Article
Endocrinology & Metabolism
Jo E. Lewis, Orla RM. Woodward, Danae Nuzzaci, Christopher A. Smith, Alice E. Adriaenssens, Lawrence Billing, Cheryl Brighton, Benjamin U. Phillips, John A. Tadross, Sarah J. Kinston, Ernesto Ciabatti, Berthold Goettgens, Marco Tripodi, David Hornigold, David Baker, Fiona M. Gribble, Frank Reimann
Summary: This study investigated the role of insulin-like peptide 5 (INSL5) signalling through its receptor RXFP4 in the regulation of appetite. The findings demonstrate that RXFP4(VMH) neurons in the hypothalamus play a role in food intake and preference, and hypothalamic RXFP4 signalling can be targeted to manipulate feeding behavior.
MOLECULAR METABOLISM
(2022)
Article
Biotechnology & Applied Microbiology
Chris M. Vermeer, Larissa J. Bons, Robbert Kleerebezem
Summary: Using microbial enrichment cultures for the production of waste-derived polyhydroxyalkanoates (PHAs) is a promising technology. This research investigates the use of isobutyrate and butyrate as sole carbon sources for a microbial enrichment culture and found that isobutyrate has distinct effects on microbial community development, PHA productivity, and composition. Furthermore, the study identifies the production of a unique PHA, poly(3-hydroxyisobutyrate) (PHiB), by a dominant microorganism, demonstrating the potential of mixed microbial communities for the discovery of new metabolic pathways and polymers.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Oncology
Federica Donnarumma, Valeria Tucci, Concetta Ambrosino, Lucia Altucci, Vincenzo Carafa
Summary: This review summarizes the current research findings on the structural features and biological role of the novel targetable epigenetic enzyme NAA60, which has unique enzymatic properties and cellular localization, and plays a significant role in regulating gene transcription activation and protein action.
CLINICAL EPIGENETICS
(2022)
Article
Chemistry, Multidisciplinary
Luciana Randazzo, Michela Ricca, Anna Arcudi, Maria Antonietta Zicarelli, Francesco Lia, Fabrizio Sudano, Andrea Maria Gennaro, Mauro Francesco La Russa
Summary: This research is a stylistic and archaeometric study of an ancient marble female bust recently discovered in Southern Italy. The research aimed to establish the authenticity and origin of the artwork, as well as provide information about its composition and any previous restoration interventions. Various analytical techniques were used, and the results confirmed the originality of the artifact, emphasizing its importance in the Italian cultural heritage catalog.
APPLIED SCIENCES-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Djamila Onesime, Lea Vidal, Stephane Thomas, Celine Henry, Veronique Martin, Gwenaelle Andre, Piotr Kubiak, Philippe Minard, Ewelina Celinska, Jean-Marc Nicaud
Summary: Yarrowia lipolytica has been found to have a family of extracellular fatty acid binding proteins, proposed to be named eFbp1 to eFbp4. The exact mechanism of action of these proteins remains to be elucidated, but they are expected to have applications in lipid biotechnology, such as improving fatty acid production and bioconversion.
MICROBIAL CELL FACTORIES
(2022)
Article
Cardiac & Cardiovascular Systems
P. R. R. van Gorp, J. Zhang, J. Liu, R. Tsonaka, H. Mei, S. O. Dekker, C. Bart, T. De Coster, H. Post, A. J. R. Heck, M. J. Schalij, D. E. Atsma, D. A. Pijnappels, A. A. F. de Vries
Summary: This study used conditionally immortalized iAMs cells to identify and characterize genes with unknown functions in cardiomyocyte differentiation. Sbk2 was identified as a regulator of atrial sarcomerogenesis.
CIRCULATION RESEARCH
(2022)
Review
Clinical Neurology
Cedric Gollion, Roberto De Icco, David W. Dodick, Hakan Ashina
Summary: This article critically appraises the evidence for and against premonitory symptoms in migraine being due to hypothalamic dysfunction. While there are some physiological effects and neuroimaging results associated with premonitory symptoms, the available evidence is limited by methodologic issues and inconsistent definitions. Therefore, whether to attribute premonitory symptoms to hypothalamic dysfunction requires more rigorously designed studies to determine.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Astronomy & Astrophysics
Arpan Ghosh, Saurabh Sharma, Joe P. Ninan, Devendra K. Ojha, Bhuwan C. Bhatt, Shubham Kanodia, Suvrath Mahadevan, Gudmundur Stefansson, R. K. Yadav, A. S. Gour, Rakesh Pandey, Tirthendu Sinha, Neelam Panwar, John P. Wisniewski, Caleb Canas, Andrea S. J. Lin, Arpita Roy, Fred Hearty, Lawrence Ramsey, Paul Robertson, Christian Schwab
Summary: The Gaia Alert System issued an alert for Gaia 20eae on August 28, 2020, identifying it as a new member of the FUor/EXor family. The brightening of Gaia 20eae is attributed to intrinsic changes in its spectral energy distribution, with strong turbulent outflow and accretion signatures observed during the current outburst phase.
