Review
Immunology
Aysegul Aksan, Karima Farrag, Sami Aksan, Oliver Schroeder, Juergen Stein
Summary: This passage discusses the relationship between iron deficiency and cancer, highlighting the impact of iron deficiency on colorectal cancer incidence and treatment response. It emphasizes the importance of balancing iron intake to avoid both deficiencies and excesses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Oliver Phipps, Matthew J. Brookes, Hafid O. Al-Hassi
Summary: Iron levels play a crucial role in the pathogenesis of colorectal cancer, with both excessive and insufficient iron intake being associated with negative outcomes on cancer immunosurveillance and treatment response.
Review
Oncology
Luji Huang, Wangji Li, Yan Lu, Qinuo Ju, Manzhao Ouyang
Summary: Iron, an essential trace element in the human body, plays a crucial role in various biochemical reactions and physiological processes. It is associated with the occurrence and development of colorectal cancer. While iron deficiency can induce cell apoptosis, it can also lead to the production of harmful free radicals. Dietary iron, especially heme iron, is believed to be one of the leading causes of colorectal cancer. Abnormal iron metabolism is observed in patients with colorectal cancer, affecting absorption, storage, utilization, and exportation. Understanding the alterations in iron metabolism during the onset and advancement of colorectal cancer can provide new insights into the role and mechanism of iron in the body.
FRONTIERS IN ONCOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Amina Selimovic, Goknur Kara, Emir Baki Denkbas
Summary: In this study, gelatin-coated magnetic iron oxide nanoparticles loaded with mTOR-silencing siRNA were synthesized and demonstrated to have a significant therapeutic effect in colorectal cancer cells. Compared with a commercial siRNA transfection reagent, these nanoparticles showed similar or better inhibition of cell viability.
MATERIALS TODAY COMMUNICATIONS
(2022)
Review
Gastroenterology & Hepatology
Zikai Wang, Wanyue Dan, Nana Zhang, Jingyuan Fang, Yunsheng Yang
Summary: Colorectal cancer is on the rise in China, possibly due to economic development, lifestyle changes, and dietary habits. The gut microbiota plays a crucial role in the development of colorectal cancer, with dysbiosis, specific pathogenic microbes, metabolites, virulence factors, and microbial carcinogenic mechanisms all contributing to its initiation and progression. Gut microbiota biomarkers have potential applications in screening and diagnosing colorectal cancer, while interventions targeting the gut microbiota could improve treatment efficacy and reduce intestinal toxic effects. Chinese researchers have made significant progress in understanding the role of gut microbiota in colorectal cancer, but further studies are needed to explore the underlying mechanisms and develop novel therapeutic and preventive strategies.
Article
Gastroenterology & Hepatology
Paulina Wieszczy, Elisabeth Waldmann, Magnus Loberg, Jaroslaw Regula, Maciej Rupinski, Marek Bugajski, Kathryn Gray, Mette Kalager, Monika Ferlitsch, Michal F. Kaminski, Michael Bretthauer
Summary: The study showed that the performance of colonoscopists may affect colorectal cancer risk after adenoma removal. Individuals with low-risk or high-risk adenomas examined by low-performing colonoscopists had significantly higher colorectal cancer incidence compared to those examined by high-performing colonoscopists.
Review
Oncology
Saverio Caini, Sofia Chioccioli, Elisa Pastore, Miriam Fontana, Katia Tortora, Giovanna Caderni, Giovanna Masala
Summary: This study conducted a meta-analysis to investigate the association between fish consumption and colorectal cancer (CRC) risk, and found that increased fish consumption may protect against CRC development. Preclinical studies also identified multiple mechanisms through which fish components can inhibit colorectal carcinogenesis. These findings have important implications for dietary recommendations for cancer prevention.
Review
Food Science & Technology
Burhan Basaran, Burcu Cuvalci, Guzin Kaban
Summary: Acrylamide, a potential carcinogenic compound, is a contaminant formed during the thermal processing of various commonly consumed foods. The health risks associated with acrylamide exposure are still not fully understood, leading to extensive research on its relationship with cancer risk. This study focused on epidemiological research, specifically examining the associations between dietary acrylamide exposure and cancer risk.
Article
Oncology
Xuan Zhou, Lijuan Wang, Jiarui Xiao, Jing Sun, Lili Yu, Han Zhang, Xiangrui Meng, Shuai Yuan, Maria Timofeeva, Philip J. Law, Richard S. Houlston, Kefeng Ding, Malcolm G. Dunlop, Evropi Theodoratou, Xue Li
Summary: Alcohol consumption is associated with colorectal cancer risk, and DNA methylation may be one of the mechanisms by which alcohol exerts its carcinogenic effect on colorectal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Devin Abrahami, Emily Gibson McDonald, Mireille E. Schnitzer, Alan N. Barkun, Samy Suissa, Laurent Azoulay
Summary: The study found that while any use of PPIs did not increase the risk of colorectal cancer compared to H2RAs, prolonged use may be associated with a modest increased risk of this malignancy.
