Article
Multidisciplinary Sciences
Sara M. Hendrickson, Archana Thomas, Kamm Prongay, Andrew J. Haertel, Laura M. Garzel, Leanne Gill, Tasha Barr, Nicholas S. Rhoades, Rachel Reader, Mark Galan, Julie M. Carroll, Charles T. Roberts, Lina Gao, Ian J. Amanna, Ilhem Messaoudi, Mark K. Slifka
Summary: Environmental enteric dysfunction (EED) is associated with malnutrition and infant growth stunting, and is characterized by small intestine pathologies. This study found that infant rhesus macaques exposed to enteric pathogens linked to human growth stunting showed EED and growth faltering, with histopathology also observed in the large intestine. The findings suggest that the large intestine may be an important target for intervention in EED.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Medicinal
Richard L. Guerrant, David T. Bolick, Jonathan R. Swann
Summary: Inexpensive animal models, such as mice, are valuable in evaluating the efficacy of potential interventions for enteric parasitic and bacterial infections, which are common global health concerns. Dietary deficiencies have significant effects on diarrhea and enteropathy outcomes in mice, with variations observed depending on the specific pathogens involved.
ACS INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Zemichael Gizaw, Alemayehu Worku Yalew, Bikes Destaw Bitew, Jiyoung Lee, Michael Bisesi
Summary: Stunting is a global public health issue, and one-third of children in rural areas of Ethiopia are affected. The prevalence of stunting is associated with poor dietary intake, poor hygiene and sanitation conditions, enteric infections, and environmental enteric dysfunction (EED).
SCIENTIFIC REPORTS
(2022)
Article
Veterinary Sciences
Alison C. Manchester, Steven Dow, Lyndah Chow, Jason Gagne, Michael R. Lappin
Summary: Exclusive feeding of an amino acid-based kibble (EL) improved clinical signs in dogs with chronic enteropathy (CE), and the changes in fecal microbiome were associated with the response to the diet.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Kanta Chandwe, Paul Kelly
Summary: There is increasing recognition of the importance of the mucosal barrier in gastrointestinal and systemic diseases. Bovine colostrum contains a variety of beneficial factors that have potential to contribute to mucosal healing in a range of conditions. Animal models demonstrate benefits in certain diseases, while human trials show efficacy in treating inflammatory bowel disease and infectious diarrhea. Further research is needed to better understand the role of bovine colostrum in therapy.
Review
Nutrition & Dietetics
Long T. Nguyen, Carol A. Pollock, Sonia Saad
Summary: The developmental programming hypothesis suggests that adverse environmental insults during critical developmental periods increase the risk of diseases in later life. Kidneys are susceptible to such insults, particularly due to peri-gestational nutrition, which affects kidney development and metabolism. Recent studies have identified oxidative stress, mitochondrial dysfunction, epigenetic modifications, and metabolic changes as potential novel pathways for therapeutic intervention.
Article
Medicine, General & Internal
Robert J. Schillinger, Simutanyi Mwakamui, Chola Mulenga, Mizinga Tembo, Phoebe Hodges, Ellen Besa, Kanta Chandwe, Victor O. Owino, Christine A. Edwards, Paul Kelly, Douglas J. Morrison
Summary: A C-13-SBT was developed that was easy to perform, generated clear enrichment of (CO2)-C-13 in breath samples, and clearly reports sucrase activity. Further work is needed to validate it and understand its applications in evaluating EE.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Anais Levescot, Georgia Malamut, Nadine Cerf-Bensussan
Summary: Coeliac disease is an immune enteropathy induced by genetic and environmental factors. The antigluten immune response and epithelial damage are key events in its pathogenesis, with the JAK/STAT pathway playing a crucial role. However, there are still many unanswered questions and challenges, such as the variability of the disease and improving the patients' quality of life.
