Article
Oncology
Agnes Bocian-Jastrzebska, Anna Malczewska-Herman, Violetta Rosiek, Beata Kos-Kudla
Summary: This study investigated the potential relationship between leptin, adiponectin, and the leptin-adiponectin ratio with the grade, stage, and metastases of PanNENs. It was found that adiponectin concentration was significantly higher in the control group compared to the study group, and both leptin and adiponectin levels were higher in females than males. An increased leptin-adiponectin ratio was observed in well-differentiated PanNENs and PanNENs with low Ki-67. Additionally, lower leptin levels and a decreased leptin-adiponectin ratio were found in PanNENs with distal disease. These findings suggest that leptin, adiponectin, and their ratio may serve as potential biomarkers for the diagnosis, prognosis, and prediction of PanNENs.
Article
Nutrition & Dietetics
Sara Becerril, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Amaia Mentxaka, Gabriela Neira, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: Biological sex and aging play a role in obesity development and type 2 diabetes, affecting the secretion of leptin and adiponectin. The Adpn/Lep ratio is proposed as a reliable biomarker for adipose tissue dysfunction. The study found that female mice were more metabolically protected from obesity and its comorbidities than males, with an increased Adpn/Lep ratio in aged females negatively correlated with body weight gain and insulin resistance.
Article
Medicine, General & Internal
Sylwia Sluczanowska-Glabowska, Marzena Staniszewska, Mariola Marchlewicz, Ewa Duchnik, Karolina Luczkowska, Krzysztof Safranow, Boguslaw Machalinski, Andrzej Pawlik
Summary: Psoriasis is a common chronic skin disease characterized by hyperproliferation of keratinocytes, parakeratosis, and T-cell infiltration. Adipose tissue produces adipokines, including leptin, resistin, and adiponectin, which may play a role in the pathogenesis of psoriasis. This study examined the plasma levels of adiponectin, leptin, and resistin in psoriasis patients and their correlation with disease activity parameters and clinical parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Olenka Caffo, Penny A. Ralston, Jennifer L. Lemacks, Iris Young-Clark, Kandauda (K. A. S. ) Wickrama, Jasminka Z. Ilich
Summary: This study found that serum leptin in midlife and older African Americans is closely related to factors such as gender, body mass index, waist circumference, hip circumference, with a particular emphasis on females. Greater attention is needed for potential leptin resistance risk in African American females.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Medicine, General & Internal
Chia-Wen Lu, Kuen-Cheh Yang, Yu-Chiao Chi, Tsan-Yu Wu, Chien-Hsieh Chiang, Hao-Hsiang Chang, Kuo-Chin Huang, Wei-Shiung Yang
Summary: Lean non-alcoholic fatty liver disease (NAFLD) is similar to overweight NAFLD and should be detected early. The adiponectin-leptin ratio (AL ratio) may serve as a reliable marker for early detection of lean NAFLD independent of insulin resistance.
ANNALS OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Aneta Slabuszewska-Jozwiak, Aron Lukaszuk, Marta Janicka-Kosnik, Artur Wdowiak, Grzegorz Jakiel
Summary: Obesity is strongly associated with the development of endometrial cancer, and adipokines such as adiponectin and leptin may play a role in this process. Understanding the signaling pathway of these cytokines in endometrial cancerogenesis could potentially lead to targeted therapies and fertility-sparing treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ahmed Abdel-Razik, Nasser Mousa, Walaa Shabana, Ahmed H. Yassen, Mostafa Abdelsalam, Mohamed M. Wahba, Eman Mohamed Helmy, Ahmed M. Tawfik, Khaled Zalata, Ahmad S. Hasan, Rania Elhelaly, Rasha Elzehery, Aya Ahmed Fathy, Niveen El-Wakeel, Waleed Eldars
Summary: This study found that increased central obesity and leptin/adiponectin ratio (LAR) were independently associated with the development of PVT in non-cirrhotic NAFLD patients, suggesting that they may be considered as risk factors in the multifactorial pathogenesis of PVT.
