Review
Biochemistry & Molecular Biology
Alice Chaplin, Ramon Maria Rodriguez, Juan Jose Segura-Sampedro, Aina Ochogavia-Segui, Dora Romaguera, Gwendolyn Barcelo-Coblijn
Summary: Obesity is a major risk factor for colorectal cancer, and visceral adipose tissue may play a key role in tumor development and progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Barbara Politynska, Olga Pokorska, Anna M. Wojtukiewicz, Magdalena Sawicka, Marta Mysliwiec, Kenneth V. Honn, Stephanie C. Tucker, Marek Z. Wojtukiewicz
Summary: Cancer patients have a higher risk of developing depression, which can lead to decreased quality of life, worse prognosis, and higher mortality. The underlying pathophysiological mechanism connecting depression and cancer is still unclear, but recent studies have implicated neuroinflammatory mechanisms in the etiology of depression. These mechanisms may result in chronic inflammation in the brain, contributing to the development of depression. Three major routes, involving proinflammatory mediators, are likely implicated in cancer-related depression: the activation of the kynurenine pathway, impairment of the hypothalamic-pituitary-adrenal axis, and glutamate excitotoxicity via the glutamatergic pathway. Understanding these dysregulated mechanisms and other emerging pathways may provide insights for therapeutic targeting and improve the care of cancer patients.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Public, Environmental & Occupational Health
Farshad Teymoori, Ebrahim Mokhtari, Mitra Kazemi Jahromi, Hossein Farhadnejad, Parvin Mirmiran, Mohammadreza Vafa, Fereidoun Azizi
Summary: This study aimed to investigate the association of the Empirical Dietary Index for Hyperinsulinemia (EDIH) and Empirical Lifestyle Index for Hyperinsulinemia (ELIH) with the risk of obesity phenotypes among Iranian adults. The findings revealed that higher ELIH scores were associated with greater risks for MUO and MHO incidence, while higher EDIH scores were related to an increased risk of MUO but not MHO. This suggests that a high insulinemic potential of diet and lifestyle may lead to an increase in the simultaneous occurrence of obesity with metabolic disorders in Iranian adults.
Article
Nutrition & Dietetics
Yingxue Han, Hao Wu, Siyuan Sun, Rong Zhao, Yifan Deng, Shenming Zeng, Juan Chen
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in premenopausal women. It has a multifaceted etiology involving genetic and epigenetic factors, hormonal dysfunction, and insulin resistance. High-fat diets are associated with the development of metabolic disorders and worsen the consequences of PCOS by increasing insulin resistance and inflammatory adipokines. Effective management of PCOS requires lifestyle interventions and, in some cases, medical or surgical interventions.
Article
Biochemistry & Molecular Biology
Samrein B. M. Ahmed, Nada Radwan, Sara Amer, Narjes Saheb Sharif-Askari, Amena Mahdami, Kamel A. A. Samara, Rabih Halwani, Herbert F. F. Jelinek
Summary: Diabetes mellitus affects cellular functions through altered glucose metabolism and has been linked to cancer development. This study found that hyperglycemia combined with hyperinsulinemia has a potential effect on the progression of breast cancer cells, with differential expression of 45 genes observed. Additionally, 15 genes were found to be upregulated in breast tumor tissues of diabetic patients with breast cancer. These findings emphasize the importance of monitoring diabetes-related metabolic alterations in improving breast cancer outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Moniek van Zutphen, Hendriek C. Boshuizen, Marlou-Floor Kenkhuis, Evertine Wesselink, Anne J. M. R. Geijsen, Johannes H. W. de Wilt, Henk K. van Halteren, Ernst Jan Spillenaar Bilgen, Eric T. P. Keulen, Maryska L. G. Janssen-Heijnen, Stephanie O. Breukink, Martijn J. L. Bours, Dieuwertje E. Kok, Renate M. Winkels, Matty P. Weijenberg, Ellen Kampman, Franzel J. B. van Duijnhoven
Summary: The study found that having a healthy lifestyle and improving lifestyle after a colorectal cancer diagnosis does not increase the risk of cancer recurrence, but significantly reduces the risk of all-cause mortality.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Franck Paganelli, Giovanna Mottola, Julien Fromonot, Marion Marlinge, Pierre Deharo, Regis Guieu, Jean Ruf
Summary: The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains unclear. While HHCy is associated with inflammation and atherosclerosis, lowering homocysteine (HCy) levels does not significantly impact cardiovascular risk. However, the HCy degradation product hydrogen sulfide (H2S) may play a cardioprotective role in the cardiovascular system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Green & Sustainable Science & Technology
A. Frehner, H. H. E. Van Zanten, C. Schader, I. J. M. De Boer, G. Pestoni, S. Rohrmann, A. Muller
Summary: This study investigated the relationship between sociodemographic and lifestyle factors and different sustainability impacts of diets in Switzerland. Results showed that actions on food groups for health, social, or environmental reasons may affect societal groups differently, with reductions of some food groups, especially different types of meat, offering large potentials for synergies on multiple impact categories.
