Article
Gastroenterology & Hepatology
Mirco Glitscher, David Heiler Martin, Kathrin Woytinek, Benjamin Schmidt, Denna Tabari, Catharina Scholl, Julia C. Stingl, Evelyn Seelow, Mira Choi, Eberhard Hildt
Summary: The study found that HEV infection leads to decreased cellular cholesterol levels and affects lipid concentrations in patients. Modulating intracellular cholesterol content through drug treatment can impact HEV release, with cholesterol playing a crucial role in this process. This highlights the potential of targeting cholesterol metabolism as an antiviral strategy against HEV.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jia Zhang, Yuqi Zhou, Zhaoting Jiang, Chenhui He, Bo Wang, Qi Wang, Zeqian Wang, Tong Wu, Xiaoqi Chen, Ziwei Deng, Chunying Li, Zhe Jian
Summary: In this study, novel sunscreen products based on melanin-inspired PDA nanoparticles were designed and prepared, showing superior effects in protecting against photodamage and photoaging. The mechanism of action of the sunscreen was also investigated, providing new insights for the development of sun protection products.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yasunari Haseda, Lisa Munakata, Chiyo Kimura, Yumi Kinugasa-Katayama, Yasuko Mori, Ryo Suzuki, Taiki Aoshi
Summary: The DOTAP/D35/aluminum salt adjuvant developed in this study induced strong T cell and antibody responses against a model protein antigen with a single immunization. In vitro studies showed that strong mutual interactions among the adjuvant component and the model antigen were important factors for this efficient immune induction. In vivo imaging of the antigen distribution indicated that the DOTAP component in the adjuvant formulation elicited transient antigen accumulation at draining lymph nodes, possibly by antigen uptake DC migration.
Article
Chemistry, Multidisciplinary
Changguo Gong, Xiao Zhang, Min Shi, Feng Li, Shuang Wang, Yan Wang, Yugang Wang, Wei Wei, Guanghui Ma
Summary: Research shows that under low-pH conditions, the uptake efficiency of tumor exosomes increases while retaining cell specificity. A glycerolipid self-aggregation-based mechanism is revealed through lipidomics analysis and molecular simulations to enhance homologous uptake. By using near-infrared irradiation to induce exosome rupture and release chemodrugs, a smart drug delivery platform is developed for enhanced antitumor effects.
Article
Multidisciplinary Sciences
Hossam G. Tohamy, Mahmoud S. El-Neweshy, Mohamed Mohamed Soliman, Samy Sayed, Mustafa Shukry, Heba I. Ghamry, Hoda Abd-Ellatieff
Summary: The study found that royal jelly has a protective effect against HDU-induced hepatic injury by maintaining the hepatic oxidative/antioxidative status, reducing inflammation, and inhibiting cell apoptosis. This suggests that royal jelly could be used as an adjuvant therapy in patients on long-term HDU medication.
Article
Multidisciplinary Sciences
Zhengyun Liu, Yan Xu, Wanling Zhang, Xinghong Gao, Guo Luo, Hong Song, Jie Liu, Huan Wang
Summary: JS-K, a nitric oxide-releasing diazeniumdiolates, showed efficacy against Hepatitis B virus (HBV)-positive HepG2.2.15 cells by affecting the expression of various proteins. Among the differentially expressed proteins, TAGLN was identified as a potential important target for JS-K against HBV-positive liver cancer cells.
SCIENTIFIC REPORTS
(2021)
Article
Integrative & Complementary Medicine
Canhong Wang, Deqian Peng, Yangyang Liu, Yulan Wu, Peng Guo, Jianhe Wei
Summary: The study showed that agarwood alcohol extracts have a positive effect on ethanol-induced gastric ulcers by reducing ulcer occurrence and inhibiting oxidation and inflammation processes.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Review
Developmental Biology
Cristian O'Flaherty, Eleonora Scarlata
Summary: This review focuses on the enzymatic antioxidant mechanisms of spermatozoa to combat oxidative stress, highlighting the differences among mammalian species. The balance between reactive oxygen species (ROS) production and antioxidant enzymes is crucial for sperm capacitation and quality. Understanding the molecular mechanisms affected by oxidative stress and developing personalized antioxidant therapy are of paramount importance for diagnosing and treating male infertility associated with oxidative damage.
Article
Cell Biology
Yang Huang, Jinglan Li, Wenzhe Li, Nanping Ai, Haiying Jin
Summary: Age-related cataract is a major cause of vision impairment worldwide. Biliverdin and bilirubin redox pair may have therapeutic effects on this condition by protecting lens epithelial cells from damage and regulating certain molecular pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)