Review
Veterinary Sciences
Virginie Gaillard, Sylvie Chastant, Gary England, Oliver Forman, Alexander J. German, Jan S. Suchodolski, Cecilia Villaverde, Pascale Chavatte-Palmer, Franck Peron
Summary: This article reviews the early-life risk factors for obesity, chronic enteropathy, and chronic behavioral problems in dogs and cats. It discusses the importance of understanding these risk factors in order to improve preventive veterinary care and husbandry practices. The article also explores the challenges of studying developmental origins of health and disease (DOHaD) in these species and proposes strategies to increase knowledge in this area.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Wan Yan Zhou, Xiu Ying Liu, Ming Ming Wang, Li Ping Liang, Le Liu, De Kai Zheng, Jocelyn A. Silvester, Wen Jun Ma, Wei Wu, Gui Yuan Ji, Yan Jun Xu, Xiao Jun Xu, Ciaran P. Kelly, Ye Chen
Summary: The seroprevalence of CD in the general Chinese population was 0.27%, while that in the high-risk population was 8.34%. Biopsy-confirmed CD prevalence in high-risk Chinese populations was 4.44%. Seroprevalence varied with geographical origin, being higher in northern China. Early diagnosis by serological screening and generous testing in those with vague symptoms, especially in northern China, are recommended.
JOURNAL OF DIGESTIVE DISEASES
(2021)
Review
Endocrinology & Metabolism
Michael Mah, Mark Febbraio, Sarah Turpin-Nolan
Summary: Biomarkers play crucial roles in describing biological processes and monitoring intervention strategies. Lipid biomarkers are used in clinical settings to predict and monitor metabolic diseases, such as specific circulating ceramides as predictors of cardiovascular disease and type 2 diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Yusriya Al Rawahi, Omar Al Sunaidi, Mohammed Al-Masqari, Adawiya Al Jamei, Dafalla Rahamtalla, Almundher Al-Maawali
Summary: Biallelic SPINT2 pathogenic variants can cause congenital diarrhea and enteropathy, but this study reported a case where the patient only presented with diarrhea symptoms and had no additional extra-intestinal features. The patient was found to have a novel homozygous variant in the SPINT2 gene, and in vitro functional studies confirmed the loss of inhibitory activity of intestinal serine proteases caused by this variant.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Medicine, General & Internal
Benjamin S. Daines, Alfred Kankam, Sadia Tanami, Rajesh Nambiar
Summary: Chronic use of olmesartan can lead to rare drug-induced enteropathy, causing symptoms such as diarrhea, weight loss, and reduced quality of life. The mechanism of this enteropathy is poorly understood, posing challenges in diagnosis.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Yue Sun, Changsen Leng, Sven C. D. van Ijzendoorn
Summary: Microvillus inclusion disease (MVID) is a rare congenital disorder characterized by severe diarrhea, dehydration, and weight loss. A retrospective study of 117 MVID cases suggests that fetal bowel abnormalities identified by prenatal ultrasound are present in approximately 60% of cases and correlate with postnatal symptoms and risk of fatality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Adrienne Clermont, Rodney Sufra, Jean Lookens Pierre, Michelle Nour Mourra, Elizabeth L. Fox, Vanessa Rouzier, Eliezer Dade, Stephano St-Preux, Joseph Inddy, Hilaire Erline, Fleurijean Pierre Obed, Lily D. Yan, Miranda Metz, Myung Hee Lee, Daniel W. Fitzgerald, Marie Marcelle Deschamps, Jean W. Pape, Margaret L. McNairy
Summary: Poor diets contribute to the high burden of noncommunicable diseases in Haiti, particularly among low-income adults. Inadequate intake of fruits and vegetables, high consumption of fried food and sugar-sweetened beverages, and the preference for adding salt and oil to meals are the key dietary patterns observed. Young males of low socioeconomic status present the highest risk. Public health campaigns targeting this population group, particularly household cooks, are necessary to address the growing NCD burden.
