Review
Biochemistry & Molecular Biology
Kamila P. Liput, Adam Lepczynski, Magdalena Ogluszka, Agata Nawrocka, Ewa Polawska, Agata Grzesiak, Brygida Slaska, Chandra S. Pareek, Urszula Czarnik, Mariusz Pierzchala
Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Ligang Yang, Chao Yang, Zhixiu Song, Min Wan, Hui Xia, Xian Yang, Dengfeng Xu, Da Pan, Hechun Liu, Shaokang Wang, Guiju Sun
Summary: Postprandial metabolism plays significant roles in various pathological conditions, and the n-6/n-3 polyunsaturated fatty acid ratio is closely associated with physiological disorders. This study investigated the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control and hypertriglyceridemia rats. The results showed that the n-6/n-3 PUFA ratio influenced the postprandial response of triglyceride, total cholesterol, tumor necrosis factor alpha, malondialdehyde, and reactive oxygen species in both normal control and hypertriglyceridemia rats.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Gonzalez-Benjumea, Dolores Linde, Juan Carro, Rene Ullrich, Martin Hofrichter, Angel T. Martinez, Ana Gutierrez
Summary: Research on epoxide metabolites from n-3 and n-6 polyunsaturated fatty acids has shown that fungal unspecific peroxygenases can convert these fatty acids into mono-epoxides with high regio- and enantioselectivity. Specifically, Agrocybe aegerita and Collariella virescens enzymes demonstrated 91% conversion rates with strict regioselectivity. This study highlights the potential synthetic utility of fungal peroxygenases in fatty acid epoxidation.
Article
Biochemistry & Molecular Biology
Simona Mattioli, Giulia Collodel, Cinzia Signorini, Elisa Cotozzolo, Daria Noto, Daniela Cerretani, Lucia Micheli, Anna Ida Fiaschi, Gabriele Brecchia, Laura Menchetti, Elena Moretti, Camille Oger, Claudio De Felice, Cesare Castellini
Summary: The study found that the oxidative status and lipid pathways of the liver were widely modulated by PUFA and vitamin E administration, while the oxidative profile of the testis seemed to be particularly affected, opposite to its lipid profile, and the brain was modulated by dietary PUFA.
Article
Cardiac & Cardiovascular Systems
Anthony D. Pisaniello, Peter J. Psaltis, Peta M. King, Ge Liu, Robert A. Gibson, Joanne Tm Tan, MyNgan Duong, Tracy Nguyen, Christina A. Bursill, Matthew Worthley, Stephen J. Nicholls, Belinda A. Di Bartolo
Summary: The study demonstrates that EPA supplementation is more effective than DHA in reducing acute and chronic vascular inflammation, providing a rationale for the cardiovascular benefit observed with high-dose omega-3 fatty acid administration.
Article
Nutrition & Dietetics
Muhan Li, Qiaoyu Shi, Xueyi Jiang, Xuanyi Liu, Wei Han, Xiuqin Fan, Ping Li, Kemin Qi
Summary: Paternal supplementation of n-3 PUFAs before conception improves brain development and function in offspring, and affects gene imprinting. This finding suggests the potential of paternal nutritional intervention to address mental health issues in subsequent generations.
FRONTIERS IN NUTRITION
(2022)
Review
Nutrition & Dietetics
Alexandra Podpeskar, Roman Crazzolara, Gabriele Kropshofer, Benjamin Hetzer, Bernhard Meister, Thomas Mueller, Christina Salvador
Summary: The review highlights the significance of adequate nutrition and the role of n-3 polyunsaturated fatty acids in childhood cancer, emphasizing the need for further research and clinical trials to confirm their anti-cancer effects.
Article
Cardiac & Cardiovascular Systems
Are Annesonn Kalstad, Peder Langeland Myhre, Kristian Laake, Sjur Hansen Tveit, Erik Berg Schmidt, Paal Smith, Dennis Winston Trygve Nilsen, Arnljot Tveit, Morten Wang Fagerland, Svein Solheim, Ingebjorg Seljeflot, Harald Arnesen
Summary: The addition of 1.8g n-3 PUFA to standard care did not result in a significant reduction in cardiovascular events during a 2-year follow-up in elderly patients with recent AMI.
Article
Biochemistry & Molecular Biology
Jiaomei Li, Yi Wan, Zhaohong Zheng, Huaqi Zhang, Yang Li, Xiaofei Guo, Kelei Li, Duo Li
Summary: Our study found that a maternal diet rich in n-3 PUFAs significantly reduces the risk of offspring developing mammary cancer, and supplementation of maternal n-3 PUFAs can also alter the composition of offspring's gut microbiota and decrease the levels of inflammatory factors.
Review
Nutrition & Dietetics
Alice Cartoni Mancinelli, Simona Mattioli, Cornelia Twining, Alessandro Dal Bosco, Ann M. Donoghue, Komala Arsi, Elisa Angelucci, Diletta Chiattelli, Cesare Castellini
Summary: This study provides an overview of the main strategies for enriching and preserving n-3 LC-PUFA in poultry products, which include dietary supplementation and improving rearing conditions. Additionally, factors such as genotype, rearing system, transport, and cooking processes can impact the content of this fatty acid in poultry products.
Article
Clinical Neurology
Erika F. H. Saunders, Dahlia Mukherjee, Tiffany Myers, Emily Wasserman, Ahmad Hameed, Venkatesh Bassappa Krishnamurthy, Beth Maclntosh, Anthony Domenichiello, Christopher E. Ramsden, Ming Wang
Summary: The study investigated the preliminary efficacy of a high n-3 plus low n-6 (H3-L6) dietary intervention in improving mood stability in Bipolar Disorder (BD) patients. Results showed that the H3-L6 group had reduced variability in mood, energy, irritability, and pain compared to the control group, but no significant differences were found in mean ratings of mood symptoms between the two groups. The dietary intervention showed potential in improving mood symptom variability in BD participants.
Article
Nutrition & Dietetics
Estefania Aparicio, Carla Martin-Grau, Cristina Bedmar, Nuria Serrat Orus, Josep Basora, Victoria Arija
Summary: This study found that factors such as high education levels, older age, consumption of fish and seafood, and non-smoking are significantly associated with serum fatty acid concentrations in pregnant women, leading to a better omega-3 fatty acid profile. Further research is needed to explore the health consequences of these findings.
Article
Nutrition & Dietetics
William S. Harris, Nathan L. Tintle, JoAnn E. Manson, Adam H. Metherel, Jennifer G. Robinson
Summary: The study investigated the effects of menopausal hormone therapy on the RBC PUFA concentrations in postmenopausal women, revealing an increase in DHA and a decrease in DPA levels after HT. This suggests that HT may stimulate the synthesis of DHA and DPA, highlighting the need for further research into the clinical implications of these changes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
James H. J. O'Keefe, Evan L. O'Keefe, Carl J. Lavie
Summary: Impressive scientific evidence supports the use of omega-3 in the treatment and prevention of heart failure. The GISSI-HF trial showed that omega-3 can reduce the rate of death or hospitalization for cardiovascular reasons, as well as overall mortality, in patients with heart failure. This benefit was consistent across different subgroups.
JACC-HEART FAILURE
(2022)
Review
Chemistry, Medicinal
Djenisa H. A. Rocha, Diana C. G. A. Pinto, Artur M. S. Silva
Summary: Inflammation is the organism's response to injury and a major cause of death worldwide. Chronic inflammatory diseases pose the greatest threat to human health, and seaweeds offer potential as a source of anti-inflammatory compounds for drug development.