ASTROPHYSICAL JOURNAL
(2022)
Article
Physiology
Jingjing Gao, Rui Gao, Hu Li, Xi Liu, Pan Gao, Junhua Du, Hui Jiang, Xiansheng Zhang
Summary: Ejaculation is a complex process with unclear factors, leading to ejaculation dysfunction. Gene polymorphism may play a role in lifelong premature ejaculation (LPE), but identifying the actual genetic loci has been unsuccessful. This study aims to identify the genetic loci contributing to LPE through rat models and whole-transcriptome sequencing, providing a theoretical basis for targeted therapy.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yu Zheng, Xinda Xu, Fanglu Chi, Ning Cong
Summary: Ischemia-reperfusion (I/R) injury can cause cell death and organ dysfunction, and different types of cell death occur during this process. Pyroptosis, closely related to I/R injury, may be targeted for the treatment of I/R injury by focusing on its signaling pathways and key regulators.
Article
Nutrition & Dietetics
Alessio Molfino, Sara Emerenziani, Giuseppe Tonini, Daniele Santini, Antonietta Gigante, Michele Pier Luca Guarino, Chiara Nuglio, Giovanni Imbimbo, Annalisa La Cesa, Michele Cicala, Maurizio Muscaritoli
Summary: This study evaluated the prevalence of anorexia, hypophagia, and cachexia in patients with gastrointestinal or lung cancer at time of diagnosis. The results showed that 68% of patients had cachexia, 57% had anorexia, and 48% had hypophagia. These conditions had negative impacts on patients' nutritional intake, indicating a need for early multimodal strategies to improve food intake.
FRONTIERS IN NUTRITION
(2023)
Article
Nutrition & Dietetics
Isabel van Ackern, Angela Kuhla, Bjoern Kuhla
Summary: The endocannabinoid system is crucial in regulating food intake, with pharmacological activation increasing intake in energy-deficient stages, particularly in intermittent feeders. Injection of 2-AG and AEA can boost food intake in the short term, with varying responses to food deprivation, 2-AG showing higher sensitivity than AEA.
Review
Cell Biology
Ying-Qi Song, Chun Wu, Ke-Jia Wu, Quan-Bin Han, Xiang-Min Miao, Dik-Lung Ma, Chung-Hang Leung
Summary: The ubiquitin-proteasome system plays a crucial role in regulating cellular protein degradation, affecting processes like cell cycle control and DNA repair. Aberrant ubiquitination and degradation of tumor suppressor proteins can lead to cancer growth and metastasis. Targeting the ubiquitination cascade reaction has emerged as a potential strategy for treating malignant diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Entomology
Krzysztof. J. J. Rudzinski, Dorota Staszek, Monika Asztemborska, Lidia Sukovata, Jerzy Raczko, Marek Cieslak, Andrzej Kolk, Rafal Szmigielski
Summary: The larvae of the pine-tree lappet moth are harmful defoliators of pine trees in Europe and Asia. The discovery of unknown components of their sex pheromone opens up possibilities for improving trapping methods and monitoring systems. The study identified new components and tested their attractiveness to male moths. The findings provide a basis for developing more effective lures.
Article
Environmental Sciences
Baohong Yu, Yajun Peng, Jieru Xu, Dan Qin, Tiancong Gao, Haiyan Zhu, Shihao Zuo, Hongchuan Song, Jinyan Dong
Summary: The plant Youngia japonica has the typical properties of a Cd hyperaccumulator, showing enhanced growth at low Cd concentrations but inhibited growth at high Cd concentrations. The application of Cd(II) in soil significantly affects plant growth and biomass. Enzyme activities in Y. japonica have implications for soils contaminated with Cd.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)