Article
Nutrition & Dietetics
Benjamin J. J. McCormick, Stephanie A. Richard, Laura E. Murray-Kolb, Gagandeep Kang, Aldo A. M. Lima, Estomih Mduma, Margaret N. Kosek, Elizabeth T. Rogawski McQuade, Eric R. Houpt, Pascal Bessong, Sanjaya Shrestha, Zulfiqar Bhutta, Tahmeed Ahmed, Laura E. Caulfield
Summary: This study found that exclusive breastfeeding for the first 6 months of life was associated with a lower likelihood of detecting certain enteric pathogens and delayed the first detection of some bacterial and viral pathogens in stool samples.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Andrew E. Rosselot, Miri Park, Mari Kim, Toru Matsu-Ura, Gang Wu, Danilo E. Flores, Krithika R. Subramanian, Suengwon Lee, Nambirajan Sundaram, Taylor R. Broda, Heather A. McCauley, Jennifer A. Hawkins, Kashish Chetal, Nathan Salomonis, Noah F. Shroyer, Michael A. Helmrath, James M. Wells, John B. Hogenesch, Sean R. Moore, Christian Hong
Summary: The study shows that human intestinal organoids and enteroids exhibit circadian rhythms and demonstrate circadian phase-dependent responses to Clostridium difficile toxin B. Mouse and human enteroids display anti-phasic necrotic cell death responses to TcdB.
Article
Nutrition & Dietetics
Mark D. DeBoer, Sarah E. Elwood, James A. Platts-Mills, Elizabeth T. Rogawski McQuade, Joann M. McDermid, Rebecca J. Scharf, Samwel Jatosh, Estomih Mduma
Summary: The study found that male infants showed poorer growth compared to females in the first 6 months, but only had smaller head circumference at 9 months. Illness or hospitalization were not found to be mediators of growth differences between genders, but at 3 months, male infants with reported illness exhibited greater decline in weight compared to females.
JOURNAL OF NUTRITION
(2022)
Article
Environmental Sciences
Josh M. Colston, Benjamin F. Zaitchik, Hamada S. Badr, Eleanor Burnett, Syed Asad Ali, Ajit Rayamajhi, Syed M. Satter, Daniel Eibach, Ralf Krumkamp, Jurgen May, Roma Chilengi, Leigh M. Howard, Samba O. Sow, M. Jahangir Hossain, Debasish Saha, M. Imran Nisar, Anita K. M. Zaidi, Suman Kanungo, Inacio Mandomando, Abu S. G. Faruque, Karen L. Kotloff, Myron M. Levine, Robert F. Breiman, Richard Omore, Nicola Page, James A. Platts-Mills, Ulla Ashorn, Yue-Mei Fan, Prakash Sunder Shrestha, Tahmeed Ahmed, Estomih Mduma, Pablo Penatero Yori, Zulfiqar Bhutta, Pascal Bessong, Maribel P. Olortegui, Aldo A. M. Lima, Gagandeep Kang, Jean Humphrey, Andrew J. Prendergast, Robert Ntozini, Kazuhisa Okada, Warawan Wongboot, James Gaensbauer, Mario T. Melgar, Tuula Pelkonen, Cesar Mavacala Freitas, Margaret N. Kosek
Summary: Diarrheal disease, a major health problem for children, is influenced by climate factors such as temperature, humidity, and soil moisture. This study analyzed data from multiple countries and found that different enteropathogens have different responses to climate variables. Temperature, soil moisture, and humidity are particularly influential parameters, and climate change may lead to shifts in the relative burden of diarrhea-causing agents.
