Article
Geriatrics & Gerontology
Dalila Scaturro, Fabio Vitagliani, Pietro Terrana, Sofia Tomasello, Lawrence Camarda, Giulia Letizia Mauro
Summary: The study evaluated the incidence of hypomagnesemia in patients with lateral fragility fracture and found that half of the patients had hypomagnesemia, with a higher incidence of the subclinical form. The treatment group showed significant improvements in blood magnesium levels, pain scores, functional assessments, and quality of life questionnaires.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Peng Wan, Weidan Wang, Lizhen Zheng, Ling Qin, Ke Yang
Summary: A novel one-step electrodeposition synthesis of drug loaded coating was proposed in this study to improve the treatment effect of osteoporotic fractures. The coating enhanced the proliferation and differentiation of osteoblasts, while showing no significant inhibition on osteoclasts.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Review
Nutrition & Dietetics
Darren G. Candow, Scott C. Forbes, Ben Kirk, Gustavo Duque
Summary: Sarcopenia, characterized by age-related reduction in muscle mass, strength, and physical performance, is associated with various age-related health conditions. Creatine supplementation, especially when combined with resistance training, shows promising effects on muscle, bone, and fat mass, as well as strength and physical performance in healthy older adults. However, more research is needed on the efficacy of creatine supplementation in older adults with specific conditions like osteoporosis and sarcopenic obesity.
Article
Nutrition & Dietetics
Jie Wang, Fei Xing, Ning Sheng, Zhou Xiang
Summary: This study explored the association between dietary magnesium intake and magnesium depletion score (MDS) among American adults with osteoporosis. The results showed a negative correlation between dietary magnesium intake and osteoporosis in individuals with magnesium intake below the recommended daily intake. The combination of MDS and dietary magnesium intake may be more comprehensive in screening for osteoporosis, and early monitoring and interventions may be necessary for those with insufficient dietary magnesium intake or high MDS scores.
FRONTIERS IN NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Nanfu Deng, Niharika Mallepally, Frederick B. Peng, Aleem Kanji, Marco Marcelli, Ruben Hernaez
Summary: Low serum testosterone is associated with increased morbidity and mortality in cirrhosis patients. Testosterone supplementation improved intermediate endpoints, but there was no conclusive data on clinical outcomes.
LIVER INTERNATIONAL
(2021)
Article
Nutrition & Dietetics
Hwee-Yeong Ng, Wei-Hung Kuo, You-Lin Tain, Foong-Fah Leung, Wen-Chin Lee, Chien-Te Lee
Summary: The prevalence of MetS is increasing, and there is a close link between hypomagnesemia and MetS. Administration of SGLT2 inhibitors has been reported to increase serum magnesium levels in patients with diabetes. In an animal model of MetS, high fructose intake combined with a low-magnesium diet induced MetS and hypomagnesemia. Dapagliflozin and magnesium sulfate supplementation improved the features of MetS and increased serum magnesium levels, with dapagliflozin enhancing TRPM6-mediated trans-epithelial magnesium transport in renal tubule cells.
Review
Nutrition & Dietetics
Ligia J. Dominguez, Nicola Veronese, Stefano Ciriminna, Jose Luis Perez-Albela, Vania Flora Vasquez-Lopez, Santiago Rodas-Regalado, Giovanna Di Bella, Angela Parisi, Federica Tagliaferri, Mario Barbagallo
Summary: This systematic review and meta-analysis aimed to investigate the impact of serum magnesium on the risk of fractures. Four papers with a total of 119,755 participants were included in the systematic review. The findings suggested that lower serum magnesium concentrations were associated with a significantly higher risk of incident fractures. Further research is needed to confirm these results in other populations and explore the potential role of serum magnesium in fracture prevention.
Article
Nutrition & Dietetics
Liam E. Fouhy, Kelsey M. Mangano, Xiyuan Zhang, Bess Dawson Hughes, Katherine L. Tucker, Sabrina E. Noel
Summary: This study aimed to investigate the association between the calcium-to-magnesium intake ratio and bone mineral density (BMD) and osteoporosis in Puerto Rican adults. The results showed that the highest and lowest tertiles of calcium intake had higher odds of osteoporosis compared to the middle tertile.
JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Eirini K. Kydonaki, Laura Freitas, Bruno M. Fonseca, Henrique Reguengo, Carlos Raposo Simon, Ana R. Bastos, Emanuel M. Fernandes, Raphael F. Canadas, Joaquim Miguel Oliveira, Vitor M. Correlo, Rui L. Reis, Maria Vliora, Parakevi Gkiata, Yiannis Koutedakis, Georgia Ntina, Rui Pinto, Andres E. Carrillo, Franklim Marques, Tania Amorim
Summary: The study has found that bovine colostrum supplementation positively affects bone metabolism in OVX and ORX rats, potentially through the activation of the VEGFA, FGF2, and RANKL/RANK/OPG signaling pathways.
Review
Medicine, General & Internal
Juan Carlos Sanchez-Garcia, Daniel Lopez Hernandez, Beatriz Piqueras-Sola, Jonathan Cortes-Martin, Andres Reinoso-Cobo, Maria Jose Menor-Rodriguez, Raquel Rodriguez-Blanque
Summary: This study conducted a systematic review to analyze the benefits of exercise and dietary supplements during menopause. The findings suggest that combining a nutritional supplementation plan with an exercise routine can help reduce symptoms and cope with menopause in a healthy way.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Lizhen Zheng, Le Huang, Ziyi Chen, Can Cui, Ri Zhang, Ling Qin
Summary: The study demonstrated that Mg++ supplementation successfully alleviated CS-induced muscle atrophy in rats at both functional and morphology levels, indicating translational potential for patients. This study provided evidence for the first time that Mg++ supplementation could prevent muscle atrophy, an adverse effect of CS therapy, also adopted for treating COVID-19.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Medicine, Research & Experimental
Runnan Xu, Liping Wang, Liyuan Sun, Jianghui Dong
Summary: Ischemic encephalopathy, especially ischemic stroke, is a leading cause of death and disability worldwide. The main treatment is reopening blocked blood vessels, although achieving good functional results is challenging. Magnesium, a natural calcium antagonist with neuroprotective effects, has shown potential in treating cerebral ischemia in basic studies, but clinical trials have been inconclusive. Different routes of magnesium supplementation and potential influencing factors need further exploration for future treatment directions.
Review
Veterinary Sciences
Michael Ivan Lindinger
Summary: Horses that sweat for prolonged periods lose considerable amounts of water and electrolytes. Oral electrolyte supplementation is an effective strategy to replace the lost water and electrolytes. Horses should be trained to voluntarily drink the electrolyte solution before and during transport, and before and after exercise.
VETERINARY SCIENCES
(2022)
Review
Nutrition & Dietetics
Mariangela Rondanelli, Gabriella Peroni, Federica Fossari, Viviana Vecchio, Milena Anna Faliva, Maurizio Naso, Simone Perna, Enrica Di Paolo, Antonella Riva, Giovanna Petrangolini, Mara Nichetti, Alice Tartara
Summary: Research has shown that ascorbic acid (AA) plays an important role in collagen synthesis. Studies indicate a positive correlation between AA dietary intake and bone mineral density (BMD), as well as a positive correlation between AA blood concentration and BMD. For postmenopausal women, supplementing with AA can lead to approximately 3% higher BMD values.
Review
Geriatrics & Gerontology
Elizabeth M. Curtis, Cyrus Cooper, Nicholas C. Harvey
Summary: Calcium supplementation in combination with vitamin D is recommended for bone health in those deficient in these nutrients, with no convincing evidence of cardiovascular risks associated. Magnesium supplementation does not have clear benefits for musculoskeletal outcomes, while higher dietary intake and serum concentrations are protective against cardiovascular events. Strontium ranelate, available as a generic medication, has anti-fracture efficacy but an increased risk of thromboembolic disease, while hypotheses of increased myocardial infarction risk have not been widely supported.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)