Article
Neurosciences
Mariacristina Siotto, Marco Germanotta, Massimo Santoro, Valeria Cipollini, Giulia Guardati, Dionysia Papadopoulou, Elisa Bray, Alessia Mastrorosa, Irene Aprile
Summary: A pilot study involving 30 stroke patients found that serotonin levels significantly decreased after rehabilitation treatment, and this decrease was associated with worsened cognitive performance.
Article
Clinical Neurology
Shaozhen Ji, Hong Sun, Xianglan Jin, Baoxin Chen, Jing Zhou, Jiayi Zhao, Xiao Liang, Wei Shen, Yunling Zhang, Piu Chan
Summary: This study investigated cognitive outcomes in patients with post-stroke subjective cognitive complaints (SCC) within 1 year after stroke and identified factors associated with cognitive recovery. It found that some patients experienced cognitive recovery after stroke, but those with a higher education level reporting SCC earlier had poorer cognitive recovery. Male sex, higher baseline MoCA scores, coffee intake, and thalamus lesions appeared to independently predict cognitive recovery.
FRONTIERS IN NEUROLOGY
(2022)
Article
Nutrition & Dietetics
Kaoru Honaga, Naoki Mori, Tomonori Akimoto, Masahiro Tsujikawa, Michiyuki Kawakami, Tomoyuki Okamoto, Yasuyuki Sakata, Hirokazu Hamano, Yasuhiro Takeda, Kunitsugu Kondo
Summary: This study investigated the impact of whey protein and vitamin D supplementation on muscle mass and quality in post-stroke convalescent rehabilitation patients. The results showed that supplementation with whey protein and vitamin D reduced fat infiltration into the muscles. However, there were no significant differences in muscle strength and daily life activity between the groups. Long-term follow-up studies are needed to confirm the substantial benefits of this nutritional intervention for stroke survivors.
Article
Clinical Neurology
Veronika Vadinova, Aleksi J. Sihvonen, Kimberley L. Garden, Laura Ziraldo, Tracy Roxbury, Kate O'Brien, David A. Copland, Katie L. McMahon, Sonia L. E. Brownsett
Summary: This study investigated the relationship between premorbid WMH severity and longitudinal comprehension and production outcomes in aphasia. Severe WMH were found to contribute to impaired language comprehension but not production in individuals with aphasia. The findings highlight the importance of considering different language domains when studying predictors of aphasia recovery.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Behavioral Sciences
Shu-Mei Hao, Zhi-Gang Zhong, Wei-Min Qu, Zhi-Li Huang, Feng-Yan Sun, Mei-Hong Qiu
Summary: The study found that daily intraperitoneal administration of melatonin during the subacute phase after stroke significantly reduces brain tissue damage, improves motor function deficits, and promotes sleep quality by modulating sleep patterns. Melatonin treatment not only helps with neuronal survival and motor recovery, but also alleviates post-stroke sleep disturbances.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Melissa D. Stockbridge, Andreia V. Faria, Julius Fridriksson, Chris Rorden, Leonardo Bonilha, Argye E. Hillis
Summary: This study aimed to examine changes to connectivity after aphasia treatment in the first 3 months post-stroke. The results showed that high responders had significantly greater changes in connectivity with the left hemisphere language network compared to low responders. These findings suggest that post-treatment recovery primarily involves proximal connectivity restoration and may also reflect contralateral compensatory reorganization.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Bruna M. Giglio, Patricia C. B. Lobo, Gustavo D. Pimentel
Summary: The aim of this review was to analyze the effects of whey protein supplementation on body weight, fat mass, lean mass and glycemic parameters in overweight or type 2 diabetes mellitus (T2DM) subjects undergoing calorie restriction or with ad libitum intake. Although whey protein supplementation has shown positive effects on improving satiety and postprandial glycemic control, its effects in the treatment of overweight, obese individuals and those with T2DM undergoing calorie restriction or ad libitum intake are still inconclusive.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Medicine, General & Internal
Dong Hyuk Yun, Min Kyun Sohn, Jae Eun Choi, Sungju Jee
Summary: This study aimed to evaluate the intra-tester reliability of EEG-based spectral features and auditory/visual P300 latency/amplitude for subacute ischemic stroke patients. The findings showed significant reliability in EEG-based spectral characteristics and P300 latency with moderate ICC levels, indicating the potential for objective assessment of cognitive impairment in stroke patients.