Article
Nutrition & Dietetics
Samilly Albuquerque Ribeiro, Francisco Adelvane de Paula Rodrigues, Marco Antonio de Freitas Clementino, Herlice do Nascimento Veras, Rommulo Celly Lima Siqueira, Pedro Henrique Quintela Soares de Medeiros, Jeanine Morais Pereira, Marcio Flavio Araujo Guanabara Junior, Jose Kleybson de Sousa, Ana Karolina Silva Santos, Armenio Aguiar dos Santos, Bruna Leal Lima Maciel, Alexandre Havt, Aldo Angelo Moreira Lima
Summary: This study evaluated the impact of a nutrient-deficient diet on physical development and intestinal barrier function in mice. The results showed that the nutrient-deficient diet reduced weight and weight gain, and led to changes in intestinal barrier function and increased intestinal permeability.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Virology
Marco Clementino, Karene F. Cavalcante, Vania A. F. Viana, Dayara de Oliveira Silva, Caroline R. Damasceno, Jessica Fernandes de Souza, Rafhaella N. D. G. Gondim, Daniel M. de Melo Jorge, Lyvia M. V. C. Magalhaes, Erico A. G. de Arruda, Roberto da J. P. Neto, Melissa S. Medeiros, Arnnenio A. dos Santos, Pedro J. C. Magalhaes, Liana P. Mello, Eurico Arruda, Aldo A. M. Lima, Alexandre Havt
Summary: This study adopted the RT-LAMP technique to detect SARS-Cov-2 in patient samples and compared it with the RT-qPCR technique. The results showed that the RT-LAMP technique using primers N5 and Orf9 had a sensitivity of 96% and specificity of 85%, with accurate diagnosis obtained only in nasopharyngeal swabs processed via an extraction kit.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Beena Koshy, Manikandan Srinivasan, Sowmiya Gopalakrishnan, Venkata Raghava Mohan, Rebecca Scharf, Laura Murray-Kolb, Sushil John, Rachel Beulah, Jayaprakash Muliyil, Gagandeep Kang
Summary: This study found that persistent stunting in childhood is associated with a decrease in cognitive ability at 9 years of age. Children who experience catch-up growth show higher cognition scores compared to those who experience persistent stunting.
Article
Immunology
Godfrey Guga, Sarah Elwood, Caroline Kimathi, Gagandeep Kang, Margaret N. Kosek, Aldo A. M. Lima, Pascal O. Bessong, Amidou Samie, Rashidul Haque, Jose Paulo Leite, Ladaporn Bodhidatta, Najeeha Iqbal, Nicola Page, Ireen Kiwelu, Zulfiqar A. Bhutta, Tahmeed Ahmed, Jie Liu, Elizabeth T. Rogawski McQuade, Eric Houpt, James A. Platts-Mills, Estomih R. Mduma
Summary: This study describes the incidence, risk factors, clinical characteristics, and seasonality of adenovirus 40/41 diarrhea. Adenovirus 40/41 diarrhea is a common condition in children, especially infants. Children with adenovirus 40/41 diarrhea are more likely to have a fever compared to other viral etiologies, and exclusive breastfeeding can reduce the burden of this illness.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Nutrition & Dietetics
Eva Debora de Oliveira Andrade, Amanda de Sousa Reboucas, Jose Q. Filho, Ramya Ambikapathi, Laura E. Caulfield, Aldo Angelo Moreira Lima, Bruna Leal Lima Maciel
Summary: The study reveals a decline in the quality of infant feeding practices over the first 2 years of life, with a decrease in breastfeeding and an increase in the consumption of unhealthy and ultra-processed foods.