Article
Multidisciplinary Sciences
Minta Thomas, Yu-Ru Su, Elisabeth A. Rosenthal, Lori C. Sakoda, Stephanie L. Schmit, Maria N. Timofeeva, Zhishan Chen, Ceres Fernandez-Rozadilla, Philip J. Law, Neil Murphy, Robert Carreras-Torres, Virginia Diez-Obrero, Franzel J. B. van Duijnhoven, Shangqing Jiang, Aesun Shin, Alicja Wolk, Amanda I. Phipps, Andrea Burnett-Hartman, Andrea Gsur, Andrew T. Chan, Ann G. Zauber, Anna H. Wu, Annika Lindblom, Caroline Y. Um, Catherine M. Tangen, Chris Gignoux, Christina Newton, Christopher A. Haiman, Conghui Qu, D. Timothy Bishop, Daniel D. Buchanan, David R. Crosslin, David V. Conti, Dong-Hyun Kim, Elizabeth Hauser, Emily White, Erin Siegel, Fredrick R. Schumacher, Gad Rennert, Graham G. Giles, Heather Hampel, Hermann Brenner, Isao Oze, Jae Hwan Oh, Jeffrey K. Lee, Jennifer L. Schneider, Jenny Chang-Claude, Jeongseon Kim, Jeroen R. Huyghe, Jiayin Zheng, Jochen Hampe, Joel Greenson, John L. Hopper, Julie R. Palmer, Kala Visvanathan, Keitaro Matsuo, Koichi Matsuda, Keum Ji Jung, Li Li, Loic Le Marchand, Ludmila Vodickova, Luis Bujanda, Marc J. Gunter, Marco Matejcic, Mark A. Jenkins, Martha L. Slattery, Mauro D'Amato, Meilin Wang, Michael Hoffmeister, Michael O. Woods, Michelle Kim, Mingyang Song, Motoki Iwasaki, Mulong Du, Natalia Udaltsova, Norie Sawada, Pavel Vodicka, Peter T. Campbell, Polly A. Newcomb, Qiuyin Cai, Rachel Pearlman, Rish K. Pai, Robert E. Schoen, Robert S. Steinfelder, Robert W. Haile, Rosita Vandenputtelaar, Ross L. Prentice, Sebastien Kuery, Sergi Castellvi-Bel, Shoichiro Tsugane, Sonja I. Berndt, Soo Chin Lee, Stefanie Brezina, Stephanie J. Weinstein, Stephen J. Chanock, Sun Ha Jee, Sun-Seog Kweon, Susan Vadaparampil, Tabitha A. Harrison, Taiki Yamaji, Temitope O. Keku, Veronika Vymetalkova, Volker Arndt, Wei-Hua Jia, Xiao-Ou Shu, Yi Lin, Yoon-Ok Ahn, Zsofia K. Stadler, Bethany Van Guelpen, Cornelia M. Ulrich, Elizabeth A. Platz, John D. Potter, Christopher I. Li, Reinier Meester, Victor Moreno, Jane C. Figueiredo, Graham Casey, Iris Lansdorp Vogelaar, Malcolm G. Dunlop, Stephen B. Gruber, Richard B. Hayes, Paul D. P. Pharoah, Richard S. Houlston, Gail P. Jarvik, Ian P. Tomlinson, Wei Zheng, Douglas A. Corley, Ulrike Peters, Li Hsu
Summary: Polygenic risk scores (PRS) have the potential to guide precision colorectal cancer (CRC) prevention, but current PRS using European ancestry data do not perform well in non-European ancestry populations. In this study, Asian ancestry data was incorporated to improve the performance of PRS, and it was found to be significantly better in different racial and ethnic groups.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Carlotta Franchi, Ilaria Ardoino, Cristina Bosetti, Eva Negri, Diego Serraino, Anna Crispo, Attilio Giacosa, Elena Fattore, Alberto Dolci, Francesca Bravi, Federica Turati, Carlo La Vecchia, Barbara D'Avanzo
Summary: Canned fish consumption is inversely associated with colorectal cancer risk, with significant risk reduction observed for consuming one to two times per week and two or more times per week.
Review
Oncology
Golnoosh Goodarzi, Hadis Mozaffari, Tahereh Raeisi, Fatemeh Mehravar, Bahman Razi, Maryam Lafzi Ghazi, Nazila Garousi, Shahab Alizadeh, Parisa Janmohammadi
Summary: This study found through a meta-analysis that individuals with metabolically unhealthy normal-weight, metabolically healthy obesity, and metabolically unhealthy obesity have a higher risk of colorectal cancer compared to healthy normal-weight individuals, with significant associations in males but not in females.
Review
Medicine, Research & Experimental
Yunhan Wang, Zongying Zhang, Weichen Sun, Jie Zhang, Qiuyun Xu, Xiaorong Zhou, Liming Mao
Summary: Colorectal cancer is a common malignant tumor with unsatisfactory prognosis. Ferroptosis, a novel form of cell death, has shown success in eliminating cancer cells resistant to other forms of cell death. Therefore, ferroptosis may become a new direction for designing therapies for colorectal cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Mingjia Yang, Chen Zhu, Lingbin Du, Jianv Huang, Jiayi Lu, Jing Yang, Ye Tong, Meng Zhu, Ci Song, Chong Shen, Juncheng Dai, Xiangfeng Lu, Zekuan Xu, Ni Li, Hongxia Ma, Zhibin Hu, Dongfeng Gu, Guangfu Jin, Dong Hang, Hongbing Shen
Summary: Obesity is a major risk factor for colorectal cancer (CRC), but the metabolic mechanisms connecting the two are not fully known. This study used metabolomics data from two case-control studies to explore serum metabolites related to body mass index (BMI) and found a metabolomic signature for obesity. The signature was linearly associated with CRC risk in both US and Chinese cohorts. These findings shed light on the underlying mechanisms of CRC and are crucial for improving prevention strategies.