Article
Chemistry, Applied
Ai Suzuki-Iwashima, Ai Iwasawa, Mayumi Kawai, Hiroaki Kubouchi, Ryuhei Ozaki, Kazuo Miyashita, Makoto Shiota
Summary: The study demonstrated that milk SPGs extracted from butter serum inhibited the oxidation of fish oil TAG more effectively than a standard SPG (d18:1), and the reaction products from d18:0 showed stronger antioxidant activity than those from d18:1, suggesting that d18:0 may be a significant factor contributing to the difference in antioxidant activity between milk SPGs and d18:1.
Article
Biochemical Research Methods
Jing Zhao, Lipeng Qiao, Yu Xia
Summary: In this study, a MS/MS method based on CID-triggered RDD was developed to characterize sphingoid bases in depth. By applying this method in experiments, the structural diversity of sphingoid bases and novel variations in sphingolipid metabolism were revealed.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Article
Biochemistry & Molecular Biology
Daisuke Mikami, Shota Sakai, Megumi Nishimukai, Kohei Yuyama, Katsuyuki Mukai, Yasuyuki Igarashi
Summary: This study revealed that the structural differences among LCBs, particularly geometric isomerism at the C8-C9 position, significantly affected the absorption percentages and ratio of metabolites. It is the first report to elucidate that the absorption and metabolism of sphingolipids are dependent on their LCB structure. These findings could be utilized for developing functional foods that are more readily absorbed.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jing Li, Kenneth A. Satyshur, Lian-Wang Guo, Arnold E. Ruoho
Summary: Both bioactive sphingolipids and Sigma-1 receptor (S1R) chaperones are widely present in mammalian cell membranes. Endogenous compounds that regulate the S1R play an important role in controlling S1R responses to cellular stress. This study investigated the interaction between S1R and sphingosine (SPH) and N,N'-dimethylsphingosine (DMS) in intact Retinal Pigment Epithelial cells (ARPE-19) and suggested that SPH and DMS are endogenous S1R agonists. Molecular docking analysis showed strong interactions between SPH/DMS and specific residues in the S1R, indicating a membrane bilayer pathway for SPH/DMS to access the S1R beta barrel. The enzymatic control of ceramide concentrations in intracellular membranes may dictate the availability of SPH and DMS to S1R and subsequently regulate S1R activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Lili Fan, Yanmei Zhang, Jiejie Hu, Yuan Fang, Ren Hu, Wei Shi, Bin Ren, Changjian Lin, Zhong-Qun Tian
Summary: The CaP coatings prepared by electrochemical deposition exhibit a modulation on cell proliferation for different cells, with the modulation magnitude depending on cellular size and mainly attributed to the microstructure of the coatings. Crystallinity plays a significant role in the osteogenic property of OCP coatings, with high-crystalline OCP nanocrystals showing a surface rich in HPO42-.
Article
Engineering, Manufacturing
Wenjin Hu, Keith Skowronski, Yan Dong, Yongyi Shou
Summary: This study examines the impact of supply base mergers and acquisitions (M&As) on focal firms' cost of goods sold (COGS). The findings show that supply base M&As are positively associated with focal firm COGS, but this relationship is attenuated when the supply base is less concentrated and more differentiated.
PRODUCTION AND OPERATIONS MANAGEMENT
(2023)
Article
Biochemistry & Molecular Biology
Le Zhai, Yue Jiang, Yang Shi, Miao Lv, Ya-Li Pu, Hua-Lei Cheng, Jia-Yu Zhu, Ke-Wu Yang
Summary: The irregular use of antibiotics has led to the development of antibiotic-resistant bacteria, specifically metallo-beta-lactamases. This study identified eight compounds that have strong inhibitory effects on NDM-1, with one compound being the most effective inhibitor. The presence of a hydroxyl group in the compounds was found to improve their inhibitory activity. Additionally, these compounds demonstrated antibacterial effects on NDM-1-producing bacteria and showed low cytotoxicity in cell experiments.
BIOORGANIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Ludmila Zylinska, Malwina Lisek, Feng Guo, Tomasz Boczek
Summary: Vitamin C is important for antioxidant defense and its deficiency in the nervous tissue can lead to disruptions in neurotransmission and brain function. Calcium plays a crucial role in neuronal processes and Vitamin C has a unique role in regulating calcium-involved pathways in the brain.
Article
Dentistry, Oral Surgery & Medicine
Tomasz Wach, Marcin Kozakiewicz
Summary: This study demonstrates that blended collagen-calcium phosphate as a bone substitute material can achieve satisfactory and predictable outcomes in jawbone regeneration. Texture analysis revealed that all 4 features described the healing process well. Over a 12-month period, bone regeneration was confirmed by 3 of the 4 investigated features, with only Entr indicating CP remnants in the ROI.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Nutrition & Dietetics
Joungbo Ko, Choongsung Yoo, Dante Xing, Drew E. Gonzalez, Victoria Jenkins, Broderick Dickerson, Megan Leonard, Kay Nottingham, Jacob Kendra, Ryan Sowinski, Christopher J. Rasmussen, Richard B. Kreider
Summary: Recent research shows that encapsulating vitamins and minerals with liposomes can improve their bioavailability. This study aimed to compare the effects of liposomal and non-liposomal multivitamin and mineral supplements on the appearance and clearance of nutrients in the blood. The results suggest that coating a multivitamin supplement with liposomes affects the pharmacokinetic profiles of individual nutrients.
Article
Agriculture, Dairy & Animal Science
Su A. Lee, Leidy J. Torres-Mendoza, Hans H. Stein
Summary: Supplementing diets for gestating sows with vitamin D metabolites and microbial phytase can improve calcium and phosphorus balance and energy digestibility. Microbial phytase supplementation increases the digestibility and retention of calcium and phosphorus.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Ke Li, Shuiyuan Li, Fanrong Ai, Jinchao Yan, Kui Zhou
Summary: A new method was developed to prepare Sr-doped HA 3D porous scaffolds, which promote osteoblast differentiation and the formation of new bones. This alternative method is suitable for preparing ion-doping ceramic scaffolds for bone tissue engineering.
Article
Biochemistry & Molecular Biology
Paulina Kazimierczak, Joanna Wessely-Szponder, Krzysztof Palka, Adriana Barylyak, Viktor Zinchenko, Agata Przekora
Summary: This study comprehensively compared the biomedical potential of fabricated HAP- and FAP-based bone scaffolds. The results showed that FAP-based biomaterial had higher biodegradability and absorbability, but both materials had similar biocompatibility and osteoconductivity, indicating their promising potential for bone regeneration applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shuang Gao, Yu Chen, Jungang Zhao, Rongrong Jing, KeKe Guo, Lusheng Wang, Xuenan Li, Chengliang Li, Zhenlin Hu, Nuo Xu
Summary: The balance between keratinocyte proliferation and differentiation as well as the formation of the epidermal permeability barrier relies on calcium, with oat beta-glucan showing potential in promoting epidermal differentiation and barrier recovery. Mechanistically, the positive interaction between OG and the dectin-1 receptor leads to increased sensitivity of keratinocytes to extracellular Ca2+ through activation of the CaSR pathway, ultimately aiding in the maintenance of normal keratinocyte differentiation and promoting epidermal barrier recovery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Sport Sciences
Katarzyna Hodun, Adrian Chabowski, Marcin Baranowski
Summary: Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid found in all eukaryotic cells, functioning as an intracellular second messenger and being enriched in plasma and blood cells. It regulates various cellular processes and plays a crucial role in muscle physiology and pathophysiology. Studies have shown that exercise can modulate S1P metabolism in both muscle and blood.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)