Article
Clinical Neurology
Daisuke Ito, Michiyuki Kawakami, Ryota Ishii, Masahiro Tsujikawa, Kaoru Honaga, Kunitsugu Kondo, Tetsuya Tsuji
Summary: This study found that the cognitive function of patients with subacute stroke at admission is significantly associated with their discharge destination, with patients having better cognitive function more likely to be discharged home.
Article
Clinical Neurology
Jeannette Hofmeijer, Florien Ham, Gert Kwakkel
Summary: Repetitive transcranial magnetic stimulation has the potential to improve motor and cognitive outcomes after stroke, but the evidence of efficacy is challenged by unexplained variability in small sampled trials. Future large trials should collect individual patient data and conduct sufficiently powered subgroup analyses, as well as protocolized time-locked training of target behavior.
Article
Clinical Neurology
Jongwook Kim, Byoungwoo Cha, Doyoung Lee, Jong Moon Kim, MinYoung Kim
Summary: High-frequency rTMS over the ipsilesional DLPFC has beneficial effects on cognition and mood recovery in patients with subacute stroke. The improvement in cognitive abilities is more significant in patients with left hemispheric lesions, while patients with right hemispheric lesions show greater improvement in cognition.
FRONTIERS IN NEUROLOGY
(2022)
Article
Otorhinolaryngology
Jei Hak Myung, Sung-Bom Pyun
Summary: The study aimed to investigate the impact of post-stroke oral apraxia on dysphagia in patients with subacute stroke. The results showed that oral apraxia was significantly associated with dysphagia, especially in the oral and pharyngeal phases of swallowing. These findings highlight the importance of a formal assessment of oral apraxia in stroke patients with dysphagia.
Article
Clinical Neurology
Yuling Zhang, Haixin Song, Jun Wang, Xiao Xi, Philip Cefalo, Lisa J. J. Wood, Xun Luo, Qing Mei Wang
Summary: This study investigated the correlation between inflammation and post-stroke cognitive function in the subacute phase and found that serum cytokine levels had minimal predictive value for cognitive recovery.
FRONTIERS IN NEUROLOGY
(2022)
Article
Plant Sciences
Yule Wang, Huimin Wu, Zhu Han, Hongda Sheng, Yuhan Wu, Yingchao Wang, Xinran Guo, Yan Zhu, Xuecai Li, Yi Wang
Summary: This study explored the potential therapeutic possibilities of Guhong injection (GHI) for neurological and behavioral recovery after stroke and investigated the underlying molecular mechanisms and active substances. The results showed that GHI treatment improved post-stroke neural and locomotor function recovery, reduced infarct volume and histopathological damage to the cerebral cortex in mice. Network pharmacology analysis revealed that GHI's anti-stroke effect was closely related to inflammatory and apoptotic pathways. The identified active substances in GHI acted synergistically on core targets, including hydroxysafflor yellow A and baicalin.
Article
Neurosciences
Irene Aprile, Giulia Guardati, Valeria Cipollini, Dionysia Papadopoulou, Serena Monteleone, Alessandra Redolfi, Romina Garattini, Gianluigi Sacella, Fulvia Noro, Silvia Galeri, Maria Chiara Carrozza, Marco Germanotta
Summary: This study found that cognitive functions have an impact on the rehabilitation outcomes of stroke patients undergoing robotic upper limb rehabilitation. Deficits in spatial attention and executive functions affected improvement in daily living and mobility, while deficits in language, number processing, and spatial attention reduced gains in motor function.