MATERNAL AND CHILD NUTRITION
(2022)
Article
Engineering, Biomedical
Amir Bein, Cicely W. Fadel, Ben Swenor, Wuji Cao, Rani K. Powers, Diogo M. Camacho, Arash Naziripour, Andrew Parsons, Nina LoGrande, Sanjay Sharma, Seongmin Kim, Sasan Jalili-Firoozinezhad, Jennifer Grant, David T. Breault, Junaid Iqbal, Asad Ali, Lee A. Denson, Sean R. Moore, Rachelle Prantil-Baun, Girija Goyal, Donald E. Ingber
Summary: This study demonstrates the reconstitution of essential features of EED-associated intestinal injury in a human intestine-on-a-chip model. The model can be used to analyze the molecular, genetic, and nutritional bases of EED, as well as test potential therapeutics.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Elizabeth T. Rogawski McQuade, Stephanie A. Brennhofer, Sarah E. Elwood, Timothy L. McMurry, Joseph A. Lewnard, Estomih R. Mduma, Sanjaya Shrestha, Najeeha Iqbal, Pascal O. Bessong, Gagandeep Kang, Margaret Kosek, Aldo A. M. Lima, Tahmeed Ahmed, Jie Liu, Eric R. Houpt, James A. Platts-Mills
Summary: Children in low-resource settings often carry enteric pathogens without symptoms and are frequently exposed to antibiotics unknowingly. This study found that most antibiotic exposures were not targeted towards the pathogens causing the infection. Respiratory infections and diarrheal illnesses were the main causes of pathogen exposure. Bystander exposure of E. coli to antibiotics was associated with community-level resistance. Antimicrobial stewardship and illness-prevention interventions in low-resource settings could significantly reduce bystander selection and contribute to antimicrobial resistance prevention.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Nutrition & Dietetics
Mariana Duarte Bona, Carlos Henrique de Medeiros Torres, Severina Carla Vieira Cunha Lima, Ana Heloneida de Araujo Morais, Aldo Angelo Moreira Lima, Bruna Leal Lima Maciel
Summary: This systematic review assessed the association between obesity with or without MetS and alteration of intestinal barrier permeability in humans. A total of eight studies were included and categorized as moderate to high quality. The findings suggested that impaired intestinal barrier permeability was positively associated with obesity with MetS. However, the evidence quality was assessed to be very low to low according to the GRADE framework.
Article
Infectious Diseases
Elizabeth T. Rogawski McQuade, Rebecca J. Scharf, Erling Svensen, Amber Huggins, Angelina Maphula, Eliwaza Bayo, Ladislaus Blacy, Paula Pamplona E. de Souza, Hilda Costa, Eric R. Houpt, Pascal O. Bessong, Estomih R. Mduma, Aldo A. M. Lima, Richard L. Guerrant
Summary: This study found that Shigella infections and early life inflammation may have an impact on growth and cognitive outcomes during school-aged years among children in low-resource settings. High prevalence of Shigella was associated with lower height-for-age z-score at 6-8 years. However, the associations between Shigella burden and cognitive outcomes were smaller and observed only in the Brazil and Tanzania sites.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Tyciane S. Nascimento, Daniel Pinto, Ronaldo P. Dias, Ramon S. Raposo, Paulo Iury G. Nunes, Cassia R. Roque, Flavia A. Santos, Geanne M. Andrade, Jose Lucas Viana, Anne H. Fostier, Alessandra Sussulini, Jacqueline Alvarez-Leite, Carlos Fontes-Ribeiro, Joao O. Malva, Reinaldo B. Oria
Summary: This study evaluated the effects of chronic methylmercury exposure on adult mice, revealing that methylmercury leads to increased weight gain, elevated lipid and inflammation levels, oxidative stress in the hippocampus, altered amino acid levels, neuroinflammation, and negative behavioral effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Reinaldo B. Oria, Deiziane V. S. Costa, Pedro Henrique Q. S. de Medeiros, Cassia R. Roque, Ronaldo P. Dias, Cirle A. Warren, David T. Bolick, Richard L. Guerrant
Summary: This study aims to identify new biomarkers related to gut-brain axis dysfunction in children suffering from malnutrition and infection, and provides new insights into potential intervention strategies. The research found that MPO, a neutrophil-related tissue factor released during enteropathy, could drive gut-derived brain inflammation. Using a mouse model, the study showed that undernourished mice infected with Cryptosporidium displayed higher levels of intestinal inflammation markers, systemic inflammation markers, and brain inflammation markers.
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2023)