Article
Immunology
Jennifer K. Mulligan, Dianna Nord, Maria V. Villanueva, Jeb Justice, Brian Lobo, Rodney J. Schlosser, Carl Atkinson
Summary: The study reveals the regulatory role of complement activation on vitamin D metabolism in airway epithelial cells, particularly the elevated C3/C3a in patients with chronic rhinosinusitis with nasal polyps, which may impair 1,25(OH)(2)D-3 metabolism and explain limited therapeutic benefits from oral vitamin D-3 supplementation.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ana Karla Bittencourt Mendes, Paola Miranda Sulis, Fernanda Carvalho Cavalari, Diana Patricia Rey Padilla, Marcela Aragon, Joana Margarida Gaspar, Fatima Regina Mena Barreto Silva
Summary: The study investigated the short-term effects of 1,25-D-3 on insulin resistance and blood sugar, showing improvements in liver enzyme activity and serum lipids. Treatment with 1,25-D-3 was found to enhance insulin secretion and regulate glucose homeostasis through the activation of ion channels and proteins in beta cells.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Immunology
Francesca Lazzara, Rosario Amato, Chiara Bianca Maria Platania, Federica Conti, Tsung-Han Chou, Vittorio Porciatti, Filippo Drago, Claudio Bucolo
Summary: The study found that treatment with 1,25(OH)(2)D-3 can improve retinal function in age-related glaucomatous mice, reduce retinal ganglion cell death, and decrease the expression of inflammatory cytokines. This may help alleviate retinal damage in glaucoma patients and merits further clinical evaluation for the treatment of optic neuropathies.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Robert H. Mak, Uwe Querfeld, Alex Gonzalez, Sujana Gunta, Wai W. Cheung
Summary: The supplementation of 25(OH)D-3 in CKD mice showed metabolic advantages by attenuating adipose tissue browning and muscle wasting, in contrast to the repletion of 1,25(OH)(2)D-3.
Article
Veterinary Sciences
Jianhong Gu, Wenyan Min, Yutian Zhao, Xueqing Zhang, Yan Yuan, Xuezhong Liu, Jianchun Bian, Xishuai Tong, Zongping Liu
Summary: The study demonstrates that Gal-3 mediates the differentiation and bone resorption of osteoclasts regulated by 1 alpha,25(OH)(2)D-3. Inhibiting Gal-3 weakens the effects of vitamin D on osteoclastogenesis and bone resorption, while overexpression of Gal-3 enhances these effects. The upregulation of Gal-3 mRNA and RANKL expression by 1 alpha,25(OH)(2)D-3 plays a crucial role in promoting osteoclastogenesis and bone resorption.
VETERINARY SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yi Xiong, Feng Zhou, Yeyu Liu, Zumu Yi, Xinyu Wang, Yingying Wu, Ping Gong
Summary: The study suggests that in diabetic patients, advanced glycation end products (AGEs) affect angiogenesis, while 1,25D can improve angiogenesis function by inhibiting excessive autophagy and oxidative stress. Additionally, therapeutic strategies for vascular complications in diabetic patients may need to target AGEs-induced oxidative stress and autophagy.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Chemistry, Medicinal
Kouta Ibe, Haruki Nakada, Mayu Ohgami, Takeshi Yamada, Sentaro Okamoto
Summary: Novel des-D-ring interphenylene analogs of vitamin D3 were designed and synthesized, and it was found that these analogs exhibited certain VDR binding affinity and ability to promote gene transcription.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Yiraldine Herrera-Martinez, Maria Jose Contreras Gonzalez, Sergio Pedraza-Arevalo, Maria del Carmen Guerrero Martinez, Angela Rodrigo Martinez, Alberto Gonzalez Menchen, Maria Angeles Blanco Molina, Maria Angeles Galvez-Moreno, Alberto L. Moreno-Vega, Raul M. Luque, Aura D. Herrera-Martinez
Summary: Hypercalcemia is a common complication in cancer patients, usually caused by the secretion of Parathyroid hormone-related protein (PTHrP). However, this case report presents a rare source of hypercalcemia in a patient with gastrointestinal stromal tumors (GIST) - calcitriol secretion. The patient's hypercalcemia was successfully controlled with medical treatment before undergoing surgery for complete tumor resection. Molecular analysis confirmed the presence of genes associated with calcitriol-mediated mechanism in the tumor cells.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Ana Paula Zanatta, Renata Goncalves, Fabiana Ourique da Silva, Rozangela Curi Pedrosa, Leila Zanatta, Helene Bouraima-Lelong, Christelle Delalande, Fatima Regina Mena Barreto Silva
Summary: The study investigated the rapid responses of rat testis to estradiol (E-2) and 1 alpha,25(OH)(2) vitamin D-3 (1,25-D-3), revealing their effects on calcium uptake, estrogen receptors, cyclin expression, and downstream signaling pathways. Both hormones elicited rapid responses at the plasma membrane to regulate gene and protein expression related to cell cycle regulation and spermatogenesis.