JOURNAL OF CLEANER PRODUCTION
(2021)
Review
Chemistry, Multidisciplinary
Kochurani K. Johnson, Pramod Koshy, Jia-Lin Yang, Charles C. Sorrell
Summary: Nanomaterials with cancer-imaging and therapeutic properties have been a major focus of nanotheranostics. Significant progress has been made in research and clinical applications, but careful examination and evaluation of their specific in vivo preclinical status are still needed. This is crucial for the clinical translation of nanotheranostic materials, as it helps improve understanding of their biocompatibility and therapeutic effects.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Oncology
Daniela Kalla, Krzysztof Flisikowski, Kaiyuan Yang, Laura Beltran Sanguesa, Mayuko Kurome, Barbara Kessler, Valeri Zakhartchenko, Eckhard Wolf, Heiko Lickert, Dieter Saur, Angelika Schnieke, Tatiana Flisikowska
Summary: The Cre/loxP system is essential for generating animal models with precise gene expression. While pigs may not replace mice in basic research, they offer complementary resources for translational studies. CRISPR/Cas9-mediated insertion of iCre into the porcine PTF1A gene allows for the generation of Cre-driver lines for modeling human cancers in large animals.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Genetics & Heredity
Claire Wilson, Aditi Kanhere
Summary: This study speculates on the potential role of variants of lncRNAs in cancer development by drawing upon emerging research findings.
TRENDS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Yi Xiao, Yaxu Wang, Haitao Gu, Zhiquan Xu, Yunhao Tang, Hongmei He, Linglong Peng, Ling Xiang
Summary: This study suggests that adherence to a plant-based paleolithic diet and paleolithic-like lifestyle may reduce the risk of colorectal cancer. These dietary and lifestyle approaches may work by reducing inflammation, oxidative stress, and insulin levels. The study also found a stronger inverse association between the lifestyle score and the risk of colorectal cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Peripheral Vascular Disease
Jun Kyoung, Rohit R. Atluri, Tao Yang
Summary: The gut microbiota plays a crucial role in drug metabolism, including antihypertensive drugs, and understanding this interaction may lead to better therapeutic outcomes. Resistant hypertension, a subset of patients with poor response to antihypertensive medications, is linked to the gut microbiota.
Review
Cell Biology
Nora J. Foegeding, Zachary S. Jones, Mariana X. Byndloss
Summary: Landmark discoveries in the gut microbiome field have opened up new research avenues aimed at elucidating the impact of microbiota in colorectal cancer. An important challenge lies in determining the contribution of inherently variable environmental factors to carcinogenesis. Future research focused on unraveling host-microbe interactions in the colon may influence medical insights related to the prevention and treatment of colorectal cancer.
DISEASE MODELS & MECHANISMS
(2021)
Article
Biochemistry & Molecular Biology
Xing Chang, Nur Izzah Ismail, Attaur Rahman, Dachun Xu, Renee Wan Yi Chan, Sang-Ging Ong, Sang-Bing Ong
Summary: Although COVID-19 has been categorized as an endemic, the long-term effect of the disease in causing multiorgan disorders, including cardiovascular dysfunction, is gaining attention. The role of cardiac mitochondria in mediating cardiac dysfunction post-SARS-CoV-2 infection remains unclear. Further studies are crucial to unravel the association between SARS-CoV-2 infection, mitochondrial dysfunction, and cardiovascular disorders.
ANTIOXIDANTS & REDOX SIGNALING
(2023)