Article
Nutrition & Dietetics
Roberto Aquilani, Alfredo Costa, Roberto Maestri, Matteo Cotta Ramusino, Antonia Pierobon, Maurizia Dossena, Sebastiano Bruno Solerte, Anna Maria Condino, Valeria Torlaschi, Paola Bini, Mirella Boselli, Mauro Ceroni, Daniela Buonocore, Federica Boschi, Mariella Bruni, Manuela Verri
Review
Biochemistry & Molecular Biology
Simona Viglio, Paolo Iadarola, Maura D'Amato, Jan Stolk
Review
Biochemistry & Molecular Biology
Simona Viglio, Elisabeth G. Bak, Iris G. M. Schouten, Paolo Iadarola, Jan Stolk
Summary: Alpha1-antitrypsin deficiency (AATD) is a known genetic cause of chronic obstructive pulmonary disease (COPD) that can lead to respiratory problems at a young age. AAT augmentation therapy is currently the only available treatment for AATD, but its efficacy in protecting lung function decline is still under debate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Laura Pandolfi, Roberta Fusco, Vanessa Frangipane, Ramona D'Amico, Marco Giustra, Sara Bozzini, Monica Morosini, Maura D'Amato, Emanuela Cova, Giuseppina Ferrario, Patrizia Morbini, Miriam Colombo, Davide Prosperi, Simona Viglio, Davide Piloni, Rosanna Di Paola, Salvatore Cuzzocrea, Federica Meloni
SCIENTIFIC REPORTS
(2020)
Article
Nutrition & Dietetics
Roberto Aquilani, Roberto Maestri, Maurizia Dossena, Maria Teresa La Rovere, Daniela Buonocore, Federica Boschi, Manuela Verri
Summary: This retrospective study found that patients with cardiorenal syndrome type 2 had significantly reduced plasma amino acid concentrations, independent of the degree of glomerular filtration rate (GFR) damage, but correlated with hemodynamic variables.
Article
Biochemistry & Molecular Biology
Antonella De Palma, Anna Maria Agresta, Simona Viglio, Rossana Rossi, Maura D'Amato, Dario Di Silvestre, Pierluigi Mauri, Paolo Iadarola
Summary: Nasu-Hakola Disease (NHD) is a rare genetic disorder related to TREM2 and DAP12 genes, with a lack of molecular or proteomic studies. This study used MudPIT technology to characterize protein expression trends and pathways in NHD, identifying potential biomarkers for neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Roberto Aquilani, Alfredo Costa, Roberto Maestri, Matteo Cotta Ramusino, Giulia Perini, Mirella Boselli, Paolo Iadarola, Daniela Buonocore, Manuela Verri, Maurizia Dossena, Federica Boschi
Summary: The levels of amino acids in cerebrospinal fluid (CSF) are lower in Alzheimer Disease (AD) patients compared to control subjects, and these levels are dependent on the nutritional state. CSF/plasma amino acid ratios are also decreased in AD patients.
Article
Plant Sciences
Enrico Doria, Daniela Buonocore, Antonio Marra, Valeria Bonta, Andrea Gazzola, Maurizia Dossena, Manuela Verri, Cinzia Calvio
Summary: The utilization of vegetable waste for the recovery of bioactive compounds using the enzymes produced by Bacillus subtilis is a safe, cheap, and sustainable approach that can enhance the sustainability of the food production system.