FRONTIERS IN MEDICINE
(2021)
Article
Environmental Sciences
Xin Wang, Carrie A. Karvonen-Gutierrez, Bhramar Mukherjee, William H. Herman, Sung Kyun Park
Summary: The study found that urinary molybdenum was positively associated with adipokine levels, while cadmium, cesium, and lead were negatively associated with adipokine levels.
ENVIRONMENTAL RESEARCH
(2021)
Review
Nutrition & Dietetics
Hamed Varkaneh Kord, Grant M. Tinsley, Heitor O. Santos, Hamid Zand, Ali Nazary, Somaye Fatahi, Zeinab Mokhtari, Ammar Salehi-sahlabadi, Shing Cheng Tan, Jamal Rahmani, Mihnea-Alexandru Gaman, Brijesh Sathian, Amir Sadeghi, Behzad Hatami, Samira Soltanieh, Shahin Aghamiri, Hiba Bawadi, Azita Hekmatdoost
Summary: The study shows that fasting and energy-restricted diets can lead to significant reductions in serum leptin concentrations, with no significant effect on adiponectin concentrations. When energy intake is restricted to 50% or less of normal requirements, increases in adiponectin levels may be observed.
CLINICAL NUTRITION
(2021)
Article
Medicine, Research & Experimental
Zeltzin Ceja-Galicia, Diana Calderon-DuPont, Alberto Daniel, Luz Maria Chiu, Andrea Diaz-Villasenor
Summary: This study evaluated the expression of leptin and adiponectin in mature 3T3-L1 adipocytes exposed to palmitate, arsenite, or both. The results showed that the secretion of leptin and adiponectin was decreased, which could result in reduced satiety and decreased insulin sensitivity.
Review
Cardiac & Cardiovascular Systems
Shangang Zhao, Christine M. Kusminski, Philipp E. Scherer
Summary: The discovery of leptin and adiponectin established adipose tissue as an important endocrine organ in cardiovascular health. Normal levels of adiponectin and leptin are crucial for proper cardiovascular function, while both excess and insufficient levels may contribute to cardiovascular disorders. High levels of both adiponectin and leptin are a paradoxical factor in the pathogenesis of cardiovascular diseases.
CIRCULATION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Rong Huang, Yu Dong, Emile Levy, Pierre Julien, Isabelle Marc, Hua He, Ya-Jie Xu, Shu-Qin Wei, William D. Fraser, Zhong-Cheng Luo
Summary: The study found that in infancy, LGA was not associated with circulating leptin and adiponectin levels, but weight gain and current BMI may be related to adiponectin levels. Female sex was associated with lower total and HMW adiponectin concentrations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, Research & Experimental
Andreea Roxana Florian, Gheorghe Cruciat, Raluca Maria Pop, Adelina Staicu, Muresan Daniel, Stamatian Florin
Summary: This study revealed that elevated levels of leptin (L) in the early stages of pregnancy are strongly associated with the development of gestational diabetes mellitus (GDM). Meanwhile, adiponectin (AN) and CMPF levels showed no significant correlation with GDM.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Endocrinology & Metabolism
Kyoung Eun Joung, Camilia R. Martin, Sara Cherkerzian, Mark Kellogg, Mandy Brown Belfort
Summary: Leptin intake in milk was positively associated with weight gain and weight z-scores in preterm infants, while adiponectin intake was associated with length z-scores and negatively with head circumference z-scores after adjusting for protein and calorie intake. Insulin intake did not show significant associations with growth outcomes. Further research regarding the long-term effects of milk hormones is warranted.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Kajetan Kielbowski, Estera Bakinowska, Piotr Ostrowski, Bartlomiej Pala, Ewa Gromowska, Klaudia Gurazda, Pawel Dec, Andrzej Modrzejewski, Andrzej Pawlik
Summary: Psoriasis is a chronic skin condition mediated by the immune system, characterized by inflammation and excessive skin cell growth. Dendritic cells, T lymphocytes, and keratinocytes play key roles in the development of psoriasis, while the IL-23/IL-17 pathway contributes to disease progression. Adipokines secreted by adipose tissue, such as adiponectin, leptin, visfatin, and resistin, have immunomodulatory effects and may influence the progression or suppression of psoriasis. Understanding the relationship between psoriasis and adipokines could lead to new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)