Article
Biochemistry & Molecular Biology
Yixuan Jiang, Wenqiong Luo, Bin Wang, Zumu Yi, Ping Gong, Yi Xiong
Summary: The study found that in diabetes, 1,25D improves bone metabolism by inhibiting excessive autophagy. The PI3K/Akt/FoxO1 signaling pathway is involved in the osteoprotective effect of 1,25D in diabetes-induced bone loss.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Oncology
Peng Li, Xinhai Zhu, Guangchao Cao, Ruan Wu, Ke Li, Wenhui Yuan, Biyun Chen, Guodong Sun, Xichun Xia, Hua Zhang, Xiao Wang, Zhinan Yin, Ligong Lu, Yunfei Gao
Summary: This study demonstrates that serum vitamin D level is negatively correlated with the expression of PD-1, TIGIT, and Tim-3, while positively correlated with the expression of CD28 on CD8(+) and V gamma 9V delta 2(+) T cells in patients with NSCLC. The active form of vitamin D, 1 alpha,25(OH)(2)D-3, promotes the nuclear translocation of VDR and inhibits the expression of ICRs by binding to their promoter regions. In addition, VDR-mediated Ca2+ influx enhances Th1 cytokine production and increases antitumor immunity in T cells. Overall, this research highlights the pleiotropic effects of 1 alpha,25(OH)(2)D-3 in rescuing exhausted cytotoxic T cells and promoting antitumor immunity in patients with tumor.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Microbiology
Maria Elena Romero-Ibarguengoitia, Dalia Gutierrez-Gonzalez, Carlos Cantu-Lopez, Miguel Angel Sanz-Sanchez, Arnulfo Gonzalez-Cantu
Summary: This study aimed to evaluate the effect of vitamin D3 supplementation vs. dietary-hygienic measures on the SARS-CoV-2 infection rate in participants with serum 25(OH)D3 levels between 20-100 ng/mL. The results showed that participants who received vitamin D3 supplementation had a lower rate of SARS-CoV-2 infection compared to those who used dietary-hygienic measures during the 6-month follow-up.
Article
Biochemistry & Molecular Biology
Pawel Brzeminski, Adrian Fabisiak, Radomir M. Slominski, Tae-Kang Kim, Zorica Janjetovic, Ewa Podgorska, Yuwei Song, Mohammad Saleem, Sivani B. Reddy, Shariq Qayyum, Yuhua Song, Robert C. Tuckey, Venkatram Atigadda, Anton M. Jetten, Rafal R. Sicinski, Chander Raman, Andrzej T. Slominski
Summary: This study established new routes for the chemical synthesis of vitamin D-3 and its hydroxy metabolites. The compounds showed similar properties in inhibiting cell proliferation and inducing cell differentiation, as well as effects on T-cell immune activity. They also interacted with nuclear receptors in a similar manner. The findings have important implications for studying the role of these compounds in the immune system and inflammatory diseases.
BIOORGANIC CHEMISTRY
(2022)
Article
Pathology
Yi Xiao, Edward Ki Yun Leung
Summary: This study developed a rapid LC-MS/MS method for the simultaneous measurement of multiple fat-soluble vitamins. The method showed good linearity and low variability at various quality control levels.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)