Article
Biochemistry & Molecular Biology
Maria Antonietta Grignano, Stefania Bruno, Simona Viglio, Maria Antonietta Avanzini, Marta Tapparo, Marina Ramus, Stefania Croce, Chiara Valsecchi, Eleonora Francesca Pattonieri, Gabriele Ceccarelli, Federica Manzoni, Annalia Asti, Carmelo Libetta, Vincenzo Sepe, Paolo Iadarola, Marilena Gregorini, Teresa Rampino
Summary: In this study, a new organ-conditioning strategy based on MSCs/EVs delivery was proposed. The results demonstrated that EVs can protect against renal ischemia-reperfusion injury by activating the CD73/ADO system, suggesting potential clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maura D'Amato, Valentina Vertui, Laura Pandolfi, Sara Bozzini, Tommaso Fossali, Riccardo Colombo, Anna Aliberti, Marco Fumagalli, Paolo Iadarola, Camilla Dido, Simona Viglio, Federica Meloni
Summary: Neutrophils play a pathogenic role in COVID-19 by releasing Neutrophil Extracellular Traps (NETs) or human neutrophil elastase (HNE). Despite the high levels of HNE and alpha 1-antitrypsin (AAT) in bronchoalveolar lavage fluid (BALf) samples from COVID-19 patients, the formation of HNE-AAT complex was not observed. Additionally, while binding to histones, AAT does not prevent NET formation or their harmful activity.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Oncology
Roberto Aquilani, Silvia Brugnatelli, Roberto Maestri, Federica Boschi, Beatrice Filippi, Lorenzo Perrone, Annalisa Barbieri, Daniela Buonocore, Maurizia Dossena, Manuela Verri
Summary: Alterations in the immune system, particularly changes in lymphocyte percentages within total white blood cell counts, play a crucial role in predicting chemotolerance and survival time in pancreatic carcinoma patients. A lymphocyte percentage of greater than 29.7% was found to be a more effective predictor of chemotolerance and survival compared to absolute lymphocyte values or the lower limit of normal lymphocyte percentages.
Article
Immunology
Roberto Aquilani, Ginetto C. Zuccarelli, Roberto Maestri, Mirella Boselli, Maurizia Dossena, Eleonora Baldissarro, Federica Boschi, Daniela Buonocore, Manuela Verri
Summary: This retrospective study found that supplementation of essential amino acids (EAAs) in elderly patients during rehabilitation was associated with a reduced inflammatory state. Patients who received supplements showed a decrease in C-reactive protein levels and an increase in circulating lymphocytes, while those who did not receive supplements did not show these improvements.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Hajer Tlili, Anca Macovei, Daniela Buonocore, Manuela Lanzafame, Hanen Najjaa, Anita Lombardi, Andrea Pagano, Maurizia Dossena, Manuela Verri, Abdelkarim Ben Arfa, Mohamed Neffati, Enrico Doria
Summary: The study analyzed the biochemical profile of main compounds present in Rhus tripartita leaf extract and investigated its anti-leukemic potential against AML THP-1 cells. The results indicated that Rhus tripartita extract controls THP-1 cell proliferation and apoptosis via regulation of the PI3K-Akt-mTOR signaling pathway.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Geriatrics & Gerontology
Roberto Aquilani, Ginetto Carlo Zuccarelli, Roberto Maestri, Carla Rutili, Mauro Colombo, Anna Maria Condino, Annalisa Barbieri, Alessandra Cecchetti, Simona Vanzati, Edi Bonazza, Franco Lafiandra, Daniela Buonocore, Manuela Verri, Maurizia Dossena, Federica Boschi
Summary: The study found that high levels of CRP are associated with unfavorable rehabilitation outcomes in elderly inpatients, and have predictive value in this regard. It is noteworthy that a significant proportion of patients with favorable rehabilitation outcomes still exhibit severe disabilities. Therefore, further research is needed to investigate the potential reduction of CRP levels and improvement of rehabilitation outcomes.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Food Science & Technology
Enrico Doria, Eleonora Boncompagni, Antonio Marra, Maurizia Dossena, Manuela Verri, Daniela Buonocore
Summary: The food system should support human health and respect environmental sustainability principles, including recycling food waste, using biotechnologies to ensure sustainability, and promoting awareness of reducing food consumption and waste. Agricultural waste is being explored as a low-cost source for high value-added product production, with bioactive compounds showing a wide range of biological activities.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2021)
