue.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Nuria Oliveras-Canellas, Jose Maria Moreno-Navarrete, Paula M. Lorenzo, Lourdes Garrido-Sanchez, Sara Becerril, Oriol Rangel, Jessica Latorre, Elena de la Calle Vargas, Maria Pardo, Victor Valenti, Juan L. Romero-Cabrera, Wilfredo Oliva-Olivera, Camilo Silva, Carlos Dieguez, Francesc Villarroya, Miguel Lopez, Ana B. Crujeiras, Luisa-Maria Seoane, Jose Lopez-Miranda, Gema Fruhbeck, Francisco Jose Tinahones, Jose-Manuel Fernandez-Real
Summary: This study investigated how outside temperature affects adipose tissue physiology and metabolic traits. The expression of genes associated with browning and adipogenesis in the subcutaneous adipose tissue were found to be negatively associated with temperature. These findings could have implications for the relationship between the obesity pandemic and global warming.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Milton Fabian Suarez-Ortegon, Jenny Elizabeth Ordonez-Betancourth, Jose Guillermo Ortega-Avila, Ana Yibby Forero, Jose Manuel Fernandez-Real
Summary: This study evaluated the relationship between three adiposity markers and iron-deficient status in reproductive-age women. The results showed that waist circumference, waist-to-height ratio, and BMI were inversely associated with iron deficiency. Among them, waist-to-height ratio had the strongest correlation.
Article
Endocrinology & Metabolism
Silvia Gonzalez-Martinez, Eduardo Martinez-Morillo, Noelia Avello-Llano, Ana Isabel Escudero-Gomis, Elias Delgado-Alvarez, Edelmiro Luis Menendez-Torre
Summary: The objective of this study was to assess the iodine levels of pregnant women in the second trimester and analyze the impact of iodine intake on urinary iodine concentration and maternal thyroid function. The study found that the consumption of iodized salt provided protection against iodine deficiency, while the use of iodine supplements was associated with higher levels of TSH in pregnant women with autoimmune thyroid disease. The results indicate that pregnant women in the study population maintained adequate iodine status and the use of iodized salt contributed to sufficient iodine nutrition.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2023)
Article
Endocrinology & Metabolism
Tomas Gonzalez-Vidal, Diego Rivas-Otero, Alba Gutierrez-Hurtado, Carlos Alonso Felgueroso, Gema Martinez Tames, Carmen Lambert, Elias Delgado-Alvarez, Edelmiro Menendez Torre
Summary: Hypoglycemia during hospital admission is associated with poor prognosis in patients with type 2 diabetes. It is related to advanced age, previous insulin therapy, higher comorbidity index, lower body mass index, and lower baseline HbA1c values. Hypoglycemia is associated with increased in-hospital and long-term mortality, longer hospital stays, higher readmission rates, and poorer metabolic control after discharge.
DIABETOLOGY & METABOLIC SYNDROME
(2023)